Article
Cell Biology
Pengxiang Min, Lin Zhang, Yueyuan Wang, Chenxiang Qi, Yixuan Song, Maria Bibi, Yujie Zhang, Yadong Ma, Xuyang Zhao, Minjie Yu, Jun Du
Summary: The study showed that MICAL-L2 is highly expressed in human NSCLC and plays a role in promoting cancer cell proliferation by interacting with and stabilizing c-Myc protein. Depletion of MICAL-L2 led to reduced c-Myc stability and decreased cancer cell proliferation. This suggests that MICAL-L2 may be a potential therapeutic target for NSCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Daochuan He, Mengqian Chen, Lei Chang, Jianxin Gu, Fenglin Liu, Xiaodong Gao, Yuanyuan Ruan
Summary: This study investigates the impact of de novo pyrimidine synthesis on aerobic glycolysis in cancer cells, and demonstrates that it can enhance Notch signaling and up-regulate critical glycolytic enzymes. Furthermore, the study shows that up-regulation of key enzymes for pyrimidine synthesis confers chemotherapeutic resistance in gastric cancer, while inhibition of the pyrimidine biosynthetic pathway increases sensitivity to chemotherapy in cancer cells.
Article
Biochemistry & Molecular Biology
Huinan Qu, Da Qi, Xinqi Wang, Yuan Dong, Qiu Jin, Junyuan Wei, Chengshi Quan
Summary: CLDN6 is a breast cancer suppressor gene that inhibits breast cancer proliferation by suppressing c-MYC-mediated aerobic glycolysis, reducing glucose uptake and lactate production. This study provides insights into the molecular mechanisms of CLDN6 in breast cancer inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Jiancheng Wang, Ye Wang, Junfu Wang, Siwen Zhang, Zhu Yu, Kaitian Zheng, Zhao Fu, Congjun Wang, Weijia Huang, Junqiang Chen
Summary: The DEAD-box helicase (DDX) family plays a critical role in cancer initiation and progression through alternative splicing, transcription, and ribosome biogenesis. DDX56, a member of this family, is overexpressed in several cancers and exhibits an oncogenic role. This study demonstrated the aberrant expression of DDX56 in gastric cancer through high-throughput sequencing and functional studies, shedding light on its biological role and potential therapeutic target in gastric cancer.
Article
Biochemistry & Molecular Biology
Junhong Li, Fangning Wan, Junyu Zhang, Shengfeng Zheng, Yunjie Yang, Zhe Hong, Bo Dai
Summary: SMYD2 is involved in various cancers by methylating histone H3K4 and H3K36. Higher SMYD2 expression is associated with an increased risk of prostate cancer progression and relapse. Inhibition of SMYD2 restrains prostate cancer cell proliferation.
MOLECULAR CARCINOGENESIS
(2023)
Article
Medicine, Research & Experimental
Xiao-Sheng Jin, Ting-Ting Ji, Zheng-Chao Shi, Qing-Qing Zhang, Fang-Peng Ye, Wei-Lai Yu, Rong-Zhou Li
Summary: The study revealed that ZNF479 acts as an oncogene in gastric cancer, modulating the beta-catenin/c-Myc signaling pathway to promote cancer progression. This provides a new research target for future studies.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Oncology
Changyuan Kang, Lizhou Jia, Lei Hao, Ning Zhang, Yang Liu, Lingli Zhang
Summary: POM121 is overexpressed in gastric cancer tissues compared to normal gastric tissues and is associated with deep invasion, distant metastases, and TNM stage in gastric cancer patients. POM121 promotes proliferation, migration, and invasion of gastric cancer cells through the phosphorylation of the PI3K/AKT pathway and increased expression of MYC. These findings suggest that POM121 may serve as an independent prognostic factor for gastric cancer patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Qianqian Xu, Guangzhao Pan, Zhonglan Wang, Lingling Wang, Yancheng Tang, Jinyun Dong, Jiang-Jiang Qin
Summary: In this study, it was found that Platycodin D (PD) can inhibit gastric cancer cell viability by destabilizing the c-Myc protein, leading to cell cycle arrest and subsequent apoptosis. This novel molecular mechanism proposes a potential anti-cancer therapy using PD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Yingchun Zhang, Yong Zhou, Fang Wei
Summary: circABCB10 promotes the proliferation, invasion, and clonal formation of gastric cancer cells by targeting miR-1252-5p and upregulating the expression of MYC. circABCB10 functions as a sponge for miR-1252-5p in gastric cancer cells, while MYC is the target gene of miR-1252-5p. Overexpression of miR-1252-5p and knockdown of MYC can reverse the promoting effect of circABCB10 on gastric cancer.
JOURNAL OF ONCOLOGY
(2021)
Article
Cell Biology
Hanlin Ma, Fang Han, Xiaohui Yan, Gonghua Qi, Yingwei Li, Rongrong Li, Shi Yan, Cunzhong Yuan, Kun Song, Beihua Kong
Summary: Cervical cancer is the fourth most common cancer in women globally, and the overexpression of PBK in cervical cancer tissues promotes proliferation, metastasis, and cisplatin resistance of cancer cells through the ERK/c-Myc signaling pathway. Inhibition of PBK with OTS514 shows promising results in suppressing tumor growth and enhancing chemosensitivity. Further studies on PBK as a molecular target for cervical cancer treatment are warranted.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Qiang Wang, Leqi Qian, Mengyuan Tao, Jiaqi Liu, Fa-zhi Qi
Summary: The study revealed that DDX52 was significantly overexpressed in MM tissues and associated with shorter overall survival in patients, indicating its potential as a prognostic marker in MM. Downregulation of DDX52 expression in MM cell lines inhibited cell proliferation and colony formation. Additionally, DDX52 mediated oncogenesis by promoting the transcriptional activity of c-Myc, suggesting it could be a therapeutic target in MM.
Article
Biochemistry & Molecular Biology
Maozhi Hu, Yibei Zhang, Dan Gu, Xiang Chen, Matthew K. Waldor, Xiaohui Zhou
Summary: The study revealed that the T3SS effector VgpA in Vibrio parahaemolyticus interacts with the host cell nucleolus protein EBP2, leading to re-localization of c-Myc and increased cell proliferation. This interaction enhances EBP2 affinity for c-Myc, prolonging the oncoprotein's half-life and ultimately contributing to the pathogenesis of V. parahaemolyticus infection.
Article
Oncology
Yuanfei Cao, Xin Yan, Xiaojie Bai, Feng Tang, Penghui Si, Can Bai, Kuerban Tuoheti, Linfa Guo, Zuhaer Yisha, Tao Liu, Tongzu Liu
Summary: In this study, UCHL5 was found to promote the growth and migration of bladder cancer cells and increase c-Myc expression by activating the AKT/mTOR signaling pathway. This discovery provides a potential therapeutic target for bladder cancer treatment.
Article
Biochemistry & Molecular Biology
Weimei Tang, Miaomiao Pei, Jiaying Li, Nanzhu Xu, Wushuang Xiao, Zhen Yu, Jieming Zhang, Linjie Hong, Zheng Guo, Jianjiao Lin, Weiyu Dai, Yizhi Xiao, Xiaosheng Wu, Guangnan Liu, Fachao Zhi, Guoxin Li, Jing Xiong, Ye Chen, Hui Zhang, Li Xiang, Aimin Li, Side Liu, Jide Wang
Summary: miR-3648 acts as a tumor-suppressive miRNA and regulates the progression of gastric cancer by targeting the FRAT1-FRAT2/c-Myc negative feedback loop.
Article
Oncology
Xian Liu, Xiaohang Zuo, Xiaoli Sun, Xueye Tian, Yue Teng
Summary: In this study, it was found that HK2 expression is increased in ovarian carcinoma tissues and promotes cell proliferation and tumor formation. It was further discovered that HK2 enhances the activity of the Wnt/13-catenin signaling pathway, leading to the upregulation of 13-catenin, c-myc, and CyclinD1 in ovarian cancer.