Journal
PROTEOMICS
Volume 11, Issue 15, Pages 3203-3211Publisher
WILEY
DOI: 10.1002/pmic.201100158
Keywords
Bacterial adaptation responses; Enrichment strategies; Infection biology; In vivo proteomics; Microbiology
Funding
- Deutsche Forschungsgemeinschaft [SFBTRR34, GRK840]
- Alfried Krupp Foundation
- BMBF
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Infectious diseases are still a major health risk, and thus a better understanding of the interaction between human host cells and pathogenic microbes is urgently required. Since the interplay between both partners is highly complex, genome-wide analysis by OMICs approaches will likely make a major contribution to the elucidation of the pathophysiology of infection processes. In the concert of OMICs technologies, proteomics is particularly important because it reveals changes in the active players of the cell and has thus a close relationship to the phenotypic changes observed. While proteomic studies of in vitro-grown microbial pathogens are routinely established in many labs, in vivo proteomic approaches are still rare. Here, we will review the challenges and recent developments of proteomic analysis of microbial pathogens derived from cell culture or in vivo infection settings and summarize some lessons that have been learned from these studies.
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