Novel clinico–genome network modeling for revolutionizing genotype–phenotype-based personalized cancer care

Identifying and Preventing High-risk Gastric Cancer Individuals With CDH1 Mutations

(2009) Dimosthenis Ziogas et al.   ANNALS OF SURGERY

Breast Cancer Outcomes: The Crucial Role of the Breast Surgeon in the Era of Personal Genetics and Systems Biology

(2009) Dimitrios H. Roukos   ANNALS OF SURGERY

Genetics and Personal Genomics for Personalized Breast Cancer Surgery: Progress and Challenges in Research and Clinical Practice

(2009) Dimosthenis Ziogas et al.   ANNALS OF SURGICAL ONCOLOGY

CDH1 Testing: Can it Predict the Prophylactic or Therapeutic Nature of Total Gastrectomy in Hereditary Diffuse Gastric Cancer?

(2009) Dimosthenis Ziogas et al.   ANNALS OF SURGICAL ONCOLOGY

Gene set-based module discovery in the breast cancer transcriptome

(2009) Atsushi Niida et al.   BMC BIOINFORMATICS

Current concerns and challenges regarding tailored anti-angiogenic therapy in cancer

(2009) Dimitrios H Roukos et al.   Expert Review of Anticancer Therapy

Genome-wide association studies: how predictable is a person’s cancer risk?

(2009) Dimitrios H Roukos   Expert Review of Anticancer Therapy

Personalized cancer diagnostics and therapeutics

(2009) Dimitrios H Roukos   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Mea Culpawith cancer-targeted therapy: new thinking and new agents design for novel, causal networks-based, personalized biomedicine

(2009) Dimitrios H Roukos   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Twenty-One–Gene Assay: Challenges and Promises in Translating Personal Genomics and Whole-Genome Scans Into Personalized Treatment of Breast Cancer

(2009) Dimitrios H. Roukos   JOURNAL OF CLINICAL ONCOLOGY

Colorectal Hepatic Metastases: Adjuvant Chemotherapy and Survival

(2009) David J. Gallagher et al.   JOURNAL OF CLINICAL ONCOLOGY

Total and Cancer Mortality After Supplementation With Vitamins and Minerals: Follow-up of the Linxian General Population Nutrition Intervention Trial

(2009) Y.-L. Qiao et al.   JNCI-Journal of the National Cancer Institute

Toward a systems biology approach to investigate cellular networks in normal and malignant B cells

(2009) K Basso   LEUKEMIA

Personal phenotypes to go with personal genomes

(2009) Michael Snyder et al.   Molecular Systems Biology

Personalizing medicine: a systems biology perspective

(2009) Thomas S Deisboeck   Molecular Systems Biology

Inside the living cell

(2009) David S. Burz et al.   NATURE

The nuances of therapy

(2009) Lee M. Ellis et al.   NATURE

Genome sequencing: the third generation

(2009) Erika Check Hayden   NATURE

On the road to reading the RNA-interference code

(2009) Haruhiko Siomi et al.   NATURE

Protein structure determination in living cells by in-cell NMR spectroscopy

(2009) Daisuke Sakakibara et al.   NATURE

High-resolution multi-dimensional NMR spectroscopy of proteins in human cells

(2009) Kohsuke Inomata et al.   NATURE

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Dynamic modularity in protein interaction networks predicts breast cancer outcome

(2009) Ian W Taylor et al.   NATURE BIOTECHNOLOGY

Radiation Therapy for Breast Cancer

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Isolated Tumor Cells in Breast Cancer

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Does Comparative-Effectiveness Research Threaten Personalized Medicine?

(2009) Alan M. Garber et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Interactions Between Transcription Factors Cause Natural Variation in Yeast

(2009) J. Gerke et al.   SCIENCE

MATHEMATICS: Emergence of Connectivity in Networks

(2009) T. Bohman   SCIENCE

Network Analysis in the Social Sciences

(2009) S. P. Borgatti et al.   SCIENCE

Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

(2008) Antonis C. Antoniou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human Genetic and Structural Genomic Variation: Would Genome-Wide Association Studies Be the Solution for Cancer Complexity Like Alexander the Great for the “Gordian Knot”?

(2008) Dimitrios H. Roukos et al.   ANNALS OF SURGICAL ONCOLOGY

Personal Genomics and Genome-Wide Association Studies: Novel Discoveries but Limitations for Practical Personalized Medicine

(2008) Dimitrios H. Roukos   ANNALS OF SURGICAL ONCOLOGY

Molecular medicine, gene-expression profiling and molecular diagnostics: putting the cart before the horse

(2008) Stephen A Bustin   Biomarkers in Medicine

Integrative bioinformatics analysis of transcriptional regulatory programs in breast cancer cells

(2008) Atsushi Niida et al.   BMC BIOINFORMATICS

Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin

(2008) Sandra S. McAllister et al.   CELL

THE LOCI OF EVOLUTION: HOW PREDICTABLE IS GENETIC EVOLUTION?

(2008) David L. Stern et al.   EVOLUTION

Genetics and genome-wide association studies: surgery-guided algorithm and promise for future breast cancer personalized surgery

(2008) Dimitrios H Roukos   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Assessing both genetic variation (SNPs/CNVs) and gene–environment interactions may lead to personalized gastric cancer prevention

(2008) Dimitrios H Roukos   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Gene Network Inference via Structural Equation Modeling in Genetical Genomics Experiments

(2008) B. Liu et al.   GENETICS

Genetic and phenotypic analysis of B-cell post-transplant lymphoproliferative disorders provides insights into disease biology

(2008) Efsevia Vakiani et al.   HEMATOLOGICAL ONCOLOGY

Genome-wide association studies in cancer

(2008) D. F. Easton et al.   HUMAN MOLECULAR GENETICS

Use of Gene Signatures to Improve Risk Estimation in Cancer

(2008) Chiang-Ching Huang   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Current and Future Utilization of Services From Medical Oncologists

(2008) Joan L. Warren et al.   JOURNAL OF CLINICAL ONCOLOGY

Vitamins C and E and Beta Carotene Supplementation and Cancer Risk: A Randomized Controlled Trial

(2008) J. Lin et al.   JNCI-Journal of the National Cancer Institute

Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer

(2008) Helena Linardou et al.   LANCET ONCOLOGY

Quantitative genetics

(2008) Chris Gunter   NATURE

Reverse engineering the genotype–phenotype map with natural genetic variation

(2008) Matthew V. Rockman   NATURE

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

(2008) Rayjean J. Hung et al.   NATURE

Progress and challenges in genome-wide association studies in humans

(2008) Peter Donnelly   NATURE

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

(2008) Timothy J. Ley et al.   NATURE

Next-generation DNA sequencing

(2008) Jay Shendure et al.   NATURE BIOTECHNOLOGY

Multiple loci identified in a genome-wide association study of prostate cancer

(2008) Gilles Thomas et al.   NATURE GENETICS

Evidence for two independent prostate cancer risk–associated loci in the HNF1B gene at 17q12

(2008) Jielin Sun et al.   NATURE GENETICS

Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21

(2008) Albert Tenesa et al.   NATURE GENETICS

Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer

(2008) Hiromi Sakamoto et al.   NATURE GENETICS

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

(2008) Christopher I Amos et al.   NATURE GENETICS

Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer

(2008) Julius Gudmundsson et al.   NATURE GENETICS

Multiple newly identified loci associated with prostate cancer susceptibility

(2008) Rosalind A Eeles et al.   NATURE GENETICS

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

(2008) Ian PM Tomlinson et al.   NATURE GENETICS

Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks

(2008) Jun Zhu et al.   NATURE GENETICS

Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer

(2008) Simon N Stacey et al.   NATURE GENETICS

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE

Structural Genomic Variation and Personalized Medicine

(2008) Charles Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Letting the Genome out of the Bottle — Will We Get Our Wish?

(2008) David J. Hunter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer

(2008) Paul D.P. Pharoah et al.   NEW ENGLAND JOURNAL OF MEDICINE

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression

(2008) R. Shakya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33

(2008) B. Gold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking contralateral breast cancer with genetics

(2008) Dimitrios H. Roukos   RADIOTHERAPY AND ONCOLOGY

From Signals to Patterns: Space, Time, and Mathematics in Developmental Biology

(2008) J. Lewis   SCIENCE

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

In silico cancer modeling: is it ready for prime time?

(2008) Thomas S Deisboeck et al.   Nature clinical practice. Oncology

Gene–Environment Interaction in Yeast Gene Expression

(2008) Erin N Smith et al.   PLOS BIOLOGY