Article
Biochemistry & Molecular Biology
Manouchehr Ahmadi Hedayati, Delniya Khani, Hamed Bashiri
Summary: This study investigated the correlation between H. pylori virulence genes and Fgf7 gene expression in gastric antral epithelial cells. The results showed that H. pylori infection and pathogenic genes were positively correlated with Fgf7 gene expression, suggesting a potential involvement of H. pylori infection in gastric cancer development through the regulation of Fgf7 expression.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Fernanda Gonzalez, Paula Diaz, Alejandra Sandoval-Borquez, Daniela Herrera, Andrew F. G. Quest
Summary: Extracellular vesicles are important in host-pathogen interactions, playing a role in modulating inflammatory responses and promoting disease development. Both EVs from cells infected with H. pylori and H. pylori-OMVs are involved in the development of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Jacek Baj, Alicja Forma, Monika Sitarz, Piero Portincasa, Gabriella Garruti, Danuta Krasowska, Ryszard Maciejewski
Summary: Gastric cancer is a prevalent malignancy worldwide and ranks as the fourth leading cause of cancer-related deaths. The pathogenesis of gastric cancer involves the interaction between genetic and environmental factors, with Helicobacter pylori infection playing a major role. Understanding the mechanisms of H. pylori pathogenicity is crucial for developing eradication strategies to prevent carcinogenesis.
Article
Gastroenterology & Hepatology
Enming Qiu, Shaoqin Jin, Zhuo Xiao, Qianyun Chen, Qiaohui Wang, Huayong Liu, Chanfang Xie, Chong Chen, Zhou Li, Shuai Han
Summary: The study established a rapid, simple, and inexpensive noninvasive method based on CRISPR-Cas12a technology for detecting Helicobacter pylori in stool specimens. The method demonstrated high sensitivity and specificity, with the ability to distinguish H. pylori from other pathogens, making it a promising supplemental test in clinical practice. Further evaluation against gold standard tests is necessary to assess its sensitivity and specificity.
Article
Multidisciplinary Sciences
Rumiko Suzuki, Naruya Saitou, Osamu Matsuari, Seiji Shiota, Takashi Matsumoto, Junko Akada, Nagisa Kinjo, Fukunori Kinjo, Kuniko Teruya, Makiko Shimoji, Akino Shiroma, Mototsugu Kato, Kazuhito Satou, Takashi Hirano, Masahiro Asaka, Kirill Kryukov, Yoshan Moodley, Yoshio Yamaoka
Summary: Helicobacter pylori, a virulence bacterium, can be used as a marker for tracing human migration. This study identified indigenous H. pylori strains hspOkinawa and hpRyukyu in Okinawa, Japan and revealed their origin and divergence patterns.
Article
Gastroenterology & Hepatology
Nancy K. Arteaga-Resendiz, Gerardo E. Rodea, Rosa Maria Ribas-Aparicio, Alma L. Olivares-Cervantes, Juan Arturo Castelan-Vega, Jose de Jesus Olivares-Trejo, Sandra Mendoza-Elizalde, Edgar O. Lopez-Villegas, Christian Colin, Pamela Aguilar-Rodea, Alfonso Reyes-Lopez, Marcela Salazar Garcia, Norma Velazquez-Guadarrama
Summary: The hypothetical protein HP0953 is a virulence factor that plays an important role in the adhesion and infection of Helicobacter pylori, exhibiting maximum expression during the infection of gastric epithelium cells.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Nina Doerr, Nadine Dietze, Norman Lippmann, Arne C. Rodloff
Summary: With the rise of ESBLs and CTX-M enzymes, antimicrobial treatment of enterobacterial infections is increasingly challenging. Our study characterized ESBL-positive E. coli strains from blood cultures of patients in Germany, with the presence of CMY-2, CTX-M-14 and CTX-M-15 genes investigated. The results highlight the correlation between blood culture and stool specimens, emphasizing the importance of screening programs for high-risk patients.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Seiichi Kato, Benjamin D. Gold, Ayumu Kato
Summary: Many studies have shown that Helicobacter pylori infection can lead to iron deficiency or iron deficiency anemia in children. The exact pathogenesis and risk factors are still poorly understood. It is hypothesized that H. pylori competes with humans for iron in the upper gastrointestinal tract, leading to anemia. Testing and treating H. pylori infection should be considered for children with recurrent or refractory iron deficiency anemia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Sankaran Sathianarayanan, Aparna Viswanathan Ammanath, Raja Biswas, B. Anita, Sunitha Sukumaran, Baskar Venkidasamy
Summary: Several medicinal plants and their isolated compounds have shown antimicrobial activity against drug-resistant H. pylori strains through different mechanisms of action.
MICROBIAL PATHOGENESIS
(2022)
Review
Microbiology
Alejandro Tejada-Arranz, Hilde De Reuse
Summary: Helicobacter pylori is a Gram-negative bacterial pathogen that colonizes the stomach of about half of the human population worldwide, causing chronic gastritis and other serious diseases. It has evolved efficient adaptive strategies for gene expression control through transcriptional and post-transcriptional regulation.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Alain P. Gobert, Keith T. Wilson
Summary: Gastric cancer is the fifth most common cancer and the fourth most common cause of cancer-related death worldwide. The key factor in the development of gastric inflammation and disease progression is Helicobacter pylori infection, although only a small percentage of infected individuals develop gastric adenocarcinoma.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Infectious Diseases
Yalda Lucero, Anne J. Lagomarcino, Juan P. Torres, Patricia Roessler, Nora Mamani, Sergio George, Nicole Huerta, Monica Gonzalez, Miguel O'Ryan
Summary: In apparently healthy school-aged children, persistent H. pylori infection was associated with increased clinical symptoms and higher levels of the biomarker pepsinogen II, indicating early gastric involvement.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Satoshi Imai, Takuya Ooki, Naoko Murata-Kamiya, Daisuke Komura, Kamrunnesa Tahmina, Weida Wu, Atsushi Takahashi-Kanemitsu, Christopher Takaya Knight, Akiko Kunita, Nobumi Suzuki, Adriana A. Del Valle, Mayo Tsuboi, Masahiro Hata, Yoku Hayakawa, Naomi Ohnishi, Koji Ueda, Masashi Fukayama, Tetsuo Ushiku, Shumpei Ishikawa, Masanori Hatakeyama
Summary: Infection with CagA-producing H. pylori leads to gastric cancer development through disrupting DNA repair mechanisms, inhibiting apoptosis of damaged cells, and promoting somatic mutation. This hit-and-run mechanism creates a favorable environment for the initiation and progression of gastric carcinogenesis.
CELL HOST & MICROBE
(2021)
Article
Immunology
Wenjing Chi, Su Wang, Tao Liu, Wenrong Jiang, Li Ding, Yingxin Miao, Feng Yang, Jinghao Zhang, Danian Ji, Zili Xiao, Haowei Zhu, Yong Wu, Zhijun Bao, Hu Zhao, Shiwen Wang
Summary: This study established a high-throughput multiplex genetic detection assay (HMGA) for rapid identification, semi-quantification and virulence analysis of Helicobacter pylori directly from the clinical non-invasive oral samples. The HMGA showed high sensitivity and specificity for detecting H. pylori and its virulence genes in oral samples.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)