Review
Immunology
Amin Khoshbayan, Fateme Taheri, Majid Taati Moghadam, Zahra Chegini, Aref Shariati
Summary: Previous studies have linked Chlamydia pneumoniae (Cpn) infection to atherosclerosis, with recent research pointing to the importance of Cpn in atherosclerotic lesions through various mechanisms. However, inconsistent and contradictory findings exist in the literature. The bacterium is suggested to cause atherosclerosis by inducing phenotypic changes in smooth muscle cells, dysregulation of endothelin-1, and releasing pro-inflammatory cytokines from Toll-like receptor-2 (TLR2).
MICROBIAL PATHOGENESIS
(2021)
Article
Biochemistry & Molecular Biology
Atif Zafar, Hang Pong Ng, Rachel Diamond-Zaluski, Gun-Dong Kim, Ernest Ricky Chan, Sally L. Dunwoodie, Jonathan D. Smith, Ganapati H. Mahabeleshwar
Summary: The transcriptionally dynamic macrophages play key roles in the development of inflammatory vascular diseases. In this study, the CITED2 was identified as a cell-intrinsic negative regulator of inflammation in macrophages. The deficiency of CITED2 elevates pro-inflammatory gene expression and contributes to the development of atherosclerotic plaques.
Review
Biochemistry & Molecular Biology
Tatsuo Kawai, Katherine J. Elliott, Rosario Scalia, Satoru Eguchi
Summary: ADAMs play a key role in cell signaling by shedding cytokines and growth factors, leading to cell proliferation and inflammation. Among them, ADAM17 is the most extensively studied member and may have significant implications in cardiovascular diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Rida Al-Rifai, Marie Vandestienne, Jean-Remi Lavillegrand, Tristan Mirault, Julie Cornebise, Johanne Poisson, Ludivine Laurans, Bruno Esposito, Chloe James, Olivier Mansier, Pierre Hirsch, Fabrizia Favale, Rayan Braik, Camille Knosp, Jose Vilar, Giuseppe Rizzo, Alma Zernecke, Antoine-Emmanuel Saliba, Alain Tedgui, Maxime Lacroix, Lionel Arrive, Ziad Mallat, Soraya Taleb, Marc Diedisheim, Clement Cochain, Pierre-Emmanuel Rautou, Hafid Ait-Oufella
Summary: JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Xu Xu, Yefei Shi, Peipei Luan, Wenxin Kou, Bo Li, Ming Zhai, Shuangjie You, Qing Yu, Jianhui Zhuang, Weixia Jian, Mark W. Feinberg, Wenhui Peng
Summary: NLRC5 plays a crucial role in angiogenesis in tissue repair by enhancing STAT3 transcriptional activity, which provides a new target for angiogenic therapy.
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Victoria A. Khotina, Andrey V. Omelchenko, Vladislav A. Kalmykov, Alexander N. Orekhov
Summary: The VEGF family plays a crucial role in the development of atherosclerosis and related cardiovascular diseases, and has the potential to be targeted for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Panyun Wu, Tengteng Zhu, Yiyuan Huang, Zhenfei Fang, Fei Luo
Summary: Research in recent decades has revealed the presence and function of lactate in the body. Lactate, primarily produced through glycolysis, plays important roles in tissue and organ regulation, especially in the cardiovascular system. The heart, as both a net consumer and the organ with the highest lactate consumption, contributes to cardiovascular homeostasis through energy supply and signal regulation. Lactate also affects the occurrence, development, and prognosis of various cardiovascular diseases. This article aims to explore the regulation of the cardiovascular system by lactate under physiological and pathological conditions, provide a better understanding of the lactate-cardiovascular health relationship, and propose new ideas for preventing and treating cardiovascular diseases. Additionally, it summarizes the current progress in treatments targeting lactate metabolism, transport, and signaling in cardiovascular diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daniel Tortolani, Camilla Di Meo, Sara Standoli, Francesca Ciaramellano, Salam Kadhim, Eric Hsu, Cinzia Rapino, Mauro Maccarrone
Summary: Rare cannabis-derived phytocannabinoids (pCBs) have therapeutic potential in skin disorders and their anti-inflammatory effects were investigated in this study. The experiment involved using lipopolysaccharide (LPS) to induce inflammation in human keratinocytes (HaCaT cells) and measuring the levels of pro-inflammatory interleukins. The results showed that pCBs significantly reduced the release of pro-inflammatory interleukins and modulated MAPK signaling, suggesting their potential as a treatment for inflammation-related skin pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Subroto Chatterjee, Amrita Balram, Wendy Li
Summary: Lactosylceramide plays a crucial role in glycosphingolipid biosynthesis and lipid raft function, transducing external stimuli into cellular phenotypes. Its synthesis and activation by various stimuli leads to oxidative stress and inflammation, contributing to diseases like atherosclerosis and cancer through diverse signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Beatriz Prado Noronha, Juliana Vaz de Melo Mambrini, Karen Cecilia Lima Torres, Olindo Assis Martins-Filho, Andrea Teixeira-Carvalho, Maria Fernanda Lima-Costa, Sergio Viana Peixoto
Summary: This study identified changes in the immunological profile in the presence of C. pneumoniae and H. pylori infections among community-dwelling older adults. High levels of antibodies were associated with certain inflammatory markers, indicating the potential effects of biomarkers on infections by these bacteria and the immunosenescence process.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Aziz M. Rangwala, Victoria R. Mingione, George Georghiou, Markus A. Seeliger
Summary: Phosphorylation plays a vital role in regulating biological processes, and protein kinases have been extensively studied for their involvement in human health and disease. Some kinases possess additional catalytic functions in addition to phosphotransferase activity, while others have lost their catalytic activity completely. In this study, we analyzed the UniProtKB database for bifunctional protein kinases and focused on those crucial for bacterial and human cellular homeostasis. These kinases have diverse functional roles in environmental sensing, metabolic regulation, immune-host defense, and cell cycle control. This article explores their dual catalytic activities and their contributions to disease pathogenesis.
Review
Genetics & Heredity
Bingyu Wang, Xi Yang, Xinyi Sun, Jianhui Liu, Yin Fu, Bingyang Liu, Jun Qiu, Jiangfang Lian, Jianqing Zhou
Summary: Atherosclerosis is a global concern and transcription factors, particularly ATF3, play a crucial role in its development. ATF3 has distinct functions in different cell types, exacerbating oxidative stress and inflammation in endothelial cells, and acting as a negative regulator of inflammation and promoter of cholesterol metabolism in macrophages and liver cells. This suggests that ATF3 could be a potential therapeutic factor for atherosclerosis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Biochemistry & Molecular Biology
Simone Filardo, Marisa Di Pietro, Fabiana Diaco, Silvio Romano, Rosa Sessa
Summary: Studies have shown that oxidative stress and inflammation may be involved in infectious agent-related cardiovascular diseases, with SARS-CoV-2 and Chlamydia pneumoniae playing a key role in promoting reactive oxygen species and cytokine production. This review focuses on the common oxidative and inflammatory pathways associated with cardiovascular diseases caused by SARS-CoV-2 or C. pneumoniae infections, as well as discussing therapeutic and preventive approaches using natural antioxidant compounds.
Review
Biochemistry & Molecular Biology
Saleh A. Almatroodi, Ahmad Almatroudi, Amjad Ali Khan, Arshad Husain Rahmani
Summary: Cancer is a leading cause of death worldwide, and natural compounds like formononetin have been shown to inhibit cancer growth through their antioxidant and anti-inflammatory effects. Formononetin, a type of isoflavone, regulates inflammation, angiogenesis, cell cycle, and apoptosis, and has been proven effective against various cancer types. This review emphasizes the role of formononetin in different cancers and its influence on cell signaling pathways. Further clinical trials are needed to explore its potential in cancer prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ahmad Almatroudi, Khaled S. S. Allemailem, Wanian M. M. Alwanian, Basmah F. F. Alharbi, Faris Alrumaihi, Amjad Ali Khan, Saleh A. A. Almatroodi, Arshad Husain Rahmani
Summary: Cancer is a leading cause of death worldwide and its incidence is increasing. Natural compounds, such as kaempferol found in vegetables and fruits, have shown potential in cancer management with minimal side effects. Kaempferol has been proven to modulate cell signaling pathways and induce apoptosis and cell cycle arrest in cancer cells. However, more clinical trials are needed to fully explore its therapeutic role, especially in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)