The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered

The Plasticity of Oncogene Addiction: Implications for Targeted Therapies Directed to Receptor Tyrosine Kinases

(2015) Vinochani Pillay et al.   NEOPLASIA

Regulation of HGF Expression by ΔEGFR-Mediated c-Met Activation in Glioblastoma Cells

(2015) Jeannine Garnett et al.   NEOPLASIA

Mutant epidermal growth factor receptor vIII increases cell motility and clonogenecity in a prostate cell line RWPE1

(2014) M. He et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Targeting of a Conformationally Exposed, Tumor-Specific Epitope of EGFR as a Strategy for Cancer Therapy

(2012) H. K. Gan et al.   CANCER RESEARCH

Glioblastoma Stem-like Cell Lines with Either Maintenance or Loss of High-Level EGFR Amplification, Generated via Modulation of Ligand Concentration

(2012) A. Schulte et al.   CLINICAL CANCER RESEARCH

In Situ Analysis of Mutant EGFRs Prevalent in Glioblastoma Multiforme Reveals Aberrant Dimerization, Activation, and Differential Response to Anti-EGFR Targeted Therapy

(2012) A. S. Gajadhar et al.   MOLECULAR CANCER RESEARCH

Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma

(2012) B. D. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

(2012) H. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism

(2011) Anna N. Cvrljevic et al.   JOURNAL OF CELL SCIENCE

Forced Dimerization Increases the Activity of  EGFR/EGFRvIII and Enhances Its Oncogenicity

(2011) Y. Hwang et al.   MOLECULAR CANCER RESEARCH

EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway

(2011) R Bonavia et al.   ONCOGENE

Cetuximab induces mitochondrial translocalization of EGFRvIII, but not EGFR: involvement of mitochondria in tumor drug resistance?

(2011) Agnieszka Dreier et al.   TUMOR BIOLOGY

Oncogenic EGFR Signaling Activates an mTORC2-NF- B Pathway That Promotes Chemotherapy Resistance

(2011) K. Tanaka et al.   Cancer Discovery

Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation

(2011) Susie I. Ymer et al.   Cancers

Co-expression of EGFRvIII with ErbB-2 enhances tumorigenesis: EGFRvIII mediated constitutively activated and sustained signaling pathways, whereas EGF-induced a transient effect on EGFR-mediated signaling pathways

(2010) Hong Yu et al.   CANCER BIOLOGY & THERAPY

Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells

(2010) Sarah E. Golding et al.   CANCER BIOLOGY & THERAPY

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

(2010) M.-d.-M. Inda et al.   GENES & DEVELOPMENT

MAb 806 Enhances the Efficacy of Ionizing Radiation in Glioma Xenografts Expressing the de2-7 Epidermal Growth Factor Receptor

(2010) Terrance G. Johns et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma

(2010) John H. Sampson et al.   JOURNAL OF CLINICAL ONCOLOGY

Glioblastoma-derived spheroid cultures as an experimental model for analysis of EGFR anomalies

(2010) Monika Witusik-Perkowska et al.   JOURNAL OF NEURO-ONCOLOGY

Boron neutron capture therapy of EGFR or EGFRvIII positive gliomas using either boronated monoclonal antibodies or epidermal growth factor as molecular targeting agents

(2009) W. Yang et al.   APPLIED RADIATION AND ISOTOPES

Arrested neural and advanced mesenchymal differentiation of glioblastoma cells-comparative study with neural progenitors

(2009) Piotr Rieske et al.   BMC CANCER

Improved Response by Co-targeting EGFR/EGFRvIII and Src Family Kinases in Human Cancer Cells

(2009) Peter Andersen et al.   CANCER INVESTIGATION

Epidermal growth factor receptor vIII enhances tumorigenicity and resistance to 5-fluorouracil in human hepatocellular carcinoma

(2009) Huamao Wang et al.   CANCER LETTERS

Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients

(2009) K. V. Lu et al.   CANCER RESEARCH

Epidermal Growth Factor Receptor and PTEN Modulate Tissue Factor Expression in Glioblastoma through JunD/Activator Protein-1 Transcriptional Activity

(2009) Y. Rong et al.   CANCER RESEARCH

EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma

(2009) B. Mukherjee et al.   CANCER RESEARCH

Vasculostatin Inhibits Intracranial Glioma Growth and Negatively Regulates In vivo Angiogenesis through a CD36-Dependent Mechanism

(2009) B. Kaur et al.   CANCER RESEARCH

The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells

(2009) Yi Zhan et al.   EXPERIMENTAL CELL RESEARCH

Expression of EGFRvIII in Thyroid Carcinoma: Immunohistochemical Study by Camel Antibodies

(2009) Kobra Omidfar et al.   IMMUNOLOGICAL INVESTIGATIONS

EGFRvIII-induced estrogen-independence, tamoxifen-resistance phenotype correlates with PgR expression and modulation of apoptotic molecules in breast cancer

(2009) Yang Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting a unique EGFR epitope with monoclonal antibody 806 activates NF-κB and initiates tumour vascular normalization

(2009) Hui K. Gan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The EGFRvIII variant in glioblastoma multiforme

(2009) Hui K. Gan et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Genetically engineered T cells to target EGFRvIII expressing glioblastoma

(2009) Szofia S. Bullain et al.   JOURNAL OF NEURO-ONCOLOGY

Demonstration of the equivalent pharmacokinetic/pharmacodynamic dosing strategy in a multiple-dose study of gefitinib

(2009) S. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Labeling internalizing anti-epidermal growth factor receptor variant III monoclonal antibody with 177Lu: in vitro comparison of acyclic and macrocyclic ligands

(2009) Marc Hens et al.   NUCLEAR MEDICINE AND BIOLOGY

The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis

(2009) D. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding of cetuximab to the EGFRvIII deletion mutant and its biological consequences in malignant glioma cells

(2009) Barry Jutten et al.   RADIOTHERAPY AND ONCOLOGY

19F- and Fluorescently Labeled Micelles as Nanoscopic Assemblies for Chemotherapeutic Delivery

(2008) Wenjun Du et al.   BIOCONJUGATE CHEMISTRY

The ErbB signalling pathway: protein expression and prognostic value in epithelial ovarian cancer

(2008) P de Graeff et al.   BRITISH JOURNAL OF CANCER

Copy number gains inEGFRand copy number losses inPTENare common events in osteosarcoma tumors

(2008) Serena S. Freeman et al.   CANCER

Mutant Epidermal Growth Factor Receptor in Benign, Borderline, and Malignant Ovarian Tumors

(2008) K. D. Steffensen et al.   CLINICAL CANCER RESEARCH

Inhibition of Glioblastoma Growth in a Highly Invasive Nude Mouse Model Can Be Achieved by Targeting Epidermal Growth Factor Receptor but not Vascular Endothelial Growth Factor Receptor-2

(2008) T. Martens et al.   CLINICAL CANCER RESEARCH

Constitutively Activated STAT3 Frequently Coexpresses with Epidermal Growth Factor Receptor in High-Grade Gliomas and Targeting STAT3 Sensitizes Them to Iressa and Alkylators

(2008) H.-W. Lo et al.   CLINICAL CANCER RESEARCH

Molecular Targeting and Treatment of Composite EGFR and EGFRvIII-Positive Gliomas Using Boronated Monoclonal Antibodies

(2008) W. Yang et al.   CLINICAL CANCER RESEARCH

A Novel Inhibitor of Signal Transducers And Activators Of Transcription 3 Activation Is Efficacious Against Established Central Nervous System Melanoma and Inhibits Regulatory T Cells

(2008) L.-Y. Kong et al.   CLINICAL CANCER RESEARCH

Development of a Real-time RT-PCR Assay for Detecting EGFRvIII in Glioblastoma Samples

(2008) K. Yoshimoto et al.   CLINICAL CANCER RESEARCH

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

(2008) N. de la Iglesia et al.   GENES & DEVELOPMENT

Phase I/II Trial of Erlotinib and Temozolomide With Radiation Therapy in the Treatment of Newly Diagnosed Glioblastoma Multiforme: North Central Cancer Treatment Group Study N0177

(2008) Paul D. Brown et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II Study of Erlotinib Plus Temozolomide During and After Radiation Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma

(2008) Michael D. Prados et al.   JOURNAL OF CLINICAL ONCOLOGY

Lovastatin enhances gefitinib activity in glioblastoma cells irrespective of EGFRvIII and PTEN status

(2008) Catia Cemeus et al.   JOURNAL OF NEURO-ONCOLOGY

Epidermal Growth Factor Receptor 1 (EGFR1) and Its Variant EGFRvIII Regulate TATA-Binding Protein Expression through Distinct Pathways

(2008) J. A. Fromm et al.   MOLECULAR AND CELLULAR BIOLOGY

An integrated comparative phosphoproteomic and bioinformatic approach reveals a novel class of MPM-2 motifs upregulated in EGFRvIII-expressing glioblastoma cells

(2008) Brian A. Joughin et al.   Molecular BioSystems

Epidermal Growth Factor Receptor vIII Expression in U87 Glioblastoma Cells Alters Their Proteasome Composition, Function, and Response to Irradiation

(2008) K. Kim et al.   MOLECULAR CANCER RESEARCH

Preclinical pharmacokinetic/pharmacodynamic models of gefitinib and the design of equivalent dosing regimens in EGFR wild-type and mutant tumor models

(2008) S. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Gene silencing for epidermal growth factor receptor variant III induces cell-specific cytotoxicity

(2008) F. Yamoutpour et al.   MOLECULAR CANCER THERAPEUTICS

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors

(2008) Li Li et al.   NEURO-ONCOLOGY

LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII

(2008) M A Stutz et al.   ONCOGENE

Epidermal Growth Factor Receptor Expression and Mutational Analysis in Synovial Sarcomas and Malignant Peripheral Nerve Sheath Tumors

(2008) H. Tawbi et al.   ONCOLOGIST