Viewing serine/threonine protein phosphatases through the eyes of drug designers

Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits

(2013) Yuanchao Xue et al.   CELL

The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin

(2013) Simina Grigoriu et al.   PLOS BIOLOGY

Challenges and Opportunities in the Development of Protein Phosphatase-Directed Therapeutics

(2012) Sofie De Munter et al.   ACS Chemical Biology

Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Regulation of protein phosphatase 1 by intrinsically disordered proteins

(2012) Meng S. Choy et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Role and Therapeutic Potential of Ser/Thr Phosphatase PP2A in Apoptotic Signalling Networks in Human Cancer Cells

(2012) V. Janssens et al.   CURRENT MOLECULAR MEDICINE

Protein phosphatases and their regulation in the control of mitosis

(2012) Satoru Mochida et al.   EMBO REPORTS

Suppression of survival signalling pathways by the phosphatase PHLPP

(2012) Audrey K. O’Neill et al.   FEBS Journal

Small molecule tools for functional interrogation of protein tyrosine phosphatases

(2012) Rongjun He et al.   FEBS Journal

Structural basis for protein phosphatase 1 regulation and specificity

(2012) Wolfgang Peti et al.   FEBS Journal

PP1 and PP2A phosphatases - cooperating partners in modulating retinoblastoma protein activation

(2012) Victoria Kolupaeva et al.   FEBS Journal

The PP1 binding code: a molecular-lego strategy that governs specificity

(2012) Ewald Heroes et al.   FEBS Journal

Small Molecules Targeted to a Non-Catalytic “RVxF” Binding Site of Protein Phosphatase-1 Inhibit HIV-1

(2012) Tatiana Ammosova et al.   PLoS One

The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme

(2012) Nichole O'Connell et al.   STRUCTURE

Selective Inactivation of a Human Neuronal Silencing Phosphatase by a Small Molecule Inhibitor

(2011) Mengmeng Zhang et al.   ACS Chemical Biology

Exploiting the Cancer Genome: Strategies for the Discovery and Clinical Development of Targeted Molecular Therapeutics

(2011) Timothy A. Yap et al.   Annual Review of Pharmacology and Toxicology

Molecular Investigations of the Structure and Function of the Protein Phosphatase 1−Spinophilin−Inhibitor 2 Heterotrimeric Complex

(2011) Barbara Dancheck et al.   BIOCHEMISTRY

Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression

(2011) Muhan Chen et al.   CANCER CELL

Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase (PHLPP): A New Player in Cell Signaling

(2011) Noel A. Warfel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deep proteome and transcriptome mapping of a human cancer cell line

(2011) N. Nagaraj et al.   Molecular Systems Biology

Phosphatases: providing safe passage through mitotic exit

(2011) Claudia Wurzenberger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting SET/I2PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy

(2011) C H Switzer et al.   ONCOGENE

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE

Sanguinarine as a Potent and Specific Inhibitor of Protein Phosphatase 2Cin Vitroand Induces ApoptosisviaPhosphorylation of p38 in HL60 Cells

(2010) Nobuhiro ABURAI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Identification of PP2A Complexes and Pathways Involved in Cell Transformation

(2010) A. A. Sablina et al.   CANCER RESEARCH

Regulated protein kinases and phosphatases in cell cycle decisions

(2010) Bela Novak et al.   CURRENT OPINION IN CELL BIOLOGY

Flexibility in the PP1:spinophilin holoenzyme

(2010) Michael J. Ragusa et al.   FEBS LETTERS

Discovery of Small Molecule Inhibitors of the PH Domain Leucine-Rich Repeat Protein Phosphatase (PHLPP) by Chemical and Virtual Screening

(2010) Emma Sierecki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Signature of the MYPT1−PP1 Interaction

(2010) Anderson S. Pinheiro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites

(2010) Michael J Ragusa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Substrate of Greatwall Kinase, Arpp19, Controls Mitosis by Inhibiting Protein Phosphatase 2A

(2010) A. Gharbi-Ayachi et al.   SCIENCE

Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2A That Is Essential for Mitosis

(2010) S. Mochida et al.   SCIENCE

The extended PP1 toolkit: designed to create specificity

(2010) Mathieu Bollen et al.   TRENDS IN BIOCHEMICAL SCIENCES

C-terminal sequences of hsp70 and hsp90 as non-specific anchors for tetratricopeptide repeat (TPR) proteins

(2009) Andrew J. Ramsey et al.   BIOCHEMICAL JOURNAL

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

A Structural Basis for the Reduced Toxicity of Dinophysistoxin-2

(2009) Jason Huhn et al.   CHEMICAL RESEARCH IN TOXICOLOGY

PPM1D Is a Potential Therapeutic Target in Ovarian Clear Cell Carcinomas

(2009) D. S.P. Tan et al.   CLINICAL CANCER RESEARCH

Protein Phosphatase 5 Regulates the Function of 53BP1 after Neocarzinostatin-induced DNA Damage

(2009) Yoonsung Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Serine/Threonine Phosphatase Inhibition by the Archetypal Small Molecules Cantharidin and Norcantharidin

(2009) I. Bertini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Activity Relationship Studies of Fostriecin, Cytostatin, and Key Analogs, with PP1, PP2A, PP5, and ( 12- 13)-Chimeras (PP1/PP2A and PP5/PP2A), Provide Further Insight into the Inhibitory Actions of Fostriecin Family Inhibitors

(2009) M. R. Swingle et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Structure and Function of the PP2A-Shugoshin Interaction

(2009) Zheng Xu et al.   MOLECULAR CELL

Targeting Protein Serine/Threonine Phosphatases for Drug Development

(2009) J. L. McConnell et al.   MOLECULAR PHARMACOLOGY

WIP1 phosphatase at the crossroads of cancer and aging

(2009) Xavier Le Guezennec et al.   TRENDS IN BIOCHEMICAL SCIENCES

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

(2008) Xiongbin Lu et al.   CANCER AND METASTASIS REVIEWS

The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer

(2008) Teresa Golden et al.   CANCER AND METASTASIS REVIEWS

Therapeutic Protein Kinase Inhibitors

(2008) S. K. Grant   CELLULAR AND MOLECULAR LIFE SCIENCES

Activation of Protein Phosphatase 1 by a Small Molecule Designed to Bind to the Enzyme's Regulatory Site

(2008) Erin Tappan et al.   CHEMISTRY & BIOLOGY

Crystal Structures of Protein Phosphatase-1 Bound to Nodularin-R and Tautomycin: A Novel Scaffold for Structure-based Drug Design of Serine/Threonine Phosphatase Inhibitors

(2008) Matthew S. Kelker et al.   JOURNAL OF MOLECULAR BIOLOGY

The Structure of Fcp1, an Essential RNA Polymerase II CTD Phosphatase

(2008) Agnidipta Ghosh et al.   MOLECULAR CELL

Cracking the RNA polymerase II CTD code

(2008) Sylvain Egloff et al.   TRENDS IN GENETICS