Journal
FEBS LETTERS
Volume 582, Issue 13, Pages 1802-1808Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.04.061
Keywords
PBEF; interaction; vascular permeability; acute lung injury; inflammation; oxidative stress
Funding
- NHLBI NIH HHS [HL 080042, R01 HL080042-02, R01 HL080042, HL058064] Funding Source: Medline
Ask authors/readers for more resources
Identification of pre-B-cell colony-enhancing factor (PBEF) interacting partners may reveal new molecular mechanisms of PBEF in the pathogenesis of acute lung injury (ALI). The interactions between PBEF and NADH dehydrogenase subunit 1 (ND1), ferritin tight chain and interferon induced transmembrane 3 (IFITM3) in human pulmonary vascular endothelial cells were identified and validated. ND1, ferritin and IFITM3 are involved in oxidative stress and inflammation. Overexpression of PBEF increased its interactions and intracellular oxidative stress, which can be attenuated by rotenone. The interaction modeling between PBEF and ND1 is consistent with the corresponding experimental finding. These interactions may underlie a novel role of PBEF in the pathogenesis of ALI.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available