Influence of crowded cellular environments on protein folding, binding, and oligomerization: Biological consequences and potentials of atomistic modeling

Polymer crowders and protein crowders act similarly on protein folding stability

(2013) Huan-Xiang Zhou   FEBS LETTERS

Folding free energy surfaces of three small proteins under crowding: validation of the postprocessing method by direct simulation

(2013) Sanbo Qin et al.   PHYSICAL BIOLOGY

Unexpected Effects of Macromolecular Crowding on Protein Stability

(2012) Laura A. Benton et al.   BIOCHEMISTRY

Crowding effects on the small, fast-folding protein λ6–85

(2012) Sharlene Denos et al.   FARADAY DISCUSSIONS

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macromolecular Crowding and Protein Stability

(2012) Yaqiang Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Temperature dependence of protein folding kinetics in living cells

(2012) M. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-terminal acetylation is critical for forming α-helical oligomer of α-synuclein

(2012) Adam J. Trexler et al.   PROTEIN SCIENCE

Macromolecular Crowding Extended to a Heptameric System: The Co-chaperonin Protein 10

(2011) Ximena Aguilar et al.   BIOCHEMISTRY

Protein Disorder Prevails under Crowded Conditions

(2011) Cs. Szasz et al.   BIOCHEMISTRY

Effects of Macromolecular Crowding on an Intrinsically Disordered Protein Characterized by Small-Angle Neutron Scattering with Contrast Matching

(2011) Daniel Johansen et al.   BIOPHYSICAL JOURNAL

Effects of Macromolecular Crowding on the Inhibition of Virus Assembly and Virus-Cell Receptor Recognition

(2011) Verónica Rincón et al.   BIOPHYSICAL JOURNAL

Protein Stability and Folding Kinetics in the Nucleus and Endoplasmic Reticulum of Eucaryotic Cells

(2011) A. Dhar et al.   BIOPHYSICAL JOURNAL

Variable Interactions between Protein Crowders and Biomolecular Solutes Are Important in Understanding Cellular Crowding

(2011) Michael Feig et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Protein Folding Landscapes in the Living Cell

(2011) Simon Ebbinghaus et al.   Journal of Physical Chemistry Letters

Protein Crowding Tunes Protein Stability

(2011) Andrew C. Miklos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Macromolecular Crowding Fails To Fold a Globular Protein in Cells

(2011) Alexander P. Schlesinger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Volume Exclusion and Soft Interaction Effects on Protein Stability under Crowded Conditions

(2010) Andrew C. Miklos et al.   BIOCHEMISTRY

The Folding Transition-State Ensemble of a Four-Helix Bundle Protein: Helix Propensity as a Determinant and Macromolecular Crowding as a Probe

(2010) Harianto Tjong et al.   BIOPHYSICAL JOURNAL

Dependence of Protein Folding Stability and Dynamics on the Density and Composition of Macromolecular Crowders

(2010) Jeetain Mittal et al.   BIOPHYSICAL JOURNAL

Attractive Protein-Polymer Interactions Markedly Alter the Effect of Macromolecular Crowding on Protein Association Equilibria

(2010) Ming Jiao et al.   BIOPHYSICAL JOURNAL

Models of macromolecular crowding effects and the need for quantitative comparisons with experiment

(2010) Adrian H Elcock   CURRENT OPINION IN STRUCTURAL BIOLOGY

Protein folding in the cell: challenges and progress

(2010) Anne Gershenson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Macromolecular crowding converts the human recombinant PrPC to the soluble neurotoxic β-oligomers

(2010) Liqin Huang et al.   FASEB JOURNAL

Macromolecular crowding effects on protein–protein binding affinity and specificity

(2010) Young C. Kim et al.   JOURNAL OF CHEMICAL PHYSICS

Effects of Proteins on Protein Diffusion

(2010) Yaqiang Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Macromolecular Crowding Remodels the Energy Landscape of a Protein by Favoring a More Compact Unfolded State

(2010) Jiang Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Compression of random coils due to macromolecular crowding: Scaling effects

(2010) C. Le Coeur et al.   PHYSICAL REVIEW E

Generalized fundamental measure theory for atomistic modeling of macromolecular crowding

(2010) Sanbo Qin et al.   PHYSICAL REVIEW E

Structure, function, and folding of phosphoglycerate kinase are strongly perturbed by macromolecular crowding

(2010) Apratim Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rate theories for biologists

(2010) Huan-Xiang Zhou   QUARTERLY REVIEWS OF BIOPHYSICS

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Diffusion, Crowding & Protein Stability in a Dynamic Molecular Model of the Bacterial Cytoplasm

(2010) Sean R. McGuffee et al.   PLoS Computational Biology

Common Crowding Agents Have Only a Small Effect on Protein-Protein Interactions

(2009) Yael Phillip et al.   BIOPHYSICAL JOURNAL

Atomistic Modeling of Macromolecular Crowding Predicts Modest Increases in Protein Folding and Binding Stability

(2009) Sanbo Qin et al.   BIOPHYSICAL JOURNAL

Effect of Macromolecular Crowding on Protein Binding Stability: Modest Stabilization and Significant Biological Consequences

(2009) Jyotica Batra et al.   BIOPHYSICAL JOURNAL

Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage Sensitivity

(2009) Tanya Vavouri et al.   CELL

Method to Predict Crowding Effects by Postprocessing Molecular Dynamics Trajectories: Application to the Flap Dynamics of HIV-1 Protease

(2009) Sanbo Qin et al.   Journal of Physical Chemistry Letters

Nonadditive effects of mixed crowding on protein stability

(2009) Jyotica Batra et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences

(2008) Huan-Xiang Zhou et al.   Annual Review of Biophysics

Residue-Level Interrogation of Macromolecular Crowding Effects on Protein Stability

(2008) Lisa M. Charlton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tight Regulation of Unstructured Proteins: From Transcript Synthesis to Protein Degradation

(2008) J. Gsponer et al.   SCIENCE

Conformational Equilibria in Monomeric α-Synuclein at the Single-Molecule Level

(2008) Massimo Sandal et al.   PLOS BIOLOGY

Solvent-induced collapse of α-synuclein and acid-denatured cytochrome c

(2002) Artemiza S. Morar et al.   PROTEIN SCIENCE