Review
Biochemistry & Molecular Biology
Mayra Colardo, Noemi Martella, Daniele Pensabene, Silvia Siteni, Sabrina Di Bartolomeo, Valentina Pallottini, Marco Segatto
Summary: Neurotrophins are a family of growth factors initially thought to primarily mediate nervous system development and neuronal survival, but increasing evidence suggests they also play crucial roles in regulating metabolic processes such as redox balance, glucose homeostasis, and cholesterol metabolism. This review examines the signaling pathways of neurotrophins and their impact on metabolism, particularly focusing on their effects on cholesterol metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Microbiology
Hui Han, Bao Yi, Ruqing Zhong, Mengyu Wang, Shunfen Zhang, Jie Ma, Yulong Yin, Jie Yin, Liang Chen, Hongfu Zhang
Summary: Feelings of hunger and satiety play crucial roles in maintaining life; gut microbiota have been implicated in appetite control, potentially affecting host metabolic health and leading to various metabolic disorders.
Review
Immunology
Xu-Yue Zhou, Kun Chen, Jia-An Zhang
Summary: This article reviews the interactions of mast cells with T cells, Tregs, keratinocytes, adipocytes, and sensory neurons in psoriasis, highlighting the important role of mast cell-centered cell networks in the development of psoriasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hua Qi, Fan-Nv Xia, Shi Xiao, Juan Li
Summary: TRAF proteins play crucial roles in signal transduction in plants, essential for plant development and stress responses.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Review
Immunology
Lais P. Pral, Jose L. Fachi, Renan O. Correa, Marco Colonna, Marco A. R. Vinolo
Summary: Oxygen availability is crucial for microbiota composition and cellular function in the gut, with metabolites from microbiota affecting oxygen consumption. The interactions among microbiota, hypoxia/hypoxic sensors, and mammalian host cells play a key role in shaping intestinal barrier and host-microbiota-pathogens connections. Understanding these interactions may lead to new treatment options for dysbiosis and certain inflammatory and infectious diseases.
TRENDS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daniel Zalewski, Paulina Chmiel, Przemyslaw Kolodziej, Grzegorz Borowski, Marcin Feldo, Janusz Kocki, Anna Bogucka-Kocka
Summary: Abdominal aortic aneurysm (AAA) is a chronic vascular disease with high mortality rate. Abnormal regulation of angiogenesis and inflammation contributes to the disease progression. Dysregulations in key molecular pathways associated with AAA need to be further investigated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Xiaojin Feng, Deqiang Luo, Gen Wei, Fenfang Zhan, Fuzhou Hua, Guohai Xu
Summary: In summary, ncRNAs play a significant role in modulating the activation of NLRP3 inflammasome in various inflammatory diseases, providing insights for future therapeutic approaches to inflammatory diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
David Diaz-Jimenez, Joseph P. Kolb, John A. Cidlowski
Summary: The immune system plays a critical role in maintaining host homeostasis, responding to inflammatory reactions and tissue restoration. Macrophages, as tissue-resident cells, may be key regulators of organ homeostasis through glucocorticoid signaling.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Santosh Suryavanshi, Igor Kovalchuk, Olga Kovalchuk
Summary: Inflammasomes play a crucial role in immune and inflammatory regulation, being key players in the development of chronic inflammatory disorders. Cannabinoids are considered to have potential anti-inflammatory effects, especially in the treatment of chronic diseases, but the specific mechanisms are still unclear.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Satoshi Kawaguchi, Bruno Moukette, Taiki Hayasaka, Angela K. Haskell, Jessica Mah, Marisa N. Sepulveda, Yaoliang Tang, Il-man Kim
Summary: Noncoding RNAs are important in cardiac development and cardiovascular diseases. In this review, we discuss the critical roles of microRNAs, long noncoding RNAs, and circular RNAs in cardiac development and CVDs based on recent research articles. This review provides readers with a recent understanding of key ncRNAs and their mechanisms of action in cardiac development and CVDs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Horticulture
Guangwu Zhu, Chongtian Ma, Shuimiao Yu, Xueying Zhang, Jing Jiang, Xin Liu
Summary: Multiple genes related to leaf shape were discovered in the process of leaf development in tomato plants. Transcriptome sequencing and gene silencing experiments revealed that bHLH079, IAA-amino acid hydrolase, Gibberellin2ox7, Gibberellin20ox, WRKY44, and WRKY76 are endogenous regulators influencing tomato compound leaf development. This study provides a promising direction for revealing the molecular regulation mechanism underlying compound leaf development in tomatoes.
Article
Biochemistry & Molecular Biology
Yuki Kitamura, Shinji Oikawa, Jie Chang, Yurie Mori, Gaku Ichihara, Sahoko Ichihara
Summary: This study used 2D-Oxyblot and 2D-DIGE techniques to analyze carbonylated proteins induced by oxidative stress in a metabolic syndrome animal model, as well as changes in protein expression levels in adipose tissue at different stages of the syndrome. The results showed that up-regulated proteins at the pre-symptomatic stage were mainly involved in ATP production and redox reactions, while down-regulated proteins at the symptomatic stage were associated with antioxidant activity and the TCA cycle. Increased levels of carbonylated proteins, including gelsolin, may contribute to the oxidative stress state and progression of metabolic syndrome.
Review
Immunology
Zhuqing Jin, En Zheng, Candice Sareli, Pappachan E. Kolattukudy, Jianli Niu
Summary: Inflammatory response is a protective mechanism of the host, but can also lead to immunopathology and tissue damage. Recent studies on the MCPIP family of chemical molecules, particularly the role of MCPIP-1 in the NF kappa B signaling pathway, have revealed important biological functions in resolving inflammation. Understanding the roles of the MCPIP family members can provide new insights into the treatment of infections and other inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Laura Amicone, Alessandra Marchetti, Carla Cicchini
Summary: This review focuses on the role of exosome-associated circRNAs as key regulators of EMT in cancer. The relevance of these molecules in regulating the intercellular communication in TME and tumor progression is highlighted. Moreover, it suggests that exosome-associated circRNA modulation should be taken into account for cancer diagnostic and therapeutic approaches.
Review
Immunology
Ana Valle-Noguera, Anne Ochoa-Ramos, Maria Jose Gomez-Sanchez, Aranzazu Cruz-Adalia
Summary: ILC3 have been described as tissue-resident cells throughout the body, particularly in mucosal sites and classical first barrier organs. Research has focused on their role in combating pathogens, especially in the gut, but recent discoveries have shown their activity in other organs against intracellular pathogens and in response to viruses. This review compiles recent studies on ILC3s' role in defending against different microbes at mucosal surfaces, using conditional transgenic mice.
FRONTIERS IN IMMUNOLOGY
(2021)