Review
Chemistry, Medicinal
Amir Ajoolabady, Cynthia Lebeaupin, Ne N. Wu, Randal J. Kaufman, Jun Ren
Summary: This study aims to elucidate the relationship between ER stress and inflammation in obesity, and summarize potential therapeutic strategies for managing obesity through manipulating ER stress and ER stress-associated inflammation.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Helena Leal, Joao Cardoso, Patricia Valerio, Marta Quatorze, Vitor Carmona, Janete Cunha-Santos, Luis Pereira de Almeida, Claudia Pereira, Claudia Cavadas, Pedro Gomes
Summary: The protein SIRT2 is found to play a role in the regulation of hepatic lipid metabolism and its activation might be a therapeutic strategy against obesity and its metabolic complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Aline Fernandes-da-Silva, Carolline Santos Miranda, Daiana Araujo Santana-Oliveira, Brenda Oliveira-Cordeiro, Camilla Rangel-Azevedo, Flavia Maria Silva-Veiga, Fabiane Ferreira Martins, Vanessa Souza-Mello
Summary: Obesity challenges lipid and carbohydrate metabolism, leading to glucolipotoxicity and ER dysfunction, triggering ER stress and metabolic abnormalities. Dietary interventions can alleviate ER stress induced by excessive fat or sugar intake, impacting adipose tissue, liver, and pancreas function.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Tae Jin Kim, Hyun Jung Lee, Do Hyeon Pyun, A. M. Abd El-Aty, Ji Hoon Jeong, Tae Woo Jung
Summary: Valdecoxib (VAL) as a non-steroidal anti-inflammatory drug, alleviates insulin resistance through AMPK/HSPB1-mediated inhibition of inflammation and ER stress in skeletal muscle under hyperlipidemic conditions, making it a potential pharmacotherapeutic agent for management of insulin resistance and type 2 diabetes.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Hao Xie, Yu-han Wang, Xin Liu, Jia Gao, Chunliang Yang, Teng Huang, Lu Zhang, Xi Luo, Zhichao Gao, Ting Wang, Tong Yan, Yanjun Liu, Ping Yang, Qilin Yu, Shiwei Liu, Yi Wang, Fei Xiong, Shu Zhang, Qing Zhou, Cong-Yi Wang
Summary: This study revealed that the deficiency of Ubc9 in adipocytes can protect mice from obesity, insulin resistance, and hepatosteatosis induced by a high-fat diet. The lack of Ubc9 reduces endoplasmic reticulum stress and inflammatory response. Mechanistically, Ubc9 deficiency enhances the degradation of ERp44 and promotes Ero1 alpha secretion to alleviate endoplasmic reticulum stress.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Biochemistry & Molecular Biology
Qiuchi Chen, Wei Fang, Yanan Shen, Dan Xu, Qiang Chen, Kun Cui, Kangsen Mai, Qinghui Ai
Summary: This study found that the deficiency of Cideb alone does not trigger severe inflammation in the liver. However, under ER stress, the expression of Cideb is suppressed by Chop, which inhibits the transport of lipoproteins in the liver, leading to exacerbated hepatic steatosis, oxidative stress, and inflammation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Akshatha N. Srinivas, Diwakar Suresh, Deepak Suvarna, Pankaj Pathak, Suresh Giri, Suchitha Suman, Suchitha Satish, Saravana Babu P. Chidambaram, Divya Kumar
Summary: Tecomella undulata has the potential to ameliorate nonalcoholic steatohepatitis (NASH) and its effects are comparable to approved drugs used to treat human NASH. These findings provide a strong rationale for evaluating Tecomella undulata for the treatment of NASH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Jesus Burillo, Patricia Marques, Beatriz Jimenez, Carlos Gonzalez-Blanco, Manuel Benito, Carlos Guillen
Summary: This review examines the main molecular mechanisms that may be involved in the connection between type 2 diabetes and neurodegenerative diseases, with a focus on inflammation, endoplasmic reticulum stress, autophagy, and mitochondrial dysfunction.
Article
Biochemistry & Molecular Biology
Victor Enrique Sarmiento-Ortega, Diana Moroni-Gonzalez, Alfonso Diaz, Miguel Angel Garcia-Gonzalez, Eduardo Brambila, Samuel Trevino
Summary: Metabolic diseases are a global health problem, and insulin resistance is their key characteristic. By administering exogenous insulin, we successfully developed an animal model of insulin resistance and observed its progression and time-dependent molecular modifications. The results showed that this model combined with oxidative conditions at the hepatic level, but without inflammation.
Article
Pharmacology & Pharmacy
Yufeng Dai, Ruijie Xu, Jinxiang Chen, Jialong Fang, Hao Zhang, Haitao Li, Wei Chen
Summary: This study reveals the important role of the TXA2/TP receptor axis in regulating insulin resistance and hepatic lipid metabolism. Activation of the Ca2+/CaMKIIγ pathway by the TXA2/TP receptor axis promotes insulin resistance through the PERK-Chop-TRB3 signaling pathway. Inhibition of TP receptors improves hepatic steatosis and inflammation, suggesting that the TP receptor could be a potential therapeutic target for NAFLD and metabolic syndrome.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Valentina Antoniotti, Simonetta Bellone, Filipa Patricia Goncalves Correia, Caterina Peri, Sabrina Tini, Roberta Ricotti, Valentina Mancioppi, Mara Gagliardi, Daniele Spadaccini, Marina Caputo, Marco Corazzari, Flavia Prodam
Summary: This study aimed to evaluate the relationship between markers of endoplasmic reticulum stress and metabolic alterations in children and adolescents with obesity. The findings suggest that PDIA3 and CALR may be early markers of obesity and metabolic syndrome risk.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiyue Shen, Kai Luo, Juntao Yuan, Junling Gao, Bingqing Cui, Zhuoran Yu, Zhongbing Lu
Summary: DDAH1 is an important regulator of ADMA levels in NAFLD patients and plays a role in the development of NAFLD. Knockout of hepatic Ddah1 exacerbates liver steatosis and insulin resistance, while overexpression of DDAH1 attenuates NAFLD in mice. DDAH1 affects NF-KB signaling, lipid metabolism, and immune system processes in fatty livers, and reduces S100A11 expression via NF-KB, JNK, and oxidative stress-dependent manner. Strategies to increase DDAH1 activity or decrease S100A11 expression could be potential therapies for NAFLD.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Medicine, Research & Experimental
Lele Cheng, Tao Chen, Manyun Guo, Peining Liu, Xiangrui Qiao, Yuanyuan Wei, Jianqing She, Bolin Li, Wen Xi, Juan Zhou, Zuyi Yuan, Yue Wu, Junhui Liu
Summary: Recent studies have shown changes in bile acid metabolite composition in metabolic disorders, with glycoursodeoxycholic acid (GUDCA) being decreased in hyperglycemic patients. GUDCA supplementation alleviated ER stress and apoptosis, stabilizing calcium homeostasis, and ameliorated insulin resistance and hepatic steatosis in HFD-fed mice. This suggests that GUDCA may be a potential treatment option for metabolic disorders by inhibiting ER stress.
Article
Biochemistry & Molecular Biology
Alvaro Gonzalez-Dominguez, Maria Millan-Martinez, Jesus Dominguez-Riscart, Rosa Maria Mateos, Alfonso Maria Lechuga-Sancho, Raul Gonzalez-Dominguez
Summary: Metals play an important role in childhood obesity and insulin resistance, with elevated copper levels, decreased content of certain plasma proteins, and the sequestration of copper, iron, and selenium in erythrocytes being the main abnormalities caused by obesity. These metal disturbances are usually worsened in children with concomitant insulin resistance and are associated with characteristic pathogenic events such as inflammation, oxidative stress, abnormal glucose metabolism, and dyslipidemia.
Article
Cell Biology
Xiangyu Wang, Huaping Zhang, Pengfu Zhang, Shulan Hao, Xi Yang, Xin Zhou
Summary: The study found that LPS levels were significantly associated with inflammatory factors, as well as the expression of ER stress-related genes and proteins in patients with MS.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Ok-Kyung Kim, Woojin Jun, Jeongmin Lee
Article
Dermatology
Ok-Kyung Kim, Minhee Lee, Han Ol Kwon, Dasom Lee, Jeongjin Park, Eungpil Kim, Yanghee You, Young Tae Lim, Woojin Jun, Jeongmin Lee
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2018)
Article
Nutrition & Dietetics
Ok-Kyung Kim, Jeong Moon Yun, Minhee Lee, Soo-Jeung Park, Dakyung Kim, Dong Hwan Oh, Hong-Sik Kim, Ga-Yeon Kim
Review
Nutrition & Dietetics
Yujeong Kim, Ok-Kyung Kim
Summary: Recent research has shown that extracellular microRNAs from adipose tissue are involved in the development of insulin resistance. Certain miRNAs, such as miR-27a, miR-34a, miR-141-3p, miR-155, miR210, and miR-222, secreted from adipose tissue can impact the insulin signaling pathway in metabolic tissue, contributing to conditions like obesity and type 2 diabetes. Understanding the roles of these miRNAs may offer potential for developing therapeutics for obesity and metabolic disorders.
ADVANCES IN NUTRITION
(2021)
Article
Chemistry, Multidisciplinary
Soo-Jeung Park, Dakyung Kim, Jong-Lae Kim, Mi-Ryeong Park, Tae Gi Kim, Ok-Kyung Kim, Da-Eun Nam
APPLIED SCIENCES-BASEL
(2020)
Article
Biochemistry & Molecular Biology
Ok-Kyung Kim, Dakyung Kim, Minhee Lee, Seong-Hoo Park, Wakana Yamada, Sangwon Eun, Jeongmin Lee
Summary: The standardized edible bird's nest extract showed potential in preventing UVB irradiation-induced oxidative stress and photoaging by increasing skin hydration, suppressing melanogenesis, and reducing wrinkle formation, while activating pathways related to skin health.
Article
Plant Sciences
Ok-Kyung Kim, Jeong-Moon Yun, Minhee Lee, Dakyung Kim, Jeongmin Lee
Summary: The combination of Chrysanthemum indicum L. and Cornus officinalis Siebold and Zucc. extracts showed stronger effects in reducing uric acid levels and increasing the expression of organic anion transporters compared to individual extracts, suggesting potential for the development of natural anti-hyperuricemic functional foods.
Article
Nutrition & Dietetics
Minhee Lee, Dakyung Kim, Hyunji Kim, Sukyung Jo, Ok-Kyung Kim, Jeongmin Lee
Summary: The study demonstrated that Glycine max (L.) Merr. fermented using Lactobacillus delbrueckii ssp. delbrueckii Rosell-187 (Gastro-AD (R)) can alleviate ethanol/HCl-induced gastric damage, with gastro-protective effects such as reducing gastric acid secretion, increasing prostaglandin E2 levels, and decreasing inflammatory factors levels.
Article
Chemistry, Medicinal
Shintae Kim, Yanghee You, Ok-Kyung Kim, Jeongmin Lee, Jin Woong Chung, Sangin Shim, Kyungmi Kim, Jeongjin Park, Woojin Jun
Summary: Silymarin was found to inhibit weight and fat mass gain in obese mice, while increasing muscle mass and grip strength. The study also revealed that silymarin prevents muscle atrophy by modulating protein degradation and synthesis factors.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Chemistry, Medicinal
Jeongjin Park, Dakyung Kim, Minhee Lee, Sangshin Han, Woojin Jun, Hyun Mook Jung, Yean Kyoung Koo, Gwi Hwan Na, Sang Hun Han, Jehee Han, Ok-Kyung Kim
Summary: This study found that enzyme-treated caviar powder extract (CV) can protect keratinocytes against oxidative stress and inflammation induced by UVB irradiation by increasing antioxidant enzyme activities, elevating sphingomyelin and hyaluronic acid levels, and reducing inflammatory cytokine production.
Article
Chemistry, Medicinal
Ok-Kyung Kim, Jeong Moon Yun, Dakyung Kim, Soo-Jeung Park, Chungil Lee, Eun Byeol Go, Jae Sil Kim, Sang Yong Park, Jeongmin Lee
Summary: This study found that krill oil supplementation can reduce cholesterol levels in hypercholesterolemic rats induced by high-cholesterol diet through multiple mechanisms, and it can prevent atherosclerosis.
Article
Food Science & Technology
Yujeong Kim, Taesang Son, Jeongjin Park, Woojin Jun, Ok-Kyung Kim
Summary: This study found that exosomes from adipose tissue of obese mice can cause insulin resistance in both muscle and liver. However, the effects of exosomes on metabolism during the development of insulin resistance vary between these tissues.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Dakyung Kim, Eun-hye Choi, Ju Young Lee, Hye-Jeong See, Hye-Jin Kim, Yunhi Cho, Ok-Kyung Kim, Jeongmin Lee
Summary: This study investigated the protective effects of glucocerebroside-containing buttermilk concentrated powder (GCBM) on oxidative stress and photoaging in UVB-irradiated hairless mice. The results showed that dietary supplementation with GCBM increased antioxidant enzyme activity, reduced pro-inflammatory cytokine expression, inhibited wrinkle formation, and increased skin moisturization.
Article
Nutrition & Dietetics
Jihee Lee, Inae Jeong, Ok-Kyung Kim
Summary: This study investigates the effects of different dietary patterns on lipid metabolism in the liver and adipose tissue. The results show that high-fat/sucrose diet leads to increased fibrosis, inflammation, and lipogenesis in the liver, while high-fat diet leads to increased lipolysis. In adipose tissue, high-fat diet leads to increased adipogenesis, fatty acid transport, and lipolysis, while high-fat/sucrose diet leads to increased inflammation and lipogenesis. Liver-derived exosomes play a crucial role in obesity-related metabolic diseases.
Article
Chemistry, Medicinal
Jeongjin Park, Dakyung Kim, Minhee Lee, Geum Duck Park, Soo Ro Kim, Yanxiu Jiang, Woojin Jun, Ok-Kyung Kim, Jeongmin Lee
Summary: This study showed that unripe pear extract (UP) could protect against UVB-induced damage in both mouse skin and keratinocytes. UP treatment increased antioxidant enzyme activities and reduced cytokine production in UVB-irradiated keratinocytes, indicating its potential as a protective agent against photoaging.
JOURNAL OF MEDICINAL FOOD
(2023)
