Neisseriaproteomics for antigen discovery and vaccine development

Identification of vaccine antigens using integrated proteomic analyses of surface immunogens from serogroup B Neisseria meningitidis

(2014) Nikos Tsolakos et al.   Journal of Proteomics

Immuno-proteomic analysis of human immune responses to experimental Neisseria meningitidis outer membrane vesicle vaccines identifies potential cross-reactive antigens

(2014) Jeannette N. Williams et al.   VACCINE

Quantification by LC–MSE of outer membrane vesicle proteins of the Bexsero® vaccine

(2014) Chiara Tani et al.   VACCINE

Immunogenicity and Safety of a Meningococcal Serogroup A, C, Y and W Glycoconjugate Vaccine, ACWY-TT

(2013) Helen Findlow et al.   ADVANCES IN THERAPY

Potential of the adhesin complex protein ofNeisseria meningitidisfor next-generation meningococcal vaccines

(2013) Miao-Chiu Hung et al.   Expert Review of Vaccines

Bacterial resistance mechanism: what proteomics can elucidate

(2013) Thais Bergamin Lima et al.   FASEB JOURNAL

Quantitative Proteomics Reveals Distinct Differences in the Protein Content of Outer Membrane Vesicle Vaccines

(2013) Bas van de Waterbeemd et al.   JOURNAL OF PROTEOME RESEARCH

Protein arrays as tool for studies at the host–pathogen interface

(2013) Raúl Manzano-Román et al.   Journal of Proteomics

Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment

(2013) Ulrich Vogel et al.   LANCET INFECTIOUS DISEASES

Role of Factor H Binding Protein in Neisseria meningitidis Virulence and Its Potential as a Vaccine Candidate To Broadly Protect against Meningococcal Disease

(2013) L. K. McNeil et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Identification of the immunoproteome of the meningococcus by cell surface immunoprecipitation and MS

(2013) J. Newcombe et al.   MICROBIOLOGY-SGM

Immunization with recombinant Chaperonin60 (Chp60) outer membrane protein induces a bactericidal antibody response against Neisseria meningitidis

(2013) Renee Phillips et al.   VACCINE

Diversity of Canadian meningococcal serogroup B isolates and estimated coverage by an investigational meningococcal serogroup B vaccine (4CMenB)

(2013) Julie A. Bettinger et al.   VACCINE

Conservation of Meningococcal Antigens in the Genus Neisseria

(2013) A. Muzzi et al.   mBio

The proteomic future: where mass spectrometry should be taking us

(2012) Jay J. Thelen et al.   BIOCHEMICAL JOURNAL

Unbiased Selective Isolation of Protein N-terminal Peptides from Complex Proteome Samples Using Phospho Tagging (PTAG) and TiO2-based Depletion

(2012) Geert P. M. Mommen et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteomic Analysis of Neisseria gonorrhoeae Biofilms Shows Shift to Anaerobic Respiration and Changes in Nutrient Transport and Outermembrane Proteins

(2012) Nancy J. Phillips et al.   PLoS One

Deep metaproteomic analysis of human salivary supernatant

(2012) Pratik Jagtap et al.   PROTEOMICS

The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: Immunological, functional and structural characterization of the antigens

(2012) Davide Serruto et al.   VACCINE

Meningococcal vaccine development – from glycoconjugates against MenACWY to proteins against MenB – potential for broad protection against meningococcal disease

(2012) Peter M. Dull et al.   VACCINE

The Neisseria meningitidis Macrophage Infectivity Potentiator Protein Induces Cross-Strain Serum Bactericidal Activity and Is a Potential Serogroup B Vaccine Candidate

(2011) Miao-Chiu Hung et al.   INFECTION AND IMMUNITY

Large-Scale Identification of Bacteria–Host Crosstalk by Affinity Chromatography: Capturing the Interactions ofStreptococcus suisProteins with Host Cells

(2011) Bo Chen et al.   JOURNAL OF PROTEOME RESEARCH

Mapping phosphoproteins in Neisseria meningitidis serogroup A

(2011) Giulia Bernardini et al.   PROTEOMICS

Proteome analysis of host-pathogen interactions: Investigation of pathogen responses to the host cell environment

(2011) Frank Schmidt et al.   PROTEOMICS

The Role of the Exopolyphosphatase PPX in Avoidance byNeisseria meningitidisof Complement-mediated Killing

(2010) Qian Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative proteomic analysis of biofilm and planktonic cells of Neisseria meningitidis

(2010) Tessa van Alen et al.   PROTEOMICS

Improved OMV vaccine against Neisseria meningitidis using genetically engineered strains and a detergent-free purification process

(2010) Bas van de Waterbeemd et al.   VACCINE

Characterization of meningococcal serogroup B outer membrane vesicle vaccines from strain 44/76 after growth in different media

(2010) Nikos Tsolakos et al.   VACCINE

Molecular characterization and identification of proteins regulated by Hfq inNeisseria meningitidis

(2009) Yvonne Pannekoek et al.   FEMS MICROBIOLOGY LETTERS

The RNA Chaperone Hfq Is Involved in Stress Response and Virulence in Neisseria meningitidis and Is a Pleiotropic Regulator of Protein Expression

(2009) L. Fantappie et al.   INFECTION AND IMMUNITY

Immunoproteomic Analysis of the Development of Natural Immunity in Subjects Colonized by Neisseria meningitidis Reveals Potential Vaccine Candidates

(2009) J. N. Williams et al.   INFECTION AND IMMUNITY

Candidate verification of iron-regulated Neisseria meningitidis proteins using isotopic versions of tandem mass tags (TMT) and single reaction monitoring

(2009) Helen L. Byers et al.   Journal of Proteomics

Manganese regulation of virulence factors and oxidative stress resistance in Neisseria gonorrhoeae

(2009) Hsing-Ju Wu et al.   Journal of Proteomics

Towards the Immunoproteome of Neisseria meningitidis

(2009) Tom A. Mendum et al.   PLoS One

Broad spectrum O-linked protein glycosylation in the human pathogen Neisseria gonorrhoeae

(2009) A. Vik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of proteins of Neisseria meningitidis induced under iron-limiting conditions using the isobaric tandem mass tag (TMT) labeling approach

(2009) Peter van Ulsen et al.   PROTEOMICS

Identification of new epidemiological molecular markers by comparative proteomics of serogroup A meningococcal isolates from three pandemic waves

(2009) Giulia Bernardini et al.   Proteomics Clinical Applications

Properties and clinical performance of vaccines containing outer membrane vesicles from Neisseria meningitidis

(2009) Johan Holst et al.   VACCINE

Identification of new meningococcal serogroup B surface antigens through a systematic analysis of neisserial genomes

(2009) Rolando Pajon et al.   VACCINE

Reverse transcriptase-PCR differential display analysis of meningococcal transcripts during infection of human cells: Up-regulation of priA and its role in intracellular replication

(2008) Adelfia Talà et al.   BMC MICROBIOLOGY

The surface-associated elongation factor Tu is concealed for antibody binding on viable pneumococci and meningococci

(2008) Jan Kolberg et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis

(2008) C. Schoen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunoproteomic identification of the hypothetical protein NMB1468 as a novel lipoprotein ubiquitous inNeisseria meningitidis with vaccine potential

(2008) Chi-An Hsu et al.   PROTEOMICS