Heat shock protein 70 – the next chaperone to target in the treatment of human acute myelogenous leukemia?

Pharmacologic targeting of the PI3K/mTOR pathway controls release of angioregulators from primary human acute myeloid leukemia cells and their neighboring stromal cells

(2015) Håkon Reikvam et al.   Oncotarget

Heat shock proteins 27, 40, and 70 as combinational and dual therapeutic cancer targets

(2013) Jeanette R. McConnell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antileukaemic effect of PI3K-mTOR inhibitors in acute myeloid leukaemia-gene expression profiles reveal CDC25B expression as determinate of pharmacological effect

(2013) Håkon Reikvam et al.   BRITISH JOURNAL OF HAEMATOLOGY

Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition

(2013) Anna Budina-Kolomets et al.   CANCER BIOLOGY & THERAPY

Predicting effects of kinase inhibitor in therapy for myeloid malignancies – the challenges in capturing disease heterogeneity

(2013) Håkon Reikvam et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Increased antileukemic effects in human acute myeloid leukemia by combining HSP70 and HSP90 inhibitors

(2013) Håkon Reikvam et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Stress proteins are used by the immune system for cognate interactions with anti-inflammatory regulatory T cells

(2013) Willem van Eden et al.   FEBS LETTERS

The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma

(2013) M. Chatterjee et al.   HAEMATOLOGICA

Acute myeloid leukaemia in adults

(2013) Felicetto Ferrara et al.   LANCET

In silico design of small peptide-based Hsp90 inhibitor: A novel anticancer agent

(2013) Uday Kumar Gupta et al.   MEDICAL HYPOTHESES

A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent

(2013) Gregor M. Balaburski et al.   MOLECULAR CANCER RESEARCH

Functional Analysis of Hsp70 Inhibitors

(2013) Rainer Schlecht et al.   PLoS One

The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia

(2013) Hanne Fredly et al.   Clinical Epigenetics

Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents

(2013) Hanne Fredly et al.   Clinical Epigenetics

Disease-stabilizing treatment with all-trans retinoic acid and valproic acid in acute myeloid leukemia: Serum hsp70 and hsp90 levels and serum cytokine profiles are determined by the disease, patient age, and anti-leukemic treatment

(2012) Hanne Fredly et al.   AMERICAN JOURNAL OF HEMATOLOGY

Novel inhibitors of heat shock protein Hsp70-mediated luciferase refolding that bind to DnaJ

(2012) Joel A. Cassel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of HSP70: A challenging anti-cancer strategy

(2012) Anastasia R. Goloudina et al.   CANCER LETTERS

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Targeted Anti-leukemic Therapy as Disease-stabilizing Treatment for Acute Myeloid Leukemia Relapse after Allogeneic Stem Cell Transplantation: Will it be Possible to Combine these Strategies with Retransplantation or Donor Lymphocyte Infusions?

(2012) Hakon Reikvam et al.   CURRENT CANCER DRUG TARGETS

Hsp70 Protein Complexes as Drug Targets

(2012) Victoria A. Assimon et al.   CURRENT PHARMACEUTICAL DESIGN

Bortezomib Added to Daunorubicin and Cytarabine During Induction Therapy and to Intermediate-Dose Cytarabine for Consolidation in Patients With Previously Untreated Acute Myeloid Leukemia Age 60 to 75 Years: CALGB (Alliance) Study 10502

(2012) Eyal C. Attar et al.   JOURNAL OF CLINICAL ONCOLOGY

The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach

(2012) Jan J. Cornelissen et al.   Nature Reviews Clinical Oncology

Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

(2012) Jay P. Patel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rhodacyanine Derivative Selectively Targets Cancer Cells and Overcomes Tamoxifen Resistance

(2012) John Koren et al.   PLoS One

Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis

(2012) M. J. C. van Herwijnen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management

(2011) Elihu H. Estey   AMERICAN JOURNAL OF HEMATOLOGY

Acute myeloid leukaemia in the elderly: a review

(2011) Daniel A. Pollyea et al.   BRITISH JOURNAL OF HAEMATOLOGY

Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status - consequences and potentials for pharmacological intervention

(2011) Håkon Reikvam et al.   BRITISH JOURNAL OF HAEMATOLOGY

Future perspectives: should Th17 cells be considered as a possible therapeutic target in acute myeloid leukemia patients receiving allogeneic stem cell transplantation?

(2011) Elisabeth Ersvær et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?

(2011) Marissa V. Powers et al.   CELL CYCLE

Regulation of survival gene hsp70

(2011) Jordan Thomas Silver et al.   CELL STRESS & CHAPERONES

Hsp70, a messenger from hyperthermia for the immune system

(2011) Anna Jolesch et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Phase I and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia

(2011) S. H. Kaufmann et al.   HAEMATOLOGICA

Interaction between the Human Mitochondrial Import Receptors Tom20 and Tom70in VitroSuggests a Chaperone Displacement Mechanism

(2011) Anna C. Y. Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Advances in Acute Myeloid Leukemia

(2011) Alan Burnett et al.   JOURNAL OF CLINICAL ONCOLOGY

Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones

(2011) Aikaterini Rousaki et al.   JOURNAL OF MOLECULAR BIOLOGY

A Small Molecule That Binds to an ATPase Domain of Hsc70 Promotes Membrane Trafficking of Mutant Cystic Fibrosis Transmembrane Conductance Regulator

(2011) Hyungseoph J. Cho et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

HSP70 Inhibition by the Small-Molecule 2-Phenylethynesulfonamide Impairs Protein Clearance Pathways in Tumor Cells

(2011) J. I.-J. Leu et al.   MOLECULAR CANCER RESEARCH

Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators

(2011) D. M. Huryn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antileukemic activity of the HSP70 inhibitor pifithrin-μ in acute leukemia

(2011) M Kaiser et al.   Blood Cancer Journal

Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101

(2011) Marc J. Braunstein et al.   Journal of Oncology

Death by chaperone: HSP90, HSP70 or both?

(2010) Marissa V. Powers et al.   CELL CYCLE

KRIBB11 Inhibits HSP70 Synthesis through Inhibition of Heat Shock Factor 1 Function by Impairing the Recruitment of Positive Transcription Elongation Factor b to thehsp70Promoter

(2010) Young Ju Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combination of Intensive Chemotherapy and Anticancer Vaccines in the Treatment of Human Malignancies: The Hematological Experience

(2010) Knut Liseth et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target

(2010) Christopher G. Evans et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expression of heat shock protein 70 and NKG2D ligands in acute myeloid leukemia cell lines

(2010) Ilona Hromadnikova et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia

(2010) J E Lancet et al.   LEUKEMIA

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody

(2010) S. Stangl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells

(2009) A. J. Steele et al.   BLOOD

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

(2009) H. Dohner et al.   BLOOD

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

(2009) Andrew J. Massey et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Heat Shock Protein 90 – a Potential Target in the Treatment of Human Acute Myelogenous Leukemia

(2009) H. Reikvam et al.   CURRENT CANCER DRUG TARGETS

Facilitating Akt Clearance via Manipulation of Hsp70 Activity and Levels

(2009) John Koren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Azacitidine Prolongs Overall Survival Compared With Conventional Care Regimens in Elderly Patients With Low Bone Marrow Blast Count Acute Myeloid Leukemia

(2009) Pierre Fenaux et al.   JOURNAL OF CLINICAL ONCOLOGY

Cell-surface expression of Hsp70 on hematopoietic cancer cells after inhibition of HDAC activity

(2009) Helle Jensen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Clinical correlation of circulating heat shock protein 70 in acute leukemia

(2009) Chen-Hsiung Yeh et al.   LEUKEMIA RESEARCH

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

(2009) J. I-Ju Leu et al.   MOLECULAR CELL

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

(2009) Hyungjin Kim et al.   MOLECULAR CELL

A Novel Class of Small Molecule Inhibitors of Hsp90

(2008) Fang Yi et al.   ACS Chemical Biology

Roles of Heat Shock Proteins and γδT Cells in Inflammation

(2008) Mark I. Hirsh et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Structural and Functional Diversities between Members of the Human HSPB, HSPH, HSPA, and DNAJ Chaperone Families†

(2008) Michel J. Vos et al.   BIOCHEMISTRY

Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling

(2008) Laila Al Shaer et al.   BRITISH JOURNAL OF HAEMATOLOGY

Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

(2008) Marissa V. Powers et al.   CANCER CELL

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

The BAG proteins: a ubiquitous family of chaperone regulators

(2008) M. Kabbage et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Chaperone machines in action

(2008) Helen R Saibil   CURRENT OPINION IN STRUCTURAL BIOLOGY

The dual immunoregulatory roles of stress proteins

(2008) Alan Graham Pockley et al.   TRENDS IN BIOCHEMICAL SCIENCES