Review
Chemistry, Multidisciplinary
Qi Jiang, Shufang Zhang
Summary: Osteoarthritis (OA) is a common age-related degenerative disease that poses economic and societal burdens, especially with the increasing aging population. Stimulus-responsive nanoplatforms offer improved therapeutic strategies for OA, with potential benefits such as enhanced control, longer retention time, higher loading rates, and increased sensitivity. This review summarizes the advanced application of stimulus-responsive drug delivery nanoplatforms, categorized by endogenous and exogenous stimuli, and discusses the opportunities, restrictions, and limitations of these systems.
Article
Multidisciplinary Sciences
Pedro P. G. Guimaraes, Christian G. Figueroa-Espada, Rachel S. Riley, Ningqiang Gong, Lulu Xue, Tomasz Sewastianik, Peter S. Dennis, Claudia Loebel, Amanda Chung, Sarah J. Shepherd, Rebecca M. Haley, Alex G. Hamilton, Rakan El-Mayta, Karin Wang, Robert Langer, Daniel G. Anderson, Ruben D. Carrasco, Michael J. Mitchell
Summary: Multiple myeloma (MM) is a hematologic malignancy that colonizes the bone marrow and lacks effective therapies. Endothelial cells in the bone marrow microenvironment, specifically Cyclophilin A (CyPA), play a critical role in MM progression and chemotherapeutic resistance. In this study, researchers developed a nanoparticle-based approach using RNA interference (RNAi) technology to target CyPA and inhibit MM cell extravasation. The strategy demonstrated promising results in vitro and in a murine xenograft model, indicating its potential as a therapeutic strategy for MM.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Pharmacology & Pharmacy
Siwei Song, Hui Xia, Mengfei Guo, Sufei Wang, Shujing Zhang, Pei Ma, Yang Jin
Summary: Macrophages play a key role in the immune response, with diversity and plasticity being key characteristics. Research has focused on the correlation between macrophages and cancer, inflammatory, or autoimmune disorders, while the development of macrophage nanomedicine-based disease treatment is increasingly important in light of traditional treatment inadequacies.
Article
Nanoscience & Nanotechnology
Zuzana Skubalova, Simona Rex, Martina Sukupova, Martin Zahalka, Petr Skladal, Jan Pribyl, Hana Michalkova, Akila Weerasekera, Vojtech Adam, Zbynek Heger
Summary: This study encapsulated tyrosine kinase inhibitors (TKIs) vandetanib and lenvatinib into a biomacromolecular ferritin-based delivery system. Passive loading of TKIs showed higher anticancer activity compared to active loading, which affected the stability and rigidity of ferritins.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Nanoscience & Nanotechnology
Xi Luo, Sudan Wu, Meng Xiao, Huan Gu, Huan Zhang, Jianping Chen, Yang Liu, Chen Zhang, Jinming Zhang
Summary: Zein, derived from corn, is recognized as one of the safest biological materials by the US FDA. It has valuable characteristics that make it popular for preparing drug carriers to improve the therapeutic effect of antitumor drugs. However, the clinical translation of drug-loaded zein-based carriers is challenging due to insufficient research and strong hydrophobicity. This paper aims to introduce the interactions between loaded drugs and zein, administration routes, and the functionalization of zein-based drug delivery systems, demonstrating its potential and promoting further application.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Multidisciplinary Sciences
Sarah J. Shepherd, Xuexiang Han, Alvin J. Mukalel, Rakan El-Mayta, Ajay S. Thatte, Jingyu Wu, Marshall S. Padilla, Mohamad-Gabriel Alameh, Neha Srikumar, Daeyeon Lee, Drew Weissman, David Issadore, Michael J. Mitchell
Summary: Lipid nanoparticles (LNPs) are an important delivery technology that has achieved significant breakthroughs in mRNA therapeutics and vaccines. Researchers have developed a microfluidic chip to address the challenges in LNP production, achieving scalable production rates while maintaining the physical properties and efficacy of LNPs. The vaccines formulated using this chip have shown promising results in preclinical studies, demonstrating the feasibility of commercial production.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Nanoscience & Nanotechnology
Sauradip Chaudhuri, Martha J. Fowler, Cassandra Baker, Sylwia A. Stopka, Michael S. Regan, Lindsey Sablatura, Colton W. Broughton, Brandon E. Knight, Sarah E. Stabenfeldt, Nathalie Y. R. Agar, Rachael W. Sirianni
Summary: This research introduces a novel nanocarrier platform for encapsulating HDACi, improving drug delivery efficiency, and providing insights into the structural requirements for effective drug loading and self-assembly of nanoparticles. The optimized CDN nanoparticles show promising results in slowing tumor growth and increasing exposure of tumors to drugs, indicating a step forward in HDACi therapy for better disease treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Thomas G. Meikle, Durga Dharmadana, Soren V. Hoffmann, Nykola C. Jones, Calum J. Drummond, Charlotte E. Conn
Summary: This study utilized lipid-based cubosomes as delivery vehicles for antimicrobial peptides, increasing AMP loading efficiency by manipulating electrostatic charge and enhancing antimicrobial activity of nanoparticles. This approach provides a foundation for designing more effective and targeted antibiotic therapies.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Seyedmehdi Hossaini Nasr, Xuefei Huang
Summary: Nanomedicine is a powerful tool that can target atherosclerotic plaques, and the advances in designing nanoparticles with therapeutic effects on these plaques have been summarized to stimulate further development and future translation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Haoyuan Yin, Hongdan Lu, Yaokun Xiong, Lu Ye, Chuanhui Teng, Xiang Cao, Shengnan Li, Shanbo Sun, Wentao Liu, Wei Lv, Hongliang Xin
Summary: The smart nanocarrier mP-NPs-DNase/PTX can degrade NETs structure by releasing DNase I at tumor tissue, mediate tumor cell uptake through exposed cell penetrating peptide, and exert cytotoxic effect by releasing PTX. It shows potential as a NET-regulated nanocarrier for inhibiting malignant tumor growth and metastasis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Pharmacology & Pharmacy
Hannah C. Zierden, Rachel L. Shapiro, Kevin DeLong, Davell M. Carter, Laura M. Ensign
Summary: Preterm birth is defined as delivery before 37 weeks of gestation, with 15 million infants born prematurely globally each year, increasing the risk of mortality and health challenges. While the only FDA approved therapy for preventing preterm birth in the U.S. has faced recent setbacks, interdisciplinary efforts are underway to develop next generation therapies to prevent preterm birth and save infant lives. This research aims to better identify women at risk for preterm birth, prevent premature labor, and ultimately improve outcomes for newborns.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Biotechnology & Applied Microbiology
Saquib Waheed, Zhibin Li, Fangyingnan Zhang, Anna Chiarini, Ubaldo Armato, Jun Wu
Summary: The rapid development of nanomedicine and nanoparticle materials has the potential to revolutionize healthcare by improving the effectiveness, bioavailability, targeting, and safety of drugs. Nanoparticles have unique properties that make them ideal for medical applications, but they must overcome biological barriers to deliver drugs to specific locations. Biointerface engineering can help overcome these barriers and optimize drug delivery in a personalized manner.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Yong-Jiang Li, Jun-Yong Wu, Jihua Liu, Wenjie Xu, Xiaohan Qiu, Si Huang, Xiong-Bin Hu, Da-Xiong Xiang
Summary: Artificial exosomes, produced through nanobiotechnology, have emerged as effective drug delivery carriers and include various types such as nanovesicles, exosome-mimetic, and hybrid exosomes. These artificial exosomes offer solutions to overcome limitations of natural exosomes and are considered powerful alternatives for drug delivery.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Aida Falgas, Victor Pallares, Ugutz Unzueta, Yaiza Nunez, Jorge Sierra, Alberto Gallardo, Lorena Alba-Castellon, Maria Antonia Mangues, Patricia Alamo, Antonio Villaverde, Esther Vazquez, Ramon Mangues, Isolda Casanova
Summary: T22-AUR, a nanoconjugate targeting CXCR4(+) DLBCL cells, demonstrates potent anticancer effects without off-target toxicity, showing promise as an effective therapy for these patients.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Durgaramani Sivadasan, Muhammad H. Sultan, Saad S. Alqahtani, Shamama Javed
Summary: Cubosomes, similar to liposomes, are lipid vesicles created with specific amphiphilic lipids and a suitable stabiliser. They have gained significant attention as active drug delivery vehicles and are used in multiple methods such as oral, ocular, transdermal, and chemotherapeutic drug delivery. Cubosomes have potential advantages in cancer therapeutics due to their cubic structure, large surface area, simple manufacturing process, biodegradability, ability to encapsulate various compounds, targeted and controlled release, and biodegradability of lipids. This review critically analyses the composition, preparation techniques, drug encapsulation approaches, drug loading, release mechanism, and applications of cubosomes, as well as the challenges in optimizing parameters for enhanced loading capacities and future potentialities.
Article
Cardiac & Cardiovascular Systems
Christopher F. Spurney, Francis M. McCaffrey, Avital Cnaan, Lauren P. Morgenroth, Sunil J. Ghelani, Heather Gordish-Dressman, Adrienne Arrieta, Anne M. Connolly, Timothy E. Lotze, Craig M. McDonald, Robert T. Leshner, Paula R. Clemens
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2015)
Article
Clinical Neurology
Anne M. Connolly, Elizabeth C. Malkus, Jerry R. Mendell, Kevin M. Flanigan, J. Philip Miller, Jeanine R. Schierbecker, Catherine A. Siener, Paul T. Golumbek, Craig M. Zaidman, Craig M. McDonald, Linda Johnson, Alina Nicorici, Peter I. Karachunski, John W. Day, Jason M. Kelecic, Linda P. Lowes, Lindsay N. Alfano, Basil T. Darras, Peter B. Kang, Janet Quigley, Amy E. Pasternak, Julaine M. Florence
Article
Clinical Neurology
Mariacristina Scoto, Alexander M. Rossor, Matthew B. Harms, Sebahattin Cirak, Mattia Calissano, Stephanie Robb, Adnan Y. Manzur, Amaia Martinez Arroyo, Aida Rodriguez Sanz, Sahar Mansour, Penny Fallon, Irene Hadjikoumi, Andrea Klein, Michele Yang, Marianne De Visser, W. C. G. (Truus) Overweg-Plandsoen, Frank Baas, J. Paul Taylor, Michael Benatar, Anne M. Connolly, Muhammad T. Al-Lozi, John Nixon, Christian G. E. L. de Goede, A. Reghan Foley, Catherine Mcwilliam, Matthew Pitt, Caroline Sewry, Rahul Phadke, Majid Hafezparast, W. Kling Chong, Eugenio Mercuri, Robert H. Baloh, Mary M. Reilly, Francesco Muntoni
Article
Clinical Neurology
Raghav Govindarajan, Stanley J. Iyadurai, Anne Connolly, Craig Zaidman
NEUROMUSCULAR DISORDERS
(2015)
Article
Genetics & Heredity
Phillipa J. Lamont, William Wallefeld, David Hilton-Jones, Bjarne Udd, Zohar Argov, Alexandru C. Barboi, Carsten Bonneman, Kym M. Boycott, Kate Bushby, Anne M. Connolly, Nicholas Davies, Alan H. Beggs, Gerald F. Cox, Jahannaz Dastgir, Elizabeth T. DeChene, Rebecca Gooding, Heinz Jungbluth, Nuria Muelas, Johanna Palmio, Sini Penttila, Eric Schmedding, Tiina Suominen, Volker Straub, Christopher Staples, Peter Y. K. Van den Bergh, Juan J. Vilchez, Kathryn R. Wagner, Patricia G. Wheeler, Elizabeth Wraige, Nigel G. Laing
Article
Clinical Neurology
Ching H. Wang, James J. Dowling, Kathryn North, Mary K. Schroth, Thomas Sejersen, Frederic Shapiro, Jonathan Bellini, Hali Weiss, Marc Guillet, Kimberly Amburgey, Susan Apkon, Enrico Bertini, Carsten Bonnemann, Nigel Clarke, Anne M. Connolly, Brigitte Estournet-Mathiaud, Dominic Fitzgerald, Julaine M. Florence, Richard Gee, Juliana Gurgel-Giannetti, Allan M. Glanzman, Brittany Hofmeister, Heinz Jungbluth, Anastassios C. Koumbourlis, Nigel G. Laing, Marion Main, Leslie A. Morrison, Craig Munns, Kristy Rose, Pamela M. Schuler, Caroline Sewry, Kari Storhaug, Mariz Vainzof, Nanci Yuan
JOURNAL OF CHILD NEUROLOGY
(2012)
Article
Clinical Neurology
Michael M. Segal, Marc S. Williams, Andrea L. Gropman, Alcy R. Torres, Rob Forsyth, Anne M. Connolly, Ayman W. El-Hattab, Seth J. Perlman, Debopam Samanta, Sumit Parikh, Steven G. Pavlakis, Lynn K. Feldman, Rebecca A. Betensky, Sidney M. Gospe
JOURNAL OF CHILD NEUROLOGY
(2014)
Article
Clinical Neurology
Adam P. Ostendorf, Anne M. Connolly
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2013)
Article
Clinical Neurology
Katharine Bushby, Richard Finkel, Brenda Wong, Richard Barohn, Craig Campbell, Giacomo P. Comi, Anne M. Connolly, John W. Day, Kevin M. Flanigan, Nathalie Goemans, Kristi J. Jones, Eugenio Mercuri, Ros Quinlivan, James B. Renfroe, Barry Russman, Monique M. Ryan, Mar Tulinius, Thomas Voit, Steven A. Moore, H. Lee Sweeney, Richard T. Abresch, Kim L. Coleman, Michelle Eagle, Julaine Florence, Eduard Gappmaier, Allan M. Glanzman, Erik Henricson, Jay Barth, Gary L. Elfring, Allen Reha, Robert J. Spiegel, Michael W. O'Donnell, Stuart W. Peltz, Craig M. McDonald
Article
Clinical Neurology
D. M. Escolar, A. Zimmerman, T. Bertorini, P. R. Clemens, A. M. Connolly, L. Mesa, K. Gorni, A. Kornberg, H. Kolski, N. Kuntz, Y. Nevo, C. Tesi-Rocha, K. Nagaraju, S. Rayavarapu, L. P. Hache, J. E. Mayhew, J. Florence, F. Hu, A. Arrieta, E. Henricson, R. T. Leshner, J. K. Mah
Article
Clinical Neurology
Anne M. Connolly, Julaine M. Florence, Mary M. Cradock, Elizabeth C. Malkus, Jeanine R. Schierbecker, Catherine A. Siener, Charlie O. Wulf, Pallavi Anand, Paul T. Golumbek, Craig M. Zaidman, J. Philip Miller, Linda P. Lowes, Lindsay N. Alfano, Laurence Viollet-Callendret, Kevin M. Flanigan, Jerry R. Mendell, Craig M. McDonald, Erica Goude, Linda Johnson, Alina Nicorici, Peter I. Karachunski, John W. Day, Joline C. Dalton, Janey M. Farber, Karen K. Buser, Basil T. Darras, Peter B. Kang, Susan O. Riley, Elizabeth Shriber, Rebecca Parad, Kate Bushby, Michelle Eagle
NEUROMUSCULAR DISORDERS
(2013)
Article
Clinical Neurology
Kathryn N. North, Ching H. Wang, Nigel Clarke, Heinz Jungbluth, Mariz Vainzof, James J. Dowling, Kimberly Amburgey, Susana Quijano-Roy, Alan H. Beggs, Caroline Sewry, Nigel G. Laing, Carsten G. Boennemann
NEUROMUSCULAR DISORDERS
(2014)
Article
Clinical Neurology
Craig M. McDonald, Heather Gordish-Dressman, Erik K. Henricson, Tina Duong, Nanette C. Joyce, Sanjay Jhawar, Mika Leinonen, Fengming Hsu, Anne M. Connolly, Avital Cnaan, Richard T. Abresch
NEUROMUSCULAR DISORDERS
(2018)
Article
Clinical Neurology
Anne M. Connolly, Julaine M. Florence, Mary M. Cradock, Michelle Eagle, Kevin M. Flanigan, Craig M. McDonald, Peter I. Karachunski, Basil T. Darras, Kate Bushby, Elizabeth C. Malkus, Paul T. Golumbek, Craig M. Zaidman, J. Philip Miller, Jerry R. Mendell
PEDIATRIC NEUROLOGY
(2014)