Towards the rational design of antimicrobial proteins

Two Human Host Defense Ribonucleases against Mycobacteria, the Eosinophil Cationic Protein (RNase 3) and RNase 7

(2013) David Pulido et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In SilicoPrediction andIn VitroCharacterization of Multifunctional Human RNase3

(2013) Pei-Chun Lien et al.   Biomed Research International

The expanding world of extracellular traps: not only neutrophils but much more

(2013) Oliver Goldmann et al.   Frontiers in Immunology

Antimicrobial Action and Cell Agglutination by the Eosinophil Cationic Protein Are Modulated by the Cell Wall Lipopolysaccharide Structure

(2012) David Pulido et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural determinants of the eosinophil cationic protein antimicrobial activity

(2012) Ester Boix et al.   BIOLOGICAL CHEMISTRY

Antimicrobial activity of human eosinophil granule proteins: involvement in host defence against pathogens

(2012) Anu Malik et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Eosinophil extracellular DNA traps: molecular mechanisms and potential roles in disease

(2012) Shida Yousefi et al.   CURRENT OPINION IN IMMUNOLOGY

An insertion in loop L7 of human eosinophil-derived neurotoxin is crucial for its antiviral activity

(2012) Deepa Sikriwal et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Exploring New Biological Functions of Amyloids: Bacteria Cell Agglutination Mediated by Host Protein Aggregation

(2012) Marc Torrent et al.   PLoS Pathogens

The Generation of Antimicrobial Peptide Activity: A Trade-off between Charge and Aggregation?

(2011) Marc Torrent et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bovine Pancreatic Ribonuclease: Fifty Years of the First Enzymatic Reaction Mechanism

(2011) Claudi M. Cuchillo et al.   BIOCHEMISTRY

Role of unique basic residues in cytotoxic, antibacterial and antiparasitic activities of human eosinophil cationic protein

(2011) Anubha Singh et al.   BIOLOGICAL CHEMISTRY

Refining the Eosinophil Cationic Protein Antibacterial Pharmacophore by Rational Structure Minimization

(2011) Marc Torrent et al.   JOURNAL OF MEDICINAL CHEMISTRY

Connecting Peptide Physicochemical and Antimicrobial Properties by a Rational Prediction Model

(2011) Marc Torrent et al.   PLoS One

Describing the Mechanism of Antimicrobial Peptide Action with the Interfacial Activity Model

(2010) William C. Wimley   ACS Chemical Biology

Eosinophil Cationic Protein Aggregation: Identification of an N-Terminus Amyloid Prone Region

(2010) Marc Torrent et al.   BIOMACROMOLECULES

Comparison of human RNase 3 and RNase 7 bactericidal action at the Gram-negative and Gram-positive bacterial cell wall

(2010) Marc Torrent et al.   FEBS Journal

The eight human “canonical” ribonucleases: Molecular diversity, catalytic properties, and special biological actions of the enzyme proteins

(2010) Salvatore Sorrentino   FEBS LETTERS

Activity and turnover of eosinophil and neutrophil granulocytes are altered in visceral leishmaniasis

(2010) Amir I. Elshafie et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Eosinophil-induced neurotoxicity: The role of eosinophil cationic protein/RNase 3

(2010) Susanna Navarro et al.   JOURNAL OF NEUROIMMUNOLOGY

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment

(2009) Marc Torrent et al.   BIOCHEMICAL JOURNAL

Eosinophil Cationic Protein High-Affinity Binding to Bacteria-Wall Lipopolysaccharides and Peptidoglycans†

(2008) Marc Torrent et al.   BIOCHEMISTRY

Eosinophil-Derived Neurotoxin / RNase 2: Connecting the Past, the Present and the Future

(2008) H. Rosenberg   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The Antipathogen Activities of Eosinophil Cationic Protein

(2008) Ester Boix et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Characterization of Molecular Interactions between Eosinophil Cationic Protein and Heparin

(2008) Tan-chi Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of C-type Lectin Antimicrobial Activity by a Flexible N-terminal Prosegment

(2008) Sohini Mukherjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2–MyD88 signal pathway in dendritic cells and enhances Th2 immune responses

(2008) De Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RNase A ribonucleases and host defense: an evolving story

(2008) Helene F. Rosenberg   JOURNAL OF LEUKOCYTE BIOLOGY