Article
Biochemistry & Molecular Biology
Fotian Xie, Yuanming Zhong, Dongmei Wang, Kwok Fai So, Jia Xiao, Yi Lv
Summary: This study found that metformin can protect against lipid formation in ALD by activating the LKB1/AMPK/ACC axis. This research is important for understanding the lipid metabolism mechanisms in ALD and developing therapeutic strategies for ALD.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Pharmacology & Pharmacy
Xuewen Wang, Ziwei Liang, Hong Xiang, Yanqiu Li, Shuhua Chen, Hongwei Lu
Summary: LKB1 plays a crucial role in regulating macrophage functions in atherosclerosis, including influencing lipid metabolism, inflammation, endoplasmic reticulum stress, and autophagy. Decreased expression of LKB1 exacerbates vascular injury and foam cell formation in atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Mohammed Bourouh, Paola A. Marignani
Summary: Liver kinase B1 (LKB1) is a crucial tumor suppressor kinase that plays a role in various malignancies. It inhibits the growth and division of cancer cells by regulating metabolic pathways. Loss of LKB1 leads to metabolic reprogramming and promotes malignant growth of cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Ali Molaei, Emad Molaei, Hamidreza Sadeghnia, Wallace Hayes, Gholamreza Karimi
Summary: Cardiovascular diseases are the leading cause of morbidity and mortality worldwide, and liver kinase B1 (LKB1) plays a crucial role in the heart. LKB1 activity is associated with improved cardiac function and cardioprotective effects. Activation of the LKB1 signaling pathway offers potential for the prevention and treatment of heart diseases.
Article
Pharmacology & Pharmacy
Khoa Nguyen, Katherine Hebert, Emily McConnell, Nicole Cullen, Thomas Cheng, Susanna Awoyode, Elizabeth Martin, Weina Chen, Tong Wu, Suresh K. Alahari, Reza Izadpanah, Bridgette M. Collins-Burow, Sean B. Lee, David H. Drewry, Matthew E. Burow
Summary: The liver is an important organ involved in biological functions such as digestion, nutrient storage, and detoxification. It plays an active role in regulating metabolism and is susceptible to hepatocellular carcinoma, which is often associated with chronic inflammation. LKB1 signaling has been found to regulate cellular metabolism and has a tumor suppressive role in many cancers. Using the KMPlotter database, this review correlates RNA levels of LKB1 signaling genes with hepatocellular carcinoma patient survival outcomes and identifies potential biomarkers for clinical use.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jun H. Heo, Sang R. Lee, Seong Lae Jo, Je-Won Ko, Hyo-Jung Kwon, Eui-Ju Hong
Summary: The incidence of non-alcoholic fatty liver disease (NAFLD) increases in males aged >45 years, which indicates that androgens are associated with the development and/or progression of NAFLD, although excess dietary intake is the primary causative factor. Our study demonstrates that testosterone can influence the development of NAFLD by increasing the expression of AMP-activated protein kinase (AMPK) and LKB1 and modulating the AMPK-ACC signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Shuang Qu, Qiao Liao, Cheng Yu, Yue Chen, Hao Luo, Xuewei Xia, Duofen He, Zaicheng Xu, Pedro A. Jose, Zhuxin Li, Wei Eric Wang, Qing Rex Lyu, Chunyu Zeng
Summary: The regenerative potential of cardiomyocytes in adult mammals is limited. This study discovered that liver kinase B1 (LKB1) negatively regulates cardiomyocyte proliferation and identified Yes-associated protein (YAP) as its downstream effector. Moreover, AMPK plays a crucial role in the LKB1-mediated regulation of cardiomyocyte proliferation. These findings suggest the involvement of the LKB1-AMPK-YAP axis in cardiomyocyte proliferation and its potential as a target for cardiac regeneration.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Review
Medicine, Research & Experimental
Guangli Lu, Zhen Wu, Jia Shang, Zhenxing Xie, Chaoran Chen, Chuning Zhang
Summary: Metformin is the first-line option for treating diabetic patients and has various pharmacological actions, including antitumor, anti-aging, and ovarian protection effects. Recent research has shown that autophagy is a crucial mechanism through which metformin exerts its pharmacological actions, although the effects on autophagy remain inconsistent.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Cell Biology
Edward J. Calabrese, Evgenios Agathokleous, Rachna Kapoor, Gaurav Dhawan, Walter J. Kozumbo, Vittorio Calabrese
Summary: Metformin induced hormetic biphasic dose responses across multiple organ systems and cell types, enhancing resilience to chemical stresses through an anti-inflammatory molecular network, thereby delaying the onset and progression of neurodegenerative and chronic diseases.
AGEING RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Jan Pencik, Cecile Philippe, Michaela Schlederer, Emine Atas, Matteo Pecoraro, Sandra Grund-Groeschke, Wen (Jess) Li, Amanda Tracz, Isabel Heidegger, Sabine Lagger, Karolina Trachtova, Monika Oberhuber, Ellen Heitzer, Osman Aksoy, Heidi A. Neubauer, Bettina Wingelhofer, Anna Orlova, Nadine Witzeneder, Thomas Dillinger, Elisa Redl, Georg Greiner, David D'Andrea, Johnny R. Ostman, Simone Tangermann, Ivana Hermanova, Georg Schaefer, Felix Sternberg, Elena E. Pohl, Christina Sternberg, Adam Varady, Jaqueline Horvath, Dagmar Stoiber, Tim I. Malcolm, Suzanne D. Turner, Eileen E. Parkes, Brigitte Hantusch, Gerda Egger, Stefan Rose-John, Valeria Poli, Suneil Jain, Chris W. D. Armstrong, Gregor Hoermann, Vincent Goffin, Fritz Aberger, Richard Moriggl, Arkaitz Carracedo, Cathal McKinney, Richard D. Kennedy, Helmut Klocker, Michael R. Speicher, Dean G. Tang, Ali A. Moazzami, David M. Heery, Marcus Hacker, Lukas Kenner
Summary: PTEN and STAT3 are frequently co-deleted genes in metastatic prostate cancer (mPCa). STAT3 controls mPCa through the LKB1/pAMPK/mTORC1/CREB signaling pathway, and metformin can inhibit mPCa growth.
Review
Chemistry, Medicinal
Navid Omidkhoda, Sina Mahdiani, A. Wallace Hayes, Gholamreza Karimi
Summary: This article summarizes in vitro and in vivo studies on the effect of natural bioactive compounds on NAFLD through the LKB1/AMPK signaling pathway, providing clues for finding new therapeutic agents for NAFLD management.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Tian Xia, Di Chen, Xiaolong Liu, Huan Qi, Wen Wang, Huan Chen, Ting Ling, Wuxiyar Otkur, Chen-Song Zhang, Jongchan Kim, Sheng-Cai Lin, Hai-long Piao
Summary: In this study, it was found that intracellular MDK interacts with LKB1 and STRAD, leading to the disruption of the LKB1-STRAD-Mo25 complex. As a result, the activity of LKB1 is decreased, dampening the activation of AMPK. Additionally, MDK expression is significantly upregulated in liver, kidney, and breast cancers, and is inversely correlated with phosphorylated AMPK levels.
CELL DEATH & DISEASE
(2022)
Article
Pharmacology & Pharmacy
Xiahenazi Aiyasiding, Hai-Han Liao, Hong Feng, Nan Zhang, Zheng Lin, Wen Ding, Han Yan, Zi-Ying Zhou, Qi-Zhu Tang
Summary: This study revealed that LQ alleviates pressure overload-induced cardiac hypertrophy in vivo and inhibits Ang II-induced cardiomyocyte hypertrophy in vitro via activating cAMP/PKA/LKB1/AMPKα2 signaling. These findings suggest that LQ might be a valuable adjunct to therapeutic approaches for treating pathological cardiac remodeling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Qing-Bo Lu, Yi Ding, Yao Liu, Zi-Chao Wang, Yu-Jie Wu, Kai -Ming Niu, Ke-Xue Li, Ji -Ru Zhang, Hai-Jian Sun
Summary: Metrnl plays a protective role in diabetic cardiomyopathy and may serve as a therapeutic target or regimen.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Plant Sciences
Yong Zhang, Ruiqi Wang, Yanan Yang, Ning Ma, Zhi Zhou, Yinfeng Tan, Lin Dong, Yiying Li, Weiying Lu, Chongming Wu, Xiaopo Zhang
Summary: This study found that laurolitsine (LL) has potent antidiabetic effects in vitro and in vivo, improving insulin resistance, glucose metabolism, and promoting weight loss. Its mechanisms of actions involve the regulation of the hepatic LKB1/AMPK pathway and gut microbiota.
Review
Biochemistry & Molecular Biology
Joanna Dulinska-Litewka, Przemyslaw Halubiec, Agnieszka Lazarczyk, Oskar Szafranski, Yoav Sharoni, James A. McCubrey, Bartosz Gasiorkiewicz, Torsten Bohn
Summary: Research on carotenoids has focused on the human prostate, involving cell signaling, growth, and differentiation in prostate tissue. The current review aims to emphasize the potential of carotenoids for preventing and treating prostatic diseases, summarizing findings from the past decade.
Review
Oncology
Alberto M. Martelli, Camilla Evangelisti, Francesca Paganelli, Francesca Chiarini, James A. McCubrey
Summary: GSK-3 consists of two isoforms, alpha and beta, that are constitutively active but can be inactivated through phosphorylation by upstream kinases. It was initially considered a tumor suppressor, but it has also been found to have oncogenic properties in promoting pathways critical for cancer cell proliferation, survival, and drug-resistance.
Review
Biochemistry & Molecular Biology
Joanna Dulinska-Litewka, Yoav Sharoni, Przemyslaw Halubiec, Agnieszka Lazarczyk, Oskar Szafranski, James A. McCubrey, Bartosz Gasiorkiewicz, Piotr Laidler, Torsten Bohn
Summary: Carotenoids, including lycopene and beta-carotene, play important roles in intra- and intercellular signaling, cell growth, and differentiation of prostate tissue. This review summarizes research on the role of carotenoids in prostate physiology and pathology over the past decade.
Review
Oncology
Stefano Ratti, Camilla Evangelisti, Sara Mongiorgi, Alessia De Stefano, Antonietta Fazio, Francesca Bonomini, Matilde Y. Follo, Irene Faenza, Lucia Manzoli, Bhavwanti Sheth, Magdalena C. Vidalle, Scott T. Kimber, Nullin Divecha, Lucio Cocco, Roberta Fiume
Summary: PPIns and their modulating enzymes play critical roles in regulating key cellular functions, with enzymes having distinct subcellular organelle profiles and regulation in the nucleus. AML is characterized by dysregulation of epigenetic signaling, and targeting PPIns pathways may lead to new combination therapies. Inhibiting different parts of PPIns signaling unit could control selective outputs for more specific and less toxic outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Camilla Evangelisti, Isabella Rusciano, Sara Mongiorgi, Giulia Ramazzotti, Giovanna Lattanzi, Lucia Manzoli, Lucio Cocco, Stefano Ratti
Summary: B-type lamins are essential components of the nuclear lamina and play key roles in nuclear functions, cellular processes, and organogenesis. Mutations or fluctuations in their expression levels are critical for the onset of various diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Stefano Ratti, Isabella Rusciano, Sara Mongiorgi, Irene Neri, Alessandra Cappellini, Pietro Cortelli, Pann-Ghill Suh, James A. McCubrey, Lucia Manzoli, Lucio Cocco, Giulia Ramazzotti
Summary: The overexpression of Lamin B1 in ADLD astrocytes affects cell survival signaling pathways, reduces astrocyte survival, and disrupts cell proliferation and cycle progression, leading to apoptosis. Additionally, it triggers a tentative activation of survival pathways that are ineffective.
Article
Biochemistry & Molecular Biology
James Andrew McCubrey, Stephen L. Abrams, Linda S. Steelman, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Paolo Lombardi, Agnieszka Gizak, Przemyslaw Duda
Summary: The study indicates that TP53 reactivator APR-246 can increase the therapeutic potential of many modified berberine compounds, which is of significance for pancreatic ductal adenocarcinoma.
Article
Cell Biology
Francesca Chiarini, Francesca Paganelli, Tommaso Balestra, Cristina Capanni, Antonietta Fazio, Maria Cristina Manara, Lorena Landuzzi, Stefania Petrini, Camilla Evangelisti, Pier-Luigi Lollini, Alberto M. Martelli, Giovanna Lattanzi, Katia Scotlandi
Summary: Lamin A plays a significant role in Ewing Sarcoma by affecting cell migration and invasiveness. Low expression of Lamin A is associated with increased aggressiveness and metastatic load in patients. This effect is linked to altered nuclear envelope proteins and increased nuclear retention of YAP/TAZ. Overexpression of Lamin A or pharmacological modulation of its maturation can prevent cell invasiveness and improve therapeutic strategies for Ewing Sarcoma.
CELL DEATH & DISEASE
(2022)
Review
Cell Biology
Alberto M. Martelli, Francesca Paganelli, Camilla Evangelisti, Francesca Chiarini, James A. McCubrey
Summary: GSK-3 is a multifunctional protein kinase involved in various physiological processes and plays a crucial role in cancer cell pathobiology. While often inactivated in cancer cells, GSK-3 isoforms can also act as tumor promoters in certain contexts.
Article
Cell Biology
Stephen L. Abrams, Przemyslaw Duda, Shaw M. Akula, Linda S. Steelman, Matilde L. Follo, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Giuseppe Montalto, Maria Rita Emma, Melchiorre Cervello, Dariusz Rakus, Agnieszka Gizak, James A. McCubrey
Summary: TP53 mutation is common in pancreatic cancer and promotes tumor growth and metastasis. APR-246, a molecule that restores wildtype TP53 function, can increase the sensitivity of PDAC cells to chemotherapy. Introduction of WT-TP53 enhances sensitivity to TP53 reactivators, chemotherapeutic drugs, and signal transduction inhibitors in PDAC cells.
Article
Chemistry, Medicinal
Manuela Labbozzetta, Paola Poma, Marco Tutone, James A. McCubrey, Maurizio Sajeva, Monica Notarbartolo
Summary: Drug resistance in cancer therapy is a major problem, involving multiple factors. This study found that the compounds phytol and heptacosane from Euphorbia intisy essential oil can improve P-gp-mediated drug transport and reverse drug resistance in tumor cells.
Review
Cell Biology
James A. McCubrey, Li Yang, Stephen L. Abrams, Linda S. Steelman, Matilde Y. Follo, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Giuseppa Augello, Melchiorre Cervello
Summary: This review discusses the roles of TP53 and miRs in the PDAC tumor microenvironment and how mutated TP53 and loss of miR expression contribute to tumor progression.
Review
Biochemistry & Molecular Biology
Alberto M. M. Martelli, Francesca Paganelli, Serena Truocchio, Carla Palumbo, Francesca Chiarini, James A. A. McCubrey
Summary: The Hedgehog (HH) signaling network is an important regulator of embryonic development. However, abnormal activation of HH signaling has been found in various malignant disorders, promoting proliferation, survival, and therapeutic resistance of neoplastic cells. In this review, the biological roles and pathophysiology of the HH pathway in normal T-cell lymphopoiesis and T-ALL are summarized, along with potential therapeutic strategies to target the HH pathway in T-ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Vittoria Marvi, Irene Neri, Camilla Evangelisti, Giulia Ramazzotti, Sofia Asioli, Matteo Zoli, Diego Mazzatenta, Niccolo Neri, Luca Morandi, Caterina Tonon, Raffaele Lodi, Enrico Franceschi, James A. McCubrey, Pann-Ghill Suh, Lucia Manzoli, Stefano Ratti
Summary: Phospholipases are crucial enzymes that hydrolyze phospholipids, the most abundant species in the biological membranes of healthy human brain cells. They generate lipid mediators that play essential roles in intra- and inter-cellular signaling, regulating various cellular mechanisms involved in tumor progression and aggressiveness.