CD44: a validated target for improved delivery of cancer therapeutics

CD44-Targeting for Antitumor Drug Delivery: A New SN-38-Hyaluronan Bioconjugate for Locoregional Treatment of Peritoneal Carcinomatosis

(2012) A. Serafino et al.   CURRENT CANCER DRUG TARGETS

Biological and clinical relevance of stem cells in pancreatic adenocarcinoma

(2012) Zeshaan A Rasheed et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

CD44 in hematological neoplasias

(2011) Magdalena Katharina Hertweck et al.   ANNALS OF HEMATOLOGY

Polymer Shelled Microparticles for a Targeted Doxorubicin Delivery in Cancer Therapy

(2011) Barbara Cerroni et al.   BIOMACROMOLECULES

Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic® for tumor-targeted delivery of docetaxel

(2011) Hyun-Jong Cho et al.   BIOMATERIALS

Hyaluronan-grafted particle clusters loaded with Mitomycin C as selective nanovectors for primary head and neck cancers

(2011) Gideon Bachar et al.   BIOMATERIALS

The eradication of breast cancer and cancer stem cells using octreotide modified paclitaxel active targeting micelles and salinomycin passive targeting micelles

(2011) Yang Zhang et al.   BIOMATERIALS

Targeting Hyaluronidase for Cancer Therapy: Antitumor Activity of Sulfated Hyaluronic Acid in Prostate Cancer Cells

(2011) A. Benitez et al.   CANCER RESEARCH

Salinomycin - A New Cancer Drug Candidate

(2011) Adam Huczynski   Chemical Biology & Drug Design

Self-assembled nanoparticles of hyaluronic acid/poly(dl-lactide-co-glycolide) block copolymer

(2011) Young-Il Jeong et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Characterization of CD44-Mediated Cancer Cell Uptake and Intracellular Distribution of Hyaluronan-Grafted Liposomes

(2011) Hussaini Syed Sha Qhattal et al.   MOLECULAR PHARMACEUTICS

The in vivo behavior and antitumor activity of doxorubicin-loaded poly(γ-benzyl l-glutamate)-block-hyaluronan polymersomes in Ehrlich ascites tumor-bearing BalB/c mice

(2011) Kamal Kumar Upadhyay et al.   Nanomedicine-Nanotechnology Biology and Medicine

Combinatorial Selection of DNA Thioaptamers Targeted to the HA Binding Domain of Human CD44

(2010) Anoma Somasunderam et al.   BIOCHEMISTRY

Paclitaxel-clusters coated with hyaluronan as selective tumor-targeted nanovectors

(2010) Ilia Rivkin et al.   BIOMATERIALS

The intracellular drug delivery and anti tumor activity of doxorubicin loaded poly(γ-benzyl l-glutamate)-b-hyaluronan polymersomes

(2010) Kamal K. Upadhyay et al.   BIOMATERIALS

Hyaluronic acid–paclitaxel: effects of intraperitoneal administration against CD44(+) human ovarian cancer xenografts

(2010) Ilaria De Stefano et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Generation of a stable anti-human CD44v6 scFv and analysis of its cancer-targeting ability in vitro

(2010) Yinting Chen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CD44, a therapeutic target for metastasising tumours

(2010) Véronique Orian-Rousseau   EUROPEAN JOURNAL OF CANCER

Cancer cell specific targeting of nanogels from acetylated hyaluronic acid with low molecular weight

(2010) Wooram Park et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Nanostructured hyaluronic acid-based materials for active delivery to cancer

(2010) Dmitri A Ossipov   Expert Opinion on Drug Delivery

Hydrotropic hyaluronic acid conjugates: Synthesis, characterization, and implications as a carrier of paclitaxel

(2010) Gurusamy Saravanakumar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Monoclonal antibody therapy directed against human acute myeloid leukemia stem cells

(2010) R Majeti   ONCOGENE

Biomimetic Doxorubicin Loaded Polymersomes from Hyaluronan-block-Poly(γ-benzyl glutamate) Copolymers

(2009) K. Kumar Upadhyay et al.   BIOMACROMOLECULES

Self-assembled hyaluronic acid nanoparticles for active tumor targeting

(2009) Ki Young Choi et al.   BIOMATERIALS

CD44 targeting reduces tumour growth and prevents post-chemotherapy relapse of human breast cancers xenografts

(2009) E Marangoni et al.   BRITISH JOURNAL OF CANCER

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities

(2009) B. P. Toole   CLINICAL CANCER RESEARCH

Efficient Tumor Targeting by Polysaccharide Decked Polyethylenimine Based Nanocomposites

(2009) Atul Pathak et al.   Journal of Biomedical Nanotechnology

Combined treatment of human MCF-7 breast carcinoma with antibody, cationic lipid and hyaluronic acid using ex vivo assays

(2009) Dorota Bartusik et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

In Situ Cross-Linkable High Molecular Weight Hyaluronan−Bisphosphonate Conjugate for Localized Delivery and Cell-Specific Targeting: A Hydrogel Linked Prodrug Approach

(2009) Oommen P. Varghese et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipoplexes Targeting the CD44 Hyaluronic Acid Receptor for Efficient Transfection of Breast Cancer Cells

(2009) Claudio Surace et al.   MOLECULAR PHARMACEUTICS

CD44-Targeted Microparticles for Delivery of Cisplatin to Peritoneal Metastases

(2009) Shyh-Dar Li et al.   MOLECULAR PHARMACEUTICS

Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer

(2009) Anekant Jain et al.   Nanomedicine-Nanotechnology Biology and Medicine

Biodistribution imaging of a paclitaxel-hyaluronan bioconjugate

(2009) Alessandra Banzato et al.   NUCLEAR MEDICINE AND BIOLOGY

The Use of Amino Acid Linkers in the Conjugation of Paclitaxel with Hyaluronic Acid as Drug Delivery System: Synthesis, Self-Assembled Property, Drug Release, and In Vitro Efficiency

(2009) Dingcheng Xin et al.   PHARMACEUTICAL RESEARCH

Hyaluronic Acid−Paclitaxel Conjugate Micelles: Synthesis, Characterization, and Antitumor Activity

(2008) Hyukjin Lee et al.   BIOCONJUGATE CHEMISTRY

A Pilot Human Evaluation of a Formulation of Irinotecan and Hyaluronic Acid in 5-Fluorouracil-Refractory Metastatic Colorectal Cancer Patients

(2008) Peter Gibbs et al.   CHEMOTHERAPY

Targeting Hyaluronan Interactions in Malignant Gliomas and Their Drug-Resistant Multipotent Progenitors

(2008) A. G. Gilg et al.   CLINICAL CANCER RESEARCH

A Paclitaxel-Hyaluronan Bioconjugate Targeting Ovarian Cancer Affords a Potent In vivo Therapeutic Activity

(2008) A. Banzato et al.   CLINICAL CANCER RESEARCH

The Development of Hyaluronan as a Drug Transporter and Excipient for Chemotherapeutic Drugs

(2008) Tracey Brown   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

In vitro and cell uptake studies for targeting of ligand anchored nanoparticles for colon tumors

(2008) Anekant Jain et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Targeting Hyaluronan Interactions in Spinal Cord Astrocytomas and Diffuse Pontine Gliomas

(2008) Bernard L. Maria et al.   JOURNAL OF CHILD NEUROLOGY

An insight on hyaluronic acid in drug targeting and drug delivery

(2008) Awesh K. Yadav et al.   JOURNAL OF DRUG TARGETING

Preparation and characterization of HA–PEG–PCL intelligent core–corona nanoparticles for delivery of doxorubicin

(2008) Awesh Kumar Yadav et al.   JOURNAL OF DRUG TARGETING

Targeting the leukemic stem cell: the Holy Grail of leukemia therapy

(2008) N Misaghian et al.   LEUKEMIA

Novel Types of Carborane-Carrier Hyaluronan Derivatives via “Click Chemistry”

(2008) Chiara Di Meo et al.   MACROMOLECULAR BIOSCIENCE

Anticancer Therapeutics: Targeting Macromolecules and Nanocarriers to Hyaluronan or CD44, a Hyaluronan Receptor

(2008) Virginia M. Platt et al.   MOLECULAR PHARMACEUTICS

RNA Aptamer Blockade of Osteopontin Inhibits Growth and Metastasis of MDA-MB231 Breast Cancer Cells

(2008) Zhiyong Mi et al.   MOLECULAR THERAPY

Design, Synthesis and Applications of Hyaluronic Acid-Paclitaxel Bioconjugates†

(2008) Francesca Leonelli et al.   MOLECULES

Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma

(2008) Herbert Riechelmann et al.   ORAL ONCOLOGY

Targeting CD44v6 Expressed in Head and Neck Squamous Cell Carcinoma: Preclinical Characterization of an 111In-Labeled Monoclonal Antibody

(2008) Karl Sandström et al.   TUMOR BIOLOGY