Article
Multidisciplinary Sciences
Yu-Chi Liu, Fernando Morales-Wong, Moushmi Patil, Sang Beom Han, Nyein C. Lwin, Ericia Pei Wen Teo, Heng Pei Ang, Nur Zah M. Yussof, Jodhbir S. Mehta
Summary: In femtosecond laser-assisted keratoplasty, a liquid interface is preferred over a flat interface for better control of intraocular pressure, reduced corneal endothelial damage, and more precise laser cutting.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Andrea Lucisano, Vincenzo Scorcia, Andrea Taloni, Costanza Rossi, Raffaella Gioia, Giuseppe Giannaccare
Summary: In this study, the visual and topographic outcomes of large (9.0 mm) versus conventional (8.0 mm) deep anterior lamellar keratoplasty (DALK) for the treatment of keratoconus (KC) were compared, based on the different localization of corneal ectasia. The results showed that large 9.0-mm DALK provided better anatomical outcomes, particularly in eyes with corneal ectasia extending beyond the central 8.0 mm.
Article
Medicine, General & Internal
Ping Wang, Qingqin Gao, Guanyu Su, Wei Wang, Lingjuan Xu, Guigang Li
Summary: The objective of this study was to analyze the clinical features and risk factors of Urrets-Zavalia syndrome (UZS) after penetrating keratoplasty (PKP). The incidence of UZS after PKP was 15.13%, and 33.33% of these patients recovered spontaneously. UZS may be more likely to occur in patients with keratoconus. Postoperative transient high IOP may increase the incidence of UZS after PKP for keratoconus.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Shih-Jung Yeh, Ko-Hua Chen, Tung-Mei Kuang, Catherine Jui-Ling Liu, Mei-Ju Chen
Summary: In patients with corneal edema after PKP, NCT and Tono-Pen tend to overestimate IOP, while iCare provides readings similar to GAT. Poor agreement is observed between NCT/Tono-Pen and GAT, but iCare shows clinically acceptable agreement with GAT. In normal corneas, CCT and CC affect the readings of GAT, NCT, and iCare.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Article
Ophthalmology
Chhavi Saini, Emma C. Davies, Lawson Ung, James Chodosh, Joseph B. Ciolino, Ula Jurkunas, Eleftherios Paschalis, Roberto Pineda, Hajirah N. Saeed, Jia Yin, Lucy Q. Shen
Summary: This retrospective cohort study assessed the risk factors and cumulative incidence of glaucoma development and progression within 1-2 years following corneal transplant surgery. The results showed that a significant proportion of patients developed glaucoma or exhibited glaucoma progression within 1 year after corneal transplantation. DSEK surgery, KPro implantation, and postoperative high intraocular pressure spikes were independently associated with glaucoma development or progression. Thus, minimizing postoperative IOP spikes and co-management with a glaucoma specialist may be necessary in these cases.
Article
Biochemistry & Molecular Biology
Yuki Kusano, Takefumi Yamaguchi, Sota Nishisako, Takehiro Matsumura, Masaki Fukui, Kazunari Higa, Toshihiro Inoue, Jun Shimazaki
Summary: This study found that specific cytokine levels in the aqueous humor are associated with the development of peripheral anterior synechiae after corneal transplantation, leading to refractory glaucoma and vision loss. Inflammatory alterations in the aqueous humor microenvironment may play a key role in the formation of peripheral anterior synechiae and glaucoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Eren Aytekin, Sibel Bozdag Pehlivan
Summary: Current treatment approaches for keratoconus include options such as penetrating keratoplasty, deep anterior lamellar keratoplasty, and corneal collagen cross-linking. Early diagnosis and halting the disease with CXL methods are becoming crucial in clinical practice.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Ophthalmology
Alexander Haendel, Jan Niklas Lueke, Sebastian Siebelmann, Jeremy Franklin, Sigrid Roters, Mario Matthaei, Bjoern O. Bachmann, Claus Cursiefen, Deniz Hos
Summary: This study compared the outcomes of deep anterior lamellar keratoplasty (DALK) and penetrating keratoplasty (PK) in keratoconic eyes with or without previous hydrops. The results showed that visual outcome, astigmatism, and maximum keratometry (K-max) were similar between eyes with and without previous hydrops, regardless of the surgical method. However, eyes with previous hydrops had a higher risk of complications.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Dominika Janiszewska-Bil, Barbara Czarnota-Nowakowska, Katarzyna Krysik, Anita Lyssek-Boron, Dariusz Dobrowolski, Beniamin Oskar Grabarek, Edward Wylegala
Summary: A comparative study on keratoconus patients undergoing DALK and PK showed that DALK had lower ECL and fewer adverse events, making it a beneficial alternative to PK with similar visual outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Ying Yuan, Xiaoyuan Liu, Li Zhou, Wuchun Ding, Liying Zhang, Jinhua Zheng
Summary: A 22-year-old lady with serious keratoconus developed infectious endophthalmitis after penetrating keratoplasty, caused by carbapenem-resistant Klebsiella pneumoniae. The donor corneal button may have played a role in transmitting the infection, as the donor had carbapenem-resistant Klebsiella pneumoniae in a sputum culture. Nosocomial infections are typically severe, rapidly progressive, and difficult to treat. The infection was finally resolved after the patient underwent therapeutic penetrating keratoplasty again.
FRONTIERS IN MEDICINE
(2023)
Article
Ophthalmology
Massimo Busin, Cristina Bovone, Vincenzo Scorcia, Erika Rimondi, Yoav Nahum, James Myerscough, Angeli Christy Yu
Summary: This study investigated the ultrastructure of the natural plane of separation in grafted corneas and the outcomes of stromal peeling. The results showed a high success rate of stromal exchange and significant improvement in visual acuity at three years postoperatively, with low endothelial cell loss over time.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Cathy Hopkinson, Elinor Curnow, Daniel F. P. Larkin, Jeremy Prydal, Stephen Tuft
Summary: This study compares surgeon-specific corneal transplantation outcomes using Kaplan-Meier survival curves and funnel plots. The results show that risk-adjustment provides more accurate results, and funnel plots are a visually accessible method for comparison.
Article
Medicine, General & Internal
Riccardo Vinciguerra, Robert Herber, Yan Wang, Fengju Zhang, Xingtao Zhou, Ji Bai, Keming Yu, Shihao Chen, Xuejun Fang, Frederik Raiskup, Paolo Vinciguerra
Summary: This study aimed to evaluate the difference in Corvis ST dynamic corneal response parameters between Caucasian and Chinese healthy subjects. After matching for age, IOP, and CCT, significant differences were found in SPA1, ARTh, and SSI values between the two ethnic groups, while other parameters did not show significant differences.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Myrsini Petrelli, Helene Savopol, Emmanouil Blavakis, Petros Petrou, Konstantinos Droutsas, George D. Kymionis
Summary: This study presents a new surgical technique, corneal plication, for the management of high astigmatism and progressive corneal graft protrusion after PKP for keratoconus. A patient with a history of keratoconus underwent the surgery and achieved satisfactory visual and anatomical outcomes.
Article
Ophthalmology
Sofia E. Murillo, Ayesha Shariff, Jonathan H. Lass, Loretta B. Szczotka-Flynn
Summary: This case series demonstrates the presence of acute focal edema suggestive of corneal hydrops in patients wearing ScCLs with longstanding PKs and recurrent ectasia. Although similar events have occurred as part of the natural history of post-PK corneas for keratoconus, the proximity of ScCL refitting to two of the events suggests some association.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
Jie Zhang, Amatul M. Ahmad, Hannah Ng, Jane Shi, Charles N. J. McGhee, Dipika V. Patel
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Mohammed Ziaei, Akilesh Gokul, Hans Vellara, Dipika Patel, Charles N. J. McGhee
Summary: This study found that in eyes with keratoconus, epithelial debridement increased the anterior corneal prolateness and tended to increase astigmatism while shifting its axis towards the against-the-rule orientation.
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2021)
Article
Ophthalmology
Helen Danesh-Meyer, Charles N. J. McGhee
Summary: Ophthalmologists are at high risk of COVID-19 infection due to their close contact with patients and equipment-intensive clinics. Measures such as social distancing and wearing masks are recommended to prevent transmission. Further studies are needed to explore the role of the conjunctiva in disease transmission.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Letter
Ophthalmology
Jina V. Han, Charles N. J. McGhee
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Jessica C. Trollip, Jay J. Meyer, Charles N. J. McGhee, Kevin Liu, Helen Danesh-Meyer, Rachael L. Niederer
Summary: Band keratopathy is a rare complication of herpes zoster ophthalmicus. Older age, high intraocular pressure, and number of recurrences are associated with an increased risk for band keratopathy. Corneal melt is a serious complication, with uveitis and disodium EDTA chelation treatment being associated with increased risk. Treatment with EDTA chelation should be approached with caution due to the significant risk of severe complications.
Article
Ophthalmology
Akilesh Gokul, Mohammed Ziaei, Jeremy J. Mathan, Jina Han, Stuti L. Misra, Dipika Patel, Charles N. J. McGhee
Summary: This study investigated the epidemiologic, demographic, and clinical characteristics of keratoconus patients managed by optometrists in New Zealand. The results showed that keratoconus is relatively common in New Zealand, with most patients having mild to moderate disease. However, Maori and Pacific Peoples may have greater disease severity.
Article
Anatomy & Morphology
Peter W. Hadden, Dane A. Gerneke, Charles N. J. McGhee, Jie Zhang
Summary: In this study, the skeletal elements present in the penguin eye and orbit were imaged using macro photographs and micro-CT, revealing that the penguin scleral ring not only maintains the shape of the eye but also provides protection and a site of insertion for rectus muscles. The extreme variability in the os opticus suggests that it is not essential to normal function.
JOURNAL OF MORPHOLOGY
(2021)
Article
Ophthalmology
Jay J. Meyer, Charlotte A. Jordan, Dipika V. Patel, Akilesh Gokul, Simon J. Dean, Suheb Ahmed, Shanu Subbiah, Charles N. J. McGhee
Summary: This study demonstrates that CXL is effective in reducing maximum keratometry and maintaining better visual acuity for at least 5 years in patients with progressive keratoconus. However, complications may occur in some participants and require careful consideration.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Aaron P. C. Ong, Jie Zhang, Andrea L. Vincent, Charles N. J. McGhee
Summary: Megalocornea and anterior megalophthalmos disorders are characterized by a corneal diameter > 12.5 mm, often congenital and associated with syndromes. Megalocornea spectrum disorders are distinguished from keratoglobus by their typically progressive nature. Surgical management can be challenging due to specific anatomical features.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Jie Zhang, Mohammed Ziaei, James McKelvie, Charles N. J. McGhee, Dipika Patel
Summary: The study investigated the in vivo biocompatibility of an acellular collagen-based scaffold for anterior lamellar keratoplasty in a rabbit model. Results showed that the scaffold supported corneal re-epithelialization without signs of rejection but further modifications are needed for better integration.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ye Li, Akilesh Gokul, Charles McGhee, Mohammed Ziaei
Summary: The study found that both devices showed good repeatability but poor agreement in biometric measurements in keratoconus patients. There was no significant difference in repeatability between eyes with or without prior crosslinking or contact lens wear, but the interchangeable use of the two devices is not recommended.
Article
Multidisciplinary Sciences
Ye Li, Akilesh Gokul, Charles McGhee, Mohammed Ziaei
Summary: This study investigated the repeatability of corneal thickness and epithelial thickness measurements in keratoconus patients using AS-OCT. The results showed that AS-OCT provides reliable measurements in both central and peripheral cornea, and a history of CXL has no significant impact on the repeatability of measurements.
Article
Multidisciplinary Sciences
Alexander Buckenham Boyle, Soobin Namkung, William Shew, Akilesh Gokul, Charles N. J. McGhee, Mohammed Ziaei
Summary: This study assessed the agreement and repeatability of horizontal visible iris diameter (HVID) or white-to-white (WTW) measurements between four imaging modalities. The results indicated significant differences in measurements among the devices, with Galilei G2 showing the highest repeatability and Orbscan IIz the lowest.
Article
Ophthalmology
Xu Chen, Jiaxin Zhao, Katja C. Iselin, Davide Borroni, Davide Romano, Akilesh Gokul, Charles N. J. McGhee, Yitian Zhao, Mohammad-Reza Sedaghat, Hamed Momeni-Moghaddam, Mohammed Ziaei, Stephen Kaye, Vito Romano, Yalin Zheng
Summary: The study evaluated the accuracy of convolutional neural networks technique in detecting keratoconus using colour-coded corneal maps obtained by a Scheimpflug camera. Results showed that the CNN model has excellent detection performance and can accurately differentiate between different severities of the disease, with potential for screening and management of keratoconus.
BMJ OPEN OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Ioannis N. Petropoulos, Kathryn C. Fitzgerald, Jonathan Oakley, Georgios Ponirakis, Adnan Khan, Hoda Gad, Pooja George, Dirk Deleu, Beatriz G. Canibano, Naveed Akhtar, Ashfaq Shuaib, Ahmed Own, Taimur Malik, Daniel B. Russakoff, Joseph L. Mankowski, Stuti L. Misra, Charles N. J. McGhee, Peter Calabresi, Shiv Saidha, Saadat Kamran, Rayaz A. Malik
Summary: Axonal loss is the main determinant of disease progression in multiple sclerosis, and corneal confocal microscopy was found to be useful in detecting corneal axonal loss in different courses of MS. The study confirmed significant corneal axonal loss in MS patients, including those with clinically isolated syndrome, using two independent segmentation methods. The corneal nerve parameters were comparably reduced in different courses of MS, with excellent reproducibility between the algorithms.
SCIENTIFIC REPORTS
(2021)