Utilization of the cellular stress response to sensitize cancer cells to TRAIL-mediated apoptosis

TRAP1 regulation of mitochondrial life or death decision in cancer cells and mitochondria-targeted TRAP1 inhibitors

(2012) Byoung-Heon Kang   BMB Reports

PPARγ agonists enhance ET-743–induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcoma

(2012) Elizabeth Charytonowicz et al.   JOURNAL OF CLINICAL INVESTIGATION

Chop (Ddit3) Is Essential for D469del-COMP Retention and Cell Death in Chondrocytes in an Inducible Transgenic Mouse Model of Pseudoachondroplasia

(2011) Karen L. Posey et al.   AMERICAN JOURNAL OF PATHOLOGY

ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2

(2011) Rosa Martín-Pérez et al.   APOPTOSIS

Sorafenib induces apoptotic cell death in human non-small cell lung cancer cells by down-regulating mammalian target of rapamycin (mTOR)-dependent survivin expression

(2011) Young-Sun Kim et al.   BIOCHEMICAL PHARMACOLOGY

Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5: Involvement of ROS-dependent ER-stress

(2011) Dong-Oh Moon et al.   BIOCHEMICAL PHARMACOLOGY

5, 7-Dimethoxyflavone sensitizes TRAIL-induced apoptosis through DR5 upregulation in hepatocellular carcinoma cells

(2011) Jian-Feng Yang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models

(2011) Thomas C. Chen et al.   CANCER LETTERS

Modulation of CCAAT/Enhancer Binding Protein Homologous Protein (CHOP)-dependent DR5 Expression by Nelfinavir Sensitizes Glioblastoma Multiforme Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)

(2011) Xiaobing Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells

(2011) Markus D. Siegelin et al.   JOURNAL OF CLINICAL INVESTIGATION

Endoplasmic reticulum stress inducers, but not imatinib, sensitize Philadelphia chromosome-positive leukemia cells to TRAIL-mediated apoptosis

(2011) Xiaochun Zhang et al.   LEUKEMIA RESEARCH

BRCA1 Loss Induces GADD153-Mediated Doxorubicin Resistance in Prostate Cancer

(2011) P. De Luca et al.   MOLECULAR CANCER RESEARCH

Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation

(2011) In Young Kim et al.   NEURO-ONCOLOGY

Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling

(2010) Sook Kyung Park et al.   BREAST CANCER RESEARCH AND TREATMENT

Heat Shock Protein 60 Regulation of the Mitochondrial Permeability Transition Pore in Tumor Cells

(2010) J. C. Ghosh et al.   CANCER RESEARCH

ROS and CHOP Are Critical for Dibenzylideneacetone to Sensitize Tumor Cells to TRAIL through Induction of Death Receptors and Downregulation of Cell Survival Proteins

(2010) Sahdeo Prasad et al.   CANCER RESEARCH

Novel combination of Celecoxib and proteasome inhibitor MG132 provides synergistic antiproliferative and proapoptotic effects in human liver tumor cells

(2010) Antonella Cusimano et al.   CELL CYCLE

Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways

(2010) L Zhang et al.   CELL DEATH AND DIFFERENTIATION

Histone Deacetylase Inhibitors and 15-Deoxy- 12,14-Prostaglandin J2 Synergistically Induce Apoptosis

(2010) M. Koyama et al.   CLINICAL CANCER RESEARCH

A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease

(2010) C. T. Chu   HUMAN MOLECULAR GENETICS

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer

(2010) Ssu-Ming Huang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Molecular Symbiosis of CHOP and C/EBP  Isoform LIP Contributes to Endoplasmic Reticulum Stress-Induced Apoptosis

(2010) C.-B. Chiribau et al.   MOLECULAR AND CELLULAR BIOLOGY

Global Targeting of Subcellular Heat Shock Protein-90 Networks for Therapy of Glioblastoma

(2010) M. D. Siegelin et al.   MOLECULAR CANCER THERAPEUTICS

Treatment with Panobinostat Induces Glucose-Regulated Protein 78 Acetylation and Endoplasmic Reticulum Stress in Breast Cancer Cells

(2010) Rekha Rao et al.   MOLECULAR CANCER THERAPEUTICS

The Matrix Peptide Exporter HAF-1 Signals a Mitochondrial UPR by Activating the Transcription Factor ZC376.7 in C. elegans

(2010) Cole M. Haynes et al.   MOLECULAR CELL

Role of Endoplasmic Reticulum Stress in α-TEA Mediated TRAIL/DR5 Death Receptor Dependent Apoptosis

(2010) Richa Tiwary et al.   PLoS One

Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents

(2010) M. Namdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells

(2009) Eleonora Costantino et al.   CANCER LETTERS

A Ruthenium-Containing Organometallic Compound Reduces Tumor Growth through Induction of the Endoplasmic Reticulum Stress Gene CHOP

(2009) Xiangjun Meng et al.   CANCER RESEARCH

The Tumor Suppressor Par-4 Activates an Extrinsic Pathway for Apoptosis

(2009) Ravshan Burikhanov et al.   CELL

Epigenetic Silencing of Death Receptor 4 Mediates Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance in Gliomas

(2009) A. Elias et al.   CLINICAL CANCER RESEARCH

Molecular mechanisms of the LPS-induced non-apoptotic ER stress-CHOP pathway

(2009) Y. Nakayama et al.   JOURNAL OF BIOCHEMISTRY

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

(2009) Byoung Heon Kang et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppression of NF- B by Cyclosporin A and Tacrolimus (FK506) via Induction of the C/EBP Family: Implication for Unfolded Protein Response

(2009) S. Du et al.   JOURNAL OF IMMUNOLOGY

Aggravated Endoplasmic Reticulum Stress as a Basis for Enhanced Glioblastoma Cell Killing by Bortezomib in Combination with Celecoxib or Its Non-Coxib Analogue, 2,5-Dimethyl-Celecoxib

(2008) A. Kardosh et al.   CANCER RESEARCH

Coupling of Endoplasmic Reticulum Stress to CDDO-Me-Induced Up-regulation of Death Receptor 5 via a CHOP-Dependent Mechanism Involving JNK Activation

(2008) W. Zou et al.   CANCER RESEARCH

Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response

(2008) N Moisoi et al.   CELL DEATH AND DIFFERENTIATION

Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis

(2008) Holger Hetschko et al.   FEBS Journal

To kill a tumor cell: the potential of proapoptotic receptor agonists

(2008) Avi Ashkenazi et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteasome inhibitor PS-341 (VELCADE) induces stabilization of the TRAIL receptor DR5 mRNA through the 3'-untranslated region

(2008) K. Kandasamy et al.   MOLECULAR CANCER THERAPEUTICS

Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

(2008) Avi Ashkenazi   NATURE REVIEWS DRUG DISCOVERY

Quercetin promotes degradation of survivin and thereby enhances death-receptor–mediated apoptosis in glioma cells

(2008) Markus D. Siegelin et al.   NEURO-ONCOLOGY