Article
Neurosciences
Akanksha Kushwaha, Mahendra Kumar Thakur
Summary: Histone post-translational modifications are important for the regulation of long-term memory and neuronal immediate early genes (IEGs). This study investigates the relationship between changes in H3K9 trimethylation and memory decline in a scopolamine-induced amnesic mouse model. The results show that silencing Suv39h1 reduces H3K9 trimethylation levels and improves recognition memory by increasing the expression of IEGs.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Alexia Klonou, Penelope Korkolopoulou, Antonios N. Gargalionis, Dimitrios S. Kanakoglou, Hector Katifelis, Maria Gazouli, Sarantis Chlamydas, Andreas Mitsios, Theodosis Kalamatianos, George Stranjalis, Marios S. Themistocleous, Kostas A. Papavassiliou, Spyros Sgouros, Athanasios G. Papavassiliou, Christina Piperi
Summary: Alterations in global histone methylation play a crucial role in oncogenesis and progression of pediatric astrocytomas. Differential patterns of epigenetic regulator expression were observed between pilocytic and diffusely infiltrating astrocytomas. SUV39H1 was identified as an independent prognostic factor with significant impact on disease-specific survival.
Article
Cell Biology
Ruoyu Li, Yungshan Teng, Yuqing Guo, Jianhan Ren, Runze Li, Haotian Luo, Danying Chen, Zhicai Feng, Zheng Fu, Xuenong Zou, Weicai Wang, Chen Zhou
Summary: Aging-related diseases are associated with inflammation, also known as inflammaging. Senescent cells secrete factors that contribute to inflammation, called SASP. SUV39H1, a protein involved in chromatin regulation, was found to decrease with aging and inhibit SASP by modifying the epigenetic marks of certain genes.
MECHANISMS OF AGEING AND DEVELOPMENT
(2023)
Article
Ophthalmology
Shuai Yang, Weiwei Chen, Shanshan Jin, Guangying Luo, Xia Jing, Qi Liu, Peter S. Reinach, Jia Qu, Dongsheng Yan
Summary: This study reveals the crucial role of SUV39H1 in corneal epithelial cell proliferation during wound healing, mediated by H3K9me3-dependent suppression of p27. These findings suggest that epigenetic modifiers such as SUV39H1 could be potential therapeutic approaches to accelerate corneal repair.
Review
Biochemistry & Molecular Biology
Daniel G. Sausen, Maimoona S. Bhutta, Elisa S. Gallo, Harel Dahari, Ronen Borenstein
Summary: EBV is often latent in immunocompetent individuals, but perturbations in the host immune system can lead to viral reactivation and various related illnesses. Understanding the interaction between the virus, stress, and the immune system is crucial for effective treatment.
Article
Virology
Fang Lu, Urvi Zankharia, Olga Vladimirova, Yanjie Yi, Ronald G. Collman, Paul M. Lieberman
Summary: HIV-infected macrophages have a unique epigenetic control pattern, with viral genomes maintained in a noncanonical bivalent state. These findings may contribute to the discovery of new mechanisms for controlling chronic HIV expression in infected macrophages.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Joanna W. Y. Ho, Lili Li, Kai Yau Wong, Gopesh Srivastava, Qian Tao
Summary: The expression pattern of EBV genes in PTCL was mainly latency II, but occasionally fully lytic infection could also be detected. These findings have implications for the future development of EBV-targeting therapeutics for this cancer.
Editorial Material
Medicine, Research & Experimental
James T. Pearson
Summary: Epigenome changes in chronic cardiovascular stress involve open chromatin and modifications of histone lysine residues. Set7 has been found to play an important role in cardiovascular remodeling and cardiac dysfunction.
Article
Biochemistry & Molecular Biology
Florent Bernaudat, Montse Gustems, Johannes Guenther, Mizar F. Oliva, Alexander Buschle, Christine Goebel, Priscilla Pagniez, Julien Lupo, Luca Signor, Christoph W. Mueller, Patrice Morand, Michael Sattler, Wolfgang Hammerschmidt, Carlo Petosa
Summary: This study elucidated the mechanism by which ZEBRA binds to CpG-methylated ZRE during viral replication, with a preference for CpG methylation marks. Mutational analysis showed the crucial role of a ZEBRA-specific serine in this selective binding.
NUCLEIC ACIDS RESEARCH
(2022)
Review
Oncology
Merrin Man Long Leong, Maria Li Lung
Summary: Epstein-Barr virus (EBV) infection is associated with various malignancies and can disrupt epigenetic regulation, influencing the development of cancer. The interaction between EBV and the host genome in different cancer types results in unique epigenetic features, suggesting that EBV may utilize different latency proteins to manipulate the epigenetic modulators in host cells for pathogenesis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Svetlana Sharifulina, Valentina Dzreyan, Valeria Guzenko, Svetlana Demyanenko
Summary: The study found that the levels and intracellular localization of DNMT1 and G9a proteins changed in penumbra neurons and astrocytes in the rat cerebral cortex after stroke. Inhibition of DNMT1 and G9a protected penumbra cells from apoptosis and reduced the volume of cerebral infarction induced by stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Jiaxin Liu, Jia-nan Li, Hongyu Wu, Panpan Liu
Summary: Epigenetic regulation plays a crucial role in lymphoma development and is closely associated with various malignancies. Understanding these epigenetic mechanisms can guide the development of clinical treatments.
FRONTIERS IN ONCOLOGY
(2022)
Review
Virology
Takayuki Murata, Atsuko Sugimoto, Tomoki Inagaki, Yusuke Yanagi, Takahiro Watanabe, Yoshitaka Sato, Hiroshi Kimura
Summary: Epstein-Barr virus (EBV) is a causative agent of infectious mononucleosis and several types of cancer, establishing a lifelong latent infection. Reactivation involves various regulatory mechanisms, in addition to just progeny production.
Article
Biochemistry & Molecular Biology
Praphatson Malat, Tipaya Ekalaksananan, Chukkris Heawchaiyaphum, Supawadee Suebsasana, Sittiruk Roytrakul, Yodying Yingchutrakul, Chamsai Pientong
Summary: Andrographolide inhibits the reactivation of Epstein-Barr virus in EBV-positive cancer cells by inhibiting EBV lytic genes, possibly through histone modifications.
Article
Cell Biology
Marni E. Cueno, Noriaki Kamio, Keisuke Seki, Tomoko Kurita-Ochiai, Kuniyasu Ochiai
CELL STRESS & CHAPERONES
(2015)
Article
Biochemistry & Molecular Biology
Keisuke Seki, Marni E. Cueno, Noriaki Kamio, Yuko Saito, Atsushi Kamimoto, Tomoko Kurita-Ochiai, Kuniyasu Ochiai
Article
Neurosciences
Hidekazu Nagashima, Masamichi Shinoda, Kuniya Honda, Noriaki Kamio, Masahiro Watanabe, Tatsuro Suzuki, Naoyuki Sugano, Shuichi Sato, Koichi Iwata
Article
Dentistry, Oral Surgery & Medicine
Hidekazu Nagashima, Masamichi Shinoda, Kuniya Honda, Noriaki Kamio, Akira Hasuike, Naoyuki Sugano, Yoshinori Arai, Shuichi Sato, Koichi Iwata
JOURNAL OF ORAL SCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Noriaki Kamio, Kenichi Imai, Kazufumi Shimizu, Marni E. Cueno, Muneaki Tamura, Yuko Saito, Kuniyasu Ochiai
CELLULAR AND MOLECULAR LIFE SCIENCES
(2015)
Article
Chemistry, Medicinal
Mayumi Hayata, Norihisa Watanabe, Noriaki Kamio, Muneaki Tamura, Keiko Nodomi, Kiyotaka Tanaka, Arunasiri Iddamalgoda, Hiromasa Tsuda, Yorimasa Ogata, Shuichi Sato, Kouichiro Ueda, Kenichi Imai
JOURNAL OF NATURAL MEDICINES
(2019)
Article
Biotechnology & Applied Microbiology
Marni E. Cueno, Noriaki Kamio, Kenichi Imai, Manabu Ohya, Muneaki Tamura, Kuniyasu Ochiai
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Ryo Koike, Marni E. Cueno, Keiko Nodomi, Muneaki Tamura, Noriaki Kamio, Hajime Tanaka, Ai Kotani, Kenichi Imai
Article
Biochemistry & Molecular Biology
Yuwa Takahashi, Norihisa Watanabe, Noriaki Kamio, Sho Yokoe, Ryuta Suzuki, Shuichi Sato, Toshimitsu Iinuma, Kenichi Imai
Summary: Periodontitis may be a risk factor for exacerbating COVID-19, promoting SARS-CoV-2 infection and worsening inflammation in the lower respiratory tract.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Noriaki Kamio, Mayumi Hayata, Muneaki Tamura, Hajime Tanaka, Kenichi Imai
Summary: Chronic periodontitis is a risk factor for pneumonia, and periodontopathic bacteria enhance pneumococcal adhesion to human alveoli by inducing PAFR expression. Among the virulence factors of Porphyromonas gingivalis, gingipains play a key role in this process.
Article
Biochemistry & Molecular Biology
Yuwa Takahashi, Marni E. Cueno, Noriaki Kamio, Toshimitsu Iinuma, Yoshiyuki Hasegawa, Kenichi Imai
Summary: The study demonstrates that Porphyromonas gingivalis Mfa1 protein can interact functionally with human bronchial epithelial cells, inducing an inflammatory response involving IL-8 and IL-6 gene expression and protein levels. Specifically, Mfa1-TLR2 showed a functional interaction, suggesting a potential role in pulmonary disease development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ryuta Suzuki, Noriaki Kamio, Tadayoshi Kaneko, Yoshiyuki Yonehara, Kenichi Imai
Summary: Fusobacterium nucleatum may play a role in exacerbation of chronic obstructive pulmonary disease (COPD), causing inflammatory responses and exacerbating disease progression.
Article
Dentistry, Oral Surgery & Medicine
Naoki Murakami, Kenji Yoshikawa, Kohei Tsukada, Noriaki Kamio, Yoshinori Hayashi, Suzuro Hitomi, Yuki Kimura, Ikuko Shibuta, Ayaka Osada, Shuichi Sato, Koichi Iwata, Masamichi Shinoda
Summary: This study examines the involvement of butyric acid (BA) in periodontal pain sensitivity in Porphyromonas gingivalis (P. gingivalis)-induced periodontitis. The results suggest that gingival BA modulates periodontal mechanical nociception via GPR41 signaling.
JOURNAL OF ORAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Ryuta Suzuki, Noriaki Kamio, Kozue Sugimoto, Shuichiro Maruoka, Yasuhiro Gon, Tadayoshi Kaneko, Yoshiyuki Yonehara, Kenichi Imai
Summary: There is a correlation between periodontopathic bacteria and pulmonary diseases, although the molecular mechanisms are not yet fully understood. This study investigated the effects of Fusobacterium nucleatum on the expression of MMP9 in mouse lung and human alveolar epithelial cells. The results indicate that F. nucleatum can induce MMP9 expression, suggesting its potential role in the onset of pulmonary diseases.