Article
Biochemistry & Molecular Biology
Jingwei Cai, Tianyi Chen, Zhiyu Jiang, Jiafei Yan, Zhengtao Ye, Yeling Ruan, Liye Tao, Zefeng Shen, Xiao Liang, Yifan Wang, Junjie Xu, Xiujun Cai
Summary: Studies have shown that matrix stiffness plays a role in the development of hepatocellular carcinoma (HCC). By analyzing the TCGA-LIHC database and GEO datasets, researchers identified three distinct metabolic subtypes in HCC with different prognoses and features. They found that long-chain acyl-CoA dehydrogenase (ACADL) is a mechanoreactive enzyme that regulates lipid metabolism in HCC cells in response to matrix stiffness. The study also revealed that the YAP/TEAD4 transcriptional complex regulates ACADL expression in HCC cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Oncology
Mehak Passi, Stefan Zahler
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide, with most cases being associated with chronic liver fibrosis which leads to increased liver tissue stiffness. Changes in tissue stiffness affect mechanical signaling pathways, modulating the progression of HCC-related genes. However, mechanical signaling pathways are still less emphasized in comparison to classical biochemical signaling pathways in our understanding of cancer.
Review
Biochemistry & Molecular Biology
Kuo-Shyang Jeng, I-Shyan Sheen, Shu-Sheng Lin, Chuen-Miin Leu, Chiung-Fang Chang
Summary: Endoglin (CD105) is a vital protein associated with angiogenesis in hepatocellular carcinoma (HCC), potentially serving as a diagnostic or prognostic factor. Combining TRC105, an antibody against endoglin, with sorafenib can achieve partial response. While antiangiogenic therapy carries risks, combination therapy with endoglin inhibitors or other targeted therapies shows promise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Cecilia Bergonzini, Kim Kroese, Annelien J. M. Zweemer, Erik H. J. Danen
Summary: Integrins play a crucial role in mediating adhesive interactions between cells and their environment, and their dysregulation is closely associated with cancer progression. Despite promising preclinical results, targeting integrin adhesion complexes in clinical trials for cancer therapy has not met expectations so far, possibly due to variable integrin expression, redundancy in integrin function, distinct roles at different disease stages, and sequestering by tumor-derived extracellular vesicles. However, improving therapeutic delivery at the tumor site through integrin binding ligands is emerging as a successful approach in enhancing the efficacy and safety of conventional therapeutics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chengfei Yang, Jiang Zhao, Chuanchuan Lin, Ye Gao, Jing Luo, Fan He, Zhenqiang Fang, Zhongjun Li, Qian Ran, Zhenxing Yang
Summary: This study revealed higher levels of succinylation in BPH compared to healthy prostate, and succinylated proteins influenced the activation of the extracellular matrix. Inhibition of integrin receptors significantly improved prostate hyperplasia.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell Biology
Olivia R. Grafinger, Genya Gorshtein, Tyler Stirling, Jennifer Geddes-McAlister, Marc G. Coppolino
Summary: Integrin signaling is crucial for the establishment of focal adhesions and invadopodia formation in malignant cancer cells, promoting tumor cell invasion and metastasis through localized adhesion and degradation of the ECM. Inhibition of 81 integrin hinders the internalization and recycling of MT1-MMP, ultimately leading to a loss of invasive behavior.
CELLULAR SIGNALLING
(2021)
Article
Chemistry, Analytical
Yao Wang, Jasmine Jin, Haoqing Jerry Wang, Lining Arnold Ju
Summary: Interactions between cancer cells and the extracellular matrix (ECM) in the tumor microenvironment are crucial for tumorigenesis, invasion, and metastasis. A novel acoustic force spectroscopy method using z-Movi((R)) technology was developed to quantify the cell-ECM adhesion strength in a fast, simple, and high-throughput manner. This platform enables functional assessment of cell adhesion molecules with high predictability and reproducibility.
Article
Oncology
Xin Liu, Yi Hu, Cairong Li, Jiayu Chen, Xiaohong Liu, Yang Shen, Yangtao Xu, Wenliang Chen, Ximing Xu
Summary: This study found that YEATS2 was upregulated in hepatocellular carcinoma (HCC) tissues and was associated with a poor prognosis. Overexpression of YEATS2 promoted tumor proliferation, migration, and invasion through the PI3K/AKT signaling pathway and extracellular matrix remodeling. These findings suggest that YEATS2 could be a potential therapeutic target for HCC.
Article
Oncology
Guixi Zheng, Hakim Bouamar, Matyas Cserhati, Carla R. Zeballos, Isha Mehta, Habil Zare, Larry Broome, Ruolei Hu, Zhao Lai, Yidong Chen, Francis E. Sharkey, Meenakshi Rani, Glenn A. Halff, Francisco G. Cigarroa, Lu-Zhe Sun
Summary: The study found that ITGA6 is upregulated in HCC tumors and has a malignant promoting role in HCC cells through integrin alpha 6 beta 4 complex. Thus, integrin alpha 6 beta 4 may be a therapeutic target for treating HCC patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Miao Li, Xi Zhang, Mimi Wang, Yaohui Wang, Jiali Qian, Xiaoxia Xing, Zhiming Wang, Yang You, Kun Guo, Jie Chen, Dongmei Gao, Yan Zhao, Lan Zhang, Rongxin Chen, Jiefeng Cui, Zhenggang Ren
Summary: Piezo1 and integrin beta 1 interact with each other in hepatocellular carcinoma (HCC), promoting matrix stiffness-driven angiogenesis through Ca2+ influx and HIF-1α ubiquitination.
CANCER COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Zheng Peng, Meng Hao, Haibo Tong, Hongmei Yang, Bin Huang, Zhigang Zhang, Kathy Qian Luo
Summary: This study investigates the heterotypic intercellular interactions between liver cancer cells and fibroblasts and identifies fibronectin and integrin-??5??1 as key regulatory molecules in promoting liver cancer cell growth. The study also finds that the upregulation of fibronectin, integrin-??5, and integrin-??1 is associated with microvascular invasion in HCC tumors.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jihun Song, Gun-Jae Jeong, Tae-Jin Lee, Sung-Won Kim, Yu-Jin Kim, Suk Ho Bhang
Summary: A new method of delivering ECMs-enriched human adipose derived stem cells using a novel polymer significantly improved therapeutic angiogenesis in ischemic wound sites, enhancing blood flow and blood vessel regeneration in mouse models compared to traditional enzyme-based methods.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yaru Guo, Siqin Ma, Mingming Xu, Yan Wei, Xuehui Zhang, Ying Huang, Ying He, Boon Chin Heng, Lili Chen, Xuliang Deng
Summary: Angiogenesis is crucial in tissue engineering and regenerative medicine, and the interplay between ECs and the ECM plays a significant role in tip cell specification. HtrA3 protein is shown to be involved in this process, promoting tip cell morphogenesis through ECM degradation and integrin beta 1-related signaling pathways. This study suggests that HtrA3 could potentially serve as a therapeutic agent for enhancing angiogenesis and targeting pathological angiogenesis.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Mariela Puebla, Pablo J. Tapia, Hilda Espinoza
Summary: This review focuses on the role of astrocytes in angiogenesis, highlighting their function as scaffolds and stabilizing factors, as well as the phenotypic differences in glioblastoma. Understanding the interaction between endothelial cells and astrocytes is crucial for comprehending the process of angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Yaru Guo, Feng Mei, Ying Huang, Siqin Ma, Yan Wei, Xuehui Zhang, Mingming Xu, Ying He, Boon Chin Heng, Lili Chen, Xuliang Deng
Summary: This study demonstrates that matrix stiffness promotes sprouting of endothelial cells and regulates the formation of tip cells through a specific signaling axis. The findings have significant implications for biomaterial design and treatment of pathological conditions.
BIOACTIVE MATERIALS
(2022)
Article
Urology & Nephrology
Min He, Yanhua Wu, Zhen Xie, Zhilian Li, Li Hao, Guohui Liu, Qiang He, Yuanjiang Liao, Rizwangul Ghappar, Hongwei Peng, Jinglie Xie, Xiaohong Wei, Yusheng Zhang, Qiongyi Huang, Yuanhan Chen, Xinling Liang
Summary: Pesticide intoxication is a major risk factor for acute kidney injury, with herbicides posing the greatest risk. Severe renal disease is associated with AKI. Different categories of pesticides result in varying degrees of AKI, which significantly increase in-hospital mortality rates.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Genetics & Heredity
Guoqing Li, Xi Yang, Lingbo Wang, Yuncheng Pan, Siyuan Chen, Lingyue Shang, Yicheng Zhang, Yucheng Wu, Zixue Zhou, Qing Chen, Xue Zhang, Ling Zhang, Yingchen Wang, Jinsong Li, Li Jin, Yanhua Wu, Xiaojin Zhang, Feng Zhang
Summary: The study found an association between NHEJ1 haploinsufficiency and POI, potentially leading to ovarian insufficiency. Through research on familial and sporadic cases, as well as validation in a mouse model, the importance of the NHEJ1 gene in POI was revealed.
JOURNAL OF MEDICAL GENETICS
(2022)
Article
Geriatrics & Gerontology
Wei Liu, Xing-ji Lian, Yuan-han Chen, Yi-ping Zou, Jie-shan Lin, Yan-hua Wu, Feng Yu, Wen-xue Hu, Wen-ke Hao
Summary: The study found that among older hospitalized patients, the incidence of HA-AKI was high, with severity correlating with worse in-hospital outcomes and higher resource utilization. HA-AKI incidence and exposure to nephrotoxic drugs were associated with an increased risk of in-hospital mortality.
Article
Urology & Nephrology
Yuanhan Chen, Yanhua Wu, Penghua Hu, Xia Fu, Shuangxin Liu, Li Song, Wei Dong, Xueqing Yu, Xinling Liang
Summary: During the COVID-19 pandemic, the psychological status of patients and medical staff in hemodialysis centers in Guangdong province was not significantly affected. The implementation of comprehensive preventative measures prevented cluster outbreaks of COVID-19 in these centers. This survey may offer guidance for other regions facing a similar situation.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Pathology
Yueqi Wang, Yanhua Wu, Jing Jiang, Yangyu Zhang, Yingli Fu, Min Zheng, Xuerong Tao, Jiaxin Yi, Dongmei Mu, Xueyuan Cao
Summary: This meta-analysis explored the association between bromodomain protein 4 expression and patient prognosis, and found that high expression of bromodomain protein 4 is associated with lymph node and distant metastasis, advanced TNM stage, poorly differentiated tumors, and shorter overall survival time.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Spectroscopy
Wei Zhang, Yanhua Wu, Xin Liu, Yibing Liu, Yue Zhang, Wei Wang, Xiaowei Mu, Rui Su, Ying Sun, Daqian Song, Xinghua Wang
Summary: A universal ratiometric fluorescence and colorimetric dual-mode sensing platform based on iron and nitrogen co-doped carbon dots (Fe/N-CDs) has been developed for detecting hydrogen peroxide (H2O2) and related metabolites in human fluid. The platform demonstrated excellent selectivity and sensitivity towards H2O2, xanthine, and uric acid, making it a potential tool for monitoring H2O2 metabolism in the human body.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Cell Biology
Yanhua Wu, Khizar Hayat, Yufei Hu, Jianfeng Yang
Summary: This review examines recent research on the role of lncRNAs in the progression of cholangiocarcinoma and their potential as promising clinical biomarkers and therapeutic targets for this type of cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Ying-Li Fu, Yan-Hua Wu, Dong-Hui Cao, Zhi-Fang Jia, Ao Shen, Jing Jiang, Xue-Yuan Cao
Summary: This study explored the association between 5-hmC levels and the progression and prognosis of gastric cancer (GC) patients with or without H. pylori infection. The results showed that high levels of 5-hmC were a favorable prognostic factor in GC patients, especially in H. pylori-negative subgroups.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Genetics & Heredity
Lingyue Shang, Shuting Ren, Xi Yang, Feng Zhang, Li Jin, Xiaojin Zhang, Yanhua Wu
Summary: This study identified two rare EIF4ENIF1 variants in two sporadic Han Chinese POI patients, providing insights into genetic counseling and suggesting the contribution of EIF4ENIF1 variants in female infertility.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2022)
Article
Environmental Sciences
Jiawen Ji, Jinze Huang, Niannian Cao, Xianghong Hao, Yanhua Wu, Yongqiang Ma, Dong An, Sen Pang, Xuefeng Li
Summary: This study investigated the toxic effects of 6PPD and its metabolites on adult zebrafish using machine vision. Abnormal behaviors induced by 6PPD and its metabolites were observed and analyzed using meandering, body angle, top time, and 3D trajectory. Changes in neurotransmitters were also measured to explore the causes of abnormal behavior. The study provides important insights into the biological toxicity of 6PPD and its metabolites.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biotechnology & Applied Microbiology
Donghui Cao, Tongrong Su, Yanhua Wu, Zhifang Jia, Yingli Fu, Yuanlin Sun, Meishan Jin, Yueqi Wang, Jiaxin Yi, Yingnan Cui, Yuzheng Zhang, Haiyong Lv, Limei Qu, Jing Jiang, Xueyuan Cao
Summary: This study found that PTEN expression was downregulated in gastric tumors and was associated with clinical characteristics such as histological grade and invasion depth. High PTEN expression was positively correlated with PD-L1 expression in gastric cancer. The results suggest that PTEN expression may serve as a useful marker for gastric cancer progression and the selection of immunotherapy-based treatments.
ONCOTARGETS AND THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Zhiming Mo, Penghua Hu, Zhiyong Xie, Yanhua Wu, Zhilian Li, Lei Fu, Yuanhan Chen, Xinling Liang, Huaban Liang, Wei Dong
Summary: The ACEF II score has value in predicting in-hospital death and AKI-D in Chinese patients undergoing cardiac surgery. It performs similarly to the ACEF score in predicting in-hospital death in elective surgery, but has better predictive ability in non-elective surgery.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Nutrition & Dietetics
Yuzheng Zhang, Yanhua Wu, Yangyu Zhang, Donghui Cao, Hua He, Xueyuan Cao, Yuehui Wang, Zhifang Jia, Jing Jiang
Summary: Higher levels of dietary inflammation are associated with increased risks of depression and mortality. This study found a positive association between the energy-adjusted DII score and depression risk, as well as an increased risk of all-cause and cardiovascular disease-related mortality in relation to higher DII scores and depressive symptoms. However, these associations were not significant among cancer survivors.
FRONTIERS IN NUTRITION
(2022)
Article
Urology & Nephrology
Fangxiao Xia, Wenke Hao, Jinxiu Liang, Zhi Zhao, Yanhua Wu, Feng Yu, Wenxue Hu, Xiaowu Fang, Wei Liu
Summary: This study aimed to evaluate the accuracy of eleven GFR equations in different subgroups of an elderly Chinese hospitalized population and found that the BIS2 and FAS(Cr-Cys) equations might be the best choice to evaluate glomerular filtration rate in Chinese elderly patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Virology
Zi-Da Zhen, Na Wu, Dong-Ying Fan, Jun-Hong Ai, Zheng-Ran Song, Jia-Tong Chang, Pei-Gang Wang, Yan-Hua Wu, Jing An
Summary: Zika virus infection can lead to microcephaly and neurological symptoms, early administration of growth hormone can improve cognitive function in mice, and growth hormone effectively reduces brain damage by decreasing cell apoptosis and inflammatory response instead of inhibiting viral replication.
