Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia

Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease

(2012) Richard P. Davis et al.   CIRCULATION

Synaptic plasticity of NMDA receptors: mechanisms and functional implications

(2012) David L Hunt et al.   CURRENT OPINION IN NEUROBIOLOGY

The role of the α7 nicotinic receptor in cognitive processing of persons with schizophrenia

(2012) Christopher G. AhnAllen   CURRENT OPINION IN PSYCHIATRY

Recent Development of Radioligands for Imaging α7 Nicotinic Acetylcholine Receptors in the Brain

(2012) Jun Toyohara et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Nicotine-Induced Upregulation of Native Neuronal Nicotinic Receptors Is Caused by Multiple Mechanisms

(2012) A. P. Govind et al.   JOURNAL OF NEUROSCIENCE

Puzzling over schizophrenia: Schizophrenia, social environment and the brain

(2012) Heike Tost et al.   NATURE MEDICINE

Puzzling over schizophrenia: Schizophrenia as a pathway disease

(2012) Patrick F Sullivan   NATURE MEDICINE

Genetic architectures of psychiatric disorders: the emerging picture and its implications

(2012) Patrick F. Sullivan et al.   NATURE REVIEWS GENETICS

Reduced Chrna7 expression in mice is associated with decreases in hippocampal markers of inhibitory function: implications for neuropsychiatric diseases

(2012) C.E. Adams et al.   NEUROSCIENCE

NMDA receptors and metaplasticity: Mechanisms and possible roles in neuropsychiatric disorders

(2012) Charles F. Zorumski et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Molecular actions of smoking cessation drugs at  4 2 nicotinic receptors defined in crystal structures of a homologous binding protein

(2012) B. Billen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of RG3487 at the α7β2 nicotinic acetylcholine receptor expressed in Xenopus oocytes

(2011) Tanya L. Wallace et al.   BIOCHEMICAL PHARMACOLOGY

The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function

(2011) Tanguy Araud et al.   BIOCHEMICAL PHARMACOLOGY

Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease

(2011) Tanya L. Wallace et al.   BIOCHEMICAL PHARMACOLOGY

Effects of phenothiazine-class antipsychotics on the function of α7-nicotinic acetylcholine receptors

(2011) Abrar Ashoor et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

City living and urban upbringing affect neural social stress processing in humans

(2011) Florian Lederbogen et al.   NATURE

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

Timing-Dependent Septal Cholinergic Induction of Dynamic Hippocampal Synaptic Plasticity

(2011) Zhenglin Gu et al.   NEURON

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses

(2011) Julie M. Miwa et al.   NEURON

EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors

(2011) Jos Prickaerts et al.   NEUROPHARMACOLOGY

Alpha7 Nicotinic Acetylcholine Receptors Modulate Motivation to Self-Administer Nicotine: Implications for Smoking and Schizophrenia

(2011) Darlene H Brunzell et al.   NEUROPSYCHOPHARMACOLOGY

Differential Immediate and Sustained Memory Enhancing Effects of Alpha7 Nicotinic Receptor Agonists and Allosteric Modulators in Rats

(2011) Morten S. Thomsen et al.   PLoS One

High vs Low Frequency Neural Oscillations in Schizophrenia

(2011) L. V. Moran et al.   SCHIZOPHRENIA BULLETIN

Mutations in familial nocturnal frontal lobe epilepsy might be associated with distinct neurological phenotypes

(2011) Ortrud K. Steinlein et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and d-Tubocurarine by Different Cys-Loop Receptors

(2011) Marijke Brams et al.   PLOS BIOLOGY

Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity

(2011) Matthijs B. Verhoog et al.   NEURAL PLASTICITY

Associated proteins: The universal toolbox controlling ligand gated ion channel function

(2010) Tanguy Araud et al.   BIOCHEMICAL PHARMACOLOGY

Immediate and Sustained Improvements in Working Memory After Selective Stimulation of α7 Nicotinic Acetylcholine Receptors

(2010) Stacy A. Castner et al.   BIOLOGICAL PSYCHIATRY

Effects of an Alpha 7-Nicotinic Agonist on Default Network Activity in Schizophrenia

(2010) Jason R. Tregellas et al.   BIOLOGICAL PSYCHIATRY

Characterization of [3H]CHIBA-1001 binding to α7 nicotinic acetylcholine receptors in the brain from rat, monkey, and human

(2010) Yuko Tanibuchi et al.   BRAIN RESEARCH

Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of α7 nicotinic receptors and internalization of NMDA receptors

(2010) H Shen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Why do patients with schizophrenia smoke?

(2010) Georg Winterer   CURRENT OPINION IN PSYCHIATRY

Animal models for autosomal dominant frontal lobe epilepsy: on the origin of seizures

(2010) Ortrud K Steinlein   Expert Review of Neurotherapeutics

Function of Partially Duplicated Human α7 Nicotinic Receptor SubunitCHRFAM7AGene

(2010) Ana M. de Lucas-Cerrillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single- and Multiple-Dose Pharmacokinetics, Safety, and Tolerability of the Selective α7 Neuronal Nicotinic Receptor Agonist, ABT-107, in Healthy Human Volunteers

(2010) Ahmed A. Othman et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel α7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models

(2010) Christopher J. O’Donnell et al.   JOURNAL OF MEDICINAL CHEMISTRY

RG3487, a Novel Nicotinic  7 Receptor Partial Agonist, Improves Cognition and Sensorimotor Gating in Rodents

(2010) T. L. Wallace et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Schizophrenia: The drug deadlock

(2010) Alison Abbott   NATURE

Human memory strength is predicted by theta-frequency phase-locking of single neurons

(2010) Ueli Rutishauser et al.   NATURE

Kinetics of brain nicotine accumulation in dependent and nondependent smokers assessed with PET and cigarettes containing 11C-nicotine

(2010) J. E. Rose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lynx for Braking Plasticity

(2010) M. J. Higley et al.   SCIENCE

Lynx1, a Cholinergic Brake, Limits Plasticity in Adult Visual Cortex

(2010) H. Morishita et al.   SCIENCE

A randomised, double-blind, placebo-controlled trial of tropisetron in patients with schizophrenia

(2010) Akihiro Shiina et al.   Annals of General Psychiatry

Preclinical and the first clinical studies on [11C]CHIBA-1001 for mapping α7 nicotinic receptors by positron emission tomography

(2009) Jun Toyohara et al.   ANNALS OF NUCLEAR MEDICINE

A reversible model of the cognitive impairment associated with schizophrenia in monkeys: Potential therapeutic effects of two nicotinic acetylcholine receptor agonists

(2009) Jerry J. Buccafusco et al.   BIOCHEMICAL PHARMACOLOGY

Nicotine-induced upregulation of nicotinic receptors: Underlying mechanisms and relevance to nicotine addiction

(2009) Anitha P. Govind et al.   BIOCHEMICAL PHARMACOLOGY

Structural and functional diversity of native brain neuronal nicotinic receptors

(2009) Cecilia Gotti et al.   BIOCHEMICAL PHARMACOLOGY

[3H]Chlorpromazine Photolabeling of theTorpedoNicotinic Acetylcholine Receptor Identifies Two State-Dependent Binding Sites in the Ion Channel

(2009) David C. Chiara et al.   BIOCHEMISTRY

A 2-base pair deletion polymorphism in the partial duplication of the α7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia

(2009) Melissa L. Sinkus et al.   BRAIN RESEARCH

A Novel Nicotinic Acetylcholine Receptor Subtype in Basal Forebrain Cholinergic Neurons with High Sensitivity to Amyloid Peptides

(2009) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

To See or Not to See: Prestimulus   Phase Predicts Visual Awareness

(2009) K. E. Mathewson et al.   JOURNAL OF NEUROSCIENCE

Procognitive and Neuroprotective Activity of a Novel  7 Nicotinic Acetylcholine Receptor Agonist for Treatment of Neurodegenerative and Cognitive Disorders

(2009) R. Roncarati et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues

(2009) Pierre-Jean Corringer et al.   JOURNAL OF PHYSIOLOGY-LONDON

Atypical antipsychotics as noncompetitive inhibitors of α4β2 and α7 neuronal nicotinic receptors

(2009) Vladimir P. Grinevich et al.   NEUROPHARMACOLOGY

Nicotine induction of theta frequency oscillations in rodent hippocampus in vitro

(2009) C.B. Lu et al.   NEUROSCIENCE

Nicotinic receptor channelopathies and epilepsy

(2009) Ortrud K. Steinlein et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A cog in cognition: How the α7 nicotinic acetylcholine receptor is geared towards improving cognitive deficits

(2009) Steven C. Leiser et al.   PHARMACOLOGY & THERAPEUTICS

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

Nicotine self-medication of cognitive-attentional processing

(2008) David E. Evans et al.   ADDICTION BIOLOGY

Initial Phase 2 Trial of a Nicotinic Agonist in Schizophrenia

(2008) Robert Freedman et al.   AMERICAN JOURNAL OF PSYCHIATRY

Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics

(2008) Neal L. Benowitz   Annual Review of Pharmacology and Toxicology

Olanzapine improves deficient sensory inhibition in DBA/2 mice

(2008) Johanna K. Simosky et al.   BRAIN RESEARCH

Altered hippocampal circuit function in C3H α7 null mutant heterozygous mice

(2008) C.E. Adams et al.   BRAIN RESEARCH

Clinical Pharmacology of Nicotine: Implications for Understanding, Preventing, and Treating Tobacco Addiction

(2008) NL Benowitz   CLINICAL PHARMACOLOGY & THERAPEUTICS

Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties

(2008) Karin R. Tietje et al.   CNS Neuroscience & Therapeutics

Positive Allosteric Modulation of the  7 Nicotinic Acetylcholine Receptor: Ligand Interactions with Distinct Binding Sites and Evidence for a Prominent Role of the M2-M3 Segment

(2008) D. Bertrand et al.   MOLECULAR PHARMACOLOGY

Presynaptic  7- and  2-Containing Nicotinic Acetylcholine Receptors Modulate Excitatory Amino Acid Release from Rat Prefrontal Cortex Nerve Terminals via Distinct Cellular Mechanisms

(2008) J. A. Dickinson et al.   MOLECULAR PHARMACOLOGY

Rare chromosomal deletions and duplications increase risk of schizophrenia

(2008) Jennifer L. Stone et al.   NATURE

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

Large recurrent microdeletions associated with schizophrenia

(2008) Hreinn Stefansson et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

The selective nicotinic acetylcholine receptor α7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain

(2008) Dominik Feuerbach et al.   NEUROPHARMACOLOGY

[11C]CHIBA-1001 as a Novel PET Ligand for α7 Nicotinic Receptors in the Brain: A PET Study in Conscious Monkeys

(2008) Kenji Hashimoto et al.   PLoS One

The partial α7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus

(2007) Laura Lagostena et al.   NEUROPHARMACOLOGY