Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development

Chronic phase of Chagas disease: why should it be treated? A comprehensive review

(2014) José Rodrigues Coura et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

An Image-Based Algorithm for Precise and Accurate High Throughput Assessment of Drug Activity against the Human Parasite Trypanosoma cruzi

(2014) Seunghyun Moon et al.   PLoS One

Design, structure–activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi

(2013) Martine Keenan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Complexes ofTrypanosoma cruziSterol 14α-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease

(2013) Tatiana Y. Hargrove et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New, Combined, and Reduced Dosing Treatment Protocols Cure Trypanosoma cruzi Infection in Mice

(2013) J. M. Bustamante et al.   JOURNAL OF INFECTIOUS DISEASES

Global economic burden of Chagas disease: a computational simulation model

(2013) Bruce Y Lee et al.   LANCET INFECTIOUS DISEASES

Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase

(2013) Qing-Hua Hu et al.   Scientific Reports

Time-dependent, reversible, oxaborole inhibition of Escherichia coli leucyl-tRNA synthetase measured with a continuous fluorescence assay

(2012) Adam B. Shapiro et al.   ANALYTICAL BIOCHEMISTRY

Benznidazole-Related Adverse Drug Reactions and Their Relationship to Serum Drug Concentrations in Patients with Chronic Chagas Disease

(2012) María-Jesús Pinazo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

American Trypanosomiasis (Chagas Disease)

(2012) Anis Rassi et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Effects of amiodarone and posaconazole on the growth and ultrastructure of Trypanosoma cruzi

(2012) Phercyles Veiga-Santos et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Benznidazole-Resistance in Trypanosoma cruzi Is a Readily Acquired Trait That Can Arise Independently in a Single Population

(2012) Ana Maria Mejia et al.   JOURNAL OF INFECTIOUS DISEASES

Analogues of Fenarimol Are Potent Inhibitors of Trypanosoma cruzi and Are Efficacious in a Murine Model of Chagas Disease

(2012) Martine Keenan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Trypanosoma cruzi Discrete Typing Units in Chagas disease patients from endemic and non-endemic regions of Argentina

(2012) C. I. CURA et al.   PARASITOLOGY

In vivosusceptibility to benznidazole ofTrypanosoma cruzistrains from the western Brazilian Amazon

(2012) Ana P. M. Teston et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Fexinidazole: A Potential New Drug Candidate for Chagas Disease

(2012) Maria Terezinha Bahia et al.   PLoS Neglected Tropical Diseases

An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages

(2012) Jair L. Siqueira-Neto et al.   PLoS Neglected Tropical Diseases

Recent developments in sterol 14-demethylase inhibitors for Chagas disease

(2012) Frederick S. Buckner et al.   International Journal for Parasitology-Drugs and Drug Resistance

Visual Genome-Wide RNAi Screening to Identify Human Host Factors Required for Trypanosoma cruzi Infection

(2011) Auguste Genovesio et al.   PLoS One

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

(2011) Robert T. Jacobs et al.   PLoS Neglected Tropical Diseases

Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis

(2010) B. Nare et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effects of Ravuconazole Treatment on Parasite Load and Immune Response in Dogs Experimentally Infected with Trypanosoma cruzi

(2010) L. d. F. Diniz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Identification ofTrypanosoma cruziDiscrete Typing Units in End‐Stage Chronic Chagas Heart Disease and Reactivation after Heart Transplantation

(2010) Juan Miguel Burgos et al.   CLINICAL INFECTIOUS DISEASES

A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease

(2010) Bianca P. Olivieri et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Structural Insights into Inhibition of Sterol 14α-Demethylase in the Human PathogenTrypanosoma cruzi

(2010) Galina I. Lepesheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trypanosoma cruzi benznidazole susceptibility in vitro does not predict the therapeutic outcome of human Chagas disease

(2010) Margoth Moreno et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole

(2010) Chiung-Kuang Chen et al.   PLoS Neglected Tropical Diseases

Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches

(2009) Julio A. Urbina   ACTA TROPICA

Chagas disease in Spain, the United States and other non-endemic countries

(2009) Joaquim Gascon et al.   ACTA TROPICA

Genotyping of Trypanosoma cruzi: Systematic Selection of Assays Allowing Rapid and Accurate Discrimination of All Known Lineages

(2009) Michael D. Lewis et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

An Estimate of the Burden of Chagas Disease in the United States

(2009) Caryn Bern et al.   CLINICAL INFECTIOUS DISEASES

Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities

(2009) Rodolfo Viotti et al.   Expert Review of Anti-Infective Therapy

Comparative phylogeography of Trypanosoma cruzi TCIIc: New hosts, association with terrestrial ecotopes, and spatial clustering

(2009) Arlei Marcili et al.   INFECTION GENETICS AND EVOLUTION

The BENEFIT trial: testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease

(2009) J Antonio Marin-Neto et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI

(2009) B Zingales et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

The molecular epidemiology and phylogeography of Trypanosoma cruzi and parallel research on Leishmania: looking back and to the future

(2009) M. A. MILES et al.   PARASITOLOGY

Feasibility, Drug Safety, and Effectiveness of Etiological Treatment Programs for Chagas Disease in Honduras, Guatemala, and Bolivia: 10-Year Experience of Médecins Sans Frontières

(2009) Oliver Yun et al.   PLoS Neglected Tropical Diseases

Genome-Scale Multilocus Microsatellite Typing of Trypanosoma cruzi Discrete Typing Unit I Reveals Phylogeographic Structure and Specific Genotypes Linked to Human Infection

(2009) Martin S. Llewellyn et al.   PLoS Pathogens

Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: The BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT)

(2008) Jose Antonio Marin-Neto et al.   AMERICAN HEART JOURNAL

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

(2008) Shane R. Wilkinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA