Article
Multidisciplinary Sciences
Aaron E. Chiou, Chuang Liu, Ines Moreno-Jimenez, Tengteng Tang, Wolfgang Wagermaier, Mason N. Dean, Claudia Fischbach, Peter Fratzl
Summary: Factors secreted by breast cancer may promote disturbed bone growth before metastasis, potentially affecting the initial seeding of tumor cells.
Review
Pharmacology & Pharmacy
Claire L. Ihle, Sabrina J. Wright-Hobart, Philip Owens
Summary: The survival rate of breast cancer patients has improved, but metastatic breast cancer still causes high mortality. Metastasis mainly occurs in the bone, and current treatment methods focus on palliative care and slowing down the progression. Recent advances in molecularly targeted agents have made breakthroughs in the treatment of metastatic breast cancer, but immunotherapies have not been fully applied in estrogen receptor-positive tumors. Therapeutic approaches targeting the bone microenvironment of metastatic breast cancer have potential applications in other bone-resident cancers.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Paola Maroni, Paola Bendinelli, Alessandro Fulgenzi, Anita Ferraretto
Summary: Bone metastasis is a severe complication of common cancers like breast and prostate cancer, reducing survival rates and quality of life. Following a Mediterranean diet can prevent cancer and improve patient health, potentially impacting the spread of cancer to the bones.
Review
Genetics & Heredity
Jingyao Cui, Haoran Chen, Kaiwen Zhang, Xin Li
Summary: Wnt pathway plays a crucial role in cancer bone metastasis and targeted therapeutic strategies have shown promise. Current progress includes research on pharmacological Wnt modulators against breast cancer bone metastasis and exploration of emerging therapeutic strategies based on Wnt pathway-related targets, providing new ideas for the development of Wnt-based intervention strategies in the future.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Biochemistry & Molecular Biology
Paola Maroni, Paola Bendinelli, Anita Ferraretto, Giovanni Lombardi
Summary: Bone metastases are a major issue in the progression of breast cancer, posing a significant treatment challenge. Interleukin-11 plays a key role in bone metastasis and could be a candidate for anti-metastatic therapy. Further research is needed to understand the contribution of different cytokines in breast cancer progression and develop effective therapeutic strategies.
Review
Oncology
Marie-Therese Haider, Daniel J. Smit, Hanna Taipaleenmaeki
Summary: This article summarizes the recent research progress on miRNAs in breast cancer bone metastasis. MiRNAs not only affect the function of cancer cells, but also play an important role in key cells of the bone microenvironment. In addition, the article discusses the potential application of miRNAs as therapeutic targets and elaborates on the advantages and challenges of miRNA treatment.
Article
Multidisciplinary Sciences
Ana Luisa Correia, Joao C. Guimaraes, Priska Auf Der Maur, Duvini De Silva, Marcel P. Trefny, Ryoko Okamoto, Sandro Bruno, Alexander Schmidt, Kirsten Mertz, Katrin Volkmann, Luigi Terracciano, Alfred Zippelius, Marcus Vetter, Christian Kurzeder, Walter Paul Weber, Mohamed Bentires-Alj
Summary: The study investigates how different tissue-specific microenvironments can either inhibit or support the progression of breast cancer in the liver. It identifies the interplay between natural killer (NK) cells and activated hepatic stellate cells (aHSCs) as a master switch of cancer dormancy, suggesting that therapies aimed at normalizing the NK cell pool may be successful in preventing metastatic outgrowth.
Article
Oncology
Lina Marie, Dina Braik, Nayef Abdel-Razeq, Hala Abu-Fares, Ahmad Al-Thunaibat, Hikmat Abdel-Razeq
Summary: Breast cancer with de novo bone-only metastasis has distinct clinical features and prognosis compared to subsequent bone-only metastasis. Patients with de novo bone-only metastasis have shorter overall survival.
CANCER MANAGEMENT AND RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Andrea Bortolin, Estrela Neto, Meriem Lamghari
Summary: Calcium plays a crucial role in various physiological processes as a signalling mediator. It is involved in pathways that control fast responses like neuronal action potential firing and slow processes like gene transcriptional regulation. In pathological conditions, these mechanisms are also implicated in tumor cell reprogramming and pain regulation. Understanding the interactions between these mechanisms can lead to the identification of new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Jeremy F. Kane, Rachelle W. Johnson
Summary: Parathyroid-hormone-related protein (PTHrP) is involved in bone destruction in breast cancer cells. Its behavior in breast cancer is different than in normal cells, as it moves around inside the cells instead of binding to a receptor. This review discusses the conflicting results of studies and explores the molecular basis for these discrepancies.
Article
Engineering, Biomedical
Martina Crippa, Giuseppe Talo, Anais Lamouline, Sara Bolis, Chiara Arrigoni, Simone Bersini, Matteo Moretti
Summary: The specific interactions between the host microenvironment and cancer cells drive the organ-specific metastasis of breast cancer to bone. This study analyzed the migratory behavior of neutrophils when exposed to breast cancer cells colonizing the bone and their contribution to the growth of breast cancer micrometastases. A microfluidic system was designed to study the mechanisms of interaction between circulating immune cells and organ-specific micrometastases in a bone-mimicking microenvironment.
MATERIALS TODAY BIO
(2022)
Review
Biochemistry & Molecular Biology
Andy Goebel, Stefania Dell'Endice, Nikolai Jaschke, Sophie Paehlig, Amna Shahid, Lorenz C. Hofbauer, Tilman D. Rachner
Summary: Inflammation plays a critical role in bone metastasis by supporting the survival, migration, invasion, and growth of tumor cells, serving as a key factor in the tumorigenesis and progression of cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Lucija Kovacevic, Mislav Cavka, Zlatko Marusic, Elvira Kresic, Andrija Stajduhar, Lora Grbanovic, Ivo Dumic-Cule, Maja Prutki
Summary: CT-guided bone lesion biopsy has high diagnostic accuracy in confirming bone metastases and assessing hormone receptor status in patients with breast cancer. This study suggests that CT-guided biopsy is crucial for patients with breast cancer and suspicious bone lesions.
Article
Biochemistry & Molecular Biology
Milene N. O. Moritz, Alyssa R. Merkel, Ean G. Feldman, Heloisa S. Selistre-de-Araujo, Julie A. Rhoades (Sterling)
Summary: The expression of α2β1 integrin is inversely correlated with bone metastatic potential in breast cancer. Overexpression of the α2 integrin subunit increases primary tumor growth and dissemination to bone, with no impact on tumor establishment and bone destruction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Qinyu Han, Shi Qiu, Huiwen Hu, Wenjing Li, Xiangguo Dang, Xiangqi Li
Summary: Bone is the most common site of metastasis from breast cancer, causing significant impact on patients' quality of life and mortality. The molecular mechanism of breast cancer cells metastasizing to bone involves the complex interaction between cancer cells and the bone microenvironment, although the exact mechanism is not yet clear. Recent studies have highlighted the significance of the Hippo signaling pathway in breast cancer metastasis, especially in bone metastasis, although the specific molecular mechanism remains to be fully understood. This review discusses the role of the Hippo signaling pathway in breast cancer metastasis, particularly in bone metastasis, to establish a solid theoretical foundation for further research and the development of targeted therapies.
FRONTIERS IN ONCOLOGY
(2023)
Editorial Material
Oncology
Lauren M. Postlewait, Anthony Lucci
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Natalia Partain, Lauren M. Postlewait, Mediget Teshome, Kelly Rosso, Carolyn Hall, Juhee Song, Salyna Meas, Sarah M. DeSnyder, Bora Lim, Vicente Valero, Wendy Woodward, Naoto T. Ueno, Henry Kuerer, Anthony Lucci
Summary: In this retrospective study, MRM in de novo stage IV IBC patients is an independent factor associated with improved OS. Our findings strongly support the need for prospective randomized trials evaluating possible survival benefits of MRM in de novo stage IV IBC patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Michael G. White, Andrew Lee, Diego Vicente, Carolyn Hall, Michael P. Kim, Matthew H. G. Katz, Jeffrey E. Lee, Naruhiko Ikoma, Anthony Lucci, Ching-Wei D. Tzeng
Summary: This study investigated the safety and feasibility of intraoperative portal vein blood (PVB) collection during pancreatic ductal adenocarcinoma (PDAC) resection. PVB circulating tumor cell (CTC) counts were significantly correlated with overall survival (OS), providing a potential new avenue for future research and clinical treatment.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Devarati Mitra, Gabriel Ologun, Emily Z. Keung, Ryan P. Goepfert, Rodabe N. Amaria, Merrick I. Ross, Jeffrey E. Gershenwald, Anthony Lucci, Sarah B. Fisher, Michael A. Davies, Jeffrey E. Lee, Andrew J. Bishop, Ahsan S. Farooqi, Jennifer Wargo, B. Ashleigh Guadagnolo
Summary: This study found that nodal recurrence is the primary driver of early disease relapse for patients with SLN-positive melanoma who do not undergo CLND. Patients with LVI, two or more involved nodes, or > 1 mm nodal disease are at particularly high risk of nodal relapse.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Leisha C. Elmore, Henry M. Kuerer, Carlos H. Barcenas, Benjamin D. Smith, Makesha Miggins, Anthony Lucci, Abigail S. Caudle, Funda Meric-Bernstam, Kelly K. Hunt, Mediget Teshome
Summary: For breast cancer patients receiving NST and experiencing disease progression, the study found a high proportion of patients died and developed distant metastasis. Triple-negative breast cancer patients had a higher risk of death. Despite surgical management, survival rates were still poor.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Editorial Material
Oncology
Lauren M. Postlewait, Anthony Lucci
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Taiwo Adesoye, Oluwatowo Babayemi, Lauren M. Postlewait, Sarah M. DeSnyder, Susie X. Sun, Wendy A. Woodward, Naoto T. Ueno, Kelly K. Hunt, Anthony Lucci, Mediget Teshome
Summary: This study evaluated the age-related differences in patients with inflammatory breast cancer (IBC) and found no significant disparities in demographics, treatment patterns, or clinical outcomes between patients aged 40 years or younger and those aged 65 years or older. These findings do not support age-related treatment de-escalation in IBC.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Taiwo Adesoye, Anthony Lucci
Summary: Inflammatory breast cancer is a rare and aggressive form of breast cancer that requires diagnosis and treatment based on clinical symptoms, with no evidence supporting de-escalation of surgical therapy. Delayed reconstruction is recommended to avoid recurrence and potential delays in adjuvant therapy.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Lauren M. Postlewait, Mediget Teshome, Taiwo Adesoye, Sarah M. DeSnyder, Bora Lim, Henry M. Kuerer, Isabelle Bedrosian, Susie X. Sun, Wendy A. Woodward, Huong T. Le-Petross, Vicente Valero, Naoto T. Ueno, Anthony Lucci
Summary: Inflammatory breast cancer (IBC) patients have a high rate of de novo stage IV disease, with approximately 8.3% presenting with contralateral axillary metastasis (CAM) at diagnosis. CAM was best detected with ultrasound and PET imaging. Routine contralateral axillary ultrasound is recommended for staging all IBC patients to facilitate early diagnosis and guide future clinical trials for CAM management and outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Lyndsey J. Kilgore, Brittany L. Murphy, Lauren M. Postlewait, Diana H. Liang, Isabelle Bedrosian, Anthony Lucci, Henry M. Kuerer, Kelly K. Hunt, Mediget Teshome
Summary: This study evaluated the impact of the COVID-19 pandemic on 2019-2020 Breast Surgical Oncology fellows, finding that clinical experience was altered while operative experience remained largely unaffected. Some fellows delayed general surgery board examinations due to the pandemic and experienced increased stress levels.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Dhruvajyoti Roy, Anthony Lucci, Michail Ignatiadis, Stefanie S. Jeffrey
TRENDS IN MOLECULAR MEDICINE
(2021)
Editorial Material
Dermatology
Yuling Wang, Vijaya Ramachandran, Dawen Sui, Kejing Xu, Lauren E. Haydu, Shenying Fang, Jennifer L. McQuade, Sarah B. Fisher, Anthony Lucci, Emily Z. Keung, Jennifer Wargo, Jeffrey E. Gershenwald, Merrick I. Ross, Jeffrey E. Lee
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Oncology
Balraj Singh, Vanessa N. Sarli, Anthony Lucci
Summary: Using a cell culture model, researchers found that JIB-04 can sensitize resistant breast cancer cells to chemotherapy drugs and increase the expression of PD-L1 in cancer cells, which may have clinical applications in improving the treatment of triple-negative breast cancer.
Review
Biochemistry & Molecular Biology
Sridevi Addanki, Salyna Meas, Vanessa Nicole Sarli, Balraj Singh, Anthony Lucci
Summary: Liquid biopsies are a non-invasive method for detecting cancer biomarkers through a simple blood draw. These circulating markers have significant prospects in evaluating patients' prognosis, monitoring therapy response, and developing precision medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Balraj Singh, Vanessa N. Sarli, Ryan D. Milligan, Hannah E. Kinne, Anna Shamsnia, Laura J. Washburn, Sridevi Addanki, Anthony Lucci
Summary: We treated highly metabolically adaptable triple-negative inflammatory breast cancer cells with JQ1 and found that it inhibited therapy-resistant cells. Although JQ1 couldn't kill these resistant cells, it sensitized them to treatment with doxorubicin and paclitaxel. Additionally, JQ1 reduced PD-L1 protein levels, indicating a potential improvement in immunotherapy response.
