Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Johanna Wolfsberger, Habib A. M. Sakil, Leilei Zhou, Niek van Bree, Elena Baldisseri, Sabrina de Souza Ferreira, Veronica Zubillaga, Marina Stantic, Nicolas Fritz, Johan Hartman, Charlotte Rolny, Margareta T. Wilhelm
Summary: Low levels of TAp73 are correlated with an increased NF-kappa B-regulated inflammatory signature in breast cancer, leading to hyperactivation of NF-kappa B pathway and secretion of Ccl2, which results in accumulation and phenotype transformation of pro-tumoral macrophages. These findings suggest that TAp73 regulates macrophage accumulation and phenotype in breast cancer through inhibition of the NF-kappa B pathway.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Tamara N. Ramirez-Pavez, Maria Martinez-Esparza, Antonio J. Ruiz-Alcaraz, Pilar Marin-Sanchez, Francisco Machado-Linde, Pilar Garcia-Penarrubia
Summary: Endometriosis, an estrogen-dependent gynecological disorder, involves immune dysregulation and the role of macrophages in its pathology. Further research on the characteristics of the peritoneal immune system is needed to enhance diagnostic and therapeutic tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Daniela Verzella, Jessica Cornice, Paola Arboretto, Davide Vecchiotti, Mauro Di Vito Nolfi, Daria Capece, Francesca Zazzeroni, Guido Franzoso
Summary: NF-kappa B pathway plays a crucial role in cancer, but there is no effective NF-kappa B inhibitor for treatment yet. Researchers are focusing on developing new drugs targeting upstream regulators or downstream effectors of the NF-kappa B signaling pathway.
Article
Biochemistry & Molecular Biology
Ruimeng Yang, Ming Zhan, Miaomiao Guo, Hao Yuan, Yiqin Wang, Yiyue Zhang, Wenqing Zhang, Saijuan Chen, Hugues de The, Zhu Chen, Jun Zhou, Jun Zhu
Summary: Microglia, the primary immune cells in the central nervous system, are regulated by the cerebral white matter hyperintensities susceptibility gene PDCD11, which plays a crucial role in microglia differentiation during zebrafish development.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Microbiology
Dania AlQasrawi, Ebraheem Naser, Saleh A. Naser
Summary: The study reveals that nicotine enhances macrophage survival during Mycobacterium avium subspecies paratuberculosis (MAP) infection in Crohn's disease smokers through upregulating alpha 7nAChR expression, inhibiting autophagy, and upregulating NF-kappa B subunits expression. This involves the NF-kappa B p100/p52 signaling pathway, inducing anti-apoptosis and enhancing macrophage survival.
Article
Cell Biology
Anna Santarsiero, Paolo Convertini, Simona Todisco, Ciro L. Pierri, Anna De Grassi, Niamh C. Williams, Dominga Iacobazzi, Giulio De Stefano, Luke A. J. O'Neill, Vittoria Infantino
Summary: Macrophage stimulation by pathogen-associated molecular patterns drives a proinflammatory response through the activation of metabolic enzyme ATP citrate lyase (ACLY) and the subsequent NF-kappa B acetylation. The activation of ACLY leads to increased expression of proinflammatory genes, forming a proinflammatory loop involving SLC25A1 and ACLY genes.
Article
Multidisciplinary Sciences
Huibin Yu, Chen Peng, Chi Zhang, Ana M. M. Stoian, Loubna Tazi, Greg Brennan, Stefan Rothenburg
Summary: This study investigates the interaction between the Myxoma virus and the host protein kinase R (PKR). The results show that the MYXV M156 protein inhibits PKR in brush rabbits more strongly than in European rabbits. The moderate inhibition of PKR in European rabbits leads to the activation of the proinflammatory nuclear factor kappa B (NF-kappa B) pathway, which may contribute to the increased virulence of MYXV in European rabbits.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Fisheries
Chohelee Choudhury, Ritwik Mazumder, Rajib Biswas, Mahuya Sengupta
Summary: The study investigated the effects of cadmium exposure on the immune response and molecular changes in monocytes/macrophages of Channa punctatus. Results showed alterations in hematological profile, tissue damage, impaired innate immune parameters, ROS generation, and induced inflammation, highlighting the role of NF-kappa B pathway and proinflammatory cytokines such as TNF-alpha, IL-1 beta, IL-6, and IL-12.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Denuja Karunakaran, My-Anh Nguyen, Michele Geoffrion, Dianne Vreeken, Zachary Lister, Henry S. Cheng, Nicola Otte, Patricia Essebier, Hailey Wyatt, Joshua W. Kandiah, Richard Jung, Francis J. Alenghat, Ana Mompeon, Richard Lee, Calvin Pan, Emma Gordon, Adil Rasheed, Aldons J. Lusis, Peter Liu, Ljubica Perisic Matic, Ulf Hedin, Jason E. Fish, Liang Guo, Frank Kolodgie, Renu Virmani, Janine M. van Gils, Katey J. Rayner
Summary: The study indicates that RIPK1 plays a central role in driving inflammation in atherosclerosis by activating the NF-kappa B pathway and promoting the release of inflammatory cytokines. Knockdown of RIPK1 reduces inflammatory cell activation and protects against the progression of atherosclerosis. These findings suggest RIPK1 as a potential therapeutic target to reduce residual inflammation in patients at high risk of coronary artery disease.
Article
Biology
Nicholas Sim, Yinghui Li
Summary: p52-induced ETS1 overexpression in glioma cells remodels the genome-wide regulatory network of p52 and ETS1 to transcriptionally drive cancer progression. Chronic inflammation promotes glioma progression by activating NF-kappa B signalling, which promotes cancer cell invasion and angiogenesis. Non-canonical NF-kappa B activation directly regulates p52 at the ETS1 promoter, leading to its overexpression and impacting the genomic landscape of ETS1 in a glioma-specific manner.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Veronica De Paolis, Fabio Maiullari, Maila Chirivi, Marika Milan, Chiara Cordiglieri, Francesca Pagano, Alessandra Rita La Manna, Elena De Falco, Claudia Bearzi, Roberto Rizzi, Chiara Parisi
Summary: The cellular heterogeneity in the tumor environment of breast cancer is complex, involving various cell types with different functions. The physical properties of the tumor extracellular matrix play a crucial role in protecting the tumor niche. TAMs with an immunosuppressive phenotype are important for establishing a tumor phenotype that evades the immune system. NF-kappa B transcription factors have a connection between inflammation and cancer. In TAMs, an unusual association of NF-kappa B components affects the stiffness of the tumor extracellular matrix.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Giovanna Carra, Lidia Avalle, Laura Secli, Mara Brancaccio, Alessandro Morotti
Summary: NF-kappa B is not only a transcription factor regulating gene expression within the nucleus, but also has functions within cellular organelles. The crosstalk between NF-kappa B and cellular organelles is significant for anticancer therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Hao-yue Zhang, Hai-Rong Zeng, Hui-Zhen Wei, Xia-Yan Chu, Hui-Ting Zhu, Bei Zhao, Yang Zhang
Summary: This study found that TXYF has a therapeutic effect in DSS-induced mice and improves colitis symptoms by inhibiting M1 polarization and promoting M2 polarization of macrophages. The therapeutic effect of TXYF may be achieved by suppressing the activation of the NF-kappa B/NLRP3 signaling pathway.
Article
Public, Environmental & Occupational Health
Bo Li, Bocen Chen, Xiaoli Wang, Man Xiao, Kan Zhang, Wenjiao Ye, Da Zhao, Xiaohua Wang, Yan Yu, Jun Li, Xun Xu, Wenhui Zhang, Yanhua Zhang
Summary: NUCKS1 is overexpressed in endometriosis, and inhibition of NUCKS1 can inhibit cell viability and migration, and increase apoptosis. NUCKS1 promotes the progress of endometriosis through activating the PI3K and NF-κB pathways, and VEGF is also involved in this process.
