Functional Aspects of Redox Control During Neuroinflammation

The cross-talk between NF-κB and HIF-1: further evidence for a significant liaison: Figure 1

(2015) Agnes Görlach et al.   BIOCHEMICAL JOURNAL

A Key Role for Redox Signaling in Rapid P2X7 Receptor-Induced IL-1  Processing in Human Monocytes

(2014) J. Hewinson et al.   JOURNAL OF IMMUNOLOGY

Fibrillar Amyloid-  Peptides Activate Microglia via TLR2: Implications for Alzheimer's Disease

(2014) M. Jana et al.   JOURNAL OF IMMUNOLOGY

Potent Anti-Inflammatory and Neuroprotective Effects of TGF- 1 Are Mediated through the Inhibition of ERK and p47phox-Ser345 Phosphorylation and Translocation in Microglia

(2014) L. Qian et al.   JOURNAL OF IMMUNOLOGY

The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation

(2014) N. G. Innamorato et al.   JOURNAL OF IMMUNOLOGY

Cortical Expression of Peroxisome Proliferator-activated Receptor-α after Human Brain Contusion

(2013) D Feng et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Nitrosative protein tyrosine modifications: biochemistry and functional significance

(2011) Woon-Seok Yeo et al.   BMB Reports

Neuroprotective effects of novel phosphatidylglycerol-based phospholipids in the 6-hydroxydopamine model of Parkinson's disease

(2010) S. Crotty et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets

(2009) Vincent Jaquet et al.   ANTIOXIDANTS & REDOX SIGNALING

Stress-induced neuroinflammation: mechanisms and new pharmacological targets

(2009) C.D. Munhoz et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway

(2009) H-A Park et al.   CELL DEATH AND DIFFERENTIATION

Preconditioning paradigms and pathways in the brain.

(2009) K. B Shpargel et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

NF-κB, a Potential Therapeutic Target for the Treatment of Multiple Sclerosis

(2009) J. Yan et al.   CNS & Neurological Disorders-Drug Targets

Galantamine protects against oxidative stress induced by amyloid-beta peptide in cortical neurons

(2009) Joana B. Melo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

IL-1β induces MMP-9 expression via a Ca2+-dependent CaMKII/JNK/c-JUN cascade in rat brain astrocytes

(2009) Cheng-Ying Wu et al.   GLIA

Partial role of TLR4 as a receptor responding to damage-associated molecular pattern

(2009) Kyung-Mi Lee et al.   IMMUNOLOGY LETTERS

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation

(2009) T. Trang et al.   JOURNAL OF NEUROSCIENCE

Identification of major S-nitrosylated proteins in murine experimental autoimmune encephalomyelitis

(2009) Oscar A. Bizzozero et al.   JOURNAL OF NEUROSCIENCE RESEARCH

S-nitrosylation of PTEN Invovled in Ischemic Brain Injury in Rat Hippocampal CA1 Region

(2009) Dong-Sheng Pei et al.   NEUROCHEMICAL RESEARCH

Glutathionylation of the Pro-apoptotic Protein p53 in Alzheimer’s Disease Brain: Implications for AD Pathogenesis

(2009) Fabio Di Domenico et al.   NEUROCHEMICAL RESEARCH

Cysteine Redox Potential Determines Pro-Inflammatory IL-1β Levels

(2009) Smita S. Iyer et al.   PLoS One

A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury

(2009) T. A. Prime et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct and specific inactivation of protein tyrosine kinases in the Src and FGFR families by reversible cysteine oxidation

(2009) D. J. Kemble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease

(2009) A. H. K. Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

(2009) Dong-Hyung Cho et al.   SCIENCE

Nitric Oxide Links Mitochondrial Fission to Alzheimer's Disease

(2009) B. Westermann   Science Signaling

P2-154: Effect of tau phosphorylation at PKA sites on its biochemical function

(2008) Yuting Jiang et al.   Alzheimers & Dementia

Molecular Mechanisms and Clinical Implications of Reversible Protein S-Glutathionylation

(2008) John J. Mieyal et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Stress Involvement in α-Synuclein Oligomerization in Parkinson's Disease Cybrids

(2008) A. Raquel Esteves et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice

(2008) Olivia Dean et al.   BEHAVIOURAL BRAIN RESEARCH

ROCK, PAK, and Toll of synapses in Alzheimer’s disease

(2008) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of hypoxia-inducible factor-1α by NF-κB

(2008) Patrick van Uden et al.   BIOCHEMICAL JOURNAL

A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells

(2008) Fernando Correa et al.   BIOCHEMICAL PHARMACOLOGY

Novel functions of the α-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease

(2008) Qingli Shi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

NADPH oxidase as a therapeutic target in Alzheimer's disease

(2008) Michelle L Block   BMC NEUROSCIENCE

Activation of cerebral peroxisome proliferator-activated receptors gamma exerts neuroprotection by inhibiting oxidative stress following pilocarpine-induced status epilepticus

(2008) Xin Yu et al.   BRAIN RESEARCH

Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFκB activity

(2008) S Shu-Jung Hu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Manganese Superoxide Dismutase Modulates Hypoxia-Inducible Factor-1  Induction via Superoxide

(2008) S. Kaewpila et al.   CANCER RESEARCH

Molecular Mechanisms and Pathophysiology of Necrotic Cell Death

(2008) Nele Vanlangenakker et al.   CURRENT MOLECULAR MEDICINE

PET Imaging of the Peripheral Benzodiazepine Receptor: Monitoring Disease Progression and Therapy Response in Neurodegenerative Disorders

(2008) Janine Doorduin et al.   CURRENT PHARMACEUTICAL DESIGN

Cyclooxygenase-2 in Synaptic Signaling

(2008) Hongwei Yang et al.   CURRENT PHARMACEUTICAL DESIGN

Crucial structural role for the PH and C1 domains of the Vav1 exchange factor

(2008) Jonathan Rapley et al.   EMBO REPORTS

Redox properties of the A-domain of the HMGB1 protein

(2008) Debashish Sahu et al.   FEBS LETTERS

PPARα ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-κB and AP-1 pathways

(2008) Sriram Ramanan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

(2008) Yvonne M.W. Janssen-Heininger et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from Mild Cognitive Impairment

(2008) Paloma Bermejo et al.   FREE RADICAL RESEARCH

Tuning Microenvironments: Induction of Regulatory T Cells by Dendritic Cells

(2008) Yasmine Belkaid et al.   IMMUNITY

Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

(2008) Hirotaka Kazama et al.   IMMUNITY

Critical Role of Cysteine Residue 81 of Macrophage Migration Inhibitory Factor (MIF) in MIF-induced Inhibition of p53 Activity

(2008) Haiyoung Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Direct Redox Regulation of Protein Kinase C Isoenzymes Mediates Oxidant-induced Neuritogenesis in PC12 Cells

(2008) Rayudu Gopalakrishna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pivotal Advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis

(2008) Åsa Andersson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione

(2008) Francesc X. Soriano et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2in cortical neurons

(2008) Phullara B. Shelat et al.   JOURNAL OF NEUROCHEMISTRY

Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress

(2008) Kang-Woo Lee et al.   JOURNAL OF NEUROCHEMISTRY

Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity

(2008) Dan Zhang et al.   Journal of Neuroinflammation

Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway

(2008) Teresa F Pais et al.   Journal of Neuroinflammation

Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt

(2008) Bin Xing et al.   Journal of Neuroinflammation

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

(2008) Solomon S Shaftel et al.   Journal of Neuroinflammation

Neuroinflammation and Oxidation/Nitration of  -Synuclein Linked to Dopaminergic Neurodegeneration

(2008) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Toll-Like Receptor 2 Acts as a Natural Innate Immune Receptor to Clear Amyloid  1-42 and Delay the Cognitive Decline in a Mouse Model of Alzheimer's Disease

(2008) K. L. Richard et al.   JOURNAL OF NEUROSCIENCE

The HMGB1 Receptor RAGE Mediates Ischemic Brain Damage

(2008) S. Muhammad et al.   JOURNAL OF NEUROSCIENCE

Nuclear Factor- B Activation and Postischemic Inflammation Are Suppressed in CD36-Null Mice after Middle Cerebral Artery Occlusion

(2008) A. Kunz et al.   JOURNAL OF NEUROSCIENCE

Proteomic identification of nitrated brain proteins in traumatic brain-injured rats treated postinjury with gamma-glutamylcysteine ethyl ester: Insights into the role of elevation of glutathione as a potential therapeutic strategy for traumatic brain injury

(2008) Tanea T. Reed et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mitochondrial localization of DJ-1 leads to enhanced neuroprotection

(2008) Eunsung Junn et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Extensive Nitration of Neurofilament Light Chain in the Hippocampus Is Associated with the Cognitive Impairment Induced by Amyloid   in Mice

(2008) T. Alkam et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

(2008) Ludwig Kappos et al.   LANCET

Melatonin prevents amyloid protofibrillar induced oxidative imbalance and biogenic amine catabolism

(2008) Masilamoni J. Gunasingh et al.   LIFE SCIENCES

Evaluation of Dimebon in cellular model of Huntington's disease

(2008) Jun Wu et al.   Molecular Neurodegeneration

The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease

(2008) Nibaldo C Inestrosa et al.   Molecular Neurodegeneration

Relevance of COX-2 gene expression in dementia with lewy bodies associated with Alzheimer pathology

(2008) Marisa Saldaña et al.   MOVEMENT DISORDERS

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Molecular recognition of nitrated fatty acids by PPARγ

(2008) Yong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A possible link between astrocyte activation and tau nitration in Alzheimer's disease

(2008) Juan F. Reyes et al.   NEUROBIOLOGY OF DISEASE

Free Copper, Ferroxidase and SOD1 Activities, Lipid Peroxidation and NO x Content in the CSF. A Different Marker Profile in Four Neurodegenerative Diseases

(2008) Marie-Catherine Boll et al.   NEUROCHEMICAL RESEARCH

Contribution of NMDA and Non-NMDA Receptors to In vivo Glutamate-Induced Calpain Activation in the Rat Striatum. Relation to Neuronal Damage

(2008) Perla Del Río et al.   NEUROCHEMICAL RESEARCH

Opposite action of hippocampal CB1 receptors in memory reconsolidation and extinction

(2008) L. de Oliveira Alvares et al.   NEUROSCIENCE

A new APE1/Ref-1-dependent pathway leading to reduction of NF- B and AP-1, and activation of their DNA-binding activity

(2008) K. Ando et al.   NUCLEIC ACIDS RESEARCH

Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling

(2008) J. C. Juarez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying changes in the thiol redox proteome upon oxidative stress in vivo

(2008) L. I. Leichert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyotrophic lateral sclerosis: Protein chaperone dysfunction revealed by proteomic studies of animal models

(2008) Mohit Raja Jain et al.   Proteomics Clinical Applications

UCB Pharma research day—25 October 2007 ‘Glia-neuron interactions and purinergic receptors in neurological disorders’

(2008) Geoffrey Burnstock et al.   Purinergic Signalling

Uric Acid and Neuroprotection

(2008) Peter H. Proctor   STROKE

Delayed Treatment With Minocycline Ameliorates Neurologic Impairment Through Activated Microglia Expressing a High-Mobility Group Box1–Inhibiting Mechanism

(2008) Kazuhide Hayakawa et al.   STROKE

Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytes

(2008) Xinjing Luo et al.   ARTHRITIS RESEARCH & THERAPY

Oncogenic Ras-Induced Morphologic Change Is through MEK/ERK Signaling Pathway to Downregulate Stat3 at a Posttranslational Level in NIH3T3 Cells

(2008) Hsuan-Heng Yeh et al.   NEOPLASIA

Molecular Mechanisms and Potential Clinical Significance of S-Glutathionylation

(2007) Isabella Dalle–Donne et al.   ANTIOXIDANTS & REDOX SIGNALING

Emerging Roles of S-Nitrosylation in Protein Misfolding and Neurodegenerative Diseases

(2007) Tomohiro Nakamura et al.   ANTIOXIDANTS & REDOX SIGNALING

S-Glutathionylation of metallothioneins by nitrosative/oxidative stress

(2007) Manuela Casadei et al.   EXPERIMENTAL GERONTOLOGY

Keap1 modification and nuclear accumulation in response to S-nitrosocysteine

(2007) Barbara J. Buckley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Carnosic acid, acatechol-typeelectrophilic compound, protects neurons bothin vitroandin vivothrough activation of the Keap1/Nrf2 pathway viaS-alkylation of targeted cysteines on Keap1

(2007) Takumi Satoh et al.   JOURNAL OF NEUROCHEMISTRY

Stress proteins in CNS inflammation

(2007) JM van Noort   JOURNAL OF PATHOLOGY

APOE genotype-specific differences in the innate immune response

(2007) Michael P. Vitek et al.   NEUROBIOLOGY OF AGING

Transporters for L-glutamate: An update on their molecular pharmacology and pathological involvement

(2006) P M Beart et al.   BRITISH JOURNAL OF PHARMACOLOGY

Rat Brain Thioltransferase : Regional Distribution, Immunological Characterization, and Localization by Fluorescent In Situ Hybridization

(2003) Sadguna Balijepalli et al.   JOURNAL OF NEUROCHEMISTRY