☆ 4.7 Editorial Material

More than antioxidant: N-acetyl-L-cysteine in a murine model of endometriosis

FERTILITY AND STERILITY (2010)

Journal

FERTILITY AND STERILITY

Volume 94, Issue 7, Pages 2905-2908

Publisher

ELSEVIER SCIENCE INC

DOI: 10.1016/j.fertnstert.2010.06.038

Keywords

Cyclooxygenase-2; differentiation; E-cadherin; invasiveness; Ki-67; matrix metalloproteinase 9; proliferation

Categories

Obstetrics & Gynecology Reproductive Biology

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Abstract

N-acetyl-L-cysteine exerts a complex action on endometrial cells, involving regulation of gene expression and protein activity and location, all converging into a decreased proliferation and a switch toward a differentiating, less invasive, and less inflammatory phenotype. Also considering the lack of undesired side effects, including unaffected fertility potential, this suggests a beneficial use of NAC in endometriosis clinical treatment. (Fertil Steril (R) 2010;94:2905-8. (c) 2010 by American Society for Reproductive Medicine.)

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