Targeting NR4A1 (TR3) in cancer cells and tumors

Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth

(2010) S.-O. Lee et al.   CANCER RESEARCH

A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro

(2010) Jing-jing Liu et al.   CANCER RESEARCH

Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours

(2010) N. Azoitei et al.   GUT

Inhibition of NFκB and Pancreatic Cancer Cell and Tumor Growth by Curcumin Is Dependent on Specificity Protein Down-regulation

(2010) Indira Jutooru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease

(2010) Michael A. Pearen et al.   MOLECULAR ENDOCRINOLOGY

Induction and intracellular localization of Nur77 dictate fenretinide-induced apoptosis of human liver cancer cells

(2009) Hui Yang et al.   BIOCHEMICAL PHARMACOLOGY

Peroxisome proliferator-activated receptor γ-dependent activity of indole ring-substituted 1,1-bis(3′-indolyl)-1-(p-biphenyl)methanes in cancer cells

(2009) Jingjing Guo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Paclitaxel Directly Binds to Bcl-2 and Functionally Mimics Activity of Nur77

(2009) C. Ferlini et al.   CANCER RESEARCH

Enhancement of Docetaxel Anticancer Activity by a Novel Diindolylmethane Compound in Human Non-Small Cell Lung Cancer

(2009) N. Ichite et al.   CLINICAL CANCER RESEARCH

Chromodomain helicase/adenosine triphosphatase DNA binding protein 1-like (CHD1l) gene suppresses the nucleus-to-mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survival

(2009) Leilei Chen et al.   HEPATOLOGY

Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells

(2009) Rebecca A. Stein et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

p21 Expression Is Induced by Activation of Nuclear Nerve Growth Factor-Induced B  (Nur77) in Pancreatic Cancer Cells

(2009) S.-O. Lee et al.   MOLECULAR CANCER RESEARCH

Estrogen-related receptor-  antagonist inhibits both estrogen receptor-positive and estrogen receptor-negative breast tumor growth in mouse xenografts

(2009) M. J. Chisamore et al.   MOLECULAR CANCER THERAPEUTICS

Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas

(2009) Neil J. McKenna et al.   MOLECULAR ENDOCRINOLOGY

Activation of Nerve Growth Factor-Induced B  by Methylene-Substituted Diindolylmethanes in Bladder Cancer Cells Induces Apoptosis and Inhibits Tumor Growth

(2009) S. Dae Cho et al.   MOLECULAR PHARMACOLOGY

A Short Nur77-Derived Peptide Converts Bcl-2 from a Protector to a Killer

(2008) Siva Kumar Kolluri et al.   CANCER CELL

Cancer chemotherapy with indole-3-carbinol, bis(3′-indolyl)methane and synthetic analogs

(2008) Stephen Safe et al.   CANCER LETTERS

Modulation of Orphan Nuclear Receptor Nur77-Mediated Apoptotic Pathway by Acetylshikonin and Analogues

(2008) Jie Liu et al.   CANCER RESEARCH

Estrogen-Related Receptor α Is Critical for the Growth of Estrogen Receptor–Negative Breast Cancer

(2008) Rebecca A. Stein et al.   CANCER RESEARCH

Curcumin Decreases Specificity Protein Expression in Bladder Cancer Cells

(2008) G. Chadalapaka et al.   CANCER RESEARCH

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase

(2008) P. Lei et al.   CARCINOGENESIS

Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria

(2008) H.-Z. Chen et al.   CARCINOGENESIS

Structure-dependent activation of endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer by 1,1-bis(3′-indoly)-1-(p-substituted phenyl)methanes

(2008) Ping Lei et al.   MOLECULAR CANCER THERAPEUTICS

The Induction of Orphan Nuclear Receptor Nur77 Expression by n-Butylenephthalide as Pharmaceuticals on Hepatocellular Carcinoma Cell Therapy

(2008) Y.-L. Chen et al.   MOLECULAR PHARMACOLOGY

Cytosporone B is an agonist for nuclear orphan receptor Nur77

(2008) Yanyan Zhan et al.   Nature Chemical Biology

1,1-bis(3′-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells

(2007) Sung Dae Cho et al.   MOLECULAR CARCINOGENESIS