Strategy to reduce free radical species in Alzheimer’s disease: an update of selected antioxidants

Proinflammatory Stimuli are Needed for Induction of Microglial Cell-Mediated AβPP244–C and Aβ-Neurotoxicity in Hippocampal Cultures

(2017) Gigliola Ramírez et al.   JOURNAL OF ALZHEIMERS DISEASE

Constant Illumination Induces Alzheimer-Like Damages with Endoplasmic Reticulum Involvement and the Protection of Melatonin

(2017) Zhi-Qun Ling et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria and Antioxidant Targeted Therapeutic Strategies for Alzheimer's Disease

(2017) Magali Dumont et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons

(2017) Maria Manczak et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Oxidative Stress in the Progression of Alzheimer's Disease

(2017) Rukhsana Sultana et al.   JOURNAL OF ALZHEIMERS DISEASE

Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect ofN-acetyl-cysteine

(2014) Paola Gamba et al.   AGING CELL

Brain metabolic dysfunction at the core of Alzheimer's disease

(2014) Suzanne M. de la Monte et al.   BIOCHEMICAL PHARMACOLOGY

The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease

(2014) Li Fang Ng et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Effect of Souvenaid on Functional Brain Network Organisation in Patients with Mild Alzheimer’s Disease: A Randomised Controlled Study

(2014) Hanneke de Waal et al.   PLoS One

Vitamin E and memantine in Alzheimer's disease: Clinical trial methods and baseline data

(2013) Maurice W. Dysken et al.   Alzheimers & Dementia

Abeta, oxidative stress in Alzheimer disease: Evidence based on proteomics studies

(2013) Aaron M. Swomley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Trans-ferulic acid-based solid lipid nanoparticles and their antioxidant effect in rat brain microsomes

(2013) Sonia Trombino et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Ferulic acid: Pharmacological and toxicological aspects

(2013) Cesare Mancuso et al.   FOOD AND CHEMICAL TOXICOLOGY

Lymphocyte mitochondria: toward identification of peripheral biomarkers in the progression of Alzheimer disease

(2013) Rukhsana Sultana et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: Implications for low vitamin D-dependent age-related cognitive decline

(2013) Jeriel T.R. Keeney et al.   FREE RADICAL BIOLOGY AND MEDICINE

Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of α-/γ-tocotrienols and γ-tocopherol

(2013) F. Mangialasche et al.   JOURNAL OF INTERNAL MEDICINE

Souvenaid®: A new approach to management of early Alzheimer’s disease

(2013) C. W. Ritchie et al.   Journal of Nutrition Health & Aging

A randomized controlled Alzheimer’s disease prevention trial’s evolution into an exposure trial: The preadvise trial

(2013) R. J. Kryscio et al.   Journal of Nutrition Health & Aging

Mass spectrometry and redox proteomics: Applications in disease

(2013) D. Allan Butterfield et al.   MASS SPECTROMETRY REVIEWS

Nutritional approaches in the risk reduction and management of Alzheimer's disease

(2013) Weiqian Mi et al.   NUTRITION

Ferulic Acid Is a Nutraceutical β-Secretase Modulator That Improves Behavioral Impairment and Alzheimer-like Pathology in Transgenic Mice

(2013) Takashi Mori et al.   PLoS One

The S-Connect study: results from a randomized, controlled trial of Souvenaid in mild-to-moderate Alzheimer’s disease

(2013) Raj C Shah et al.   Alzheimers Research & Therapy

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Oxidative modification of lipoic acid by HNE in Alzheimer disease brain

(2013) Sarita S. Hardas et al.   Redox Biology

Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression

(2012) D. Allan Butterfield et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants for Alzheimer Disease

(2012) Douglas R. Galasko et al.   ARCHIVES OF NEUROLOGY

Vitamin E in aging, dementia, and Alzheimer's disease

(2012) Yash B. Joshi et al.   BIOFACTORS

Protective Effects of Ferulic Acid in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mouse Model of Alzheimer Disease

(2012) Ji-Jing Yan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Vitamin D-binding protein interacts with Aβ and suppresses Aβ-mediated pathology

(2012) M Moon et al.   CELL DEATH AND DIFFERENTIATION

Circadian System Functionality, Hippocampal Oxidative Stress, and Spatial Memory in the APPswe/PS1dE9 Transgenic Model of Alzheimer Disease: Effects of Melatonin or Ramelteon

(2012) Beatriz Baño Otalora et al.   CHRONOBIOLOGY INTERNATIONAL

Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells

(2012) Wen-Yong Huang et al.   CNS Neuroscience & Therapeutics

Vitamin D insufficiency and mild cognitive impairment: cross-sectional association

(2012) C. Annweiler et al.   EUROPEAN JOURNAL OF NEUROLOGY

Therapeutic effect of organoselenium dietary supplementation in a sporadic dementia of Alzheimer's type model in rats

(2012) Simone Pinton et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Selenium and human health

(2012) Margaret P Rayman   LANCET

Effect of One-Year Vitamin C- and E-Supplementation on Cerebrospinal Fluid Oxidation Parameters and Clinical Course in Alzheimer’s Disease

(2012) Sönke Arlt et al.   NEUROCHEMICAL RESEARCH

Antioxidant Therapies for Alzheimer's Disease

(2012) Ye Feng et al.   Oxidative Medicine and Cellular Longevity

Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer, Inhibits Amyloid-β-Mediated Alzheimer's Disease-Associated Pathogenesis In Vitro and In Vivo

(2012) Rongbiao Pi et al.   PLoS One

Practice effects in a longitudinal, multi-center Alzheimer’s disease prevention clinical trial

(2012) Erin L Abner et al.   Trials

Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications

(2011) D. Allan Butterfield et al.   ANTIOXIDANTS & REDOX SIGNALING

Vitamin D and the brain

(2011) Lauren R. Harms et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer's disease mice: Implications for impaired mitochondrial biogenesis and synaptic damage

(2011) Marcus J. Calkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Natural substances and Alzheimer's disease: From preclinical studies to evidence based medicine

(2011) Cesare Mancuso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress

(2011) Jorge Garrido et al.   BIOCHIMIE

Neuroprotector effect of p,p'-methoxyl-diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism

(2011) Simone Pinton et al.   CELL BIOCHEMISTRY AND FUNCTION

Nutritional Approaches to Modulate Oxidative Stress in Alzheimers Disease

(2011) C. B. Pocernich et al.   Current Alzheimer Research

Nuclear and mitochondrial DNA oxidation in Alzheimer's disease

(2011) Renato X. Santos et al.   FREE RADICAL RESEARCH

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Curcumin and Alzheimer Disease: This Marriage Is Not to Be Performed

(2011) Cesare Mancuso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease

(2011) M. J. McManus et al.   JOURNAL OF NEUROSCIENCE

Tocopherols and tocotrienols plasma levels are associated with cognitive impairment

(2011) Francesca Mangialasche et al.   NEUROBIOLOGY OF AGING

Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse

(2011) Yoelvis García-Mesa et al.   NEUROBIOLOGY OF AGING

Amelioration of social isolation-triggered onset of early Alzheimer's disease-related cognitive deficit by N-acetylcysteine in a transgenic mouse model

(2011) Ya-Hsin Hsiao et al.   NEUROBIOLOGY OF DISEASE

Tricyclodecan-9-yl-Xanthogenate (D609) Mechanism of Actions: A Mini-Review of Literature

(2011) Rao Muralikrishna Adibhatla et al.   NEUROCHEMICAL RESEARCH

Oxidative Stress and β-Amyloid Protein in Alzheimer’s Disease

(2011) Zhiyou Cai et al.   NEUROMOLECULAR MEDICINE

Proteomic analysis of brain proteins in APP/PS-1 human double mutant knock-in mice with increasing amyloid β-peptide deposition: Insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild cognitive

(2011) Renã A. S. Robinson et al.   PROTEOMICS

Alzheimer's disease - input of vitamin D with mEmantine assay (AD-IDEA trial): study protocol for a randomized controlled trial

(2011) Cédric Annweiler et al.   Trials

Toxicity of Neurons Treated with Herbicides and Neuroprotection by Mitochondria-Targeted Antioxidant SS31

(2011) Tejaswini P. Reddy et al.   International Journal of Environmental Research and Public Health

Serum Nitrosative Stress Levels Are Increased in Alzheimer Disease but Not in Vascular Dementia

(2010) Konukoğlu Dildar et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Efficacy of a medical food in mild Alzheimer's disease: A randomized, controlled trial

(2010) Philip Scheltens et al.   Alzheimers & Dementia

Development of Mitochondria-targeted Aromatic-cationic Peptides for Neurodegenerative Diseases

(2010) Hazel H. Szeto   Annals of the New York Academy of Sciences

Vitamin D and Risk of Cognitive Decline in Elderly Persons

(2010) David J. Llewellyn   ARCHIVES OF INTERNAL MEDICINE

Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease☆

(2010) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer’s disease model

(2010) Niall M. Corcoran et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A

(2010) Xifei Yang et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Alterations of plasma magnesium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities in patients with Alzheimer’s disease

(2010) Huseyin Vural et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Abnormal Mitochondrial Dynamics—A Novel Therapeutic Target for Alzheimer's Disease?

(2010) Bo Su et al.   MOLECULAR NEUROBIOLOGY

Treatment of Alzheimer’s Disease with a Cholinesterase Inhibitor Combined with Antioxidants

(2010) Umberto Cornelli   Neurodegenerative Diseases

Oxidative stress in Alzheimer disease: A possibility for prevention

(2010) David J. Bonda et al.   NEUROPHARMACOLOGY

Organoselenium improves memory decline in mice: Involvement of acetylcholinesterase activity

(2010) Simone Pinton et al.   NEUROSCIENCE LETTERS

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

(2010) J. van Eersel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin D and gastrointestinal diseases: inflammatory bowel disease and colorectal cancer

(2010) Maitreyi Raman et al.   Therapeutic Advances in Gastroenterology

Melatonin Fails to Improve Sleep or Agitation in Double-Blind Randomized Placebo-Controlled Trial of Institutionalized Patients With Alzheimer Disease

(2009) Philip R. Gehrman et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Functional Aspects of Redox Control During Neuroinflammation

(2009) Sergio Rosales-Corral et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria: A therapeutic target in neurodegeneration

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Therapeutic use of tea derivatives: all that glitters is not gold

(2009) C. Mancuso et al.   BLOOD

Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type

(2009) Tauheed Ishrat et al.   BRAIN RESEARCH

Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD

(2009) Tanea T. Reed et al.   BRAIN RESEARCH

Tacrine-Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties

(2009) María Isabel Fernández-Bachiller et al.   ChemMedChem

Stearyl ferulate-based solid lipid nanoparticles for the encapsulation and stabilization of β-carotene and α-tocopherol

(2009) Sonia Trombino et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Vitamin D deficiency and mortality

(2009) Armin Zittermann et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Organoselenium (Sel-Plex diet) decreases amyloid burden and RNA and DNA oxidative damage in APP/PS1 mice

(2009) Mark A. Lovell et al.   FREE RADICAL BIOLOGY AND MEDICINE

In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid β-peptide of APP

(2009) D. Allan Butterfield et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders

(2009) Rommy von Bernhardi et al.   JOURNAL OF NEUROCHEMISTRY

The effect of acetyl-L-carnitine and R-α-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease

(2009) Justin C. Shenk et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The response of γ vitamin E to varying dosages of α vitamin E plus vitamin C

(2009) Absalon D. Gutierrez et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

(2009) Jennifer L. Tomic et al.   NEUROBIOLOGY OF DISEASE

Selenium attenuates Aβ production and Aβ-induced neuronal death

(2009) A-Ryeong Gwon et al.   NEUROSCIENCE LETTERS

Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling women

(2009) Richard D. Semba et al.   NUTRITION RESEARCH

Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice

(2009) F.E. Harrison et al.   NUTRITIONAL NEUROSCIENCE

Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis

(2009) Marzia Perluigi et al.   Proteomics Clinical Applications

Curcumin in clinical practice: myth or reality?

(2009) Cesare Mancuso et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?

(2008) Barry Halliwell   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Peptides and proteins in plasma and cerebrospinal fluid as biomarkers for the prediction, diagnosis, and monitoring of therapeutic efficacy of Alzheimer's disease

(2008) Christopher D. Aluise et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ferulic acid and its therapeutic potential as a hormetin for age-related diseases

(2008) Eugenio Barone et al.   BIOGERONTOLOGY

Design and synthesis of tacrine–ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates

(2008) Lei Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel dextran hydrogel linking trans-ferulic acid for the stabilization and transdermal delivery of vitamin E

(2008) Roberta Cassano et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Serum 25-Hydroxyvitamin D Concentration and Cognitive Impairment

(2008) David J. Llewellyn et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Coenzyme Q10 Attenuates β-Amyloid Pathology in the Aged Transgenic Mice with Alzheimer Presenilin 1 Mutation

(2008) Xifei Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

N-acetylcysteine prevents β-amyloid toxicity by a stimulatory effect on p35/cyclin-dependent kinase 5 activity in cultured cortical neurons

(2008) Ya-Hsin Hsiao et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Different protection of K252a and N-acetyl-L-cysteine against amyloid-β peptide-induced cortical neuron apoptosis involving inhibition of MLK3-MKK7-JNK3 signal cascades

(2008) Yan Xu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Protective effect of quercetin in primary neurons against Aβ(1–42): relevance to Alzheimer's disease

(2008) Mubeen Ahmad Ansari et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Melatonin and Bright-Light Treatment for Rest–Activity Disruption in Institutionalized Patients with Alzheimer's Disease

(2008) Glenna A. Dowling et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Melatonin prevents amyloid protofibrillar induced oxidative imbalance and biogenic amine catabolism

(2008) Masilamoni J. Gunasingh et al.   LIFE SCIENCES

Design and Synthesis of Cellulose Derivatives with Antioxidant Activity

(2007) Sonia Trombino et al.   MACROMOLECULAR BIOSCIENCE