Article
Infectious Diseases
O. Escobar-Chavarria, R. Cossio-Bayugar, P. Ramirez-Noguera, M. G. Prado-Ochoa, A. M. Velazquez-Sanchez, M. A. Munoz-Guzman, E. Angeles, F. Alba-Hurtado
Summary: Ethyl-4-bromophenylcarbamate (LQM 919) and ethyl-4-chlorophenylcarbamate (LQM 996) have the ability to induce apoptosis in Rhipicephalus microplus ovarian cells, as well as tick and mammalian cell cultures, displaying a significant acaricidal effect.
TICKS AND TICK-BORNE DISEASES
(2021)
Article
Multidisciplinary Sciences
Steven A. Chambers, Mathew Newman, Melissa M. Frangie, Alena Savenka, Alexei G. Basnakian, Mohammad A. Alam
Summary: The discovery of chimeric anti-melanoma agents with potent growth suppressor effects on melanoma cells was reported. These agents induced cell apoptosis through multiple pathways and showed greater cytotoxicity to melanoma cells compared to the commonly used agent dacarbazine.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Genetics & Heredity
Alberto Ferrigno, Giovanni Ruvolo, Giuseppina Capra, Nicola Serra, Liana Bosco
Summary: The study demonstrated a strong correlation between DFI and sperm morphology, suggesting that spermatozoa with abnormal morphology are more likely to contain DNA damage.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Xianrong Xiong, Yulei Hu, Bangting Pan, Yanjin Zhu, Xixi Fei, Qinhui Yang, Yumian Xie, Yan Xiong, Daoliang Lan, Wei Fu, Jian Li
Summary: This study found that RFRP-3 regulates apoptosis and steroidogenesis in yak cumulus cells (CCs), as well as affects the developmental potential of yak oocytes, by binding with specific G protein-coupled receptors (GPRs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Xiao Han, Min Zhang, Hong-Jie Yuan, Guo-Liang Wang, Xin-Yue Zhao, Zhi-Bin Li, Shuai Gong, Jing-He Tan
Summary: This study identified and validated new CE- and apoptosis-regulating miRNAs in cumulus cells, which could serve as biomarkers for selecting competent oocytes/embryos and for understanding the regulation of cumulus expansion and cumulus cell apoptosis by oocyte-derived factors.
MOLECULAR HUMAN REPRODUCTION
(2022)
Article
Environmental Sciences
Saihong Yan, Jun Wang, Ziting Zheng, Fenfen Ji, Liang Yan, Lihua Yang, Jinmiao Zha
Summary: Benzophenone-type ultraviolet (UV) filters (BPs) are commonly used in sunscreens, fragrances, and plastics, but they pose a great threat to aquatic organisms. This study investigated the toxicity and mechanism of BPs in Chinese rare minnows and found that they caused significant alterations in cell cycle, DNA replication, and repair pathways, as well as DNA damage and apoptosis.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Engineering, Biomedical
Irum Gul, Uzma Yunus, Muhammad Ajmal, Moazzam Hussain Bhatti, Gul-e-Saba Chaudhry
Summary: The use of polymeric thin films loaded with the anti-cancer drug CP has shown promising results in reducing side effects and improving efficacy, particularly in the treatment of breast cancer. The controlled and burst release properties of these films indicate their potential for targeted drug delivery.
BIOMEDICAL MATERIALS
(2021)
Article
Environmental Sciences
Saihong Yan, Rui Chen, Miao Wang, Jinmiao Zha
Summary: The study revealed that exposure to carbamazepine induced DNA damage and apoptosis in Chinese rare minnows through the Ras/Raf/ERK/p53 signaling pathway.
ENVIRONMENTAL POLLUTION
(2021)
Article
Plant Sciences
Shilpa Sadwal, Sanjay Bharati, Zahid Ahmad Dar, Sarvnarinder Kaur
Summary: The hydroethanolic extract of Murraya koenigii leaves (HEMKLE) shows chemopreventive effects against DMBA-induced breast cancer in rats, likely due to the presence of various phytochemicals.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Multidisciplinary Sciences
Xi Ling, Peng Zou, Lin Ao, Niya Zhou, Xiaogang Wang, Lei Sun, Huan Yang, Jinyi Liu, Jia Cao, Qing Chen
Summary: The conventional semen parameter analysis is widely used for assessing male fertility, but about 15% of infertile patients show no abnormalities in these parameters. Additional technologies are needed to explain unexplained infertility and detect hidden sperm defects. Biomarkers of sperm function can reveal sperm physiology at the molecular level and predict male fertility. Flow cytometry techniques can measure these markers accurately, but the time and potential interference need to be taken into consideration.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Cell Biology
Shangren Wang, Jiaqi Kang, Yuxuan Song, Aiqiao Zhang, Yang Pan, Zhexin Zhang, Yuezheng Li, Shuai Niu, Li Liu, Xiaoqiang Liu
Summary: This study evaluated the expression, potential functions, and mechanisms of long noncoding RNAs (lncRNAs) in the pathogenesis of varicocele-induced spermatogenic dysfunction. The results showed that these lncRNAs promote spermatogenic dysfunction by regulating the PI3K-Akt signaling pathway. These DE lncRNAs may serve as potential biomarkers for predicting the risk of spermatogenic dysfunction in varicocele and the effect of surgical repair.
CELL PROLIFERATION
(2022)
Article
Biochemistry & Molecular Biology
Wanjie Wang, Huiying Zou, Nanzhu Chen, Yaqing Tian, Haisheng Hao, Yunwei Pang, Xueming Zhao, Huabin Zhu, Dawei Yu, Weihua Du
Summary: This study found that CLDN6 is expressed in bovine cumulus cells and its knockdown inhibits cell apoptosis, induces cell proliferation, and cell cycle arrest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Andreas Nitsch, Silas Strakeljahn, Josephine M. Jacoby, Konrad F. Sieb, Alexander Mustea, Sander Bekeschus, Axel Ekkernkamp, Matthias B. Stope, Lyubomir Haralambiev
Summary: In this study, it was found that cold atmospheric pressure plasma treatment inhibits the growth, motility, and metabolism of chondrosarcoma cells by initiating apoptotic processes.
Article
Reproductive Biology
Li-Xin Cui, Ya-Qing Tian, Hai-Sheng Hao, Hui-Ying Zou, Yun-Wei Pang, Shan-Jiang Zhao, Xue-Ming Zhao, Hua-Bin Zhu, Wei-Hua Du
Summary: This study investigated the expression and function of ASH1L methyltransferase in bovine cumulus cells, focusing on its role in regulating epigenetic modification, apoptosis, and gene expression in the cells. The results showed that ASH1L knockdown led to decreased histone methylation, inhibited cell proliferation, increased apoptosis, and upregulated expression of apoptosis-related genes. The study also revealed an increase in mRNA levels of PRC2 protein subunits EZH2 and SUZ12 in cells with ASH1L knockdown.
Article
Environmental Sciences
Francielen Barroso Aragao, Ian Drumond Duarte, Dayana Effgen Fantinato, Iasmini Nicoli Galter, Graciele Lurdes Silveira, Gabriela Barreto dos Reis, Larissa Fonseca Andrade-Vieira, Silvia Tamie Matsumoto
Summary: The study showed that a tebuconazole-based fungicide may have phytotoxic, cytotoxic, and genotoxic effects on the roots and meristematic cells of L. sativa at certain concentrations.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)