Potential and limitations of regulatory T-cell therapy in solid organ transplantation

Suppression of Murine Allergic Airway Disease by IL-2:Anti-IL-2 Monoclonal Antibody-Induced Regulatory T Cells

(2014) M. S. Wilson et al.   JOURNAL OF IMMUNOLOGY

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

(2014) G. Lal et al.   JOURNAL OF IMMUNOLOGY

Immunological Outcome in Haploidentical-HSC Transplanted Patients Treated with IL-10-Anergized Donor T Cells

(2014) Rosa Bacchetta et al.   Frontiers in Immunology

Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation

(2013) A. L. Putnam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Prospective assessment of antidonor cellular alloreactivity is a tool for guidance of immunosuppression in kidney transplantation

(2013) Oriol Bestard et al.   KIDNEY INTERNATIONAL

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

CTLA4Ig Prevents Alloantibody Formation Following Nonhuman Primate Islet Transplantation Using the CD40-Specific Antibody 3A8

(2012) I. R. Badell et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+CD25+FOXP3+ T regulatory cell subpopulations

(2012) C. Scotta et al.   HAEMATOLOGICA

The impact of donor-specific anti-HLA antibodies on late kidney allograft failure

(2012) Alexandre Loupy et al.   Nature Reviews Nephrology

Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo

(2012) J. Gotot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin Antagonists Prevent Costimulatory Blockade-Resistant Transplant Rejection by CD8+ Memory T Cells

(2011) W. H. Kitchens et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Nondepleting Anti-CD40-Based Therapy Prolongs Allograft Survival in Nonhuman Primates

(2011) I. R. Badell et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly

(2011) A. Veerapathran et al.   BLOOD

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells

(2011) Yunqi Wang et al.   IMMUNITY

IL-35 production by inducible costimulator (ICOS)–positive regulatory T cells reverses established IL-17–dependent allergic airways disease

(2011) Gregory S. Whitehead et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sustained suppression by Foxp3+regulatory T cells is vital for infectious transplantation tolerance

(2011) Adrian R. Kendal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B Lymphocytes Differentially Influence Acute and Chronic Allograft Rejection in Mice

(2011) D. J. DiLillo et al.   JOURNAL OF IMMUNOLOGY

Microbial Infection-Induced Expansion of Effector T Cells Overcomes the Suppressive Effects of Regulatory T Cells via an IL-2 Deprivation Mechanism

(2011) A. Benson et al.   JOURNAL OF IMMUNOLOGY

Limiting the Amount and Duration of Antigen Exposure during Priming Increases Memory T Cell Requirement for Costimulation during Recall

(2011) T. L. Floyd et al.   JOURNAL OF IMMUNOLOGY

IL-2 Controls the Stability of Foxp3 Expression in TGF- -Induced Foxp3+ T Cells In Vivo

(2011) Q. Chen et al.   JOURNAL OF IMMUNOLOGY

Comparative study of clinical grade human tolerogenic dendritic cells

(2011) M Naranjo-Gómez et al.   Journal of Translational Medicine

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells

(2011) Erika Cretney et al.   NATURE IMMUNOLOGY

Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy

(2011) Susanna Celli et al.   NATURE MEDICINE

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis

(2011) David Saadoun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Retinoic Acid and Rapamycin Differentially Affect and Synergistically Promote the Ex Vivo Expansion of Natural Human T Regulatory Cells

(2011) Tatiana N. Golovina et al.   PLoS One

Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade

(2011) I. R. Ferrer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Host Alloreactive Memory T Cells Influence Tolerance to Kidney Allografts in Nonhuman Primates

(2011) O. Nadazdin et al.   Science Translational Medicine

Massive ex Vivo Expansion of Human Natural Regulatory T Cells (Tregs) with Minimal Loss of in Vivo Functional Activity

(2011) K. L. Hippen et al.   Science Translational Medicine

Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells

(2011) P. Sagoo et al.   Science Translational Medicine

Pathophysiologic Significance of B-Cell Clusters in Chronically Rejected Grafts

(2011) Olivier Thaunat   TRANSPLANTATION

Long-Term Allograft Tolerance Is Characterized by the Accumulation of B Cells Exhibiting an Inhibited Profile

(2010) L. Le Texier et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway

(2010) S. Gregori et al.   BLOOD

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Interleukin-2 receptor downstream events in regulatory T cells: Implications for the choice of immunosuppressive drug therapy

(2010) Robert Zeiser et al.   CELL CYCLE

The (re)emergence of B cells in organ transplantation

(2010) Mark D Stegall et al.   Current Opinion in Organ Transplantation

Molecular and functional characterization of allogantigen-specific anergic T cells suitable for cell therapy

(2010) R. Bacchetta et al.   HAEMATOLOGICA

Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

(2010) Pervinder Sagoo et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a B cell signature associated with renal transplant tolerance in humans

(2010) Kenneth A. Newell et al.   JOURNAL OF CLINICAL INVESTIGATION

Intragraft Th17 Infiltrate Promotes Lymphoid Neogenesis and Hastens Clinical Chronic Rejection

(2010) C. Deteix et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: All-Trans Retinoic Acid Sustains the Stability and Function of Natural Regulatory T Cells in an Inflammatory Milieu

(2010) X. Zhou et al.   JOURNAL OF IMMUNOLOGY

Five-Year Safety and Efficacy of Belatacept in Renal Transplantation

(2010) F. Vincenti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype

(2010) Annaick Pallier et al.   KIDNEY INTERNATIONAL

In vivo prevention of transplant arteriosclerosis by ex vivo–expanded human regulatory T cells

(2010) Satish N Nadig et al.   NATURE MEDICINE

Characterization of Protective Human CD4+CD25+ FOXP3+ Regulatory T Cells Generated with IL-2, TGF-β and Retinoic Acid

(2010) Ling Lu et al.   PLoS One

Inducing CTLA-4-Dependent Immune Regulation by Selective CD28 Blockade Promotes Regulatory T Cells in Organ Transplantation

(2010) N. Poirier et al.   Science Translational Medicine

The Generation of Donor-Specific CD4+CD25++CD45RA+ Naive Regulatory T Cells in Operationally Tolerant Patients After Pediatric Living-Donor Liver Transplantation

(2010) Hanaa Nafady-Hego et al.   TRANSPLANTATION

Contribution of Naïve and Memory T-Cell Populations to the Human Alloimmune Response

(2009) C. Macedo et al.   AMERICAN JOURNAL OF TRANSPLANTATION

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

(2009) Piotr Trzonkowski et al.   CLINICAL IMMUNOLOGY

Immunosuppressive Drugs and Tregs: A Critical Evaluation!

(2009) S. A. De Serres et al.   Clinical Journal of the American Society of Nephrology

Loss of FOXP3 expression in natural human CD4+CD25+regulatory T cells upon repetitivein vitrostimulation

(2009) Petra Hoffmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Alloantigen-specificde novo-induced Foxp3+Treg revertin vivoand do not protect from experimental GVHD

(2009) Christian Koenecke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T Cells Sequentially Migrate from Inflamed Tissues to Draining Lymph Nodes to Suppress the Alloimmune Response

(2009) Nan Zhang et al.   IMMUNITY

Plasticity of CD4+ T Cell Lineage Differentiation

(2009) Liang Zhou et al.   IMMUNITY

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mammalian Target of Rapamycin Inhibition and Alloantigen-Specific Regulatory T Cells Synergize To Promote Long-Term Graft Survival in Immunocompetent Recipients

(2009) G. Raimondi et al.   JOURNAL OF IMMUNOLOGY

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

Increased frequency of regulatory T Cells and selection of highly potent CD62L+ cells during treatment of human lung transplant recipients with rapamycin

(2009) Christian M. Lange et al.   TRANSPLANT INTERNATIONAL

The Effect of Costimulatory and Interleukin 2 Receptor Blockade on Regulatory T Cells in Renal Transplantation

(2008) J. A. Bluestone et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes

(2008) A. L. Putnam et al.   DIABETES

Tolerance-Inducing Immunosuppressive Strategies in Clinical Transplantation

(2008) Dela Golshayan et al.   DRUGS

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice

(2008) Julia Yuen-Shan Tsang et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy

(2008) Xueli Yuan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Minimization of calcineurin inhibitors to improve long-term outcomes in kidney transplantation

(2008) Dela Golshayan et al.   TRANSPLANT IMMUNOLOGY

Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion

(2007) Elaine K. Horibe et al.   TRANSPLANT IMMUNOLOGY