Article
Biochemistry & Molecular Biology
Paulina Biniecka, Saki Matsumoto, Axel Belotti, Jessie Joussot, Jian Fei Bai, Somi Reddy Majjigapu, Paul Thoueille, Dany Spaggiari, Vincent Desfontaine, Francesco Piacente, Santina Bruzzone, Michele Cea, Laurent A. A. Decosterd, Pierre Vogel, Alessio Nencioni, Michel A. A. Duchosal, Aimable Nahimana
Summary: The newly synthesized NAMPT inhibitor JJ08 exhibits a broad anticancer activity in vitro by inhibiting NAD(+) and NADP(H), generating ROS, and inducing cell death. In a mouse xenograft model of human Burkitt lymphoma, JJ08 delays tumor growth and shows potential for further evaluation in hematological malignancies.
Review
Biochemistry & Molecular Biology
Maria Lesniak, Justyna Lipniarska, Patrycja Majka, Monika Lejman, Joanna Zawitkowska
Summary: Venetoclax is a highly effective drug for the treatment of hematological malignancies, but its efficacy in pediatric hematology is still uncertain. Recent studies suggest that Venetoclax combination therapy is well-tolerated in many younger patients, despite the risk of severe infections. Current research aims to determine the activity of Venetoclax in combination with standard and high-dose chemotherapy for the treatment of acute leukemias.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Xin Huang, Hasan Md Mahmudul, Zengbei Li, Xinjie Deng, Xiaozhou Su, Zhongqing Xiao, Lingyun Zhao, Ting Liu, Hongyun Li
Summary: This mini review focuses on the use of noble metal nanomaterials (NM NMs) in the diagnosis and treatment of hematological malignancies. NM NMs have the potential to overcome the limitations of current anti-cancer drugs and have been employed for tracking and drug delivery. The construction of effective NM NMs-dependent theranostic methodology has the potential to provide interdisciplinary knowledge for the development of clinical tracing, diagnosis, and treatment of refractory hematological diseases.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Oncology
Alessio Amatu, Arianna Pani, Giorgio Patelli, Oscar M. Gagliardi, Marina Loparco, Daniele Piscazzi, Andrea Cassingena, Federica Tosi, Silvia Ghezzi, Daniela Campisi, Renata Grifantini, Sergio Abrignani, Salvatore Siena, Francesco Scaglione, Andrea Sartore-Bianchi
Summary: This study evaluated the seroconversion rate of anti-spike antibodies in solid tumor patients after receiving SARS-CoV-2 mRNA vaccines and found a lower conversion rate in cancer patients. Age and treatment type also had an impact on the conversion rate. It is suggested to consider enhanced vaccination strategies for this group of patients and closely monitor SARS-CoV-2 infection during treatment.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Immunology
Rani Chudasama, Quan Phung, Andrew Hsu, Khaldoun Almhanna
Summary: Gastrointestinal malignancies are difficult to treat with chemotherapy and radiation therapy, and there is an urgent need for novel therapeutic strategies. Immunotherapy and checkpoint inhibitors may offer new treatment options in the future.
Article
Immunology
Hao Huang, Ling Peng, Bicheng Zhang, Brian G. Till, Yonghao Yang, Xiaojie Zhang, Lingdi Zhao, Xiaomin Fu, Tiepeng Li, Lu Han, Peng Qin, Lin Chen, Xiang Yan, Yang Liu, Wenkang Wang, Zhenlong Ye, Hongle Li, Quanli Gao, Zibing Wang
Summary: The study found that low-dose gemcitabine combined with PD-1 inhibitors showed efficacy in treating patients with advanced malignancies, with an objective response rate of 29.5% and a disease control rate of 62.3%. The most common adverse effects were hematological toxicity, primarily leukopenia or thrombocytopenia.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mireia Uribe-Herranz, Nela Klein-Gonzalez, Luis Gerardo Rodriguez-Lobato, Manel Juan, Carlos Fernandez de Larrea
Summary: Hematological malignancies are a heterogeneous group of neoplasms that affect the blood, bone marrow, and lymph nodes, originating from uncontrolled growth of hematopoietic and lymphoid cells. The gut microbiota has been implicated in the genesis and progression of many diseases beyond the gut, largely through the small molecules they produce.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Richard Rosenquist, Elsa Bernard, Tom Erkers, David W. Scott, Raphael Itzykson, Philippe Rousselot, Jean Soulier, Martin Hutchings, Paivi Ostling, Lucia Cavelier, Thoas Fioretos, Karin E. Smedby
Summary: Genetic testing has been used in clinical routine diagnostics of hematological malignancies for years to improve disease classification, prognostication, patient management, and survival. Recent classifications of hematological malignancies define disease subtypes based on key recurrent genetic alterations detected by conventional methods. Through advanced sequencing techniques, broad genomic tests can now be applied to identify clinically important markers. Precision diagnostics have been implemented in myeloid and lymphoid malignancies to guide treatment selection and improve survival. The potential of monitoring measurable residual disease and functional precision medicine is also discussed.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Cell Biology
Mohammadreza Moonesi, Saeed Zaka Khosravi, Samira Molaei Ramshe, Mehdi Allahbakhshian Farsani, Saeed Solali, Mohammad Hossein Mohammadi, Majid Farshdousti Hagh, Hanie Mehdizadeh
Summary: The IGF family plays a critical role in hematologic malignancies by promoting cell division through the initiation of the PI3K/AKT signaling pathway and stimulation of cell division-related gene transcription via the Ras-GTP pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biology
Mihaela Andreescu
Summary: Concurrent infections pose significant risks to hematological malignancies patients undergoing targeted therapies. These therapies hinder the immune system, increasing the susceptibility to infectious pathogens. The evolving landscape of targeted therapies and lack of comprehensive information on infectious risks present challenges for physicians.
Review
Immunology
Paola Sindaco, Hritisha Pandey, Colleen Isabelle, Nitin Chakravarti, Jonathan Edward Brammer, Pierluigi Porcu, Anjali Mishra
Summary: Cytokines play a crucial role in regulating blood cell activation and growth in the immune system. However, excessive production of cytokines can lead to malignant transformation. This review focuses on the impact of interleukin-15 (IL-15) on the development and progression of hematological malignancies, discussing its role in cell survival, proliferation, inflammation, and treatment resistance. Therapeutic approaches for inhibiting IL-15 in blood cancers will also be reviewed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Jose C. Alvarez, Sonia I. Cuervo, Edelberto Silva, Jorge A. Diaz, Lorena L. Jimenez, Daniel S. Parra, Julio C. Gomez, Ricardo Sanchez, Jorge A. Cortes
Summary: This study found that continuous infusions of cefepime could effectively achieve PK/PD targets in patients with hematological neoplasms and post-chemotherapy febrile neutropenia.
Article
Oncology
Zhangjie Chen, Sisi Zhen, Tingting Zhang, Yuyan Shen, Aiming Pang, Donglin Yang, Rongli Zhang, Qiaoling Ma, Yi He, Jialin Wei, Weihua Zhai, Xin Chen, Erlie Jiang, Mingzhe Han, Sizhou Feng
Summary: In this study, the efficacy and safety of VEN+HMA and IC in treating hematological relapse after allo-HSCT were compared. The results showed that there were no significant differences in overall response and survival between the two groups. However, VEN+HMA was associated with a lower incidence of adverse events and aGvHD. Further research is needed to improve long-term survival.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cell & Tissue Engineering
Faroogh Marofi, Marwan Mahmood Saleh, Heshu Sulaiman Rahman, Wanich Suksatan, Moaed E. Al-Gazally, Walid Kamal Abdelbasset, Lakshmi Thangavelu, Alexei Valerievich Yumashev, Ali Hassanzadeh, Mahboubeh Yazdanifar, Roza Motavalli, Yashwant Pathak, Adel Naimi, Behzad Baradaran, Marzieh Nikoo, Farhad Motavalli Khiavi
Summary: CAR-NK cells are safer and more efficient than CAR-T cells in treating tumors, especially hematological malignancies. NK cells can be effectively engineered to express CARs with substantial cytotoxic activity against both hematological and solid tumors.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Monica Barbieri, William Zardo, Chiara Frittoli, Clara Rivolta, Valeria Valdata, Federico Bouquin, Greta Passignani, Alberto Maggiani, Momcilo Jankovic, Andrea Cossio, Andrea Biondi, Adriana Balduzzi, Francesca Lanfranconi
Summary: This study aimed to assess the feasibility, efficacy, safety, and satisfaction of osteopathic intervention in children and adolescents affected by hematological malignancies who were attending an 11-week precision-based exercise program in the hospital. The results showed that the combination of osteopathy and precision-based intervention improved patients' functional ability, with only minor reversible adverse effects noticed.
Article
Cell & Tissue Engineering
Guro Kristin Melve, Elisabeth Ersvaer, Kristin Paulsen Rye, Aymen Bushra Ahmed, Einar K. Kristoffersen, Tor Hervig, Hakon Reikvam, Kimberley Joanne Hatfield, Oystein Bruserud
Article
Biochemical Research Methods
Ida Marie Rundgren, Oystein Bruserud, Anita Ryningen, Elisabeth Ersvaer
JOURNAL OF IMMUNOLOGICAL METHODS
(2018)
Article
Physiology
Morten Kristoffersen, Oyvind Sandbakk, Espen Tonnessen, Ida Svendsen, Goran Paulsen, Elisabeth Ersvaer, Irene Nygard, Kari Rostad, Anita Ryningen, Vegard V. Iversen, Knut Skovereng, Bent R. Ronnestad, Hilde Gundersen
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Immunology
Ida Marie Rundgren, Elisabeth Ersvaer, Aymen Bushra Ahmed, Anita Ryningen, Oystein Bruserud
Article
Medicine, General & Internal
Ida Marie Rundgren, Elisabeth Ersvaer, Aymen Bushra Ahmed, Anita Ryningen, Oystein Bruserud
MEDICINA-LITHUANIA
(2020)
Article
Biochemistry & Molecular Biology
Ida Marie Rundgren, Anita Ryningen, Tor Henrik Anderson Tvedt, Oystein Bruserud, Elisabeth Ersvaer
Article
Oncology
Luca Cassetta, Kirsten Bruderek, Joanna Skrzeczynska-Moncznik, Oktawia Osiecka, Xiaoying Hu, Ida Marie Rundgren, Ang Lin, Kim Santegoets, Utku Horzum, Ana Godinho-Santos, Gennadiy Zelinskyy, Thalia Garcia-Tellez, Suncica Bjelica, Bartlomiej Taciak, Astrid Olsnes Kittang, Benedikt Hoeing, Stephan Lang, Michael Dixon, Verena Mueller, Jochen Sven Utikal, Derya Karakoc, Kerim Bora Yilmaz, Emilia Gorka, Lubomir Bodnar, Olympia Evdoxia Anastasiou, Christine Bourgeois, Robert Badura, Monika Kapinska-Mrowiecka, Mirjana Gotic, Mark ter Laan, Esther Kers-Rebel, Magdalena Krol, Juan Francisco Santibanez, Michaela Mueller-Trutwin, Ulf Dittmer, Ana Espada de Sousa, Gunes Esendagli, Gosse Adema, Karin Lore, Elisabeth Ersvaer, Viktor Umansky, Jeffrey W. Pollard, Joanna Cichy, Sven Brandau
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Physiology
Marcus S. Dasa, Morten Kristoffersen, Elisabeth Ersvaer, Lars Peder Bovim, Lise Bjorkhaug, Rolf Moe-Nilssen, Jorn V. Sagen, Inger Haukenes
Summary: The study found that the menstrual cycle does not alter acute strength and power performance on a group level in high level female team athletes.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Tor Henrik Anderson Tvedt, Stefan Rose-John, Galina Tsykunova, Aymen Bushra Ahmed, Tobias Gedde-Dahl, Elisabeth Ersvaer, Oystein Bruserud
Summary: Graft-versus-host disease (GVHD) is a common complication after stem cell transplantation and is mediated by T cells. IL-6 plays a role in both pro-inflammatory and anti-inflammatory effects, and it modulates T cell response. The study found that CD3(+)CD4(+) and CD3(+)C8(+) T cells have different responses to IL-6 signaling, and these responses are influenced by antithymocyte globulin treatment. These findings suggest that IL-6 targeting after transplantation may have varied effects on patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Tord Hettervik Froland, Ilona Heldal, Turid Aarhus Braseth, Irene Nygard, Gry Sjoholt, Elisabeth Ersvaer
Summary: Practice-based training in education is demanding, but digital games can provide complementary opportunities for training procedural skills in biomedical laboratory science education. A case study showed that the integration of a serious game in education motivated students and received positive feedback from teachers.
Proceedings Paper
Health Care Sciences & Services
Tord Hettervik Froland, Ilona Heldal, Elisabeth Ersvaer, Gry Sjoholt
Summary: This study presents a VR game for phlebotomy learning through exploration of laboratories, showcasing differences in opinions between teachers and students based on usability evaluations. Suggestions for improvements were made to enhance the gamified learning experience.
2021 INTERNATIONAL CONFERENCE ON E-HEALTH AND BIOENGINEERING (EHB 2021), 9TH EDITION
(2021)
Proceedings Paper
Health Care Sciences & Services
Tord Hettervik Froland, Ilona Heldal, Elisabeth Ersvaer, Gry Sjoholt
2020 INTERNATIONAL CONFERENCE ON E-HEALTH AND BIOENGINEERING (EHB)
(2020)
Article
Computer Science, Information Systems
Tord Hettervik Froland, Ilona Heldal, Gry Sjoholt, Elisabeth Ersvaer
Proceedings Paper
Health Care Sciences & Services
Tord Hettervik Froland, Ilona Heldal, Elisabeth Ersvaer, Gry Sjoholt, Attila Kovari
2019 E-HEALTH AND BIOENGINEERING CONFERENCE (EHB)
(2019)
Review
Hematology
Nikoleta Bizymi, Suncica Bjelica, Astrid Olsnes Kittang, Slavko Mojsilovic, Maria Velegraki, Charalampos Pontikoglou, Mikael Roussel, Elisabeth Ersvaer, Juan Francisco Santibanez, Marie Lipoldova, Helen A. Papadaki