Gene-deleted live-attenuatedTrypanosoma cruziparasites as vaccines to protect against Chagas disease

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Tc52 Amino-Terminal-Domain DNA Carried by Attenuated Salmonella enterica Serovar Typhimurium Induces Protection against a Trypanosoma cruzi Lethal Challenge

(2014) Marina N. Matos et al.   INFECTION AND IMMUNITY

Cloning and expression of transgenes using linear vectors in Trypanosoma cruzi

(2014) María de los Ángeles Curto et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin

(2014) Eduardo Sosoniuk et al.   MOLECULAR IMMUNOLOGY

Distinctive histopathology and modulation of cytokine production during oral and intraperitoneal Trypanosoma cruzi Y strain infection

(2014) CHRISTIAN C. KUEHN et al.   PARASITOLOGY

Generation of growth arrested Leishmania amastigotes: A tool to develop live attenuated vaccine candidates against visceral leishmaniasis

(2014) Angamuthu Selvapandiyan et al.   VACCINE

A Monoallelic Deletion of the TcCRT Gene Increases the Attenuation of a Cultured Trypanosoma cruzi Strain, Protecting against an In Vivo Virulent Challenge

(2014) Fernando J. Sánchez-Valdéz et al.   PLoS Neglected Tropical Diseases

Deletion of Ubiquitin Fold Modifier Protein Ufm1 Processing Peptidase Ufsp in L. donovani Abolishes Ufm1 Processing and Alters Pathogenesis

(2014) Sreenivas Gannavaram et al.   PLoS Neglected Tropical Diseases

A Dual Drug Sensitive L. major Induces Protection without Lesion in C57BL/6 Mice

(2014) Noushin Davoudi et al.   PLoS Neglected Tropical Diseases

Potential new clinical therapies for Chagas disease

(2014) Juan M Bustamante et al.   Expert Review of Clinical Pharmacology

Live Vaccination Tactics: Possible Approaches for Controlling Visceral Leishmaniasis

(2014) Noushin Saljoughian et al.   Frontiers in Immunology

Biomarkers of Safety and Immune Protection for Genetically Modified Live Attenuated Leishmania Vaccines Against Visceral Leishmaniasis – Discovery and Implications

(2014) Sreenivas Gannavaram et al.   Frontiers in Immunology

Genetically Modified Organisms and Visceral Leishmaniasis

(2014) Rudra Chhajer et al.   Frontiers in Immunology

Towards a Paradigm Shift in the Treatment of Chronic Chagas Disease

(2013) R. Viotti et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Live Attenuated Leishmania donovani p27 Gene Knockout Parasites Are Nonpathogenic and Elicit Long-Term Protective Immunity in BALB/c Mice

(2013) R. Dey et al.   JOURNAL OF IMMUNOLOGY

Status of and cost of Chagas disease worldwide

(2013) Gabriel Schmuñis   LANCET INFECTIOUS DISEASES

TcVac3 Induced Control of Trypanosoma cruzi Infection and Chronic Myocarditis in Mice

(2013) Shivali Gupta et al.   PLoS One

Differential Use of TLR2 and TLR9 in the Regulation of Immune Responses during the Infection with Trypanosoma cruzi

(2013) Humberto D. Gravina et al.   PLoS One

Plasmid Vectors and Molecular Building Blocks for the Development of Genetic Manipulation Tools for Trypanosoma cruzi

(2013) León A. Bouvier et al.   PLoS One

First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers

(2013) Michele Spring et al.   VACCINE

Preventive and therapeutic DNA vaccination partially protect dogs against an infectious challenge with Trypanosoma cruzi

(2013) Israel A. Quijano-Hernández et al.   VACCINE

Induction of immunogenicity by live attenuated Leishmania donovani centrin deleted parasites in dogs

(2013) Jacqueline Araújo Fiuza et al.   VACCINE

Perpetual expression of PAMPs necessary for optimal immune control and clearance of a persistent pathogen

(2013) Samarchith P. Kurup et al.   Nature Communications

Biological behavior of different Trypanosoma cruzi isolates circulating in an endemic area for Chagas disease in the Gran Chaco region of Argentina

(2012) Paula G. Ragone et al.   ACTA TROPICA

Genetic engineering of attenuated malaria parasites for vaccination

(2012) Shahid M Khan et al.   CURRENT OPINION IN BIOTECHNOLOGY

Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects

(2012) Eric Dumonteil et al.   Expert Review of Vaccines

Trypanosoma cruzi carrying a monoallelic deletion of the calreticulin (TcCRT) gene are susceptible to complement mediated killing and defective in their metacyclogenesis

(2012) Fernando J. Sánchez Valdéz et al.   MOLECULAR IMMUNOLOGY

Deletion of mitochondrial associated ubiquitin fold modifier protein Ufm1 inLeishmania donovaniresults in loss of β-oxidation of fatty acids and blocks cell division in the amastigote stage

(2012) Sreenivas Gannavaram et al.   MOLECULAR MICROBIOLOGY

Modeling the economic value of a Chagas’ disease therapeutic vaccine

(2012) Bruce Y. Lee et al.   Human Vaccines & Immunotherapeutics

Texas and Mexico: Sharing a Legacy of Poverty and Neglected Tropical Diseases

(2012) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

IFN-γ Plays a Unique Role in Protection against Low Virulent Trypanosoma cruzi Strain

(2012) Adele A. Rodrigues et al.   PLoS Neglected Tropical Diseases

Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease

(2011) G.A. DosReis   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

The role of Toll-like receptors and adaptive immunity in the development of protective or pathological immune response triggered by theTrypanosoma cruziprotozoan

(2011) Andrea Pellegrini et al.   Future Microbiology

A Handful Of ‘Antipoverty’ Vaccines Exist For Neglected Diseases, But The World’s Poorest Billion People Need More

(2011) Peter Hotez   HEALTH AFFAIRS

Advances and challenges towards a vaccine against Chagas disease

(2011) Israel Quijano-Hernandez et al.   Human vaccines & immunotherapeutics

Heterologous Plasmid DNA Prime-Recombinant Human Adenovirus 5 Boost Vaccination Generates a Stable Pool of Protective Long-Lived CD8+T Effector Memory Cells Specific for a Human Parasite, Trypanosoma cruzi

(2011) Paula Ordonhez Rigato et al.   INFECTION AND IMMUNITY

Oral Exposure to Trypanosoma cruzi Elicits a Systemic CD8+T Cell Response and Protection against Heterotopic Challenge

(2011) Matthew H. Collins et al.   INFECTION AND IMMUNITY

Antitrypanosomal Therapy for Chronic Chagas' Disease

(2011) Caryn Bern   NEW ENGLAND JOURNAL OF MEDICINE

Intrachromosomal tandem duplication and repeat expansion during attempts to inactivate the subtelomeric essential gene GSH1 in Leishmania

(2011) Angana Mukherjee et al.   NUCLEIC ACIDS RESEARCH

Knockout of the dhfr-ts Gene in Trypanosoma cruzi Generates Attenuated Parasites Able to Confer Protection against a Virulent Challenge

(2011) Cecilia Perez Brandan et al.   PLoS Neglected Tropical Diseases

Co-Administration of a Plasmid DNA Encoding IL-15 Improves Long-Term Protection of a Genetic Vaccine against Trypanosoma cruzi

(2011) Christopher S. Eickhoff et al.   PLoS Neglected Tropical Diseases

Tolerance and Safety of Nifurtimox in Patients with Chronic Chagas Disease

(2010) Yves Jackson et al.   CLINICAL INFECTIOUS DISEASES

The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease

(2010) Caroline Junqueira et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Trypanosoma cruzi calreticulin: A novel virulence factor that binds complement C1 on the parasite surface and promotes infectivity

(2010) Galia Ramírez et al.   IMMUNOBIOLOGY

Intranasal Vaccinations with the trans-Sialidase Antigen plus CpG Adjuvant Induce Mucosal Immunity Protective against Conjunctival Trypanosoma cruzi Challenges

(2010) O. K. Giddings et al.   INFECTION AND IMMUNITY

CD8+ T Cells Specific for Immunodominant Trans-Sialidase Epitopes Contribute to Control of Trypanosoma cruzi Infection but Are Not Required for Resistance

(2010) C. S. Rosenberg et al.   JOURNAL OF IMMUNOLOGY

Chagas disease

(2010) Anis Rassi et al.   LANCET

The innate immune response to Trypanosoma cruzi infection

(2010) Hisako Kayama et al.   MICROBES AND INFECTION

Knockout of the gene encoding the kinetoplast-associated protein 3 (KAP3) in Trypanosoma cruzi: Effect on kinetoplast organization, cell proliferation and differentiation

(2010) Flavia Sá Pereira de Souza et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Molecular mechanisms involved in the inactivation of the first component of human complement by Trypanosoma cruzi calreticulin

(2010) Carolina Valck et al.   MOLECULAR IMMUNOLOGY

The Potential Economic Value of a Trypanosoma cruzi (Chagas Disease) Vaccine in Latin America

(2010) Bruce Y. Lee et al.   PLoS Neglected Tropical Diseases

Prophylactic Efficacy of TcVac2 against Trypanosoma cruzi in Mice

(2010) Shivali Gupta et al.   PLoS Neglected Tropical Diseases

Clinical Outcomes of Thirteen Patients with Acute Chagas Disease Acquired through Oral Transmission from Two Urban Outbreaks in Northeastern Brazil

(2010) Claudilson J. C. Bastos et al.   PLoS Neglected Tropical Diseases

In Vitro and In Vivo High-Throughput Assays for the Testing of Anti-Trypanosoma cruzi Compounds

(2010) Adriana M. C. Canavaci et al.   PLoS Neglected Tropical Diseases

Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches

(2009) Julio A. Urbina   ACTA TROPICA

Chagas disease: A Latin American health problem becoming a world health problem

(2009) Gabriel A. Schmunis et al.   ACTA TROPICA

Evaluation of high efficiency gene knockout strategies for Trypanosoma cruzi

(2009) Dan Xu et al.   BMC MICROBIOLOGY

CD8+ T cells in Trypanosoma cruzi infection

(2009) Angel M Padilla et al.   CURRENT OPINION IN IMMUNOLOGY

Vaccination approaches againstTrypanosoma cruziinfection

(2009) Silvia Inés Cazorla et al.   Expert Review of Vaccines

Protective immunity against Trypanosoma cruzi

(2009) Cecilia Parodi et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Sustainability of vector control strategies in the Gran Chaco Region: current challenges and possible approaches

(2009) Ricardo E Gürtler   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

(2009) K. M. VanBuskirk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic American trypanosomiasis: parasite persistence in endomyocardial biopsies is associated with high-grade myocarditis

(2008) L. A. Benvenuti et al.   ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY

Reactivation of Chagas disease with central nervous system involvement in HIV-infected patients in Argentina, 1992–2007

(2008) Ezequiel Cordova et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

(2008) Shane R. Wilkinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prime-boost immunization with cruzipain co-administered with MALP-2 triggers a protective immune response able to decrease parasite burden and tissue injury in an experimental Trypanosoma cruzi infection model

(2008) Silvia I. Cazorla et al.   VACCINE

Immunization with an engineered mutant trans-sialidase highly protects mice from experimental Trypanosoma cruzi infection: A vaccine candidate

(2008) Germán H. Fontanella et al.   VACCINE

The Neglected Tropical Diseases of Latin America and the Caribbean: A Review of Disease Burden and Distribution and a Roadmap for Control and Elimination

(2008) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases