Rapamycin nanoparticles target defective autophagy in muscular dystrophy to enhance both strength and cardiac function

Late-life rapamycin treatment reverses age-related heart dysfunction

(2013) James M. Flynn et al.   AGING CELL

Angiogenic Impairment of the Vascular Endothelium

(2013) Mariangela Palladino et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

All-Cause Mortality and Cardiovascular Outcomes With Prophylactic Steroid Therapy in Duchenne Muscular Dystrophy

(2013) Gernot Schram et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

AMPK Activation Stimulates Autophagy and Ameliorates Muscular Dystrophy in the mdx Mouse Diaphragm

(2012) Marion Pauly et al.   AMERICAN JOURNAL OF PATHOLOGY

Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts

(2012) Ya-Jian Cheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor

(2012) Berta Vidal et al.   HUMAN MOLECULAR GENETICS

Absence of Glial α-Dystrobrevin Causes Abnormalities of the Blood-Brain Barrier and Progressive Brain Edema

(2012) Chun Fu Lien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The big picture on nanomedicine: the state of investigational and approved nanomedicine products

(2012) Michael L. Etheridge et al.   Nanomedicine-Nanotechnology Biology and Medicine

Autophagy as a new therapeutic target in Duchenne muscular dystrophy

(2012) C De Palma et al.   Cell Death & Disease

Sirolimus and its Analogs and its Effects on Vascular Diseases

(2011) Steven J. Adelman   CURRENT PHARMACEUTICAL DESIGN

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

(2011) Sebahattin Cirak et al.   LANCET

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(2011) Saman Eghtesad et al.   MOLECULAR MEDICINE

Systemic Administration of PRO051 in Duchenne's Muscular Dystrophy

(2011) Nathalie M. Goemans et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quantifying the Evolution of Vascular Barrier Disruption in Advanced Atherosclerosis with Semipermeant Nanoparticle Contrast Agents

(2011) Huiying Zhang et al.   PLoS One

Muscle weakness and atrophy are associated with decreased regenerative capacity and changes in mTOR signaling in skeletal muscles of venerable (18-24-month-old) dystrophic mdx mice

(2010) E. Mouisel et al.   MUSCLE & NERVE

Genome remodelling in a basal-like breast cancer metastasis and xenograft

(2010) Li Ding et al.   NATURE

Autophagy is defective in collagen VI muscular dystrophies and its reactivation rescues myofiber degeneration

(2010) Paolo Grumati et al.   NATURE MEDICINE

Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters

(2009) Jeong-Sun Ju et al.   Autophagy

Comparative pharmacokinetics of RAD001 (everolimus) in normal and tumor-bearing rodents

(2009) Terence O’Reilly et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth

(2009) Neelesh R. Soman et al.   JOURNAL OF CLINICAL INVESTIGATION

Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study

(2009) Maria Kinali et al.   LANCET NEUROLOGY

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

(2009) Andrew M Bellinger et al.   NATURE MEDICINE

Intramural Delivery of Rapamycin With α v β 3 -Targeted Paramagnetic Nanoparticles Inhibits Stenosis After Balloon Injury

(2008) Tillmann Cyrus et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nanoparticle pharmacokinetic profiling in vivo using magnetic resonance imaging

(2008) Anne M. Neubauer et al.   MAGNETIC RESONANCE IN MEDICINE

Synthesis and Characterization of Stable Fluorocarbon Nanostructures as Drug Delivery Vehicles for Cytolytic Peptides

(2008) Neelesh R. Soman et al.   NANO LETTERS