☆ 4.5 Article

Interactions between PBEF and oxidative stress proteins - A potential new mechanism underlying PBEF in the pathogenesis of acute lung injury

FEBS LETTERS (2008)

期刊

FEBS LETTERS

卷 582, 期 13, 页码 1802-1808

出版社

ELSEVIER SCIENCE BV

DOI: 10.1016/j.febslet.2008.04.061

关键词

PBEF; interaction; vascular permeability; acute lung injury; inflammation; oxidative stress

类别

Biochemistry & Molecular Biology Biophysics Cell Biology

资金

NHLBI NIH HHS [HL 080042, R01 HL080042-02, R01 HL080042, HL058064] Funding Source: Medline

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Reagent

摘要

Identification of pre-B-cell colony-enhancing factor (PBEF) interacting partners may reveal new molecular mechanisms of PBEF in the pathogenesis of acute lung injury (ALI). The interactions between PBEF and NADH dehydrogenase subunit 1 (ND1), ferritin tight chain and interferon induced transmembrane 3 (IFITM3) in human pulmonary vascular endothelial cells were identified and validated. ND1, ferritin and IFITM3 are involved in oxidative stress and inflammation. Overexpression of PBEF increased its interactions and intracellular oxidative stress, which can be attenuated by rotenone. The interaction modeling between PBEF and ND1 is consistent with the corresponding experimental finding. These interactions may underlie a novel role of PBEF in the pathogenesis of ALI.

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