The recognition and removal of cellular poly(ADP-ribose) signals

ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation

(2013) Karla LH Feijs et al.   Cell Communication and Signaling

Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease

(2013) Reza Sharifi et al.   EMBO JOURNAL

Poly(ADP-ribose): PARadigms and PARadoxes

(2013) Alexander Bürkle et al.   MOLECULAR ASPECTS OF MEDICINE

Poly(ADP-ribose) signaling in cell death

(2013) László Virág et al.   MOLECULAR ASPECTS OF MEDICINE

Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases

(2013) Florian Rosenthal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation

(2013) Gytis Jankevicius et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains

(2013) Alexandra H. Forst et al.   STRUCTURE

Selective Small Molecule Inhibition of Poly(ADP-Ribose) Glycohydrolase (PARG)

(2012) Kristin E. Finch et al.   ACS Chemical Biology

Large-scale preparation and characterization of poly(ADP-ribose) and defined length polymers

(2012) Edwin S. Tan et al.   ANALYTICAL BIOCHEMISTRY

The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art

(2012) Mike De Vos et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells

(2012) Catherine Fathers et al.   CELL CYCLE

APLF promotes the assembly and activity of non-homologous end joining protein complexes

(2012) Gabrielle J Grundy et al.   EMBO JOURNAL

Structural insight into the interaction of ADP-ribose with the PARP WWE domains

(2012) Fahu He et al.   FEBS LETTERS

Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination

(2012) Z. Wang et al.   GENES & DEVELOPMENT

CHFR Protein Regulates Mitotic Checkpoint by Targeting PARP-1 Protein for Ubiquitination and Degradation

(2012) Lisa Kashima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADP-ribosylhydrolase 3 (ARH3), Not Poly(ADP-ribose) Glycohydrolase (PARG) Isoforms, Is Responsible for Degradation of Mitochondrial Matrix-associated Poly(ADP-ribose)

(2012) Marc Niere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New PARP Gene with an Anti-Alphavirus Function

(2012) S. Atasheva et al.   JOURNAL OF VIROLOGY

MacroH2A1 Regulates the Balance between Self-Renewal and Differentiation Commitment in Embryonic and Adult Stem Cells

(2012) C. Creppe et al.   MOLECULAR AND CELLULAR BIOLOGY

Reanalysis of phosphoproteomics data uncovers ADP-ribosylation sites

(2012) Ivan Matic et al.   NATURE METHODS

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

(2012) Bryan A. Gibson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element

(2012) In-Kwon Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks

(2012) Ammar A E Ali et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD Derivatives

(2012) Julie A. Tucker et al.   PLoS One

Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

(2012) M.-F. Langelier et al.   SCIENCE

Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase

(2012) Mark S. Dunstan et al.   Nature Communications

Loss of Tankyrase-Mediated Destruction of 3BP2 Is the Underlying Pathogenic Mechanism of Cherubism

(2011) Noam Levaot et al.   CELL

Orphan Macrodomain Protein (Human C6orf130) Is anO-Acyl-ADP-ribose Deacylase

(2011) Francis C. Peterson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA

(2011) Marie-France Langelier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Macrodomain Proteins as NovelO-Acetyl-ADP-ribose Deacetylases

(2011) Dawei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks

(2011) C. Anne-Marie Couto et al.   JOURNAL OF CELL BIOLOGY

DNA Repair Factor APLF Is a Histone Chaperone

(2011) Pawan Vinod Mehrotra et al.   MOLECULAR CELL

PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining

(2011) Stuart L. Rulten et al.   MOLECULAR CELL

The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase

(2011) Dea Slade et al.   NATURE

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

(2011) Yue Zhang et al.   NATURE CELL BIOLOGY

Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death

(2011) Shaida A Andrabi et al.   NATURE MEDICINE

PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms

(2011) Oliver Mortusewicz et al.   NUCLEIC ACIDS RESEARCH

Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage

(2011) H. C. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos)

(2011) Y. Wang et al.   Science Signaling

Stress-Induced PARP Activation Mediates Recruitment of Drosophila Mi-2 to Promote Heat Shock Gene Expression

(2011) Magdalena Murawska et al.   PLoS Genetics

Identification of a Regulatory Segment of Poly(ADP-ribose) Glycohydrolase

(2010) Davide Botta et al.   BIOCHEMISTRY

Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4

(2010) Sophie E Polo et al.   EMBO JOURNAL

PARP is involved in replicative aging in Neurospora crassa

(2010) Gregory O. Kothe et al.   FUNGAL GENETICS AND BIOLOGY

Structural Basis of Poly(ADP-ribose) Recognition by the Multizinc Binding Domain of Checkpoint with Forkhead-associated and RING Domains (CHFR)

(2010) Jasmeen Oberoi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Zn3 Domain of Human Poly(ADP-ribose) Polymerase-1 (PARP-1) Functions in Both DNA-dependent Poly(ADP-ribose) Synthesis Activity and Chromatin Compaction

(2010) Marie-France Langelier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

(2010) Avnish Kapoor et al.   NATURE

Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose)

(2010) Sebastian Eustermann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PARP1 ADP-ribosylates lysine residues of the core histone tails

(2010) Simon Messner et al.   NUCLEIC ACIDS RESEARCH

Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response

(2010) G.-Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward a unified nomenclature for mammalian ADP-ribosyltransferases

(2010) Michael O. Hottiger et al.   TRENDS IN BIOCHEMICAL SCIENCES

A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence

(2009) Clifford J. Whatcott et al.   EXPERIMENTAL CELL RESEARCH

Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells

(2009) Katalin Erdélyi et al.   FASEB JOURNAL

Identification of the ADP-Ribosylation Sites in the PARP-1 Automodification Domain: Analysis and Implications

(2009) Zhihua Tao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding Pocket

(2009) H. Malet et al.   JOURNAL OF VIROLOGY

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

(2009) Gyula Timinszky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The histone variant macroH2A is an epigenetic regulator of key developmental genes

(2009) Marcus Buschbeck et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

(2009) Matthias Altmeyer et al.   NUCLEIC ACIDS RESEARCH

Histone macroH2A isoforms predict the risk of lung cancer recurrence

(2009) J C Sporn et al.   ONCOGENE

Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler

(2009) A. J. Gottschalk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

(2009) D. Ahel et al.   SCIENCE

Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation

(2008) W Lee Kraus   CURRENT OPINION IN CELL BIOLOGY

The single-macro domain protein LRP16 is an essential cofactor of androgen receptor

(2008) J Yang et al.   ENDOCRINE-RELATED CANCER

Poly(ADP-ribose) Binds to the Splicing Factor ASF/SF2 and Regulates Its Phosphorylation by DNA Topoisomerase I

(2008) Maria Malanga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Activities of Cellular and Viral Macro Domain Proteins in Binding of ADP-Ribose Metabolites

(2008) Maarit Neuvonen et al.   JOURNAL OF MOLECULAR BIOLOGY

APLF (C2orf13) Is a Novel Component of Poly(ADP-Ribose) Signaling in Mammalian Cells

(2008) S. L. Rulten et al.   MOLECULAR AND CELLULAR BIOLOGY

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

(2008) Ivan Ahel et al.   NATURE

Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes

(2008) Jean-Philippe Gagné et al.   NUCLEIC ACIDS RESEARCH