Article
Immunology
Xiaojia Zhu, Xudong Peng, Jing Lin, Yingxue Zhang, Hong He, Guiqiu Zhao
Summary: LXA4 alleviated inflammatory response in Aspergillus fumigatus keratitis by suppressing neutrophil infiltration, downregulating the expression of pro-inflammatory mediators, and reducing ROS production through ALX/FPR2 receptor.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Physical
Vinicius S. Nunes, Odonirio Abrahao, Alexandre P. Rogerio, Charles N. Serhan
Summary: Chronic inflammation is linked to various diseases, but it can be resolved by specialized pro-resolving mediators (SPM) such as RvD1 and AT-RvD1, which are derived from ω-3 fatty acid DHA. Both RvD1 and AT-RvD1 have anti-inflammatory and pro-resolution effects, possibly mediated by the G-protein-coupled receptor ALX/FPR2.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Biochemistry & Molecular Biology
Juan Salazar, Daniela Pirela, Manuel Nava, Ana Castro, Lisse Angarita, Heliana Parra, Samuel Duran-Aguero, Diana Marcela Rojas-Gomez, Nestor Galban, Roberto Anez, Maricarmen Chacin, Andrea Diaz, Nelson Villasmil, Juan Bautista De Sanctis, Valmore Bermudez
Summary: Cardiovascular disease (CVD) is a global public health issue with high morbidity, mortality, and economic impact. Specialized proresolving lipid mediators (SPMs), derived from fatty acids, have shown promise in resolving inflammation associated with the pathogenesis of various diseases, particularly CVD. Preclinical and clinical studies have demonstrated the therapeutic impact of SPMs in CVD, suggesting their potential as a new therapeutic alternative. Further large-scale clinical trials are needed to determine their effects in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Shayna Sandhaus, Andrew G. Swick
Summary: Specialized proresolving mediators (SPMs) are endogenous lipid metabolites that promote the resolution of inflammation. While not yet studied in the context of the novel Coronavirus, SPMs have shown potential in combating infections and inflammatory lung conditions.
Review
Biochemistry & Molecular Biology
Cassia de Faveri, Paula M. Poeta Fermino, Anna P. Piovezan, Lia K. Volpato
Summary: The pathogenesis of endometriosis is still controversial, with the inflammatory immune response playing a critical role. Pro-resolving mediators (PRMs) in endometriosis are not well understood, but research shows their potential in inhibiting disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Izabela Galvao, Eliza M. Melo, Vivian L. S. de Oliveira, Juliana P. Vago, Celso Queiroz-Junior, Monica de Gaetano, Eoin Brennan, Kevin Gahan, Patrick J. Guiry, Catherine Godson, Mauro M. Teixeira
Summary: Research suggests that AT-01-KG has therapeutic potential for arthritis by promoting neutrophil apoptosis and efficient efferocytosis to resolve inflammation, reducing tissue damage and hypernociception.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Chemistry, Medicinal
Monika Maciuszek, Antonino Cacace, Eoin Brennan, Catherine Godson, Timothy M. Chapman
Summary: FPR2/ALX plays a crucial role in maintaining host defense and orchestrating the inflammatory process by responding to various agonists. These agonists include lipids, proteins, peptides, and synthetic small molecule agonists, which promote resolution and tissue regeneration during inflammation.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Julianne M. Thornton, Kingsley Yin
Summary: Host response to bacterial infection involves leukocyte activation, inflammatory mediator release, phagocytosis, and killing of bacteria, while resolution of infection requires attenuation of neutrophil migration, neutrophil apoptosis, and other processes. Specialized Pro-resolving Mediators (SPMs) are bioactive fatty acids that play a critical role in promoting the resolution of infectious inflammation and bacterial clearance, including a novel mechanism of reducing bacterial virulence.
Article
Physiology
Elizabeth A. Townsend, Arturo Guadarrama, Lei Shi, Elon Roti Roti, Loren C. Denlinger
Summary: This study found that stimulation of P2X(7) in alveolar macrophages of patients with mild-to-moderate asthma produces eicosanoids associated with airway inflammation and resolution. The responses are partially regulated by P2X7 pore function.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Eve Blanquart, Sophie Laffont, Jean-Charles Guery
Summary: Sex steroid hormones regulate the development, maintenance, and effector functions of ILCs, impacting tissue-specific immunity. Understanding these hormone actions on ILCs is crucial for uncovering sexual disparity in human diseases and potential new drug development for chronic inflammatory diseases or cancers.
BIOMEDICAL JOURNAL
(2021)
Review
Neurosciences
Xiaoxu Wang, Yue Kong, Bingqing Zheng, Xiaomin Zhao, Mingzhe Zhao, Bin Wang, Chang Liu, Peizheng Yan
Summary: Asthma, a chronic airway inflammatory disease, is on the rise globally. The study of innate lymphoid cells (ILCs) is crucial in understanding the different endotypes of asthma. Asthma is divided into type 2 high and type 2 low endotypes based on its pathological and inflammatory features. Multiple cell types, including tissue-resident ILCs and other immune cells, play a role in the complex nature of asthma. This review focuses on the phenotypes and roles of tissue-resident ILCs in asthma endotypes, as well as therapeutic strategies based on immune cell mechanisms.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Endocrinology & Metabolism
Shabnam Radbakhsh, Niki Katsiki, Raul D. Santos, Dimitri P. Mikhailidis, Christos S. Mantzoros, Amirhossein Sahebkar
Summary: Statins not only lower cholesterol but also have anti-inflammatory and antioxidant effects, and can improve endothelial function and plaque stability. Specialized pro resolving mediators (SPMs) are endogenous lipid-derived molecules that regulate the resolution of inflammation. Statins can trigger the production of these mediators, potentially offering another anti-inflammatory pathway.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Review
Immunology
Jongho Ham, MinYeong Lim, Dongmo Kim, Hye Young Kim
Summary: Innate lymphoid cells (ILCs) are recently discovered innate immune cells that play a role in the defense against external insults in mucosal tissues. They exhibit characteristics similar to adaptive immune cells and can potentially have memory-like properties. Studies suggest that ILCs may play a significant role in the pathogenesis of asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Takahiro Matsuyama, Hiromi Matsuyama, Yoichi Dotake, Koichi Takagi, Kentaro Machida, Hiromasa Inoue
Summary: T helper type 2 cells and group 2 innate lymphoid cells play a crucial role in asthma, particularly in airway eosinophilic inflammation. These cells are activated by cytokines released by airway epithelial cells and produce high levels of type 2 cytokines. ILC2s induce airway inflammation independently of antigens and may contribute to steroid resistance. Biologics targeting these cytokines and/or their receptors have shown promise in reducing asthma exacerbations and improving lung function and quality of life in asthmatic patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Banafshe Hosseini, Bronwyn S. Berthon, Malcolm R. Starkey, Adam Collison, Rebecca F. McLoughlin, Evan J. Williams, Kristy Nichol, Peter AB. Wark, Megan E. Jensen, Carla Rebeca Da Silva Sena, Katherine J. Baines, Joerg Mattes, Lisa G. Wood
Summary: The study found that children with asthma have impaired immune responses, altered immune cell subsets, and reduced lung function. These results can help tailor management of asthma by improving our understanding of immune responses in children.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Allergy
C. Radu, C. Barnig, F. de Blay
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2016)
Editorial Material
Allergy
L. Sylvestre, J. Jegu, C. Metz-Favre, C. Barnig, S. Qi, F. de Blay
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2016)
Review
Respiratory System
J. -M. Perotin, C. Barnig
REVUE DES MALADIES RESPIRATOIRES
(2017)
Article
Immunology
Pierre Gantner, Cindy Barnig, Marialuisa Partisani, Guinevere Q. Lee, Genevieve Beck-Wirth, Jean-Pierre Faller, Martin Martinot, Mahsa Mosheni-Zadeh, Christine Cheneau, Marie-Laure Batard, Patricia Fischer, Anne Fuchs, Beatrice Uring-Lambert, Siamak Bahram, David Rey, Samira Fafi-Kremer
Article
Critical Care Medicine
Raja-Elie E. Abdulnour, Tina Gunderson, Ioanna Barkas, Jack Y. Timmons, Cindy Barnig, Michelle Gong, Daryl J. Kor, Ognjen Gajic, Daniel Talmor, Rickey E. Carter, Bruce D. Levy
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Review
Pharmacology & Pharmacy
Cindy Barnig, Nelly Frossard, Bruce D. Levy
PHARMACOLOGY & THERAPEUTICS
(2018)
Review
Respiratory System
C. Barnig, C. Martin
REVUE DES MALADIES RESPIRATOIRES
(2018)
Article
Biochemical Research Methods
Guillaume Wacht, Anh Poirot, Anne-Laure Charles, Mirjana Radosavljevic, Beatrice Uring-Lambert, Frederic de Blay, Bernard Geny, Seiamak Bahram, Cindy Barnig
JOURNAL OF IMMUNOLOGICAL METHODS
(2018)
Review
Medicine, General & Internal
Awa Bousso, Cecile Chenivesse, Cindy Barnig
Review
Immunology
Cindy Barnig, Tjitske Bezema, Philip C. Calder, Anne Charloux, Nelly Frossard, Johan Garssen, Oliver Haworth, Ksenia Dilevskaya, Francesca Levi-Schaffer, Evelyne Lonsdorfer, Marca Wauben, Aletta D. Kraneveld, Anje A. te Velde
FRONTIERS IN IMMUNOLOGY
(2019)
Review
Medicine, General & Internal
Abrar Alfatni, Marianne Riou, Anne-Laure Charles, Alain Meyer, Cindy Barnig, Emmanuel Andres, Anne Lejay, Samy Talha, Bernard Geny
JOURNAL OF CLINICAL MEDICINE
(2020)
Letter
Allergy
Anh Poirot, Guillaume Wacht, Christine Lehalle, Philippe Saas, Nelly Frossard, Bernard Geny, Frederic de Blay, Cindy Barnig
Review
Biochemistry & Molecular Biology
Cindy Barnig, Gaetan Lutzweiler, Margherita Giannini, Anne Lejay, Anne-Laure Charles, Alain Meyer, Bernard Geny
Summary: This article discusses the inflammatory response and recent discoveries in resolution pathways during skeletal muscle ischemia reperfusion. Lipid mediators play an important role in regulating the inflammatory response, reducing damage caused by ischemia reperfusion, and have potential therapeutic applications.
Letter
Allergy
Shanshan Qi, Cindy Barnig, Anne-Laure Charles, Anh Poirot, Alain Meyer, Raphael Clere-Jehl, Frederic de Blay, Bernard Geny
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2017)
Article
Immunology
Melody G. Duvall, Cindy Barnig, Manuela Cernadas, Isabell Ricklefs, Nandini Krishnamoorthy, Nicole L. Grossman, Nirav R. Bhakta, John V. Fahy, Eugene R. Bleecker, Mario Castro, Serpil C. Erzurum, Benjamin M. Gaston, Nizar N. Jarjour, David T. Mauger, Sally E. Wenzel, Suzy A. Comhair, Andrea M. Coverstone, Merritt L. Fajt, Annette T. Hastie, Mats W. Johansson, Michael C. Peters, Brenda R. Phillips, Elliot Israel, Bruce D. Levy
SCIENCE IMMUNOLOGY
(2017)
