Article
Ophthalmology
Gus Gazzard, Evgenia Konstantakopoulou, David Garway-Heath, Mariam Adeleke, Victoria Vickerstaff, Gareth Ambler, Rachael Hunter, Catey Bunce, Neil Nathwani, Keith Barton, The LiGHT Trial Study Grp
Summary: After 6 years of treatment, selective laser trabeculoplasty (SLT) has been shown to be a more effective and cost-effective primary treatment for open-angle glaucoma (OAG) and ocular hypertension (OHT) compared to intraocular pressure (IOP)-lowering eye drops. The SLT group had better glaucoma symptom scores and 69.8% of eyes in this group achieved or maintained the target IOP without the need for medical or surgical treatment.
Article
Biochemistry & Molecular Biology
Mi-Lyang Kim, Kyung Rim Sung, Junki Kwon, Go Woon Choi, Jin A. Shin
Summary: In this study, it was found that statins can promote the survival of RGCs and reduce apoptosis in a rat model of glaucoma. Additionally, statins were shown to suppress glial activation in the retina, suggesting a potential for statins in the treatment of glaucoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Anne-Sophie Simons, Julie Vercauteren, Joao Barbosa-Breda, Ingeborg Stalmans
Summary: This review evaluates two alternative schemes for glaucoma care within a hospital, shared care and virtual clinics, and finds that both schemes increase hospital efficiency and are suitable for low-risk glaucoma patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Aleksandra Zgryzniak, Joanna Przezdziecka-Dolyk, Marek Szalinski, Anna Turno-Krecicka
Summary: Selective laser trabeculoplasty (SLT) is an effective treatment for reducing intraocular pressure in open-angle glaucoma and ocular hypertension. It can be used as a primary or adjunct therapy, helping to reduce medication use and achieve target IOP with low complication rates and the potential for repeat procedures.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Susanne Krag, Dorte Larsen, Birgitte Klug Albertsen, Mia Glerup
Summary: This study investigated the risk of steroid-induced ocular hypertension in children treated with systemic glucocorticoid. It found that 56% of the children developed a steroid-induced ocular hypertensive response, and all children had their intraocular pressure normalized after withdrawal of steroid. The steroid responders were significantly younger than nonresponders.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Uttio Roy Chowdhury, J. Cameron Millar, Bradley H. Holman, Kjersten J. Anderson, Peter Dosa, Gavin W. Roddy, Michael P. Fautsch
Summary: The ATP-sensitive potassium channel openers CKLP1 and diazoxide effectively decreased IOP in ocular hypertensive animal models by reducing the episcleral venous pressure, indicating their potential therapeutic applications in ocular hypertension and glaucoma.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Review
Medicine, General & Internal
Tzu-Chen Lo, Yu-Yen Chen, Man-Chen Hung, Pesus Chou
Summary: Latanoprostene bunod (LBN) 0.024% has been shown to effectively reduce intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) and ocular hypertension (OHT). It outperforms timolol maleate 0.5% and latanoprost 0.005% in lowering IOP during a three-month follow-up period. LBN is also safe with no severe side effects reported.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Priyamvada M. Pitale, Guofu Shen, Rohini R. Sigireddi, Maria Polo-Prieto, Yong H. Park, Solomon E. Gibson, Peter D. Westenskow, Roomasa Channa, Benjamin J. Frankfort
Summary: The study revealed vascular damage in mice exposed to mild levels of induced ocular hypertension, potentially caused by abnormalities in the intermediate retinal capillary plexus (IRCP). This IRCP-specific phenotype precedes RGC loss, suggesting a possible mechanistic link for early vascular remodeling in glaucoma.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Ophthalmology
Naga Pradeep Rayana, Chenna Kesavulu Sugali, Jiannong Dai, Michael Peng, Shaohui Liu, Yucheng Zhang, Jun Wan, Weiming Mao
Summary: The study demonstrates that the CRISPR interference system effectively inhibited TGF beta 2 expression in human TM cells and targeted the promoter of the TGF beta 2 gene. In vivo experiments using CRISPR interference system in mouse eyes showed a significant decrease in TGF beta 2-induced ocular hypertension, along with reduced levels of TGF beta 2 and extracellular matrix proteins in the eyes. This suggests that CRISPR interference may be a promising therapeutic approach for treating TGF beta 2-induced ocular hypertension.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Olusola Oluyinka Olawoye, Olufunmilayo Fawole, Adeyinka O. Ashaye, Ving Fai Chan, Augusto Azuara-Blanco, Nathan Congdon
Summary: This study explores the effectiveness of community outreach screening in improving equity and access to eye care for glaucoma in Nigeria. The findings suggest that outreach screenings attract older, less educated, and lower-income individuals with lower knowledge and awareness of glaucoma compared to patients presenting spontaneously at a clinic. Furthermore, there was poor uptake of referral care due to lack of perceived need and transportation costs. Interventions such as free transportation and educational efforts may help improve the uptake of referral services and maximize equity gains.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Gavin W. Roddy, Uttio Roy Chowdhury, Kjersten J. Monson, Michael P. Fautsch
Summary: STC-1 has been shown to reduce intraocular pressure in two models of ocular hypertension with different mechanisms of outflow obstruction.
CURRENT EYE RESEARCH
(2021)
Article
Ophthalmology
Colleen M. McDowell, Krishnakumar Kizhatil, Michael H. Elliott, Darryl R. Overby, Joseph Van Batenburg-Sherwood, J. Cameron Millar, Markus H. Kuehn, Gulab Zode, Ted S. Acott, Michael G. Anderson, Sanjoy K. Bhattacharya, Jacques A. Bertrand, Terete Borras, Diane E. Bovenkamp, Lin Cheng, John Danias, Michael Lucio De Ieso, Yiqin Du, Jennifer A. Faralli, Rudolf Fuchshofer, Preethi S. Ganapathy, Haiyan Gong, Samuel Herberg, Humberto Hernandez, Peter Humphries, Simon W. M. John, Paul L. Kaufman, Kate E. Keller, Mary J. Kelley, Ruth A. Kelly, David Krizaj, Ajay Kumar, Brian C. Leonard, Raquel L. Lieberman, Paloma Liton, Yutao Liu, Katy C. Liu, Navita N. Lopez, Weiming Mao, Timur Mavlyutov, Fiona McDonnell, Gillian J. McLellan, Philip Mzyk, Andrews Nartey, Louis R. Pasquale, Gaurang C. Patel, Padmanabhan P. Pattabiraman, Donna M. Peters, Vijaykrishna Raghunathan, Ponugoti Vasantha Rao, Naga Rayana, Urmimala Raychaudhuri, Ester Reina-Torres, Ruiyi Ren, Douglas Rhee, Uttio Roy Chowdhury, John R. Samples, E. Griffen Samples, Najam Sharif, Joel S. Schuman, Val C. Sheffield, Cooper H. Stevenson, Avinash Soundararajan, Preeti Subramanian, Chenna Kesavulu Sugali, Yang Sun, Carol B. Toris, Karen Y. Torrejon, Amir Vahabikashi, Janice A. Vranka, Ting Wang, Colin E. Willoughby, Chen Xin, Hongmin Yun, Hao F. Zhang, Michael P. Fautsch, Ernst R. Tamm, Abbot F. Clark, C. Ross Ethier, W. Daniel Stamer
Summary: This article highlights the importance of using mice as a valuable model system for studying conventional outflow resistance and intraocular pressure. It also outlines the minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. These standards are expected to enhance scientific rigor and replicability of research findings.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Prabhavathi Maddineni, Ramesh B. Kasetti, Bindu Kodati, Sam Yacoub, Gulab S. Zode
Summary: PBA can reduce GC-induced OHT by degrading abnormal ECM deposition in TM and inducing MMP9 expression and activity in normal human TM cells/tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Chenna Kesavulu Sugali, Naga Pradeep Rayana, Jiannong Dai, Michael Peng, Weiming Mao
Summary: Glaucoma is a leading cause of blindness worldwide, mainly due to optic nerve damage. Elevated intraocular pressure is the most important risk factor for glaucoma. Animal models are crucial for studying glaucoma. In this study, adenoviral vector mediated TGF82 was found to increase intraocular pressure in C57BL/6J mice, with age and sex playing a role.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Medicine, General & Internal
Victoria Toumanidou, Asterios Diafas, Nikolaos Georgiadis, Ioannis Tsinopoulos
Summary: This study investigated the effect of fixed combination versus concomitant unfixed topical glaucoma treatment on patients' adherence and ocular surface health. The results showed that patients treated with a fixed combination had higher adherence rates and healthier ocular surfaces compared to the unfixed treatment group. The study provides significant evidence of the benefits of fixed combination treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)