Potential use of RNA interference in cancer therapy

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

siRNA vs. shRNA: Similarities and differences

(2009) Donald D. Rao et al.   ADVANCED DRUG DELIVERY REVIEWS

RNA Interference-Mediated Inhibition of Erythropoietin Receptor Expression Suppresses Tumor Growth and Invasiveness in A2780 Human Ovarian Carcinoma Cells

(2009) Gyorgy Paragh et al.   AMERICAN JOURNAL OF PATHOLOGY

RNA Interference Technologies and Therapeutics

(2009) Marta López-Fraga et al.   BIODRUGS

Vascular Endothelial Growth Factor-C siRNA Delivered via Calcium Carbonate Nanoparticle Effectively Inhibits Lymphangiogenesis and Growth of Colorectal Cancer In Vivo

(2009) Xiao-Wen He et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

MicroRNA-17-3p is a prostate tumor suppressor in vitro and in vivo, and is decreased in high grade prostate tumors analyzed by laser capture microdissection

(2009) Xueping Zhang et al.   CLINICAL & EXPERIMENTAL METASTASIS

CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models

(2009) W Schneiderhan et al.   GUT

RNAi targeting urokinase-type plasminogen activator receptor inhibits metastasis and progression of oral squamous cell carcinomain vivo

(2009) Hao Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

EpCAM is overexpressed in gastric cancer and its downregulation suppresses proliferation of gastric cancer

(2009) Du Wenqi et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Concepts in in vivo siRNA delivery for cancer therapy

(2009) Christopher S. Gondi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice

(2009) Adam D. Judge et al.   JOURNAL OF CLINICAL INVESTIGATION

The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic

(2009) Mark E. Davis   MOLECULAR PHARMACEUTICS

Systemic Delivery of Synthetic MicroRNA-16 Inhibits the Growth of Metastatic Prostate Tumors via Downregulation of Multiple Cell-cycle Genes

(2009) Fumitaka Takeshita et al.   MOLECULAR THERAPY

Knockdown of p21-activated Kinase 6 Inhibits Prostate Cancer Growth and Enhances Chemosensitivity to Docetaxel

(2009) Xingqiao Wen et al.   UROLOGY

Silencing of signal transducer and activator of transcription 3 expression by RNA interference suppresses growth of human hepatocellular carcinoma in tumor-bearing nude mice

(2009) Jing Li et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Tumor-specific RNAi targeting eIF4E suppresses tumor growth, induces apoptosis and enhances cisplatin cytotoxicity in human breast carcinoma cells

(2008) Ke Dong et al.   BREAST CANCER RESEARCH AND TREATMENT

Modulation of miRNA activity in human cancer: a new paradigm for cancer gene therapy?

(2008) A W Tong et al.   CANCER GENE THERAPY

A small interfering RNA targeting osteopontin as gastric cancer therapeutics

(2008) Mouchun Gong et al.   CANCER LETTERS

Atu027, a Liposomal Small Interfering RNA Formulation Targeting Protein Kinase N3, Inhibits Cancer Progression

(2008) M. Aleku et al.   CANCER RESEARCH

Adenovirus-delivered CIAPIN1 small interfering RNA inhibits HCC growth in vitro and in vivo

(2008) Xiaohua Li et al.   CARCINOGENESIS

Gene silencing of ß-catenin by RNAi inhibits cell proliferation in human esophageal cancer cellsin vitroand in nude mice

(2008) Jin-Sheng Wang et al.   DISEASES OF THE ESOPHAGUS

Inhibitory effect of siRNA targeting survivin in gastric cancer MGC-803 cells

(2008) Tao Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Inhibition of the Highly Expressed Mir-221 and Mir-222 Impairs the Growth of Prostate Carcinoma Xenografts in Mice

(2008) Neri Mercatelli et al.   PLoS One

Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs

(2008) M. Landthaler et al.   RNA