Article
Immunology
Huy Quang Quach, Krista M. Goergen, Diane E. Grill, Iana H. Haralambieva, Inna G. Ovsyannikova, Gregory A. Poland, Richard B. Kennedy
Summary: This study identified shared gene expression pathways in response to influenza and vaccinia virus stimulation in different immune cells. The immune response signaling pathways identified can be targeted for the development of broad therapeutics and vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Richard B. Kennedy, Inna G. Ovsyannikova, Iana H. Haralambieva, Diane E. Grill, Gregory A. Poland
Summary: The availability of effective smallpox vaccines was crucial for eradicating smallpox. This study utilized a poxvirus proteome array to assess the antibody response to viral proteins in smallpox vaccine recipients, revealing differences in antibody response between genders and racial/ethnic groups. The findings support the use of ACAM2000 as a replacement smallpox vaccine and demonstrate the value of poxvirus proteome microarrays in serologic surveillance studies for smallpox.
Article
Public, Environmental & Occupational Health
Hussain Haider Shah, Muhammad Khizer Molani, Naqiha Shabbir
Summary: Monkeypox is a zoonotic virus with a similar clinical appearance to smallpox. Its symptoms include fever, headache, muscle aches, and lymphadenopathy. Monkeypox can be transmitted through infected animals, direct contact, respiratory droplets, and contaminated clothing.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Microbiology
Ruikang Liu, Jeffrey L. Americo, Patricia L. Earl, Jack Villani, Catherine A. Cotter, Bernard Moss
Summary: The difference in pathogenicity between the pathogenic isolate clone 3 (CL3) and the second-generation smallpox vaccine ACAM2000 is associated with truncation of the interferon alpha/beta (IFN-alpha/beta) decoy receptor. Viruses expressing the full-length decoy receptor are more virulent in mouse models.
Article
Microbiology
Ruikang Liu, Jeffrey L. Americo, Patricia L. Earl, Jack Villani, Catherine A. Cotter, Bernard Moss
Summary: The more pathogenic Clone 3 (CL3) virus compared to ACAM2000 is attributed to the presence of a full-length IFN-alpha/beta decoy receptor in CL3 and a truncation of the receptor in ACAM2000. Experimental evidence shows that viruses expressing the full-length decoy receptor cause more severe diseases in mice.
Review
Medicine, General & Internal
Antoine Gessain, Emmanuel Nakoune, Yazdan Yazdanpanah
Summary: The article reviews the virology, epidemiology, clinical features, and treatment of monkeypox, and discusses the reported cases in the United Kingdom, Portugal, and Italy in May 2022, which led to the declaration of a global health emergency by the WHO.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Immunology
Patrice A. Mawa, Mateusz Hasso-Agopsowicz, Lawrence Lubyayi, Grace Nabakooza, Marjorie Nakibuule, Rose Blitz, Li Dun, Abha Govind, Pontiano Kaleebu, Emily L. Webb, Alison M. Elliott, Hazel M. Dockrell, Stephen Cose, Steven G. Smith
Summary: BCG vaccination induces similar immune responses to PPD but different responses to ESAT6/CFP10 in infants from Uganda and the UK. Maternal LTBI and infant exposure or infection with mycobacteria do not impact the immune response to BCG. Global differences in immune response to BCG are likely due to other factors.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Medicine, General & Internal
Peter A. Kahn, Xiaohan Ying, Michael Virata, Patrick Magahis, Sunnie Li, Walter S. Mathis
Summary: This cross-sectional study examines the correlation between the availability and accessibility of mpox vaccine sites and the number of reported cases and allocated vaccines.
Article
Immunology
Chiranjib Chakraborty, Manojit Bhattacharya, Ashish Ranjan Sharma, Kuldeep Dhama
Summary: Research has shown that smallpox vaccines can be used to prevent monkeypox, and this article discusses the importance of vaccines and vaccinations against monkeypox, while exploring potential models for the eradication of MPX in middle to low-economic countries.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Microbiology
Alba Grifoni, Yun Zhang, Alison Tarke, John Sidney, Paul Rubiro, Maria Reina-Campos, Gilberto Filaci, Jennifer M. Dan, Richard H. Scheuermann, Alessandro Sette
Summary: This study predicts potential MPXV targets using information from the Immune Epitope Database, enabling the monitoring of cellular immunity following MPXV infection and vaccination.
CELL HOST & MICROBE
(2022)
Review
Medicine, General & Internal
Santiago Presti, Sara Manti, Giuseppe Fabio Parisi, Maria Papale, Ignazio Alberto Barbagallo, Giovanni Li Volti, Salvatore Leonardi
Summary: Lactoferrin has been found to possess important properties such as anti-inflammatory, antimicrobial, antioxidant, and immunomodulating effects, making it a safe and effective option for treating various disorders, including allergic, gastrointestinal, and respiratory diseases. Its antiviral properties also make it a potential treatment option for COVID-19 patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Immunology
F. J. O'Dell, A. N. Williams, A. Poland
Summary: William Money, a significant figure in the study of smallpox disease and vaccination, conducted research that showed vaccination was not dangerous. His work in England started from serving as a house surgeon at Northampton Infirmary and later becoming a surgeon at the Royal Metropolitan Hospital in London.
Article
Biotechnology & Applied Microbiology
Ju Kim, Byeol-Hee Cho, Yong-Suk Jang
Summary: Host defense peptides are expressed in various immune cells and can selectively alter innate immune pathways in response to infections. They play important roles in both innate and adaptive immune responses, with broad-spectrum antimicrobial activity and mediating functions. This review discusses the biological functions, mechanisms of action, and potential clinical applications of human host defense peptides.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Virology
Fahima Akter, Tahira Binte Hasan, Farhana Alam, Aurpy Das, Shanta Afrin, Sadia Maisha, Abdullah Al Masud, Saif-Ur-Rahman Km
Summary: Monkeypox is a growing threat to humans, potentially linked to the decline in smallpox vaccinations. Several studies have shown that smallpox vaccination is highly effective in preventing monkeypox and provides long-lasting immunity. Unvaccinated individuals are at a significantly higher risk of monkeypox compared to vaccinated individuals. The incidence of monkeypox has increased dramatically in the Democratic Republic of the Congo since the cessation of smallpox vaccination campaigns. Despite the lack of available preventive and therapeutic agents, further research is needed to explore the role of smallpox vaccine in preventing human monkeypox.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Oncology
Jaiwoo Lee, Dongyoon Kim, Quoc-Viet Le, Yu-Kyoung Oh
Summary: Immunotherapy shows promise in cancer treatment by utilizing the host immune system to fight cancer. Researchers have developed various nanoparticles delivery systems to enhance the efficacy of immunotherapy drugs. Additionally, they have studied strategies to modulate the tumor immune environment, such as surface-ligand modification and combining with an external stimulus.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Medicine, General & Internal
Ali Alejo, Carolina Sanchez, Sylvie Amu, Padraic G. Fallon, Antonio Alcami
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Gabriela Desdin-Mico, Gonzalo Soto-Heredero, Juan Francisco Aranda, Jorge Oller, Elisa Carrasco, Enrique Gabande-Rodriguez, Eva Maria Blanco, Arantzazu Alfranca, Lorena Cusso, Manuel Desco, Borja Ibanez, Arancha R. Gortazar, Pablo Fernandez-Marcos, Maria N. Navarro, Bruno Hernaez, Antonio Alcami, Francesc Baixauli, Maria Mittelbrunn
Article
Microbiology
Tania Matamoros, Ali Alejo, Javier Maria Rodriguez, Bruno Hernaez, Milagros Guerra, Alberto Fraile-Ramos, German Andres
Article
Immunology
Jose Manuel Rojas, Ali Alejo, Jose Miguel Avia, Daniel Rodriguez-Martin, Carolina Sanchez, Antonio Alcami, Noemi Sevilla, Veronica Martin
Article
Immunology
Giselle Rangel, Juan Barcena, Noelia Moreno, Carlos P. Mata, Jose R. Caston, Ali Alejo, Esther Blanco
Summary: Chimeric RHDV VLPs displaying FMDV-derived epitopes elicit a robust neutralizing immune response in mice and pigs, affording partial clinical protection against an FMDV challenge in pigs.
Article
Virology
Carla Mavian, Alberto Lopez-Bueno, Rocio Martin, Andreas Nitsche, Antonio Alcami
Summary: This study monitored the pathogenesis of nine ECTVs in mice and reported the full-length genome sequence of eight novel ECTV isolates or strains. The research identified genes absent in strains attenuated through serial passages in culture that may play a role in virulence, and also found a set of putative genes that may be involved in enhancing viral growth in vitro.
Review
Microbiology
Francisco Javier Alvarez-de Miranda, Isabel Alonso-Sanchez, Antonio Alcami, Bruno Hernaez
Summary: TNF is an inflammatory cytokine produced in response to viral infections, promoting the recruitment and activation of leukocytes to infection sites. Poxviruses have evolved diverse molecular mechanisms to counteract TNF antiviral action, including the expression of soluble receptors or proteins that can bind and neutralize TNF.
Article
Chemistry, Medicinal
Giselle Rangel, Veronica Martin, Juan Barcena, Esther Blanco, Ali Alejo
Summary: Foot and mouth disease is highly contagious and affects cattle, sheep, and swine. Vaccination using inactivated viral strains is effective but has drawbacks. Developing a recombinant adenovirus expressing the FMDV protein may improve cross protective efficacy and immunity duration.
Review
Microbiology
Mari Cruz Martin-Delgado, Francisco Javier Martin Sanchez, Manuel Martinez-Selles, Jose Maria Molero Garcia, Santiago Moreno Guillen, Fernando Rodriguez-Artalejo, Julian Ruiz-Galiana, Rafael Canton, Pilar De Lucas Ramos, Alejandra Garcia-Botella, Alberto Garcia-Lledo, Teresa Hernandez-Sampelayo, Javier Gomez-Pavon, Juan Gonzalez del Castillo, Patricia Munoz, Maricela Valerio, Pilar Catalan, Almudena Burillo, Alejandro Cobo, Antonio Alcami, Emilio Bouza
Summary: Infection caused by Monkeypox Virus (MPVX) is primarily found in small rodents but can infect monkeys and humans. The virus is capable of passing from monkeys to humans and has caused outbreaks in various countries. The disease has an incubation period of 5-15 days and presents with pustules, fever, malaise, and headache. Diagnosis can be confirmed through PCR testing or by demonstrating the presence of the virus in other body fluids or tissues. Treatment options are available, and the prognosis is generally good, with low mortality rates.
REVISTA ESPANOLA DE QUIMIOTERAPIA
(2022)
Article
Environmental Sciences
Cristina del Alamo, Angela Vazquez-Calvo, Antonio Alcami, Juan Sanchez-Garcia-Casarrubios, Jose Luis Perez-Diaz
Summary: The experience of the COVID-19 pandemic has highlighted the importance of preventing the spread of biological agents in the air and on surfaces. This study investigates the effectiveness of the COUNTERFOG (R) technology in disinfecting viral-contaminated surfaces and measures the required disinfection time. The results show that COUNTERFOG (R) can rapidly and efficiently eliminate viruses using sodium hypochlorite solution, with the concentration and exposure time playing a critical role in disinfection efficacy.
FOOD AND ENVIRONMENTAL VIROLOGY
(2022)
Article
Environmental Sciences
Cristina del Alamo, Angela Vazquez-Calvo, Africa Sanchiz, Gil Rodriguez-Caravaca, Rocio Martin, Bruno Hernaez, Pablo Mendez-Vigo-Carranza, Juan Sanchez Garcia-Casarrubios, Antonio Alcami, Jose Luis Perez-Diaz
Summary: The COVID-19 pandemic has brought attention to the dangers of airborne transmission of pathogens. This study explores a fast method for capturing bioaerosols in air samples, which allows for quick detection of transient levels of aerosols and has revealed the presence of SARS-CoV-2 RNA in hospital rooms. The results show that the distribution of SARS-CoV-2-containing aerosols is not homogeneous, and this technology provides a valuable tool for fast decision-making and better understanding of aerosols dynamics.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Editorial Material
Multidisciplinary Sciences
Antonio Alcami
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Materials Science, Multidisciplinary
Castor Salgado, Raquel Cue, Vanesa Yuste, Laura Montalvillo-Jimenez, Pilar Prendes, Senen Paz, Angela Vazquez-Calvo, Antonio Alcami, Carolina Garcia, Enrique Martinez-Campos, Paula Bosch
Summary: Commercial polyurethane coatings were modified with 1-(hydroxymethyl)-5,5-dimethylhydantoin to enhance their antiviral activity. The modified coatings showed high inactivation of Staphylococcus aureus and human coronaviruses HCoV-229E and SARS-CoV-2. The coatings were rechargeable and maintained their virucidal activity even after multiple infection cycles.
APPLIED MATERIALS TODAY
(2023)
Article
Microbiology
Alberto Domingo Lopez-Munoz, Alberto Rastrojo, Rocio Martin, Antonio Alcami
Summary: This study reveals that HSV-1 and HSV-2 exhibit different levels of genetic diversity and mutation rates under in vitro culture conditions, with HSV-2 mutating faster. The newly emerged minor variants largely impact the coding diversity of HSV-2, possibly contributing to the evolutionary divergence of HSV-1 and HSV-2 in adapting to different anatomical niche.