Developments in virus-like particle-based vaccines for infectious diseases and cancer

Four year immunogenicity of the RTS,S/AS02A malaria vaccine in Mozambican children during a phase IIb trial

(2011) Pedro Aide et al.   VACCINE

HIV-Gag VLPs presenting trimeric HIV-1 gp140 spikes constitutively expressed in stable double transfected insect cell line

(2011) M. Tagliamonte et al.   VACCINE

Generation of HIV-1 Virus-Like Particles expressing different HIV-1 glycoproteins

(2011) M.L. Visciano et al.   VACCINE

Intranasal delivery of Norwalk virus-like particles formulated in an in situ gelling, dry powder vaccine

(2011) Lissette S. Velasquez et al.   VACCINE

Enhanced Mucosal Immune Responses to HIV Virus-Like Particles Containing a Membrane-Anchored Adjuvant

(2011) E. V. Vassilieva et al.   mBio

An Intranasally Delivered Toll-Like Receptor 7 Agonist Elicits Robust Systemic and Mucosal Responses to Norwalk Virus-Like Particles

(2010) L. S. Velasquez et al.   Clinical and Vaccine Immunology

Virus-Like Particles as Particulate Vaccines

(2010) Luigi Buonaguro et al.   CURRENT HIV RESEARCH

Patented cancer vaccines: the promising leads

(2010) Luigi Aurisicchio et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Low-dose oral immunization with lyophilized tissue of herbicide-resistant lettuce expressing hepatitis B surface antigen for prototype plant-derived vaccine tablet formulation

(2010) Tomasz Pniewski et al.   JOURNAL OF APPLIED GENETICS

Impact of Human Papillomavirus (HPV)-6/11/16/18 Vaccine on All HPV-Associated Genital Diseases in Young Women

(2010) Nubia Muñoz et al.   JNCI-Journal of the National Cancer Institute

Influenza virus-like particles as an antigen-carrier platform for the ESAT-6 epitope of Mycobacterium tuberculosis

(2010) Florian Krammer et al.   JOURNAL OF VIROLOGICAL METHODS

Progress towards development of an HIV vaccine: report of the AIDS Vaccine 2009 Conference

(2010) Anna Laura Ross et al.   LANCET INFECTIOUS DISEASES

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Virus-Like Particle Vaccine Protects against 2009 H1N1 Pandemic Influenza Virus in Mice

(2010) Fu-Shi Quan et al.   PLoS One

Multiple tandem copies of conserved gp41 epitopes incorporated in gag virus-like particles elicit systemic and mucosal antibodies in an optimized heterologous vector delivery regimen

(2010) Sumiti Jain et al.   VACCINE

Principles of vaccine design—Lessons from nature

(2010) Fred Zepp   VACCINE

Immunogenic display of diverse peptides, including a broadly cross-type neutralizing human papillomavirus L2 epitope, on virus-like particles of the RNA bacteriophage PP7

(2010) Jerri do Carmo Caldeira et al.   VACCINE

Constitutive expression of HIV-VLPs in stably transfected insect cell line for efficient delivery system

(2010) M. Tagliamonte et al.   VACCINE

Wanted, dead or alive: New viral vaccines

(2009) Ian J. Amanna et al.   ANTIVIRAL RESEARCH

A DNA replicon system for rapid high-level production of virus-like particles in plants

(2009) Zhong Huang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer

(2009) Celestia S. Higano et al.   CANCER

Virus-like particle vaccines and adjuvants: the HPV paradigm

(2009) Franco Maria Buonaguro et al.   Expert Review of Vaccines

Molecular immune signatures of HIV-1 vaccines in human PBMCs

(2009) Alessandro Monaco et al.   FEBS LETTERS

Displaying Fel d1 on virus-like particles prevents reactogenicity despite greatly enhanced immunogenicity: a novel therapy for cat allergy

(2009) Nicole Schmitz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chimeric L1-L2 Virus-Like Particles as Potential Broad-Spectrum Human Papillomavirus Vaccines

(2009) C. Schellenbacher et al.   JOURNAL OF VIROLOGY

Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women

(2009) J Paavonen et al.   LANCET

Virus-like particle vaccine activates conventional B2 cells and promotes B cell differentiation to IgG2a producing plasma cells

(2009) Sheng Zhang et al.   MOLECULAR IMMUNOLOGY

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

(2009) Johannes F. Scheid et al.   NATURE

Induction of Long-Term Protective Immune Responses by Influenza H5N1 Virus-Like Particles

(2009) Sang-Moo Kang et al.   PLoS One

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

Human immunodeficiency virus-like particles with consensus envelopes elicited broader cell-mediated peripheral and mucosal immune responses than polyvalent and monovalent Env vaccines

(2009) Sean P. McBurney et al.   VACCINE

M2e-based universal influenza A vaccine

(2009) Walter Fiers et al.   VACCINE

An HPV 16 L1-based chimeric human papilloma virus-like particles containing a string of epitopes produced in plants is able to elicit humoral and cytotoxic T-cell activity in mice

(2009) Georgina De la Rosa et al.   Virology Journal

Influenza vaccines based on virus-like particles

(2009) Sang-Moo Kang et al.   VIRUS RESEARCH

Influence of Dendritic Cells on Viral Pathogenicity

(2009) Giulia Freer et al.   PLoS Pathogens

Melanoma vaccine candidates from chimeric hepatitis B core virus-like particles carrying a tumor-associated MAGE-3 epitope

(2008) Andris Kazaks et al.   Biotechnology Journal

Gene expression profile of peripheral blood mononuclear cells in response to HIV-VLPs stimulation

(2008) Luigi Buonaguro et al.   BMC BIOINFORMATICS

Active immunization with IL-1 displayed on virus-like particles protects from autoimmune arthritis

(2008) Gunther Spohn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Recent Advances in Cancer Vaccines: An Overview

(2008) K. Itoh et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Internal Core Protein Cleavage Leaves the Hepatitis B Virus Capsid Intact and Enhances Its Capacity for Surface Display of Heterologous Whole Chain Proteins

(2008) Andreas Walker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering of SV40-based nano-capsules for delivery of heterologous proteins as fusions with the minor capsid proteins VP2/3

(2008) Takamasa Inoue et al.   JOURNAL OF BIOTECHNOLOGY

Presentation of functional foreign peptides on the surface of SV40 virus-like particles

(2008) Ryou-u Takahashi et al.   JOURNAL OF BIOTECHNOLOGY

Immunogenic Display of Diverse Peptides on Virus-like Particles of RNA Phage MS2

(2008) David S. Peabody et al.   JOURNAL OF MOLECULAR BIOLOGY

Th2 Polarization in Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus (HIV)-Infected Subjects, as Activated by HIV Virus-Like Particles

(2008) L. Buonaguro et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Inhibits Cell Surface Expression of HLA-DR, Prevents Dendritic Cell Maturation, and Induces Interleukin-10 Production

(2008) K. Saito et al.   JOURNAL OF VIROLOGY

Incorporation of Membrane-Anchored Flagellin into Influenza Virus-Like Particles Enhances the Breadth of Immune Responses

(2008) B.-Z. Wang et al.   JOURNAL OF VIROLOGY

Human papillomavirus L1 protein expressed in tobacco chloroplasts self-assembles into virus-like particles that are highly immunogenic

(2008) Alicia Fernández-San Millán et al.   PLANT BIOTECHNOLOGY JOURNAL

Cross-Clade Protective Immune Responses to Influenza Viruses with H5N1 HA and NA Elicited by an Influenza Virus-Like Particle

(2008) Rick A. Bright et al.   PLoS One

A Vaccine against Nicotine for Smoking Cessation: A Randomized Controlled Trial

(2008) Jacques Cornuz et al.   PLoS One

Respiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cells

(2008) P. A. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational fusion of chloroplast-expressed human papillomavirus type 16 L1 capsid protein enhances antigen accumulation in transplastomic tobacco

(2008) Paolo Lenzi et al.   TRANSGENIC RESEARCH

An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles

(2008) Luca Santi et al.   VACCINE

H5N1 VLP vaccine induced protection in ferrets against lethal challenge with highly pathogenic H5N1 influenza viruses

(2008) Kutubuddin Mahmood et al.   VACCINE

Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies

(2008) Marina De Filette et al.   VACCINE

Influenza-pseudotyped Gag virus-like particle vaccines provide broad protection against highly pathogenic avian influenza challenge

(2008) Joel R. Haynes et al.   VACCINE

Chimaeric HIV-1 subtype C Gag molecules with large in-frame C-terminal polypeptide fusions form virus-like particles

(2008) Richard J. Halsey et al.   VIRUS RESEARCH

Development of hepatitis B virus capsids into a whole-chain protein antigen display platform: New particulate Lyme disease vaccines

(2007) Michael Nassal et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY