Journal
ANTIOXIDANTS
Volume 12, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/antiox12051132
Keywords
plasma lipidomics; subclinical atherosclerosis; overweight; obesity; type 1 diabetes
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In this study, we investigated the plasma lipidomics profiles of patients with T1DM and explored potential associations. We found significant associations between certain lipid species and subclinical atherosclerosis, as well as differences according to overweight status. Our findings suggest that personalized approaches targeting specific lipid molecules may be useful in preventing cardiovascular disease in T1DM patients.
Here, we report on our study of plasma lipidomics profiles of patients with type 1 diabetes (T1DM) and explore potential associations. One hundred and seven patients with T1DM were consecutively recruited. Ultrasound imaging of peripheral arteries was performed using a high image resolution B-mode ultrasound system. Untargeted lipidomics analysis was performed using UHPLC coupled to qTOF/MS. The associations were evaluated using machine learning algorithms. SM(32:2) and ether lipid species (PC(O-30:1)/PC(P-30:0)) were significantly and positively associated with subclinical atherosclerosis (SA). This association was further confirmed in patients with overweight/obesity (specifically with SM(40:2)). A negative association between SA and lysophosphatidylcholine species was found among lean subjects. Phosphatidylcholines (PC(40:6) and PC(36:6)) and cholesterol esters (ChoE(20:5)) were associated positively with intima-media thickness both in subjects with and without overweight/obesity. In summary, the plasma antioxidant molecules SM and PC differed according to the presence of SA and/or overweight status in patients with T1DM. This is the first study showing the associations in T1DM, and the findings may be useful in the targeting of a personalized approach aimed at preventing cardiovascular disease in these patients.
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