Targeting ASK1 in ER stress-related neurodegenerative diseases

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

(2008) H. Nishitoh et al.   GENES & DEVELOPMENT

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

(2008) M. L. Duennwald et al.   GENES & DEVELOPMENT

Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage

(2008) Takuya Noguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1

(2008) InKi Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ASK1 and MAP2K6 as modifiers of age at onset in Huntington’s disease

(2008) Larissa Arning et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family

(2008) H M Heath-Engel et al.   ONCOGENE

ERdj5 Is Required as a Disulfide Reductase for Degradation of Misfolded Proteins in the ER

(2008) R. Ushioda et al.   SCIENCE