A role for the TIM-3/GAL-9/BAT3 pathway in determining the clinical phenotype of multiple sclerosis

TIMgenes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity

(2015) Gordon J. Freeman et al.   IMMUNOLOGICAL REVIEWS

The TIM-3 pathway ameliorates Theiler’s murine encephalomyelitis virus-induced demyelinating disease

(2014) Tomoki Kaneyama et al.   INTERNATIONAL IMMUNOLOGY

Lack of TIM-3 Immunoregulation in Multiple Sclerosis

(2014) L. Yang et al.   JOURNAL OF IMMUNOLOGY

Using EAE to better understand principles of immune function and autoimmune pathology

(2013) Manu Rangachari et al.   JOURNAL OF AUTOIMMUNITY

The Influence of T Cell Ig Mucin-3 Signaling on Central Nervous System Autoimmune Disease Is Determined by the Effector Function of the Pathogenic T Cells

(2013) S. Y. Lee et al.   JOURNAL OF IMMUNOLOGY

Differential Impact of Magnitude, Polyfunctional Capacity, and Specificity of HIV-Specific CD8+ T Cell Responses on HIV Set Point

(2013) C. Riou et al.   JOURNAL OF VIROLOGY

Galectin-9 Activates and Expands Human T-Helper 1 Cells

(2013) Marloes J. M. Gooden et al.   PLoS One

Glycobiology of immune responses

(2012) Gabriel A. Rabinovich et al.   Annals of the New York Academy of Sciences

T cell immunoglobulin-3 as a new therapeutic target for rheumatoid arthritis

(2012) Xia Li et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Immune checkpoints in central nervous system autoimmunity

(2012) Nicole Joller et al.   IMMUNOLOGICAL REVIEWS

Multiple sclerosis

(2012) Alyssa Nylander et al.   JOURNAL OF CLINICAL INVESTIGATION

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion

(2012) Manu Rangachari et al.   NATURE MEDICINE

Tim-3 Negatively Regulates Cytotoxicity in Exhausted CD8+ T Cells in HIV Infection

(2012) Ali Sakhdari et al.   PLoS One

Molecular mimicry as an inducing trigger for CNS autoimmune demyelinating disease

(2011) Emily M. L. Chastain et al.   IMMUNOLOGICAL REVIEWS

Therapeutic potential of Galectin-9 in human disease

(2011) Valerie R. Wiersma et al.   MEDICINAL RESEARCH REVIEWS

Expression of human TIM-3 and its correlation with disease activity in rheumatoid arthritis

(2011) J Lee et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Increased Tim-3 expression on peripheral lymphocytes from patients with rheumatoid arthritis negatively correlates with disease activity

(2010) Ying Liu et al.   CLINICAL IMMUNOLOGY

T-bet, a Th1 transcription factor regulates the expression of Tim-3

(2010) Ana C. Anderson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Stable form of galectin-9, a Tim-3 ligand, inhibits contact hypersensitivity and psoriatic reactions: A potent therapeutic tool for Th1- and/or Th17-mediated skin inflammation

(2009) Haruna Niwa et al.   CLINICAL IMMUNOLOGY

TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines

(2009) William D. Hastings et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The costimulatory role of TIM molecules

(2009) Roselynn Rodriguez-Manzanet et al.   IMMUNOLOGICAL REVIEWS

Costimulatory Pathways in Multiple Sclerosis: Distinctive Expression of PD-1 and PD-L1 in Patients with Different Patterns of Disease

(2009) D. Trabattoni et al.   JOURNAL OF IMMUNOLOGY

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

(2009) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

TIM-3 as a new therapeutic target in systemic lupus erythematosus

(2009) Hai-Feng Pan et al.   MOLECULAR BIOLOGY REPORTS

Mechanisms maintaining peripheral tolerance

(2009) Daniel L Mueller   NATURE IMMUNOLOGY

Myelin basic protein-specific T lymphocytes proliferation and programmed cell death in demyelinating diseases

(2008) Marina Saresella et al.   CLINICAL IMMUNOLOGY

Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis

(2008) Masako Seki et al.   CLINICAL IMMUNOLOGY