Article
Obstetrics & Gynecology
Daniel A. Dumesic, Ayli Tulberg, Karen L. Leung, Samantha C. Fisch, Tristan R. Grogan, David H. Abbott, Rajanigandha Naik, Gregorio D. Chazenbalk
Summary: In vitro differentiation of adipose stem cells into adipocytes in SC abdominal fat may predict insulin sensitivity in vivo in normal-weight women with PCOS, suggesting a potential role for hyperandrogenism in metabolic thrift. PCOS patients exhibited higher androgen levels, adipose-IR, and android fat percentage, while their adipocyte differentiation and gene expression in vitro were negatively correlated with adipose-IR and serum free testosterone but positively correlated with insulin sensitivity.
FERTILITY AND STERILITY
(2021)
Article
Cell Biology
Katarzyna J. Siemienowicz, Flavien Coukan, Stephen Franks, Mick T. Rae, W. Colin Duncan
Summary: The study suggests that aberrant adipogenesis during adolescence in patients with polycystic ovary syndrome (PCOS) affects the metabolic phenotype of adult PCOS, highlighting an opportunity for early clinical intervention to regulate adipogenesis.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Rongcai Ye, Chunlong Yan, Huiqiao Zhou, Yuanyuan Huang, Meng Dong, Hanlin Zhang, Xiaoxiao Jiang, Shouli Yuan, Li Chen, Rui Jiang, Ziyu Cheng, Kexin Zheng, Qiaoli Zhang, Wanzhu Jin
Summary: PCOS is a common endocrine disease with no effective treatment currently available. Research suggests that cold treatment can activate endogenous BAT, improve fertility and ovarian conditions in PCOS rats, serving as a novel therapeutic strategy for PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yuqin Zhang, Meili Cai, Diliqingna Dilimulati, Ziwei Lin, Hang Sun, Ran Cui, Hongxiang Fei, Xinxin Gao, Qiongjing Zeng, Xiaowen Shao, Manna Zhang, Shen Qu
Summary: This study found that a high level of visceral adipose tissue (VAT) mass is associated with an increased risk of hyperuricemia in patients with polycystic ovary syndrome (PCOS). Excessive VAT should be considered in the occurrence and development of PCOS with hyperuricemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Fangfang Di, Danfeng Gao, Lihua Yao, Runjie Zhang, Jin Qiu, Liwen Song
Summary: Polycystic ovary syndrome (PCOS) often coexists with a metabolic disorder, and dysfunction of adipose tissue, especially abdominal adipose tissue, can worsen reproductive and metabolic problems in PCOS patients. The study used LC-MS/MS to analyze adipose samples from PCOS patients, and identified PCOS biomarkers engaged in inflammatory diseases and mitochondrial beta-oxidation. In vitro experiments showed that isoleucine could ameliorate the effects of hyperandrogenism on granulosa cells and related metabolic disorders. GC-MS/MS analysis revealed significantly decreased levels of isoleucine in PCOS patients. The findings suggest that metabolome alterations could be a novel therapeutic target for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Fuensanta Navarro-Lafuente, Julian J. Arense-Gonzalo, Maria L. Sanchez-Ferrer, Maria T. Prieto-Sanchez, Ana Cutillas-Tolin, Jaime Mendiola, Evdochia Adoamnei, Esteban Gazabat-Barbado, Jesus Vioque, Alberto M. Torres-Cantero
Summary: This study suggests that higher intakes of specific fatty acids are related to some PCOS phenotypes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Endocrinology & Metabolism
Cheng Tong, Yue Wu, Zhenchao Zhuang, Zhejiong Wang, Ying Yu
Summary: Proteomics technology is important for exploring unknown areas and disease pathogenesis, but there are fewer studies on constructing clinical models using proteomics markers.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Frank Gonzalez, Robert Considine, Ola A. Abdelhadi, Jiaping Xue, Anthony J. Acton
Summary: In PCOS, saturated fat intake triggers proatherogenic inflammation pathways, independent of obesity. This effect is more pronounced in PCOS combined with obesity compared to obesity alone. Abdominal adiposity and hyperandrogenism may contribute to perpetuating proatherogenic inflammation.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Ling Zuo, Yang Hai, Ruoyu Zhang, Biao Zuo, Jiayu Tian, Pan Li, Xiumei Ke, Meng Wang, Li Ren, Xuezhi Li, Xuekuan Huang, Jianwei Wang
Summary: This study aimed to determine the therapeutic effect and pharmacological mechanism of icariin in PCOS rats. The results showed that icariin significantly improved ovarian function and reproductive endocrine disorders by regulating sex hormones, restoring the estrous cycle, and reducing ovarian morphological damage in PCOS rats. In addition, icariin also reduced weight gain and improved glucolipid metabolism in PCOS rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Qiaoli Zhang, Rongcai Ye, Yuan-Yuan Zhang, Chen-Chen Fan, Jun Wang, Shuyu Wang, Suwen Chen, Xiaowei Liu
Summary: This review discusses the importance of brown adipose tissue (BAT) in metabolism and energy expenditure, as well as its potential therapeutic role in treating polycystic ovary syndrome (PCOS). Various studies have shown that BAT can regulate the features of PCOS and increasing BAT mass or activity has been effective in the treatment of PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bojana Micic, Ana Teofilovic, Ana Djordjevic, Natasa Velickovic, Djuro Macut, Danijela Vojnovic Milutinovic
Summary: Overfeeding during the postnatal period may predispose individuals to metabolic disturbances associated with PCOS, with visceral adipose tissue (VAT) maintaining its insulin sensitivity through increased AMPK activity, while subcutaneous adipose tissue (SAT) demonstrates worsened metabolic function, leading to systemic insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Female infertility is mainly caused by ovulation disorders, with polycystic ovary syndrome (PCOS) being the most prevalent. PCOS is associated with abnormal function of estrogen and estrogen receptors (ERs), affecting cellular activities. Selective estrogen receptor modulators (SERMs) like tamoxifen and clomiphene have shown clinical applications for subfertility with PCOS, but further understanding of the role of ER in PCOS is needed.
Article
Pharmacology & Pharmacy
Rongcai Ye, Chunlong Yan, Huiqiao Zhou, Chuanhai Zhang, Yuanyuan Huang, Meng Dong, Hanlin Zhang, Jun Lin, Xiaoxiao Jiang, Shouli Yuan, Li Chen, Rui Jiang, Ziyu Cheng, Kexin Zheng, Anni Yu, Qiaoli Zhang, Lin-hu Quan, Wanzhu Jin
Summary: CK treatment significantly activates BAT, increases CXCL14 expression, and ameliorates PCOS.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Maosheng Cao, Yun Zhao, Tong Chen, Zijiao Zhao, Boqi Zhang, Chenfeng Yuan, Xin Wang, Lu Chen, Nan Wang, Chunjin Li, Xu Zhou
Summary: This study found that AMSC-EXOs can protect against metabolic disturbances, improve ovarian polycystic and enhance fertility. The study also discovered that AMSC-EXOs transfer miRNA to the liver, thereby improving metabolic dysfunction and reproductive ability in PCOS. This provides a theoretical basis for using rat adipose stem cells and their secreted exosomes to treat PCOS.
Review
Biochemistry & Molecular Biology
Susanne Schueler-Toprak, Olaf Ortmann, Christa Buechler, Oliver Treeck
Summary: This review article provides an update on the role of adipokines in polycystic ovary syndrome (PCOS) and endometriosis, as well as summarizes previous findings. The article also discusses the involvement of single nucleotide polymorphisms (SNPs) in genes coding for adipokines and their receptors, the secretome of adipocytes, and epigenetic alterations of adipokine genes. Furthermore, the article addresses the notable effects of brown adipose tissue (BAT) on PCOS.
Article
Rheumatology
Patricia Seoane-Collazo, Eva Rial-Pensado, Anxela Estevez-Salguero, Edward Milbank, Lucia Garcia-Caballero, Marcos Rios, Laura Linares-Pose, Morena Scotece, Rosalia Gallego, Jose Manuel Fernandez-Real, Ruben Nogueiras, Carlos Dieguez, Oreste Gualillo, Miguel Lopez
Summary: The study found that EA is associated with increased BAT thermogenesis and browning of subcutaneous WAT, leading to elevated energy expenditure. EA rats showed inhibition of hypothalamic AMPK, a key energy sensor in regulating central energy homeostasis. Specific genetic activation of AMPK in the ventromedial nucleus of the hypothalamus could reverse the effects of EA on energy balance, brown fat, and browning, as well as improve synovial inflammation in experimental arthritis.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Milton-Fabian Suarez-Ortegon, Stela McLachlan, Jose-Manuel Fernandez-Real, Tomi-Pekka Tuomainen, Alex Aregbesola, Sarah H. Wild
Summary: This study found that iron stores (measured by serum ferritin levels) are differently associated with type 2 diabetes (T2D), coronary heart disease (CHD), and cerebrovascular disease (CEVD) in the Scottish population. After adjusting for covariates, the association between ferritin and T2D remained significant, and the association between ferritin and CEVD became stronger when higher cutoff points for ferritin levels were considered.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Medicine, General & Internal
Andrea G. Izquierdo, Marcos C. Carreira, Hatim Boughanem, Jose M. Moreno-Navarrete, Carolina F. Nicoletti, Paula Oliver, Daniel Luis, Carla B. Nonino, Maria P. Portillo, Miguel A. Martinez-Olmos, Jose M. Fernandez-Real, Francisco J. Tinahones, J. Alfredo Martinez, Manuel Macias-Gonzalez, Felipe F. Casanueva, Ana B. Crujeiras
Summary: This study evaluated the methylation levels of the ACE2 gene in adipose tissue and leukocytes in obesity and after weight loss therapy. It was found that obesity was associated with higher ACE2 methylation levels in visceral adipose tissue and leukocytes, which could be reversed by weight loss therapy. These findings suggest a potential link between obesity-related ACE2 methylation and COVID-19 pathogenesis.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Milton Fabian Suarez-Ortegon, Alejandra Arbelaez, Jose Maria Moreno-Navarrete, Jose Guillermo Ortega-Avila, Mildrey Mosquera, Jose Manuel Fernandez-Real
Summary: Excessive body iron levels are associated with insulin resistance and cardiometabolic risk, and oxidative stress may play a role in this relationship. This study investigated the association between soluble transferrin receptor (sTfR) levels, antioxidant status, and cardiometabolic risk markers. The results showed that sTfR levels were positively correlated with total antioxidant capacity (TAC) in both men and women. In men, sTfR levels were inversely associated with waist circumference and fasting glucose, and positively associated with LDL cholesterol. The findings suggest that sTfR levels are associated with antioxidant status and specific cardiometabolic risk variables, independent of other factors such as serum ferritin and hepcidin.
Review
Endocrinology & Metabolism
Miguel Lopez, Manuel Fernandez-Real, Stanislav I. Tomarev
Summary: Classically, the regulation of energy balance has been based on central and peripheral mechanisms sensing energy, nutrients, metabolites, and hormonal cues. Recent data have added more complexity to the homeostatic regulation of metabolism by introducing the key role of olfaction in energy homeostasis. Olfactory inputs contribute to the regulation of feeding, energy expenditure, and whole body metabolism.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Alejandro Hinojosa-Moscoso, Anna Motger-Alberti, Elena De la Calle-Vargas, Marian Marti-Navas, Carles Biarnes, Maria Arnoriaga-Rodriguez, Gerard Blasco, Josep Puig, Diego Luque-Cordoba, Feliciano Priego-Capote, Jose Maria Moreno-Navarrete, Jose Manuel Fernandez-Real
Summary: Excess iron is associated with dysfunction in adipose tissue and insulin resistance. In this study, it was found that markers of iron status were linked to changes in abdominal adipose tissue over one year. These associations were mainly observed in women and non-obese subjects, and were independent of insulin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Maria Arnoriaga-Rodriguez, Yenny Leal, Jordi Mayneris-Perxachs, Vicente Perez-Brocal, Andres Moya, Wifredo Ricart, Merce Fernandez-Balsells, Jose Manuel Fernandez-Real
Summary: Sleep disruption is associated with worse glucose metabolic control and altered gut microbiota. This study found an association between rapid eye movement (REM) sleep duration and glucose levels as well as gut microbiota composition. Sleep deprivation can lead to poor glucose control and microbiota imbalance, negatively impacting metabolic health.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Luca Valenti, Elena Corradini, Leon A. Adams, Elmar Aigner, Saleh Alqahtani, Marco Arrese, Edouard Bardou-Jacquet, Elisabetta Bugianesi, Jose-Manuel Fernandez-Real, Domenico Girelli, Hannes Hagstrom, Benjamin Henninger, Kris Kowdley, Guido Ligabue, Donald McClain, Fabrice Laine, Koji Miyanishi, Martina U. Muckenthaler, Alessia Pagani, Patrizia Pedrotti, Antonello Pietrangelo, Daniele Prati, John D. Ryan, Laura Silvestri, C. Wendy Spearman, Per Stal, Emmanuel A. Tsochatzis, Francesca Vinchi, Ming-Hua Zheng, Heinz Zoller
Summary: Hyperferritinaemia is often associated with metabolic dysfunction and fatty liver and is linked to an increased risk of cardiometabolic and liver diseases. The main determinants of ferritin levels in individuals with metabolic dysfunction are genetic variants that affect iron metabolism. However, there is currently a lack of validated criteria for the diagnosis and staging of metabolic hyperferritinaemia, and the benefits of iron depletion therapy remain unclear. In this article, the authors provide an overview of the relationship between hyperferritinaemia and iron accumulation in individuals with metabolic dysfunction and propose updated definitions and staging systems, highlighting research gaps and suggesting future study designs and outcome measures.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lidia Sojo, Elena Santos-Gonzalez, Lidia Riera, Alex Aguilera, Rebeca Barahona, Paula Pellicer, Maria Buxo, Jordi Mayneris-Perxachs, Merce Fernandez-Balsells, Jose-Manuel Fernandez-Real
Summary: In this study, we investigated the plasma lipidomics profiles of patients with T1DM and explored potential associations. We found significant associations between certain lipid species and subclinical atherosclerosis, as well as differences according to overweight status. Our findings suggest that personalized approaches targeting specific lipid molecules may be useful in preventing cardiovascular disease in T1DM patients.
Article
Chemistry, Medicinal
Nuria Vilaboa, Juan Antonio Lopez, Marco de Mesa, Clara Escudero-Duch, Natalie Winfield, Melanie Bayford, Richard Voellmy
Summary: Exposure to celastrol, withaferin A, and synthetic compounds caused denaturation of luciferase reporter protein in cancer cells, leading to proteostasis disruption. Proteomic analysis revealed covalent modification of numerous cellular proteins targeted by the compounds. Important fractions of these proteins unfolded and formed aggregates. Multiple myeloma cells were particularly sensitive to these compounds. Development of a new proteostasis-disrupting therapy for multiple myeloma is suggested.
Review
Endocrinology & Metabolism
Marisel Rosell-Diaz, Jose Manuel Fernandez-Real
Summary: The decline in cognitive function and the prevalence of neurodegenerative disorders are serious threats to health in old age, with dementia affecting 50 million people worldwide. Type 2 diabetes is linked to an increased risk of cognitive impairment and dementia. Studies have shown that metformin, a medication used to treat type 2 diabetes, may partially restore gut dysbiosis related to diabetes and potentially improve cognitive function.
Article
Endocrinology & Metabolism
Jiuwen Sun, Alberic Germain, Gracia Kaglan, Florence Servant, Benjamin Lelouvier, Massimo Federici, Jose Manuel Fernandez Real, Daniela Tatiana Sala, Radu Mircea Neagoe, Anne Bouloumie, Remy Burcelin
Summary: This study found that specific bacterial families in the visceral adipose tissue of obese patients can trigger inflammation and adipose depot development. There are significant differences in the bacterial composition between obese patients and non-obese individuals. These findings generate new hypotheses regarding the relationship between obesity and gut tissue.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Endocrinology & Metabolism
Nuria Oliveras-Canellas, Jose Maria Moreno-Navarrete, Paula M. Lorenzo, Lourdes Garrido-Sanchez, Sara Becerril, Oriol Rangel, Jessica Latorre, Elena de la Calle Vargas, Maria Pardo, Victor Valenti, Juan L. Romero-Cabrera, Wilfredo Oliva-Olivera, Camilo Silva, Carlos Dieguez, Francesc Villarroya, Miguel Lopez, Ana B. Crujeiras, Luisa-Maria Seoane, Jose Lopez-Miranda, Gema Fruhbeck, Francisco Jose Tinahones, Jose-Manuel Fernandez-Real
Summary: This study investigated how outside temperature affects adipose tissue physiology and metabolic traits. The expression of genes associated with browning and adipogenesis in the subcutaneous adipose tissue were found to be negatively associated with temperature. These findings could have implications for the relationship between the obesity pandemic and global warming.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Milton Fabian Suarez-Ortegon, Jenny Elizabeth Ordonez-Betancourth, Jose Guillermo Ortega-Avila, Ana Yibby Forero, Jose Manuel Fernandez-Real
Summary: This study evaluated the relationship between three adiposity markers and iron-deficient status in reproductive-age women. The results showed that waist circumference, waist-to-height ratio, and BMI were inversely associated with iron deficiency. Among them, waist-to-height ratio had the strongest correlation.
Article
Cell Biology
Susana Aguilar, Paula Garcia-Olloqui, Lidia Amigo-Moran, Jose Luis Toran, Juan Antonio Lopez, Guillermo Albericio, Gloria Abizanda, Diego Herrero, Africa Vales, Saray Rodriguez-Diaz, Marina Higuera, Ruben Garcia-Martin, Jesus Vazquez, Carmen Mora, Gloria Gonzalez-Aseguinolaza, Felipe Prosper, Beatriz Pelacho, Antonio Bernad
Summary: Oxidative stress-induced myocardial apoptosis and necrosis play a critical role in ischemic infarction. This study identified and validated miR-935 as a highly differentially expressed miRNA in exosomes derived from human cardiac progenitor cells (CPC). Reduction of miR-935 expression promotes oxidative stress-associated apoptosis. Together with other exosomal miRNA members, miR-935 may counteract oxidative stress-related apoptosis in the CPC microenvironment.
