On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes

First Signature of Islet  -Cell-Derived Naturally Processed Peptides Selected by Diabetogenic Class II MHC Molecules

(2014) A. Suri et al.   JOURNAL OF IMMUNOLOGY

Lysosomal Cysteine and Aspartic Proteases Are Heterogeneously Expressed and Act Redundantly to Initiate Human Invariant Chain Degradation

(2014) C. M. Costantino et al.   JOURNAL OF IMMUNOLOGY

Large-Scale Characterization of Natural Ligands Explains the Unique Gluten-Binding Properties of HLA-DQ2

(2014) D. Stepniak et al.   JOURNAL OF IMMUNOLOGY

Differential Contributions of APC Subsets to T Cell Activation in Nonobese Diabetic Mice

(2014) A. M. Marleau et al.   JOURNAL OF IMMUNOLOGY

Complexes of Two Cohorts of CLIP Peptides and HLA-DQ2 of the Autoimmune DR3-DQ2 Haplotype Are Poor Substrates for HLA-DM

(2014) L.-E. Fallang et al.   JOURNAL OF IMMUNOLOGY

Thymic negative selection is functional in NOD mice

(2012) Michael Mingueneau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

How the TCR balances sensitivity and specificity for the recognition of self and pathogens

(2012) Gerald P Morris et al.   NATURE IMMUNOLOGY

Invariant chain processing is independent of cathepsin variation between primary human B cells/dendritic cells and B-lymphoblastoid cells

(2011) Michael Reich et al.   CELLULAR IMMUNOLOGY

T Cell Recognition of Autoantigens in Human Type 1 Diabetes: Clinical Perspectives

(2011) Roberto Mallone et al.   Clinical & Developmental Immunology

Gluten-dependent enteropathy and atypical human leukocyte antigen alleles

(2011) Gregory S. Harmon et al.   HUMAN PATHOLOGY

Important Lessons Derived from Animal Models of Celiac Disease

(2011) E. V. Marietta et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion

(2011) James F. Mohan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An Insertion Mutant in DQA1*0501 Restores Susceptibility to HLA-DM: Implications for Disease Associations

(2011) T. Hou et al.   JOURNAL OF IMMUNOLOGY

Understanding type 1 diabetes through genetics: advances and prospects

(2011) Constantin Polychronakos et al.   NATURE REVIEWS GENETICS

Measurement of protein synthesis using heavy water labeling and peptide mass spectrometry: Discrimination between major histocompatibility complex allotypes

(2010) Alessandra De Riva et al.   ANALYTICAL BIOCHEMISTRY

High frequency of low-risk human leukocyte antigen class II genotypes in latent celiac disease

(2010) Enrico Schirru et al.   HUMAN IMMUNOLOGY

I-Ag7 is subject to post-translational chaperoning by CLIP

(2010) C. H. Rinderknecht et al.   INTERNATIONAL IMMUNOLOGY

Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence

(2010) Woelsung Yi et al.   JOURNAL OF CLINICAL INVESTIGATION

The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity

(2010) Kenji Yoshida et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiple common variants for celiac disease influencing immune gene expression

(2010) Patrick C A Dubois et al.   NATURE GENETICS

Chromogranin A is an autoantigen in type 1 diabetes

(2010) Brian D Stadinski et al.   NATURE IMMUNOLOGY

Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

(2010) James F Mohan et al.   NATURE IMMUNOLOGY

Nomenclature for factors of the HLA system, 2010

(2010) S. G. E. Marsh et al.   TISSUE ANTIGENS

Overcoming self-destruction in the pancreas

(2009) Jennifer Nichols et al.   CURRENT OPINION IN BIOTECHNOLOGY

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation

(2009) Lars-Egil Fallang et al.   NATURE IMMUNOLOGY

Both central and peripheral tolerance mechanisms play roles in diabetes prevention in NOD-E transgenic mice

(2008) Richard J. Mellanby et al.   AUTOIMMUNITY

Dominance of an alternative CLIP sequence in the celiac disease associated HLA-DQ2 molecule

(2008) Martina Wiesner et al.   IMMUNOGENETICS

Unknown

(2008) Hye-Soon Lee et al.   MOLECULAR MEDICINE

Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?

(2007) Anish Suri et al.   CURRENT OPINION IN IMMUNOLOGY