Article
Cell Biology
Rong Liu, Jie Liu, Ping Wu, Hong Yi, Bin Zhang, Wei Huang
Summary: The study found that FLOT2 can upregulate BCAT1 transcription by maintaining c-Myc expression levels, thereby promoting NPC cell proliferation. FLOT2 and BCAT1 expression in NPC tissues are positively correlated and associated with patient prognosis.
Article
Cell Biology
Hongzhang Shen, Fuqiang Ye, Dongchao Xu, Liangliang Fang, Xiaofeng Zhang, Juanjuan Zhu
Summary: In this study, we found that the expression of MYEOV gene is associated with poor survival in patients with pancreatic ductal adenocarcinoma (PDAC) and is higher in carcinoma tissues. Elevated levels of MYEOV promote cell proliferation, invasion and migration. Further analysis revealed that MYEOV regulates the expression levels of miR-17-5p and miR-93-5p, and its association with MYC contributes to the progression of PDAC.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Ng Desi, Velda Teh, Qing Yun Tong, Chun You Lim, Hossein Tabatabaeian, Xiao Hong Chew, Avencia Sanchez-Mejias, Jia Jia Chan, Bin Zhang, Priyankaa Pitcheshwar, Bei-En Siew, Shi Wang, Kuok-Chung Lee, Choon-Seng Chong, Wai-Kit Cheong, Bettina Lieske, Ian Jse-Wei Tan, Ker-Kan Tan, Yvonne Tay
Summary: The study demonstrates that shortening of the MYC 3'UTR in colorectal cancer leads to activation of oncogenes, with miR-138 identified as a potent regulator of MYC expression and tumor growth inhibition.
Article
Biotechnology & Applied Microbiology
Qiang Wang, Leqi Qian, Mengyuan Tao, Jiaqi Liu, Fa-zhi Qi
Summary: The study revealed that DDX52 was significantly overexpressed in MM tissues and associated with shorter overall survival in patients, indicating its potential as a prognostic marker in MM. Downregulation of DDX52 expression in MM cell lines inhibited cell proliferation and colony formation. Additionally, DDX52 mediated oncogenesis by promoting the transcriptional activity of c-Myc, suggesting it could be a therapeutic target in MM.
Article
Biochemistry & Molecular Biology
Maozhi Hu, Yibei Zhang, Dan Gu, Xiang Chen, Matthew K. Waldor, Xiaohui Zhou
Summary: The study revealed that the T3SS effector VgpA in Vibrio parahaemolyticus interacts with the host cell nucleolus protein EBP2, leading to re-localization of c-Myc and increased cell proliferation. This interaction enhances EBP2 affinity for c-Myc, prolonging the oncoprotein's half-life and ultimately contributing to the pathogenesis of V. parahaemolyticus infection.
Article
Biochemistry & Molecular Biology
Jie Xu, Pengfei Shi, Fanwei Xia, Xuan Zhao, Junfan Chen, Rui Geng, Hongjuan Cui, Liqun Yang
Summary: Melanoma, a highly fatal skin cancer, is influenced by RAI14, which is associated with prognosis and affects the growth and invasive capabilities of melanoma cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Dapeng Li, Changyu Yao, Zhao Ding, Ping Liu, Xue Chen, Weiwei Liu, Fangzheng Yi, Chuanya Jiang, Hongwu Li, Yehai Liu, Jing Wu
Summary: The study reveals that PES1 expression is associated with prognosis and tumour growth in head and neck squamous cell carcinoma. It also plays a role in drug resistance and may serve as a potential cancer marker and therapeutic target for HNSCC.
Article
Biochemistry & Molecular Biology
Jing Sui, Qun Zhao, Yanqiu Zhang, Geyu Liang
Summary: The study found that LINC00961 is significantly downregulated in non-small cell lung cancer (NSCLC) tissues, and it inhibits the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p through the PI3K-AKT/MAPK/mTOR signaling pathway, thereby suppressing tumor cell proliferation and migration while promoting apoptosis. This may provide potential biomarkers for the diagnosis and treatment of NSCLC.
DNA AND CELL BIOLOGY
(2022)
Article
Cell Biology
Pengxiang Min, Lin Zhang, Yueyuan Wang, Chenxiang Qi, Yixuan Song, Maria Bibi, Yujie Zhang, Yadong Ma, Xuyang Zhao, Minjie Yu, Jun Du
Summary: The study showed that MICAL-L2 is highly expressed in human NSCLC and plays a role in promoting cancer cell proliferation by interacting with and stabilizing c-Myc protein. Depletion of MICAL-L2 led to reduced c-Myc stability and decreased cancer cell proliferation. This suggests that MICAL-L2 may be a potential therapeutic target for NSCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Jiang Jiang, Jianfang Li, Weiwu Yao, Wenfang Wang, Bowen Shi, Fei Yuan, Jingyan Dong, Huan Zhang
Summary: FOXC1 is highly expressed in patients with gastric cancer and is associated with poor prognosis by promoting the activation of the Wnt signaling pathway and regulating DKK1 expression, ultimately leading to the proliferation of GC cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Xiaojing Liu, Na Niu, Pibao Li, Liping Zhai, Ke Xiao, Wendan Chen, Xuewei Zhuang
Summary: The study found that the expression of OGFRP1 was higher in NSCLC tissues than in normal lung tissue; siOGFRP1 inhibited the proliferation, migration, and invasion of A549 and H1299 cells to inhibit the progression of NSCLC, and OGFRP1 could directly interact with miR-4640-5p to regulate the development of NSCLC through the miR-4640-5p/eIF5A axis.
CANCER CELL INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Aleksandra Boikova, Megan J. Bywater, Gregory A. Quaife-Ryan, Jasmin Straube, Lucy Thompson, Camilla Ascanelli, Trevor D. Littlewood, Gerard I. Evan, James E. Hudson, Catherine H. Wilson
Summary: The study reveals that Myc and HRas can cooperate to induce proliferation in adult mammalian cardiomyocytes, but the activity of HRas also leads to cell death, limiting its potential as a regenerative therapeutic target.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Wei Lv, Yunlong Jia, Jiali Wang, Yuqing Duan, Xuexiao Wang, Tianxu Liu, Shuwei Hao, Lihua Liu
Summary: In this study, a tumor-suppressive lncRNA called SNHG10 was identified in epithelial ovarian cancer (EOC). SNHG10 upregulated BIN1 by inhibiting the activity of miR-200a-3p, thereby suppressing the proliferation and invasion ability of EOC cells. This suggests that the SNHG10/miR-200a-3p/BIN1 axis may serve as a potential therapeutic target and predictive biomarker for treating EOC.
CELL DEATH DISCOVERY
(2022)
Article
Genetics & Heredity
Bo Zhu, Lixia Ke, Peixian Li, Xin Wang, Lan Yang, Minghua Bai, Mailin Chen
Summary: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. Despite much attention on the role of circRNAs in NSCLC, the knowledge in this area is still limited. This study discovered that circACC1 is highly expressed in NSCLC patients and negatively correlated with overall survival. Mechanistically, circACC1 promotes NSCLC cell growth by directly binding to miR-29c-3p, while MCL-1 is identified as a downstream target of miR-29c-3p in NSCLC cells.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Research & Experimental
Jia-Xing Sun, Guo-Rui Dou, Zi-Yan Yang, Liang Liang, Juan-Li Duan, Bai Ruan, Man-Hong Li, Tian-Fang Chang, Xin-Yuan Xu, Juan-Juan Chen, Yu-Sheng Wang, Xian-Chun Yan, Hua Han
Summary: The study demonstrates that miR-218 acts as a downstream effector of Notch signaling in quiescent endothelial cells, inhibiting cell proliferation and sprouting, and could be a potential treatment for angiogenesis-related diseases.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
