Review
Biochemistry & Molecular Biology
Xiaoting Xu, Xi Zhang, Yuzhu Yuan, Yongrui Zhao, Hamza M. Fares, Mengjiao Yang, Qing Wen, Reham Taha, Lixin Sun
Summary: This review systematically discusses the species differences in AhR activation effects and their modes of action, focusing on molecular configuration and activation of AhR, as well as comparison of cis-acting elements corresponding to AhR. The variations in responses seen in humans and other species following AhR activation can be attributed to both factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Giulia Liberatori, Carola Mazzoli, Fabrizio Ferraro, Lucrezia Sturba, Maria Luisa Vannuccini, Davide Baroni, Peter Alexander Behnisch, Monica Puccini, Sandra Vitolo, Ilaria Corsi
Summary: The suitability of AhR reporter gene bioassays to screen the presence and biological activity of pollutants in sewage sludge and hydrochar matrices was demonstrated in this study, supporting their usage for the assessment of potential risks associated with their further environmental applications.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Masato Honda, Xuchun Qiu, Suzanne Lydia Undap, Takeshi Kimura, Tsuguhide Hori, Yohei Shimasaki, Yuji Oshima
Summary: This study investigated the pollution levels of 6 heavy metals and 29 dioxins in intertidal and supratidal zones by collecting wharf roaches at 12 sampling sites along the coast of Northeast Japan. The predominant heavy metals were copper, zinc, and aluminum, with zinc showing the highest level. The total toxic equivalent value of PCDD/Fs ranged from values below the limit of detection.
APPLIED SCIENCES-BASEL
(2021)
Article
Cell & Tissue Engineering
Ana Nacarino-Palma, Francisco J. Gonzalez-Rico, Claudia M. Rejano-Gordillo, Ana Ordiales-Talavero, Jaime M. Merino, Pedro M. Fernandez-Salguero
Summary: Aryl hydrocarbon receptor (AhR) regulates pluripotency factors OCT4/POU5F1 and NANOG in early mouse embryogenesis, playing a crucial role in controlling pluripotency and differentiation.
Article
Toxicology
S. G. Rudyak, L. A. Usakin, E. A. Tverye, E. D. Robertson, A. A. Panteleyev
Summary: Aryl hydrocarbon receptor (AhR) expression and stability are influenced by AhR ligands. Treatment with TCDD, FICZ, and I3C caused a decrease in AhR expression. AhR degradation is regulated by proteasomal degradation and the presence of AhR antagonists, and requires the involvement of AhR dimerization partner ARNT. In addition, HDAC inhibition enhances AhR expression.
TOXICOLOGY LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Heidi Qunhui Xie, Yongchao Ma, Hualing Fu, Tuan Xu, Yali Luo, Yiyun Liu, Yangsheng Chen, Li Xu, Yingjie Xia, Bin Zhao
Summary: Acetylcholinesterase (AChE) plays important roles in cholinergic neurotransmission and is widely recognized as a biomarker for monitoring pollution by organophosphate and carbamate pesticides. Dioxin, a persistent organic pollutant, affects the nervous system and has been linked to neurodegenerative diseases and neurodevelopmental disorders, mainly through its impact on AChE and cholinergic dysfunctions. The aryl hydrocarbon receptor (AhR)-dependent pathway is a key research focus in studying the mechanisms of dioxin-induced AChE dysregulation.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Han-Bi Kim, Ji-Young Um, Bo-Young Chung, Jin-Cheol Kim, Seok-Young Kang, Chun-Wook Park, Hye-One Kim
Summary: The aryl hydrocarbon receptor (AhR) is crucial for the metabolism of xenobiotics and has been found to be associated with various diseases in different organs. Recent studies have shed light on its functions in chronic inflammatory skin diseases such as atopic dermatitis (AD) and psoriasis (PS), as well as its impact on the immune system of the skin. The therapeutic effects of AhR ligands have been demonstrated, but further research is needed to fully understand the roles of AhR in chronic inflammatory skin diseases.
Review
Biochemistry & Molecular Biology
Elizabeth Goya-Jorge, Maria Elisa Jorge Rodriguez, Maite Sylla-Iyarreta Veitia, Rosa M. Giner
Summary: The aryl hydrocarbon receptor (AhR) is a crucial transcription factor in health and disease, particularly in cancer, immunology, inflammatory conditions, and aging. Flavonoids, the largest group of natural AhR ligands in the human diet, have complex modulatory effects on AhR that need further investigation to understand their potentially harmful and beneficial effects. Flavonoids exhibit tissue, organ, and species-specific activities on AhR, suggesting potential benefits in pharmacotherapy.
Review
Biochemistry & Molecular Biology
Masutaka Furue, Yuji Ishii, Kiyomi Tsukimori, Gaku Tsuji
Summary: Poisoning by high concentrations of dioxin and its related compounds can lead to a range of serious symptoms, particularly with long-term effects on patients with Yusho. Research indicates that AHR exerts toxicity through the generation of ROS, and herbal drugs may have potential therapeutic effects for patients with Yusho.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Tuan Xu, Yali Luo, Heidi Qunhui Xie, Yingjie Xia, Yunping Li, Yangsheng Chen, Zhiling Guo, Li Xu, Bin Zhao
Summary: This study investigated the effects of the aryl hydrocarbon receptor (AhR) on cell migration in human neuroblastoma cells. Through integrative analysis of mRNA and microRNA expression profiles, it was found that the mRNA-miR networks in the axon guidance pathway may play a role in dioxin-induced directional migration of human neuroblastoma cells.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Engineering, Environmental
Wanglong Zhang, Heidi Qunhui Xie, Yunping Li, Mingxi Zhou, Zhiguang Zhou, Renjun Wang, Mark E. Hahn, Bin Zhao
Summary: The aryl hydrocarbon receptor (AHR) is a transcription factor with diverse biological functions. While initial research focused on its role in regulating drug-metabolizing enzymes and mediating the toxicity of dioxins and related compounds, recent studies have discovered additional functions of AHR. The structural similarity of emerging DLCs to dioxins has led to the observation that AHR predominantly mediates the toxic effects of these compounds. Understanding the mechanisms and impacts of traditional and emerging DLCs is important for environmental science.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Multidisciplinary Sciences
Jessica E. Kenison, Zhongyan Wang, Kangkang Yang, Megan Snyder, Francisco J. Quintana, David H. Sherr
Summary: The study shows the central role of AhR in regulating multiple immune checkpoints in oral squamous cell carcinoma. Deletion of AhR in mouse OSCC cells results in complete rejection of tumors and increased T cell activation. This suggests AhR as a potential target for modulating immune response in cancer treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Nutrition & Dietetics
Wanhui Kang, Alexa Barad, Andrew G. Clark, Yiqin Wang, Xu Lin, Zhenglong Gu, Kimberly O. O'Brien
Summary: Iron is unique among minerals because humans lack a regulatable pathway to eliminate excess iron after absorption. Iron deficiency leads to anemia, while iron overload can result in deposition in key organs. Accumulation of iron in the body increases the risk of chronic diseases. Only about 30% of variability in iron absorption can be captured by biomarkers or hormones.
ADVANCES IN NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Hevna Dhulkifle, Abdelali Agouni, Asad Zeidan, Mohammed Saif Al-Kuwari, Aijaz Parray, Mohamed Tolefat, Hesham M. Korashy
Summary: The prevalence of Autism spectrum disorder (ASD) has increased exponentially in recent decades, with traditional risk factors accounting for only a small percentage of cases. Recent research has focused on factors beyond conventional risk factors, such as environmental pollution.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Toxicology
Amanda Jurgelewicz, Peter Dornbos, Melanie Warren, Rance Nault, Anooj Arkatkar, Hui Lin, David W. Threadgill, Tim Zacharewski, John J. LaPres
Summary: The genetic variation in the AHR gene's impact on disease remains largely unknown. The study exposed 14 diverse mouse strains to TCDD for 10 days, revealing significant variability in responses based on genetic backgrounds. Using a regression-based approach, 7 genes likely regulated by AHR and/or associated with TCDD-induced phenotypes were identified, including 2 novel genes.
TOXICOLOGICAL SCIENCES
(2021)
Review
Food Science & Technology
Jonathan D. Urban, Michael C. Carakostas, Steve L. Taylor
FOOD AND CHEMICAL TOXICOLOGY
(2015)
Review
Food Science & Technology
Daniele Wikoff, Brian T. Welsh, Rayetta Henderson, Gregory P. Brorby, Janice Britt, Esther Myers, Jeffrey Goldberger, Harris R. Lieberman, Charles O'Brien, Jennifer Peck, Milton Tenenbein, Connie Weaver, Seneca Harvey, Jonathan Urban, Candace Doepker
FOOD AND CHEMICAL TOXICOLOGY
(2017)
Review
Pharmacology & Pharmacy
Daniele Wikoff, Jon D. Urban, Seneca Harvey, Laurie C. Haws
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2018)
Article
Pharmacology & Pharmacy
J. Craig Rowlands, Jonathan D. Urban, Daniele Staskal Wikoff, Robert A. Budinsky
DRUG METABOLISM AND PHARMACOKINETICS
(2011)
Article
Pharmacology & Pharmacy
Jonathan D. Urban, Robert A. Budinsky, J. Craig Rowlands
DRUG METABOLISM AND PHARMACOKINETICS
(2011)
Review
Food Science & Technology
J. D. Urban, M. C. Carakostas, D. J. Brusick
FOOD AND CHEMICAL TOXICOLOGY
(2013)
Article
Medicine, Legal
Chad M. Thompson, J. Gregory Hixon, Deborah M. Proctor, Laurie C. Haws, Mina Suh, Jonathan D. Urban, Mark A. Harris
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2012)
Article
Environmental Sciences
A. G. Bunch, C. S. Perry, L. Abraham, D. S. Wikoff, J. A. Tachovsky, J. G. Hixon, J. D. Urban, M. A. Harris, L. C. Haws
SCIENCE OF THE TOTAL ENVIRONMENT
(2014)
Correction
Environmental Sciences
A. G. Bunch, C. S. Perry, L. Abraham, D. S. Wikoff, J. A. Tachovsky, J. G. Hixon, J. D. Urban, M. A. Harris, L. C. Haws
SCIENCE OF THE TOTAL ENVIRONMENT
(2014)
Review
Environmental Sciences
Jonathan D. Urban, Daniele S. Wikoff, Alea T. G. Bunch, Mark A. Harris, Laurie C. Haws
SCIENCE OF THE TOTAL ENVIRONMENT
(2014)
Article
Toxicology
J. Craig Rowlands, Robert Budinsky, Bhaskar Gollapudi, Michael B. Black, Russell D. Wolfinger, Daniela Cukovic, Alan Dombkowski, Chad M. Thompson, Jonathan D. Urban, Russell S. Thomas
TOXICOLOGICAL SCIENCES
(2013)
Review
Pharmacology & Pharmacy
Jonathan D. Urban, Daniele S. Wikoff, Grace A. Chappell, Craig Harris, Laurie C. Haws
Review
Toxicology
Daniele S. Wikoff, Jonathan D. Urban, Caroline Ring, Janice Britt, Seneca Fitch, Robert Budinsky, Laurie C. Haws
Summary: In this study, systematic review methods and meta-regression were used to characterize the dose-response relationship of gestational exposure and epididymal sperm count. The available epidemiological data were not used due to inconsistencies, high risk of bias, and lack of biological coherence, with the focus instead on experimental animal studies. Reference dose estimates ranged from approximately 4 to 70pg/kg/day and can enhance understanding of human health risk estimates for dioxin-like compounds.
TOXICOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
J. Corey Fowler, Supriyo Bhattacharya, Jonathan D. Urban, Nagarajan Vaidehi, Richard B. Mailman
MOLECULAR PHARMACOLOGY
(2012)