SIRT1: new avenues of discovery for disorders of oxidative stress

Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury

(2011) Marta A. Paiva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Dietary nicotinic acid supplementation improves hepatic zinc uptake and offers hepatoprotection against oxidative damage

(2011) Rashmi S. Tupe et al.   BRITISH JOURNAL OF NUTRITION

Nicotinamide Blocks Proliferation and Induces Apoptosis of Chronic Lymphocytic Leukemia Cells through Activation of the p53/miR-34a/SIRT1 Tumor Suppressor Network

(2011) V. Audrito et al.   CANCER RESEARCH

Protective roles of SIRT1 in atherosclerosis

(2011) Sokrates Stein et al.   CELL CYCLE

Erythropoietin Employs Cell Longevity Pathways of SIRT1 to Foster Endothelial Vascular Integrity During Oxidant Stress

(2011) Jinling Hou et al.   CURRENT NEUROVASCULAR RESEARCH

Erythropoietin and Wnt1 Govern Pathways of mTOR, Apaf-1, and XIAP in Inflammatory Microglia

(2011) Yan Chen Shang et al.   CURRENT NEUROVASCULAR RESEARCH

EPO Relies upon Novel Signaling of Wnt1 that Requires Akt1, FoxO3a,GSK-3β, and β-Catenin to Foster Vascular Integrity during Experimental Diabetes

(2011) Zhao Zhong Chong et al.   CURRENT NEUROVASCULAR RESEARCH

Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

(2011) Yu Li et al.   FASEB JOURNAL

Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease

(2011) Nilanjan Ghosh et al.   FREE RADICAL RESEARCH

On the Role of Phosphatidylinositol 3-Kinase, Protein Kinase B/Akt, and Glycogen Synthase Kinase-3β in Photodynamic Injury of Crayfish Neurons and Glial Cells

(2011) Maxim A. Komandirov et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation

(2011) Pratibha V Nerurkar et al.   Journal of Neuroinflammation

Resveratrol prevents oxidative stress and inhibition of Na+K+-ATPase activity induced by transient global cerebral ischemia in rats

(2011) Fabrício Simão et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

(2011) Sara Fröjdö et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Over-stimulation of insulin/IGF-1 signaling by western diet may promote diseases of civilization: lessons learnt from laron syndrome

(2011) Bodo C Melnik et al.   Nutrition & Metabolism

Mammalian Target of Rapamycin: Hitting the Bull's-Eye for Neurological Disorders

(2011) Zhao Zhong Chong et al.   Oxidative Medicine and Cellular Longevity

Erythropoietin: A Hormone with Multiple Functions

(2011) Matilde Lombardero et al.   PATHOBIOLOGY

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

(2011) N. R. Sundaresan et al.   Science Signaling

Vascular Incompetence in Dialysis Patients-Protein-Bound Uremic Toxins and Endothelial Dysfunction

(2011) Noémie Jourde-Chiche et al.   SEMINARS IN DIALYSIS

Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology

(2011) Kenneth Maiese et al.   TheScientificWorldJOURNAL

Targeting Forkhead Box O1 from the Concept to Metabolic Diseases: Lessons from Mouse Models

(2010) Zhiyong Cheng et al.   ANTIOXIDANTS & REDOX SIGNALING

The Regulation of Erythropoiesis by Selenium in Mice

(2010) Naveen Kaushal et al.   ANTIOXIDANTS & REDOX SIGNALING

Forkhead Homeobox Type O Transcription Factors in the Responses to Oxidative Stress

(2010) Peter Storz   ANTIOXIDANTS & REDOX SIGNALING

Phosphatidylserine targeting for diagnosis and treatment of human diseases

(2010) Kristof Schutters et al.   APOPTOSIS

Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in ratsThis paper is one of a selection of papers published in this special issue entitled “Second International Symposium on Recent Advances in Basic, Clinical, and Social Medicine” and has undergone the Journal's usual peer review process.

(2010) Yong-Ru Chen et al.   Biochemistry and Cell Biology

Erythropoietin in neonatal brain protection: The past, the present and the future

(2010) Abdullah Kumral et al.   BRAIN & DEVELOPMENT

Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease

(2010) Mohd.Moshahid Khan et al.   BRAIN RESEARCH

Sirt1 acts in association with PPAR  to protect the heart from hypertrophy, metabolic dysregulation, and inflammation

(2010) A. Planavila et al.   CARDIOVASCULAR RESEARCH

RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

(2010) Gizem Donmez et al.   CELL

SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity

(2010) Giorgio Ramadori et al.   Cell Metabolism

Silent Information Regulator 1 Protects the Heart From Ischemia/Reperfusion

(2010) Chiao-Po Hsu et al.   CIRCULATION

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

(2010) Nirmala Hariharan et al.   CIRCULATION RESEARCH

Erythropoietin and the heart: facts and perspectives

(2010) Vittoria Mastromarino et al.   CLINICAL SCIENCE

Diabetes Mellitus: Channeling Care through Cellular Discovery

(2010) Kenneth Maiese et al.   CURRENT NEUROVASCULAR RESEARCH

Early Apoptotic Vascular Signaling is Determined by Sirt1 Through Nuclear Shuttling, Forkhead Trafficking, Bad, and Mitochondrial Caspase Activation

(2010) Jinling Hou et al.   CURRENT NEUROVASCULAR RESEARCH

Roles of FoxO1 and Sirt1 in the central regulation of food intake

(2010) Tsutomu Sasaki et al.   ENDOCRINE JOURNAL

Oxidative stress: Biomarkers and novel therapeutic pathways

(2010) Kenneth Maiese et al.   EXPERIMENTAL GERONTOLOGY

Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure

(2010) Masaya Tanno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression

(2010) Shiqin Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Potentiates Glucose-stimulated Insulin Secretion in INS-1E β-Cells and Human Islets through a SIRT1-dependent Mechanism

(2010) Laurène Vetterli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Growth factors in ischemic stroke

(2010) S. Lanfranconi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Novel Avenues of Drug Discovery and Biomarkers for Diabetes Mellitus

(2010) Kenneth Maiese et al.   JOURNAL OF CLINICAL PHARMACOLOGY

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

(2010) S. Michan et al.   JOURNAL OF NEUROSCIENCE

Resveratrol Arrests and Regresses the Development of Pressure Overload- but Not Volume Overload-Induced Cardiac Hypertrophy in Rats

(2010) Peter Wojciechowski et al.   JOURNAL OF NUTRITION

FOXO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling

(2010) Jinling Hou et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence

(2010) Limin Han et al.   NUCLEIC ACIDS RESEARCH

Wnt1 Neuroprotection Translates into Improved Neurological Function during Oxidant Stress and Cerebral Ischemia ThroughAKT1and Mitochondrial Apoptotic Pathways

(2010) Zhao Zhong Chong et al.   Oxidative Medicine and Cellular Longevity

Resveratrol Enhances Antitumor Activity of TRAIL in Prostate Cancer Xenografts through Activation of FOXO Transcription Factor

(2010) Suthakar Ganapathy et al.   PLoS One

Resveratrol Prevents the Development of Pathological Cardiac Hypertrophy and Contractile Dysfunction in the SHR Without Lowering Blood Pressure

(2009) S. J. Thandapilly et al.   AMERICAN JOURNAL OF HYPERTENSION

Protective Role of SIRT1 in Diabetic Vascular Dysfunction

(2009) Masayuki Orimo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

The Forkhead Transcription Factor FOXO3a Controls Microglial Inflammatory Activation and Eventual Apoptotic Injury through Caspase 3

(2009) Yan Shang et al.   CURRENT NEUROVASCULAR RESEARCH

TIMP3 Is Reduced in Atherosclerotic Plaques From Subjects With Type 2 Diabetes and Increased by SirT1

(2009) M. Cardellini et al.   DIABETES

Enzymes in the NAD+Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters

(2009) Tong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPAR control: it's SIRTainly as easy as PGC

(2009) Mary C Sugden et al.   JOURNAL OF ENDOCRINOLOGY

Reversible regulation of the retinoblastoma protein/E2F-1 pathway during “reverse cardiac remodelling” after ventricular unloading

(2009) Jeremias Wohlschlaeger et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by α-synuclein or amyloid-β (1-42) peptide

(2009) Diego Albani et al.   JOURNAL OF NEUROCHEMISTRY

Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress

(2009) Jianguo Lin et al.   LABORATORY INVESTIGATION

Emerging technologies in the delivery of erythropoietin for therapeutics

(2009) Ainhoa Murua et al.   MEDICINAL RESEARCH REVIEWS

The Vitamin Nicotinamide: Translating Nutrition into Clinical Care

(2009) Kenneth Maiese et al.   MOLECULES

Caloric restriction, SIRT1 and longevity

(2009) Carles Cantó et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression

(2008) Kazuhiro Hasegawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice

(2008) Q.-j. Zhang et al.   CARDIOVASCULAR RESEARCH

Enhanced Tolerance against Early and Late Apoptotic Oxidative Stress in Mammalian Neurons through Nicotinamidase and Sirtuin Mediated Pathways

(2008) Zhao Chong et al.   CURRENT NEUROVASCULAR RESEARCH

Erythropoietin and Oxidative Stress

(2008) Kenneth Maiese et al.   CURRENT NEUROVASCULAR RESEARCH

Raves and risks for erythropoietin

(2008) Kenneth Maiese et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

Neuroprotective Effects of Resveratrol on MPTP-Induced Neuron Loss Mediated by Free Radical Scavenging

(2008) Kwok-Tung Lu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Life Span Extension and Neuronal Cell Protection byDrosophilaNicotinamidase

(2008) Vitaly Balan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Inhibits Cardiac Hypertrophy via AMP-activated Protein Kinase and Akt

(2008) Anita Y. M. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

(2008) Carl Julien et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A “FOXO” in sight: Targeting Foxo proteins from conception to cancer

(2008) Kenneth Maiese et al.   MEDICINAL RESEARCH REVIEWS

SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes

(2008) T. Yoshizaki et al.   MOLECULAR AND CELLULAR BIOLOGY

DBC1 is a negative regulator of SIRT1

(2008) Ja-Eun Kim et al.   NATURE

Erythropoietin: Elucidating new cellular targets that broaden therapeutic strategies

(2008) Kenneth Maiese et al.   PROGRESS IN NEUROBIOLOGY

OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins

(2008) Kenneth Maiese et al.   TRENDS IN MOLECULAR MEDICINE

Resveratrol Reverses Hydrogen Peroxide-induced Proliferative Effects in Human Coronary Smooth Muscle Cells: A Novel Signaling Mechanism

(2007) Abdalla M. El-Mowafy et al.   ARCHIVES OF MEDICAL RESEARCH

Exercise Training Promotes SIRT1 Activity in Aged Rats

(2007) Nicola Ferrara et al.   REJUVENATION RESEARCH