Modeling resilience to schizophrenia in genetically modified mice: a novel approach to drug discovery

Life in the Fast Lane: Mammalian Disease Models in the Genomics Era

(2012) Lukas E. Dow et al.   CELL

Mitochondrial-Associated Metabolic Changes and Neurodegeneration in Huntingtons Disease - from Clinical Features to the Bench

(2012) Tatiana R. Rosenstock et al.   CURRENT DRUG TARGETS

Synaptic underpinnings of altered hippocampal function in glutaminase-deficient mice during maturation

(2012) Inna Gaisler-Salomon et al.   HIPPOCAMPUS

A pipeline for the generation of shRNA transgenic mice

(2012) Lukas E Dow et al.   Nature Protocols

After GWAS: Searching for Genetic Risk for Schizophrenia and Bipolar Disorder

(2011) Elliot S. Gershon et al.   AMERICAN JOURNAL OF PSYCHIATRY

Glycine transporter 1 as a potential therapeutic target for schizophrenia-related symptoms: Evidence from genetically modified mouse models and pharmacological inhibition

(2011) Hanns Möhler et al.   BIOCHEMICAL PHARMACOLOGY

Abnormal Trajectories of Neurodevelopment and Behavior Following In Utero Insult in the Rat

(2011) Yael Piontkewitz et al.   BIOLOGICAL PSYCHIATRY

Intermediate phenotypes in psychiatric disorders

(2011) Roberta Rasetti et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder

(2011) Emma L. Dempster et al.   HUMAN MOLECULAR GENETICS

Disc1 Point Mutations in Mice Affect Development of the Cerebral Cortex

(2011) F. H. F. Lee et al.   JOURNAL OF NEUROSCIENCE

The Netrin Receptor DCC Is Required in the Pubertal Organization of Mesocortical Dopamine Circuitry

(2011) C. Manitt et al.   JOURNAL OF NEUROSCIENCE

Novartis to shut brain research facility

(2011) Alison Abbott   NATURE

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Transcriptional and epigenetic mechanisms of addiction

(2011) Alfred J. Robison et al.   NATURE REVIEWS NEUROSCIENCE

Contributions of the d-serine pathway to schizophrenia

(2011) Viviane Labrie et al.   NEUROPHARMACOLOGY

Mouse models of genetic effects on cognition: Relevance to schizophrenia

(2011) Francesco Papaleo et al.   NEUROPHARMACOLOGY

Expanding Our Understanding of Neurobiological Mechanisms of Resilience by Using Animal Models

(2011) Israel Liberzon et al.   NEUROPSYCHOPHARMACOLOGY

From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment

(2011) Bita Moghaddam et al.   NEUROPSYCHOPHARMACOLOGY

Discovery of  -Arrestin-Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy

(2011) J. A. Allen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroimaging and the question of neurodegeneration in schizophrenia

(2011) Andreas Meyer-Lindenberg   PROGRESS IN NEUROBIOLOGY

d-cycloserine facilitation of cognitive behavioral therapy for delusions in schizophrenia

(2011) Jennifer D. Gottlieb et al.   SCHIZOPHRENIA RESEARCH

Suggestion of Roles for Both Common and Rare Risk Variants in Genome-wide Studies of Schizophrenia

(2010) Michael J. Owen et al.   ARCHIVES OF GENERAL PSYCHIATRY

Increased Synaptic Dopamine Function in Associative Regions of the Striatum in Schizophrenia

(2010) Lawrence S. Kegeles et al.   ARCHIVES OF GENERAL PSYCHIATRY

Behavioral characterization of a mutant mouse strain lacking d-amino acid oxidase activity

(2010) Min Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Development of animal models for schizophrenia

(2010) P. A. Arguello et al.   Disease Models & Mechanisms

Netrin-1 receptor in the ventral tegmental area is required for sensitization to amphetamine

(2010) Leora Yetnikoff et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Modulation of sensorimotor gating in prepulse inhibition by conditional brain glycine transporter 1 deletion in mice

(2010) Philipp Singer et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Temporal lobe grey matter volume in schizophrenia is associated with a genetic polymorphism influencing glycogen synthase kinase 3-β activity

(2010) F. Benedetti et al.   GENES BRAIN AND BEHAVIOR

Potential cytotoxic effect of hydroxypyruvate produced from D-serine by astroglial D-amino acid oxidase

(2010) S. P. Chung et al.   JOURNAL OF BIOCHEMISTRY

Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia

(2010) Emmanuel Pinard et al.   JOURNAL OF MEDICINAL CHEMISTRY

Individual Stress Vulnerability Is Predicted by Short-Term Memory and AMPA Receptor Subunit Ratio in the Hippocampus

(2010) M. V. Schmidt et al.   JOURNAL OF NEUROSCIENCE

Phospholipase D2 Ablation Ameliorates Alzheimer's Disease-Linked Synaptic Dysfunction and Cognitive Deficits

(2010) T. G. Oliveira et al.   JOURNAL OF NEUROSCIENCE

From maps to mechanisms through neuroimaging of schizophrenia

(2010) Andreas Meyer-Lindenberg   NATURE

Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia

(2010) Torfi Sigurdsson et al.   NATURE

Rethinking schizophrenia

(2010) Thomas R. Insel   NATURE

The environment and schizophrenia

(2010) Jim van Os et al.   NATURE

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia

(2010) Maria Karayiorgou et al.   NATURE REVIEWS NEUROSCIENCE

A Possible Role for the Striatum in the Pathogenesis of the Cognitive Symptoms of Schizophrenia

(2010) Eleanor H. Simpson et al.   NEURON

Phenotypic Characterization of Transgenic Mice Overexpressing Neuregulin-1

(2010) Taisuke Kato et al.   PLoS One

Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model

(2010) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AVE1625, a cannabinoid CB1 receptor antagonist, as a co-treatment with antipsychotics for schizophrenia: improvement in cognitive function and reduction of antipsychotic-side effects in rodents

(2010) Mark D. Black et al.   PSYCHOPHARMACOLOGY

The Role of Rodent Models in The Discovery of New Treatments for Schizophrenia: Updating Our Strategy

(2010) H. Moore   SCHIZOPHRENIA BULLETIN

Mutations in DCC Cause Congenital Mirror Movements

(2010) M. Srour et al.   SCIENCE

Signaling pathways in schizophrenia: emerging targets and therapeutic strategies

(2010) Caline S. Karam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Differential Targeting of the CA1 Subfield of the Hippocampal Formation by Schizophrenia and Related Psychotic Disorders

(2009) Scott A. Schobel et al.   ARCHIVES OF GENERAL PSYCHIATRY

Social Functioning Deficits in Young People at Risk for Schizophrenia

(2009) Geumsook Shim et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Using the pharmacology of latent inhibition to model domains of pathology in schizophrenia and their treatment

(2009) Ina Weiner et al.   BEHAVIOURAL BRAIN RESEARCH

Clozapine Administration in Adolescence Prevents Postpubertal Emergence of Brain Structural Pathology in an Animal Model of Schizophrenia

(2009) Yael Piontkewitz et al.   BIOLOGICAL PSYCHIATRY

Baseline and Amphetamine-Stimulated Dopamine Activity Are Related in Drug-Naïve Schizophrenic Subjects

(2009) Anissa Abi-Dargham et al.   BIOLOGICAL PSYCHIATRY

Understanding the Relation Between Anorexia Nervosa and Bulimia Nervosa in a Swedish National Twin Sample

(2009) Cynthia M. Bulik et al.   BIOLOGICAL PSYCHIATRY

Glutamatergic deficits and parvalbumin-containing inhibitory neurons in the prefrontal cortex in schizophrenia

(2009) BKY Bitanihirwe et al.   BMC Psychiatry

Update on key previously proposed candidate genes for schizophrenia

(2009) Sibylle G Schwab et al.   CURRENT OPINION IN PSYCHIATRY

Genetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice

(2009) V. Labrie et al.   GENES BRAIN AND BEHAVIOR

Challenges in the Search for Drugs to Treat Central Nervous System Disorders

(2009) S. J. Enna et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in mice

(2009) V. Labrie et al.   LEARNING & MEMORY

The neurobiology of D-amino acid oxidase and its involvement in schizophrenia

(2009) L Verrall et al.   MOLECULAR PSYCHIATRY

Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes

(2009) Juan E Belforte et al.   NATURE NEUROSCIENCE

Psychobiology and molecular genetics of resilience

(2009) Adriana Feder et al.   NATURE REVIEWS NEUROSCIENCE

Glutaminase-Deficient Mice Display Hippocampal Hypoactivity, Insensitivity to Pro-Psychotic Drugs and Potentiated Latent Inhibition: Relevance to Schizophrenia

(2009) Inna Gaisler-Salomon et al.   NEUROPSYCHOPHARMACOLOGY

Hippocampal dysfunction and disruption of dopamine system regulation in an animal model of schizophrenia

(2009) Daniel J. Lodge et al.   NEUROTOXICITY RESEARCH

Developing translational animal models for symptoms of schizophrenia or bipolar mania

(2009) Mark A. Geyer   NEUROTOXICITY RESEARCH

Review of Pathological Hallmarks of Schizophrenia: Comparison of Genetic Models With Patients and Nongenetic Models

(2009) Hanna Jaaro-Peled et al.   SCHIZOPHRENIA BULLETIN

Cognition in Mouse Models of Schizophrenia Susceptibility Genes

(2009) P. A. Arguello et al.   SCHIZOPHRENIA BULLETIN

The Neurodevelopmental Hypothesis of Schizophrenia, Revisited

(2009) S. H. Fatemi et al.   SCHIZOPHRENIA BULLETIN

Loss of Glial Glutamate and Aspartate Transporter (Excitatory Amino Acid Transporter 1) Causes Locomotor Hyperactivity and Exaggerated Responses to Psychotomimetics: Rescue by Haloperidol and Metabotropic Glutamate 2/3 Agonist

(2008) Rose-Marie Karlsson et al.   BIOLOGICAL PSYCHIATRY

Mice lacking d-amino acid oxidase activity exhibit marked reduction of methamphetamine-induced stereotypy

(2008) Atsushi Hashimoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chlorpromazine oligomer is a potentially active substance that inhibits human D-amino acid oxidase, product of a susceptibility gene for schizophrenia

(2008) Sanae Iwana et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Schizophrenia: Incriminating genomic evidence

(2008) James R. Lupski   NATURE

Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection

(2008) J. A. Lieberman et al.   PHARMACOLOGICAL REVIEWS

Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia

(2008) Viviane Labrie et al.   PSYCHOPHARMACOLOGY

Mutant huntingtin and mitochondrial dysfunction

(2008) Ella Bossy-Wetzel et al.   TRENDS IN NEUROSCIENCES